Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

Nature

Volumn 443, Issue 7107, 2006, Pages 50-55

  Lee, Jeong Woong ^a   Beebe, Kirk ^b   Nangle, Leslie A ^b   Jang, Jaeseon ^a,d   Longo Guess, Chantal M ^a   Cook, Susan A ^a   Davisson, Muriel T ^a   Sundberg, John P ^a   Schimmel, Paul ^b   Ackerman, Susan L ^a,c  

^a JACKSON LABORATORY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d Korea Bio Polytechnic   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASES; GENES; NEUROLOGY; PROTEINS; RNA;

NEURODEGENERATION; PROTEIN MISFOLDING; TRANSFER RNA (TRNA) SYNTHETASE;

ENZYME KINETICS;

AMINO ACID TRANSFER RNA LIGASE; CHAPERONE;

ENZYME ACTIVITY; GENE EXPRESSION; MUTATION; NEUROLOGY; PROTEIN; RNA;

ARTICLE; ATAXIA; CELL DEATH; CELL LOSS; ENZYME ACTIVITY; MISSENSE MUTATION; NERVE DEGENERATION; PRIORITY JOURNAL; PURKINJE CELL; RNA EDITING; SENSITIVITY ANALYSIS;

ATAXIA;

EID: 33748432548     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05096     Document Type: Article

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