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Volumn 108, Issue 2, 2006, Pages 669-677

Amurine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

Author keywords

[No Author keywords available]

Indexed keywords

MIXED LINEAGE LEUKEMIA PROTEIN; MLL AF4 FUSION PROTEIN, HUMAN; MLL AF9 FUSION PROTEIN, HUMAN; MLL-AF4 FUSION PROTEIN, HUMAN; MLL-AF9 FUSION PROTEIN, HUMAN; ONCOPROTEIN;

EID: 33745941911     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-08-3498     Document Type: Article
Times cited : (102)

References (52)
  • 1
    • 0025833975 scopus 로고
    • Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
    • U S A
    • Ziemin-van der Poel S, McCabe NR, Gill HJ, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A. 1991;88:10735-10739.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 10735-10739
    • Ziemin-van Der Poel, S.1    McCabe, N.R.2    Gill, H.J.3
  • 2
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene. 2001;20:5695-5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 3
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002;30:41-47.
    • (2002) Nat Genet , vol.30 , pp. 41-47
    • Armstrong, S.A.1    Staunton, J.E.2    Silverman, L.B.3
  • 4
    • 0027172909 scopus 로고
    • Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome
    • Chen CS, Sorensen PH, Domer PH, et al. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood. 1993;81:2386-2393.
    • (1993) Blood , vol.81 , pp. 2386-2393
    • Chen, C.S.1    Sorensen, P.H.2    Domer, P.H.3
  • 5
    • 0032831130 scopus 로고    scopus 로고
    • Mll rearrangements in haematological malignancies: Lessons from clinical and biological studies
    • Dimartino JF, Cleary ML. Mll rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol. 1999;106:614-626.
    • (1999) Br J Haematol , vol.106 , pp. 614-626
    • Dimartino, J.F.1    Cleary, M.L.2
  • 6
    • 0037954576 scopus 로고    scopus 로고
    • Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)
    • Hiwatari M, Taki T, Taketani T, et al. Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). Oncogene. 2003;22:2851-2855.
    • (2003) Oncogene , vol.22 , pp. 2851-2855
    • Hiwatari, M.1    Taki, T.2    Taketani, T.3
  • 7
    • 0028229442 scopus 로고
    • Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Rubnitz JE, Link MP, Shuster JJ, et al. Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood. 1994;84:570-573.
    • (1994) Blood , vol.84 , pp. 570-573
    • Rubnitz, J.E.1    Link, M.P.2    Shuster, J.J.3
  • 8
    • 0031918022 scopus 로고    scopus 로고
    • General Report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997
    • Secker-Walker LM. General Report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997. Leukemia. 1998;12:776-778.
    • (1998) Leukemia , vol.12 , pp. 776-778
    • Secker-Walker, L.M.1
  • 9
    • 0021948308 scopus 로고
    • Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics
    • Stong RC, Korsmeyer SJ, Parkin JL, Arthur DC, Kersey JH. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood. 1985;65:21-31.
    • (1985) Blood , vol.65 , pp. 21-31
    • Stong, R.C.1    Korsmeyer, S.J.2    Parkin, J.L.3    Arthur, D.C.4    Kersey, J.H.5
  • 10
    • 0033429143 scopus 로고    scopus 로고
    • AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
    • U S A
    • Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc Natl Acad Sci U S A. 1999;96:14535-14540.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 14535-14540
    • Taki, T.1    Kano, H.2    Taniwaki, M.3    Sako, M.4    Yanagisawa, M.5    Hayashi, Y.6
  • 11
    • 15844394270 scopus 로고    scopus 로고
    • An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J, Lavenir I, Impey H, et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell. 1996;85:853-861.
    • (1996) Cell , vol.85 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3
  • 12
    • 17044413548 scopus 로고    scopus 로고
    • The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
    • Daser A, Rabbitts TH. The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol. 2005;15:175-188.
    • (2005) Semin Cancer Biol , vol.15 , pp. 175-188
    • Daser, A.1    Rabbitts, T.H.2
  • 13
    • 9644281746 scopus 로고    scopus 로고
    • Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology
    • Muyrers-Chen I, Rozovskaia T, Lee N, et al. Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology. Oncogene. 2004;23:8639-8648.
    • (2004) Oncogene , vol.23 , pp. 8639-8648
    • Muyrers-Chen, I.1    Rozovskaia, T.2    Lee, N.3
  • 14
    • 2942631425 scopus 로고    scopus 로고
    • Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein
    • Caslini C, Serna A, Rossi V, Introna M, Biondi A. Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein. Leukemia. 2004;18:1064-1071.
    • (2004) Leukemia , vol.18 , pp. 1064-1071
    • Caslini, C.1    Serna, A.2    Rossi, V.3    Introna, M.4    Biondi, A.5
  • 15
    • 0027171040 scopus 로고
    • Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
    • U S A
    • Domer PH, Fakharzadeh SS, Chen CS, et al. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci U S A. 1993;90:7884-7888.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 7884-7888
    • Domer, P.H.1    Fakharzadeh, S.S.2    Chen, C.S.3
  • 16
    • 0027292378 scopus 로고
    • Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia
    • Hilden JM, Chen CS, Moore R, Frestedt J, Kersey JH. Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia. Cancer Res. 1993;53:3853-3856.
    • (1993) Cancer Res , vol.53 , pp. 3853-3856
    • Hilden, J.M.1    Chen, C.S.2    Moore, R.3    Frestedt, J.4    Kersey, J.H.5
  • 17
    • 1442356858 scopus 로고    scopus 로고
    • Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
    • Kumar AR, Hudson WA, Chen W, Nishiuchi R, Yao Q, Kersey JH. Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia. Blood. 2004;103:1823-1828.
    • (2004) Blood , vol.103 , pp. 1823-1828
    • Kumar, A.R.1    Hudson, W.A.2    Chen, W.3    Nishiuchi, R.4    Yao, Q.5    Kersey, J.H.6
  • 18
    • 0034678345 scopus 로고    scopus 로고
    • Developmental switches in chemokine response profiles during B cell differentiation and maturation
    • Bowman EP, Campbell JJ, Soler D, et al. Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med. 2000;191:1303-1318.
    • (2000) J Exp Med , vol.191 , pp. 1303-1318
    • Bowman, E.P.1    Campbell, J.J.2    Soler, D.3
  • 19
    • 84859160373 scopus 로고    scopus 로고
    • The Gene Quantification Web pages
    • The Gene Quantification Web pages. REST (Relative Expression Software Tool). http://www.qpcr-applications.com. Accessed December 20, 2005.
    • REST (Relative Expression Software Tool)
  • 20
    • 9144236224 scopus 로고    scopus 로고
    • Hoxa9 and Meis1 are key targets for MLLENL-mediated cellular immortalization
    • Zeisig BB, Milne T, Garcia-Cuellar MP, et al. Hoxa9 and Meis1 are key targets for MLLENL-mediated cellular immortalization. Mol Cell Biol. 2004;24:617-628.
    • (2004) Mol Cell Biol , vol.24 , pp. 617-628
    • Zeisig, B.B.1    Milne, T.2    Garcia-Cuellar, M.P.3
  • 21
    • 0019871036 scopus 로고
    • Identification of D segments of immunoglobulin heavy-chain gene and their rearrangement in T lymphocytes
    • Kurosawa Y, Bohmer HV, Haaa W, Sakano H, Trauneker A, Tonegawa S. Identification of D segments of immunoglobulin heavy-chain gene and their rearrangement in T lymphocytes. Nature. 1981;290:565-571.
    • (1981) Nature , vol.290 , pp. 565-571
    • Kurosawa, Y.1    Bohmer, H.V.2    Haaa, W.3    Sakano, H.4    Trauneker, A.5    Tonegawa, S.6
  • 22
    • 0032533243 scopus 로고    scopus 로고
    • AF4 encodes a ubiquitous protein that in both native and MLL-AF4 fusion types localizes to subnuclear compartments
    • Li Q, Frestedt JL, Kersey JH. AF4 encodes a ubiquitous protein that in both native and MLL-AF4 fusion types localizes to subnuclear compartments. Blood. 1998;92:3841-3847.
    • (1998) Blood , vol.92 , pp. 3841-3847
    • Li, Q.1    Frestedt, J.L.2    Kersey, J.H.3
  • 23
    • 0029670722 scopus 로고    scopus 로고
    • flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
    • Hunte BE, Hudak S, Campbell D, Xu Y, Rennick D. flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J Immunol. 1996;156:489-496.
    • (1996) J Immunol , vol.156 , pp. 489-496
    • Hunte, B.E.1    Hudak, S.2    Campbell, D.3    Xu, Y.4    Rennick, D.5
  • 24
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003;3:161-171.
    • (2003) Cancer Cell , vol.3 , pp. 161-171
    • So, C.W.1    Karsunky, H.2    Passegue, E.3    Cozzio, A.4    Weissman, I.L.5    Cleary, M.L.6
  • 25
    • 0038620318 scopus 로고    scopus 로고
    • Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia
    • Johnson JJ, Chen W, Hudson W, et al. Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Blood. 2003;101:3229-3235.
    • (2003) Blood , vol.101 , pp. 3229-3235
    • Johnson, J.J.1    Chen, W.2    Hudson, W.3
  • 26
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • Lavau C, Szilvassy SJ, Slany R, Cleary ML. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J. 1997;16:4226-4237.
    • (1997) EMBO J , vol.16 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 27
    • 0036660203 scopus 로고    scopus 로고
    • Bethesda proposals for classification of lymphoid neoplasms in mice
    • Morse HC 3rd, Anver MR, Fredrickson TN, et al. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002; 100:246-258.
    • (2002) Blood , vol.100 , pp. 246-258
    • Morse III, H.C.1    Anver, M.R.2    Fredrickson, T.N.3
  • 28
    • 19344368745 scopus 로고    scopus 로고
    • Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
    • Cattoretti G, Pasqualucci L, Ballon G, et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell. 2005;7:445-455.
    • (2005) Cancer Cell , vol.7 , pp. 445-455
    • Cattoretti, G.1    Pasqualucci, L.2    Ballon, G.3
  • 29
    • 0036660179 scopus 로고    scopus 로고
    • Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
    • Kogan SC, Ward JM, Anver MR, et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002;100:238-245.
    • (2002) Blood , vol.100 , pp. 238-245
    • Kogan, S.C.1    Ward, J.M.2    Anver, M.R.3
  • 30
    • 0033168716 scopus 로고    scopus 로고
    • The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis
    • Dobson CL, Warren AJ, Pannell R, et al. The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J. 1999;18:3564-3574.
    • (1999) EMBO J , vol.18 , pp. 3564-3574
    • Dobson, C.L.1    Warren, A.J.2    Pannell, R.3
  • 31
    • 0028869112 scopus 로고
    • Altered Hox expression and segmental identity in Mll-mutant mice
    • Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ. Altered Hox expression and segmental identity in Mll-mutant mice. Nature. 1995;378:505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3    Brown, G.A.4    Korsmeyer, S.J.5
  • 32
    • 0032168459 scopus 로고    scopus 로고
    • MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
    • U S A
    • Yu BD, Hanson RD, Hess JL, Horning SE, Korsmeyer SJ. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A. 1998;95:10632-10636.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 10632-10636
    • Yu, B.D.1    Hanson, R.D.2    Hess, J.L.3    Horning, S.E.4    Korsmeyer, S.J.5
  • 33
    • 0037337235 scopus 로고    scopus 로고
    • A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse
    • Isaacs AM, Oliver PL, Jones EL, et al. A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. J Neurosci. 2003;23:1631-1637.
    • (2003) J Neurosci , vol.23 , pp. 1631-1637
    • Isaacs, A.M.1    Oliver, P.L.2    Jones, E.L.3
  • 34
    • 0034662218 scopus 로고    scopus 로고
    • Altered lymphoid development in mice deficient for the mAF4 proto-oncogene
    • Isnard P, Core N, Naquet P, Djabali M. Altered lymphoid development in mice deficient for the mAF4 proto-oncogene. Blood. 2000;96:705-710.
    • (2000) Blood , vol.96 , pp. 705-710
    • Isnard, P.1    Core, N.2    Naquet, P.3    Djabali, M.4
  • 35
    • 0030050159 scopus 로고    scopus 로고
    • LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias
    • Ma C, Staudt LM. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996;87:734-745.
    • (1996) Blood , vol.87 , pp. 734-745
    • Ma, C.1    Staudt, L.M.2
  • 36
    • 0034235115 scopus 로고    scopus 로고
    • Biological and therapeutic aspects of infant leukemia
    • Biondi A, Cimino G, Pieters R, Pui CH. Biological and therapeutic aspects of infant leukemia. Blood. 2000;96:24-33.
    • (2000) Blood , vol.96 , pp. 24-33
    • Biondi, A.1    Cimino, G.2    Pieters, R.3    Pui, C.H.4
  • 38
    • 0031656062 scopus 로고    scopus 로고
    • Resistance of t(4;11) (MLL-AF4 fusion gene) leukemias to stress-induced cell death: Possible mechanism for extensive extramedullary accumulation of cells and poor prognosis
    • Kersey JH, Wang D, Oberto M. Resistance of t(4;11) (MLL-AF4 fusion gene) leukemias to stress-induced cell death: possible mechanism for extensive extramedullary accumulation of cells and poor prognosis. Leukemia. 1998; 12:1561-1564.
    • (1998) Leukemia , vol.12 , pp. 1561-1564
    • Kersey, J.H.1    Wang, D.2    Oberto, M.3
  • 40
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029-3035.
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 41
    • 13444311619 scopus 로고    scopus 로고
    • Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
    • Wang J, Iwasaki H, Krivtsov A, et al. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005;24:368-381.
    • (2005) EMBO J , vol.24 , pp. 368-381
    • Wang, J.1    Iwasaki, H.2    Krivtsov, A.3
  • 42
    • 0141925960 scopus 로고    scopus 로고
    • FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases
    • Yao Q, Nishiuchi R, Li Q, Kumar AR, Hudson WA, Kersey JH. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases. Clin Cancer Res. 2003;9:4483-4493.
    • (2003) Clin Cancer Res , vol.9 , pp. 4483-4493
    • Yao, Q.1    Nishiuchi, R.2    Li, Q.3    Kumar, A.R.4    Hudson, W.A.5    Kersey, J.H.6
  • 43
    • 0036014973 scopus 로고    scopus 로고
    • The role of MLL in hematopoiesis and leukemia
    • Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol. 2002;9:282-287.
    • (2002) Curr Opin Hematol , vol.9 , pp. 282-287
    • Ernst, P.1    Wang, J.2    Korsmeyer, S.J.3
  • 44
    • 0028301480 scopus 로고
    • Dissecting the temporal requirements for homeotic gene function
    • Castelli-Gair J, Greig S, Micklem G, Akam M. Dissecting the temporal requirements for homeotic gene function. Development. 1994;120:1983-1995.
    • (1994) Development , vol.120 , pp. 1983-1995
    • Castelli-Gair, J.1    Greig, S.2    Micklem, G.3    Akam, M.4
  • 45
    • 0029144960 scopus 로고
    • How the Hox gene Ultrabithorax specifies two different segments: The significance of spatial and temporal regulation within metameres
    • Castelli-Gair J, Akam M. How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres. Development. 1995;121:2973-2982.
    • (1995) Development , vol.121 , pp. 2973-2982
    • Castelli-Gair, J.1    Akam, M.2
  • 46
    • 0035158486 scopus 로고    scopus 로고
    • Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and -A10 genes and induces apoptosis in a human leukemia cell line, THP-1
    • Kawagoe H, Kawagoe R, Sano K. Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and -A10 genes and induces apoptosis in a human leukemia cell line, THP-1. Leukemia. 2001;15:1743-1749.
    • (2001) Leukemia , vol.15 , pp. 1743-1749
    • Kawagoe, H.1    Kawagoe, R.2    Sano, K.3
  • 47
    • 0035864734 scopus 로고    scopus 로고
    • Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4: 11) abnormality
    • Rozovskaia T, Feinstein E, Mor O, et al. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4: 11) abnormality. Oncogene. 2001;20:874-878.
    • (2001) Oncogene , vol.20 , pp. 874-878
    • Rozovskaia, T.1    Feinstein, E.2    Mor, O.3
  • 48
    • 1842579481 scopus 로고    scopus 로고
    • Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    • So CW, Karsunky H, Wong P, Weissman IL, Cleary ML. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood. 2004;103:3192-3199.
    • (2004) Blood , vol.103 , pp. 3192-3199
    • So, C.W.1    Karsunky, H.2    Wong, P.3    Weissman, I.L.4    Cleary, M.L.5
  • 49
    • 20044380143 scopus 로고    scopus 로고
    • Menin and MLL cooperatively regulate expression of cyclindependent kinase inhibitors
    • U S A
    • Milne TA, Hughes CM, Lloyd R, et al. Menin and MLL cooperatively regulate expression of cyclindependent kinase inhibitors. Proc Natl Acad Sci U S A. 2005;102:749-754.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 749-754
    • Milne, T.A.1    Hughes, C.M.2    Lloyd, R.3
  • 50
    • 25444470530 scopus 로고    scopus 로고
    • The Mll fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDK1B (p27kip1) expression
    • U S A
    • Xia Z, Popovic R, Chen J, et al. The Mll fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDK1B (p27kip1) expression. Proc Natl Acad Sci U S A. 2005;102:14028-14033.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 14028-14033
    • Xia, Z.1    Popovic, R.2    Chen, J.3
  • 51
    • 26844555530 scopus 로고    scopus 로고
    • The Menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
    • Yokoyama A, Somervaille TCP, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML. The Menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell. 2005;123:207-218.
    • (2005) Cell , vol.123 , pp. 207-218
    • Yokoyama, A.1    Somervaille, T.C.P.2    Smith, K.S.3    Rozenblatt-Rosen, O.4    Meyerson, M.5    Cleary, M.L.6
  • 52
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.