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Volumn 3, Issue , 2002, Pages 179-198

Genetics of myeloid leukemias

Author keywords

Chromosomal translocations; Hematopoiesis; Hematopoietic transcription factors; Myelodysplastic syndrome; Tyrosine kinases

Indexed keywords

BCR ABL PROTEIN; FLT3 LIGAND; IMATINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; TRANSCRIPTION FACTOR;

EID: 0036406845     PISSN: 15278204     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genom.3.032802.115046     Document Type: Review
Times cited : (454)

References (106)
  • 1
    • 0033758958 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
    • Abu-Duhier F, Goodeve A, Wilson G, Gari M, Peake I, et al. 2000. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Br. J. Haematol. 111:190-95
    • (2000) Br. J. Haematol. , vol.111 , pp. 190-195
    • Abu-Duhier, F.1    Goodeve, A.2    Wilson, G.3    Gari, M.4    Peake, I.5
  • 4
    • 0034817075 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds msin3a through its oligomerization domain
    • Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, et al. 2001. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds msin3a through its oligomerization domain. Mol. Cell. Biol. 21:6470-83
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6470-6483
    • Amann, J.M.1    Nip, J.2    Strom, D.K.3    Lutterbach, B.4    Harada, H.5
  • 5
    • 0033014304 scopus 로고    scopus 로고
    • RAS and leukemia: From basic mechanisms to gene-directed therapy
    • Beaupre DM, Kurzrock R. 1999. RAS and leukemia: From basic mechanisms to gene-directed therapy. J. Clin. Oncol. 17:1071-79
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1071-1079
    • Beaupre, D.M.1    Kurzrock, R.2
  • 6
    • 0034086061 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
    • Binns KL, Taylor PP, Sicheri F, Pawson T, Holland SJ. 2000. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol. Cell. Biol. 20:4791-805
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4791-4805
    • Binns, K.L.1    Taylor, P.P.2    Sicheri, F.3    Pawson, T.4    Holland, S.J.5
  • 7
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S, Buchdunger E, Zimmermann J, et al. 1997. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 90:4947-52
    • (1997) Blood , vol.90 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3    Buchdunger, E.4    Zimmermann, J.5
  • 8
    • 0033625358 scopus 로고    scopus 로고
    • The TEL/PDGFβR fusion protein activates STAT 1 and 5: A common mechanism for transformation by tyrosine kinase fusion proteins
    • Palmer AM, Mahajan S, Frank D, Druker BJ, et al. 2000. The TEL/PDGFβR fusion protein activates STAT 1 and 5: A common mechanism for transformation by tyrosine kinase fusion proteins. Exp. Hematol. 28:584-93
    • (2000) Exp. Hematol. , vol.28 , pp. 584-593
    • Palmer, A.M.1    Mahajan, S.2    Frank, D.3    Druker, B.J.4
  • 9
    • 0032878921 scopus 로고    scopus 로고
    • The fusion gene CbfB blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia
    • Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, et al. 1999. The fusion gene CbfB blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia. Nat. Genet. 23:144-46
    • (1999) Nat. Genet. , vol.23 , pp. 144-146
    • Castilla, L.H.1    Garrett, L.2    Adya, N.3    Orlic, D.4    Dutra, A.5
  • 10
    • 16144362555 scopus 로고    scopus 로고
    • Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
    • Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, et al. 1996. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell 87:687-96
    • (1996) Cell , vol.87 , pp. 687-696
    • Castilla, L.H.1    Wijmenga, C.2    Wang, Q.3    Stacy, T.4    Speck, N.A.5
  • 11
    • 0034893157 scopus 로고    scopus 로고
    • The role of promyelocytic zinc finger and promyelocytic leukemia in leukemogenesis and development
    • Costoya JA, Pandolfi PP. 2001. The role of promyelocytic zinc finger and promyelocytic leukemia in leukemogenesis and development. Curr. Opin. Hematol. 8:212-17
    • (2001) Curr. Opin. Hematol. , vol.8 , pp. 212-217
    • Costoya, J.A.1    Pandolfi, P.P.2
  • 12
    • 0034652210 scopus 로고    scopus 로고
    • Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for human AML
    • Cuenco GM, Nucifora G, Ren R. 2000. Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for human AML. Proc. Natl. Acad. Sci. USA 97:1760-65
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1760-1765
    • Cuenco, G.M.1    Nucifora, G.2    Ren, R.3
  • 14
    • 0034868659 scopus 로고    scopus 로고
    • Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia
    • Druker B. 2001. Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia. Semin. Hematol. 38:9-14
    • (2001) Semin. Hematol. , vol.38 , pp. 9-14
    • Druker, B.1
  • 15
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, et al. 2001. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344:1038-42
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5
  • 16
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, et al. 2001. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344:1031-37
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5
  • 17
    • 0026757174 scopus 로고
    • Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson P, Gao J, Chang KS, Look T, Whisenant E, et al. 1992. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825-31
    • (1992) Blood , vol.80 , pp. 1825-1831
    • Erickson, P.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5
  • 18
    • 0035379034 scopus 로고    scopus 로고
    • Chromosome and molecular abnormalities in myelodysplastic syndromes
    • Fenaux P. 2001. Chromosome and molecular abnormalities in myelodysplastic syndromes. Int. J. Hematol. 73:429-37
    • (2001) Int. J. Hematol. , vol.73 , pp. 429-437
    • Fenaux, P.1
  • 19
    • 0032873462 scopus 로고    scopus 로고
    • Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein
    • Fenrick R, Amann JM, Lutterbach B, Wang L, Westendorf JJ, et al. 1999. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol. Cell. Biol. 19:6566-74
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6566-6574
    • Fenrick, R.1    Amann, J.M.2    Lutterbach, B.3    Wang, L.4    Westendorf, J.J.5
  • 20
    • 0000796896 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
    • Fenski R, Flesch K, Serve S, Mizuki M, Oelmann E, et al. 2000. Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells. Br. J. Haematol. 108:322-30
    • (2000) Br. J. Haematol. , vol.108 , pp. 322-330
    • Fenski, R.1    Flesch, K.2    Serve, S.3    Mizuki, M.4    Oelmann, E.5
  • 22
    • 0029616633 scopus 로고
    • The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
    • Frank R, Zhang J, Uchida H, Meyers S, Hiebert SW, Nimer SD. 1995. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 11:2667-74
    • (1995) Oncogene , vol.11 , pp. 2667-2674
    • Frank, R.1    Zhang, J.2    Uchida, H.3    Meyers, S.4    Hiebert, S.W.5    Nimer, S.D.6
  • 23
    • 79960970901 scopus 로고    scopus 로고
    • FLT3 internal tandem duplications and survival in adult acute myeloid leukemia: Analysis of 188 intensively treated patients
    • Frohling S, Breitruck J, Schlenk R, Kreitmeier S, Tobis K, et al. 2001. FLT3 internal tandem duplications and survival in adult acute myeloid leukemia: Analysis of 188 intensively treated patients. Blood 89:717a
    • (2001) Blood , vol.89
    • Frohling, S.1    Breitruck, J.2    Schlenk, R.3    Kreitmeier, S.4    Tobis, K.5
  • 24
    • 0031723957 scopus 로고    scopus 로고
    • Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia partner ETO
    • Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, Lazar MA. 1998. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia partner ETO. Mol. Cell. Biol. 18:7185-91
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7185-7191
    • Gelmetti, V.1    Zhang, J.2    Fanelli, M.3    Minucci, S.4    Pelicci, P.G.5    Lazar, M.A.6
  • 27
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG. 1994. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307-16
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 28
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, et al. 2001. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293:876-80
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5
  • 29
    • 4244188890 scopus 로고    scopus 로고
    • Point mutations in the FLT3 gene in AML
    • Griffin JD. 2001. Point mutations in the FLT3 gene in AML. Blood 97:2193A
    • (2001) Blood , vol.97
    • Griffin, J.D.1
  • 30
    • 0031033221 scopus 로고    scopus 로고
    • Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences
    • Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. 1997. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood 89:376-87
    • (1997) Blood , vol.89 , pp. 376-387
    • Grisolano, J.L.1    Wesselschmidt, R.L.2    Pelicci, P.G.3    Ley, T.J.4
  • 31
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated FLT3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, et al. 2000. Tandem-duplicated FLT3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19:624-31
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5
  • 32
    • 0035189761 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
    • He LZ, Tolentino T, Grayson P, Zhong S, Warrell RP Jr, et al. 2001. Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. J. Clin. Invest. 108:1321-30
    • (2001) J. Clin. Invest. , vol.108 , pp. 1321-1330
    • He, L.Z.1    Tolentino, T.2    Grayson, P.3    Zhong, S.4    Warrell R.P., Jr.5
  • 33
    • 9044231364 scopus 로고    scopus 로고
    • The t(12;21) converts AML-1B from an activator to a repressor of transcription
    • Hiebert SW, Sun W, Davis JN, Golub TR, Shurtleff S, et al. 1996. The t(12;21) converts AML-1B from an activator to a repressor of transcription. Mol. Cell. Biol. 16:1349-55
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1349-1355
    • Hiebert, S.W.1    Sun, W.2    Davis, J.N.3    Golub, T.R.4    Shurtleff, S.5
  • 34
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
    • Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh E-J, Downing JR. 2002. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1:63-74
    • (2002) Cancer Cell , vol.1 , pp. 63-74
    • Higuchi, M.1    O'Brien, D.2    Kumaravelu, P.3    Lenny, N.4    Yeoh, E.-J.5    Downing, J.R.6
  • 35
    • 16944366584 scopus 로고    scopus 로고
    • Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
    • Horiike S, Yokota S, Nakao M, Iwai T, Sasai Y, et al. 1997. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia 11:1442-46
    • (1997) Leukemia , vol.11 , pp. 1442-1446
    • Horiike, S.1    Yokota, S.2    Nakao, M.3    Iwai, T.4    Sasai, Y.5
  • 36
    • 0034332068 scopus 로고    scopus 로고
    • Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis
    • Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Takeuchi K, et al. 2000. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis. Blood 96:3154-60
    • (2000) Blood , vol.96 , pp. 3154-3160
    • Imai, Y.1    Kurokawa, M.2    Izutsu, K.3    Hangaishi, A.4    Takeuchi, K.5
  • 37
    • 0032843305 scopus 로고    scopus 로고
    • High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells
    • Ishii E, Zaitsu M, Ihara K, Hara T, Miyazaki S. 1999. High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells. Pediatr. Hematol. Oncol. 16:437-41
    • (1999) Pediatr. Hematol. Oncol. , vol.16 , pp. 437-441
    • Ishii, E.1    Zaitsu, M.2    Ihara, K.3    Hara, T.4    Miyazaki, S.5
  • 38
    • 0030657013 scopus 로고    scopus 로고
    • Internal tandem duplication in the juxtatransmembrane domain of the FLT3 is not involved in blastic crisis of chronic myeloid leukemia
    • Iwai T, Yokota S, Nakao M, Kaneko H, Nakai H, et al. 1997. Internal tandem duplication in the juxtatransmembrane domain of the FLT3 is not involved in blastic crisis of chronic myeloid leukemia. Leukemia 11:1992-93
    • (1997) Leukemia , vol.11 , pp. 1992-1993
    • Iwai, T.1    Yokota, S.2    Nakao, M.3    Kaneko, H.4    Nakai, H.5
  • 39
    • 0032931560 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia
    • The Children's Cancer and Leukemia Study Group, Japan
    • Iwai T, Yokota S, Nakao M, Okamoto T, Taniwaki M, et al. 1999. Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan. Leukemia 13:38-43
    • (1999) Leukemia , vol.13 , pp. 38-43
    • Iwai, T.1    Yokota, S.2    Nakao, M.3    Okamoto, T.4    Taniwaki, M.5
  • 40
    • 0035001987 scopus 로고    scopus 로고
    • Coduplication of the MLL and FLT3 genes in patients with acute myeloid leukemia
    • Jamal R, Taketani T, Taki T, Bessho F, Hongo T, et al. 2001. Coduplication of the MLL and FLT3 genes in patients with acute myeloid leukemia. Genes Chromosomes Cancer 31:187-90
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 187-190
    • Jamal, R.1    Taketani, T.2    Taki, T.3    Bessho, F.4    Hongo, T.5
  • 41
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, et al. 2001. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N. Engl. J. Med. 344:1052-56
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3    Andersson, L.C.4    Tervahartiala, P.5
  • 42
    • 0034846550 scopus 로고    scopus 로고
    • Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies
    • Karp JE. 2001. Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies. Semin. Hematol. 38:16-23
    • (2001) Semin. Hematol. , vol.38 , pp. 16-23
    • Karp, J.E.1
  • 43
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. 2002. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood 99:310-18
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3    Williams, I.R.4    Boulton, C.L.5    Gilliland, D.G.6
  • 44
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, et al. 1999. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 93:3074-80
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3    Yokota, S.4    Minami, S.5
  • 45
    • 16944362760 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
    • Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)
    • Kiyoi H, Naoe T, Yokota S, Nakao M, Minami S, et al. 1997. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia 11:1447-52
    • (1997) Leukemia , vol.11 , pp. 1447-1452
    • Kiyoi, H.1    Naoe, T.2    Yokota, S.3    Nakao, M.4    Minami, S.5
  • 46
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, et al. 1998. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 12:1333-37
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3    Hamaguchi, M.4    Ohno, R.5
  • 47
    • 0032757551 scopus 로고    scopus 로고
    • Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia
    • Kondo M, Horibe K, Takahashi Y, Matsumoto K, Fukuda M, et al. 1999. Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia. Med. Pediatr. Oncol. 33:525-29
    • (1999) Med. Pediatr. Oncol. , vol.33 , pp. 525-529
    • Kondo, M.1    Horibe, K.2    Takahashi, Y.3    Matsumoto, K.4    Fukuda, M.5
  • 48
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplications in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk greoup and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, et al. 2001. The presence of a FLT3 internal tandem duplications in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk greoup and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98:1752-59
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5
  • 49
    • 0011128172 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 50
    • 0027265454 scopus 로고
    • Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction
    • Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, et al. 1993. Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 82:1270-76
    • (1993) Blood , vol.82 , pp. 1270-1276
    • Kozu, T.1    Miyoshi, H.2    Shimizu, K.3    Maseki, N.4    Kaneko, Y.5
  • 51
    • 0035437140 scopus 로고    scopus 로고
    • A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
    • Levis M, Tse KF, Smith BD, Garrett E, Small D. 2001. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood 98:885-87
    • (2001) Blood , vol.98 , pp. 885-887
    • Levis, M.1    Tse, K.F.2    Smith, B.D.3    Garrett, E.4    Small, D.5
  • 52
    • 79960971028 scopus 로고    scopus 로고
    • FLT3-targeted inhibitors kill FLT3-dependent modeled cells, leukemia-derived cell lines, and primary AML blasts in vitro and in vivo
    • Levis MJ, Allebach J, Tse KF, Zheng R, Baldwin BR, et al. 2001. FLT3-targeted inhibitors kill FLT3-dependent modeled cells, leukemia-derived cell lines, and primary AML blasts in vitro and in vivo. Blood 89:721a
    • (2001) Blood , vol.89
    • Levis, M.J.1    Allebach, J.2    Tse, K.F.3    Zheng, R.4    Baldwin, B.R.5
  • 53
    • 0027373893 scopus 로고
    • Fusion between transcription factor CBFB/PEBP2B and a myosin heavy chain in acute myeloid leukemia
    • Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, et al. 1993. Fusion between transcription factor CBFB/PEBP2B and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-44
    • (1993) Science , vol.261 , pp. 1041-1044
    • Liu, P.1    Tarle, S.A.2    Hajra, A.3    Claxton, D.F.4    Marlton, P.5
  • 54
    • 0033607165 scopus 로고    scopus 로고
    • The inv(16) encodes an acute myeloid leukemia 1 transcriptional core-pressor
    • Lutterbach B, Hou Y, Durst KL, Hiebert SW. 1999. The inv(16) encodes an acute myeloid leukemia 1 transcriptional core-pressor. Proc. Natl. Acad. Sci. USA 96:12822-27
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12822-12827
    • Lutterbach, B.1    Hou, Y.2    Durst, K.L.3    Hiebert, S.W.4
  • 55
    • 0034614382 scopus 로고    scopus 로고
    • A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
    • Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW. 2000. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J. Biol. Chem. 275:651-56
    • (2000) J. Biol. Chem. , vol.275 , pp. 651-656
    • Lutterbach, B.1    Westendorf, J.J.2    Linggi, B.3    Isaac, S.4    Seto, E.5    Hiebert, S.W.6
  • 56
    • 0031724804 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
    • Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, et al. 1998. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol. Cell. Biol. 18:7176-84
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7176-7184
    • Lutterbach, B.1    Westendorf, J.J.2    Linggi, B.3    Patten, A.4    Moniwa, M.5
  • 57
    • 0034548852 scopus 로고    scopus 로고
    • AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc-finger protein
    • Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. 2000. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc-finger protein. Blood 96:3939-47
    • (2000) Blood , vol.96 , pp. 3939-3947
    • Melnick, A.1    Carlile, G.W.2    McConnell, M.J.3    Polinger, A.4    Hiebert, S.W.5    Licht, J.D.6
  • 58
    • 0033997967 scopus 로고    scopus 로고
    • The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
    • Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, et al. 2000. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 20:2075-86
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2075-2086
    • Melnick, A.M.1    Westendorf, J.J.2    Polinger, A.3    Carlile, G.W.4    Arai, S.5
  • 59
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of FLT3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, Sweetser DA, Buckley JD, et al. 2001. Prevalence and prognostic significance of FLT3 internal tandem duplication in pediatric acute myeloid leukemia. Blood 97:89-94
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3    Sweetser, D.A.4    Buckley, J.D.5
  • 60
    • 0028925282 scopus 로고
    • The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
    • Meyers S, Lenny N, Hiebert SW. 1995. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol. Cell. Biol. 15:1974-82
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1974-1982
    • Meyers, S.1    Lenny, N.2    Hiebert, S.W.3
  • 61
    • 0037082499 scopus 로고    scopus 로고
    • In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: Implications for mechanisms of pathogenesis
    • Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, et al. 2002. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: Implications for mechanisms of pathogenesis. Blood 99:1364-72
    • (2002) Blood , vol.99 , pp. 1364-1372
    • Michaud, J.1    Wu, F.2    Osato, M.3    Cottles, G.M.4    Yanagida, M.5
  • 62
    • 0034554796 scopus 로고    scopus 로고
    • FLT3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, et al. 2000. FLT3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 96:3907-14
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3    Matsumura, I.4    Schmidt, R.5
  • 63
    • 0033043084 scopus 로고    scopus 로고
    • Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene
    • Nakano Y, Kiyoi H, Miyawaki S, Asou N, Ohno R, et al. 1999. Molecular evolution of acute myeloid leukaemia in relapse: Unstable N-ras and FLT3 genes compared with p53 gene. Br. J. Haematol. 104:659-64
    • (1999) Br. J. Haematol. , vol.104 , pp. 659-664
    • Nakano, Y.1    Kiyoi, H.2    Miyawaki, S.3    Asou, N.4    Ohno, R.5
  • 64
    • 0034009375 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia, a marker for the monitoring of minimal residual disease
    • Nakao M, Janssen J, Erz D, Seriu T, Bartram C. 2000. Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia, a marker for the monitoring of minimal residual disease. Leukemia 14:522-24
    • (2000) Leukemia , vol.14 , pp. 522-524
    • Nakao, M.1    Janssen, J.2    Erz, D.3    Seriu, T.4    Bartram, C.5
  • 65
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, et al. 1996. Internal tandem duplication of the FLT3 gene found in acute myeloid leukemia. Leukemia 10:1911-18
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3    Kaneko, H.4    Horiike, S.5
  • 67
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • Neubauer A, Dodge RK, George SL, Davey FR, Silver RT, et al. 1994. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood 83:1603-11
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3    Davey, F.R.4    Silver, R.T.5
  • 68
    • 0028210052 scopus 로고
    • Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes
    • Neubauer A, Greenberg P, Negrin R, Ginzton N, Liu E. 1994. Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes. Leukemia 8:638-41
    • (1994) Leukemia , vol.8 , pp. 638-641
    • Neubauer, A.1    Greenberg, P.2    Negrin, R.3    Ginzton, N.4    Liu, E.5
  • 69
    • 79960971309 scopus 로고    scopus 로고
    • D835 mutations are commonly associated with other molecular lesions in adult AML
    • Nomdedeu JF, Brunet S, Colomer D, Estivill C, Llorente J, et al. 2001. D835 mutations are commonly associated with other molecular lesions in adult AML. Blood 89:579a
    • (2001) Blood , vol.89
    • Nomdedeu, J.F.1    Brunet, S.2    Colomer, D.3    Estivill, C.4    Llorente, J.5
  • 70
    • 0032079424 scopus 로고    scopus 로고
    • Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors
    • Okuda T, Cai Z, Yang S, Lenny N, Lyu CJ, et al. 1998. Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood 91:3134-43
    • (1998) Blood , vol.91 , pp. 3134-3143
    • Okuda, T.1    Cai, Z.2    Yang, S.3    Lenny, N.4    Lyu, C.J.5
  • 71
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-30
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 72
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias
    • Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, et al. 1999. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 93:1817-24
    • (1999) Blood , vol.93 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3    Hoshino, K.4    Yamasaki, H.5
  • 73
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia
    • Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, et al. 2001. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat. Med. 7:444-51
    • (2001) Nat. Med. , vol.7 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3    Schoch, C.4    Haferlach, T.5
  • 74
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, et al. 2001. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat. Genet. 27:263-70
    • (2001) Nat. Genet. , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5
  • 75
    • 0001790293 scopus 로고    scopus 로고
    • Histone deacetylases and transcriptional therapy with their inhibitors
    • Pandolfi PP. 2001. Histone deacetylases and transcriptional therapy with their inhibitors. Cancer Chemother. Pharmacol. 48:S17-19
    • (2001) Cancer Chemother. Pharmacol. , vol.48
    • Pandolfi, P.P.1
  • 76
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the famesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
    • Peters DG, Hoover RR, Gerlach MJ, Koh EY, Zhang H, et al. 2001. Activity of the famesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood 97:1404-12
    • (2001) Blood , vol.97 , pp. 1404-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3    Koh, E.Y.4    Zhang, H.5
  • 79
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, et al. 2000. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 96:2862-69
    • (2000) Blood , vol.96 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3    Grardel-Duflos, N.4    Garand, R.5
  • 80
    • 0029045087 scopus 로고
    • The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion
    • Romana SP, Mauchauffe M, Leconiat M, Chumakov I, Le Paslier D, et al. 1995. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662-70
    • (1995) Blood , vol.85 , pp. 3662-3670
    • Romana, S.P.1    Mauchauffe, M.2    Leconiat, M.3    Chumakov, I.4    Le Paslier, D.5
  • 81
    • 0034040255 scopus 로고    scopus 로고
    • Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the FLT3 gene
    • Rombouts WJ, Blokland I, Lowenberg B, Ploemacher RE. 2000. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the FLT3 gene. Leukemia 14:675-83
    • (2000) Leukemia , vol.14 , pp. 675-683
    • Rombouts, W.J.1    Blokland, I.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 82
    • 0033639119 scopus 로고    scopus 로고
    • Stat5a/b is essential for the myelo- and lymphoproliferative disease indcued by TEL/JAK2
    • Schwaller J, Parganas E, Wang D, Cain D, Aster JC, et al. 2000. Stat5a/b is essential for the myelo- and lymphoproliferative disease indcued by TEL/JAK2. Mol. Cell 6:693-704
    • (2000) Mol. Cell , vol.6 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3    Cain, D.4    Aster, J.C.5
  • 83
  • 84
    • 0034665676 scopus 로고    scopus 로고
    • Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5
    • Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown MP, et al. 2000. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96:2277-83
    • (2000) Blood , vol.96 , pp. 2277-2283
    • Sexl, V.1    Piekorz, R.2    Moriggl, R.3    Rohrer, J.4    Brown, M.P.5
  • 85
    • 0032830638 scopus 로고    scopus 로고
    • Haploin-sufficiency of CBFA2(AML1) causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia (FPD/AML)
    • Song W-J, Sullivan MG, Legare RD, Hutchings S, Tan X, et al. 1999. Haploin-sufficiency of CBFA2(AML1) causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia (FPD/AML). Nat. Genet. 23:166-75
    • (1999) Nat. Genet. , vol.23 , pp. 166-175
    • Song, W.-J.1    Sullivan, M.G.2    Legare, R.D.3    Hutchings, S.4    Tan, X.5
  • 86
    • 0033118155 scopus 로고    scopus 로고
    • Core-binding factor: A central player in hematopoiesis and leukemia
    • Speck NA, Stacy T, Wang Q, North T, Gu TL, et al. 1999. Core-binding factor: A central player in hematopoiesis and leukemia. Cancer Res. 59 (Suppl.):1789-93
    • (1999) Cancer Res. , vol.59 , Issue.SUPPL. , pp. 1789-1793
    • Speck, N.A.1    Stacy, T.2    Wang, Q.3    North, T.4    Gu, T.L.5
  • 87
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, Appelbaum FR, Slovak ML, et al. 2001. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97:3589-95
    • (2001) Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3    Appelbaum, F.R.4    Slovak, M.L.5
  • 88
    • 0034330931 scopus 로고    scopus 로고
    • Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl-positive cells
    • Theising J, Ohno-Jones S, Kolibaba K, Druker B. 2000. Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl-positive cells. Blood 96:3195-99
    • (2000) Blood , vol.96 , pp. 3195-3199
    • Theising, J.1    Ohno-Jones, S.2    Kolibaba, K.3    Druker, B.4
  • 89
    • 79960970496 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 713 patients with acute myelogenous leukemia (AML): High prevalence in FAB-subtype M5 and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, Schaich M, Schaekel U, et al. 2001. Analysis of FLT3-activating mutations in 713 patients with acute myelogenous leukemia (AML): High prevalence in FAB-subtype M5 and identification of subgroups with poor prognosis. Blood 89:717a
    • (2001) Blood , vol.89
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schaekel, U.5
  • 90
    • 0033084227 scopus 로고    scopus 로고
    • TEL/PDGFβR induces hematologic malignancy in mice that responds to the tyrosine kinase inhibitor CGP57148
    • Tomasson MH, Williams IR, Hasserjian R, Udomsakdi C, McGrath SM, et al. 1999. TEL/PDGFβR induces hematologic malignancy in mice that responds to the tyrosine kinase inhibitor CGP57148. Blood 93:1707-14
    • (1999) Blood , vol.93 , pp. 1707-1714
    • Tomasson, M.H.1    Williams, I.R.2    Hasserjian, R.3    Udomsakdi, C.4    McGrath, S.M.5
  • 91
    • 0034895025 scopus 로고    scopus 로고
    • Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor
    • Tse KF, Novelli E, Civin CI, Bohmer FD, Small D. 2001. Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor. Leukemia 15:1001-10
    • (2001) Leukemia , vol.15 , pp. 1001-1010
    • Tse, K.F.1    Novelli, E.2    Civin, C.I.3    Bohmer, F.D.4    Small, D.5
  • 92
    • 0035927591 scopus 로고    scopus 로고
    • TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3
    • Wang L, Hiebert SW. 2001. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Oncogene 20:3716-25
    • (2001) Oncogene , vol.20 , pp. 3716-3725
    • Wang, L.1    Hiebert, S.W.2
  • 93
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    • Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. 1996. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl. Acad. Sci. USA 93:3444-49
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3444-3449
    • Wang, Q.1    Stacy, T.2    Binder, M.3    Marin-Padilla, M.4    Sharpe, A.H.5    Speck, N.A.6
  • 94
    • 0032493859 scopus 로고    scopus 로고
    • Switching signals on or off by receptor dimerization
    • Weiss A, Schlessinger J. 1998. Switching signals on or off by receptor dimerization. Cell 94:277-80
    • (1998) Cell , vol.94 , pp. 277-280
    • Weiss, A.1    Schlessinger, J.2
  • 95
    • 0031972701 scopus 로고    scopus 로고
    • The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription and blocks granulocytic differentiation
    • Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME, Hiebert SW. 1998. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription and blocks granulocytic differentiation. Mol. Cell. Biol. 18:322-33
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 322-333
    • Westendorf, J.J.1    Yamamoto, C.M.2    Lenny, N.3    Downing, J.R.4    Selsted, M.E.5    Hiebert, S.W.6
  • 96
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, Baldus C, Becknell B, et al. 2001. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study. Cancer Res. 61:7233-39
    • (2001) Cancer Res. , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3    Baldus, C.4    Becknell, B.5
  • 98
    • 0035929146 scopus 로고    scopus 로고
    • Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region
    • Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F. 2001. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell 106:745-57
    • (2001) Cell , vol.106 , pp. 745-757
    • Wybenga-Groot, L.E.1    Baskin, B.2    Ong, S.H.3    Tong, J.4    Pawson, T.5    Sicheri, F.6
  • 99
    • 0034012655 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is infrequent in infant acute leukemia
    • Japan Infant Leukemia Study Group
    • Xu F, Taki T, Eguchi M, Kamada N, Ishii E, et al. 2000. Tandem duplication of the FLT3 gene is infrequent in infant acute leukemia. Japan Infant Leukemia Study Group. Leukemia 14:945-47
    • (2000) Leukemia , vol.14 , pp. 945-947
    • Xu, F.1    Taki, T.2    Eguchi, M.3    Kamada, N.4    Ishii, E.5
  • 100
    • 0001097136 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
    • Xu F, Taki T, Yang H, Hanada R, Hongo T, et al. 1999. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br. J. Haematol. 105:155-62
    • (1999) Br. J. Haematol. , vol.105 , pp. 155-162
    • Xu, F.1    Taki, T.2    Yang, H.3    Hanada, R.4    Hongo, T.5
  • 101
    • 0011114603 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 102
    • 0034121993 scopus 로고    scopus 로고
    • Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome positive CML with t(7;11)(p15;p15)
    • Yamamoto K, Nakamura Y, Saito K, Furusawa S. 2000. Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome positive CML with t(7;11)(p15;p15). Br. J. Haematol. 109:423-26
    • (2000) Br. J. Haematol. , vol.109 , pp. 423-426
    • Yamamoto, K.1    Nakamura, Y.2    Saito, K.3    Furusawa, S.4
  • 103
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, et al. 2001. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 97:2434-39
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3    Suzuki, R.4    Kodera, Y.5
  • 104
    • 0031025416 scopus 로고    scopus 로고
    • Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene
    • Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, et al. 1997. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat. Genet. 15:303-6
    • (1997) Nat. Genet. , vol.15 , pp. 303-306
    • Yergeau, D.A.1    Hetherington, C.J.2    Wang, Q.3    Zhang, P.4    Sharpe, A.H.5
  • 105
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, Iwai T, Misawa S, et al. 1997. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia 11:1605-9
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3    Iwai, T.4    Misawa, S.5
  • 106
    • 0034700112 scopus 로고    scopus 로고
    • Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice
    • Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ. 2000. Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc. Natl. Acad. Sci. USA 97:13306-11
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13306-13311
    • Zimonjic, D.B.1    Pollock, J.L.2    Westervelt, P.3    Popescu, N.C.4    Ley, T.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.