TEL/AML1 fusion gene is a rare event in adult acute lymphoblastic leukemia

Leukemia

Volumn 10, Issue 9, 1996, Pages 1529-1530

  Raynaud, S ^a   Mauvieux, L ^b   Cayuela, J M ^c   Bastard, C ^d   Bilhou Nabera, C ^e   Debuire, B ^f   Bories, D ^g   Boucheix, C ^h   Charrin, C ⁱ   Fiere D ⁱ   Gabert, J ^j  

^a CNRS   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d Ctr Reg de Transfusion Sanguine   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f HÔPITAL PAUL BROUSSE   (France)

^g HENRI MONDOR HOSPITAL   (France)

^h INSERM   (France)

ⁱ EDOUARD HERRIOT HOSPITAL   (France)

^j INSTITUT PAOLI CALMETTES   (France)

more..

Author keywords

Adult ALL; Fusion gene; TEL AML1

Indexed keywords

CHIMERIC PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER GENETICS; CHROMOSOME TRANSLOCATION; FEMALE; GENE FUSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 9544226397     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
2. Romana SP, Mauchauffé M, LeConiat M, Chumakov I, LePalier D, Berger R, Bernard OA. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 1995; 85: 3662-3670.
3. Romana SP, Poirel H, Leconiat M, Flexor M-A, Mauchauffé M, Jonveaux P, Macintyre EA, Berger R, Bernard OA. High frequency of t(12;21) in childhood B lineage acute lymphoblastic leukemia. Blood 1995; 86: 4263-4269.
4. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC-F, Pui C-H, Grosveld G, Downing JR. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most frequent genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 1995; 9: 1985-1989.
5. Raynaud S, Cavé H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroud C, Guo C, Vilmer E, Marynen P, Grandchamp B. The (12;21) translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations in childhood acute lymphoblastic leukemia. Blood (in press).
6. Cayuela J-M, Baruchel A, Orange C, Madani A, Auclerc M-F, Daniel M-T, Schaison G, Sigaux F. TEL-AML1 fusion RNA as a new target to minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia. Blood (in press).
7. Raynaud SD, Bekri S, Leroux D, Grosgeorge J, Klein B, Bastard C, Gaudray P, Simon MP. Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies. Genes Chromos Cancer 1993; 8: 80-87.
8. Groupe Français de Cytogénétique Hématologique. Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings and outcome. A collaborative study of the groupe français de cytogénétique hématologique. Blood 1996; 87: 3135-3142.
9. Heerema NA. Cytogenetic abnormalities and molecular markers of acute lymphoblastic leukemia. Hematol Oncol Clin North Am 1990; 4: 795-820.
10. Hoelzer D. Acute lymphoblastic leukemia. Progress in children, less in adults. New Engl J Med 1993; 329: 1343-1344.