-
1
-
-
38349109606
-
Inhibition of raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis
-
Alejandro EU, Johnson JD (2008) Inhibition of raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis. J Biol Chem 283: 2407-2417.
-
(2008)
J Biol Chem
, vol.283
, pp. 2407-2417
-
-
Alejandro, E.U.1
Johnson, J.D.2
-
2
-
-
74949133820
-
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways
-
Alejandro EU, Kalynyak TB, Taghizadeh F, Gwiazda KS, Rawstron EK, Jacob KJ, Johnson JD (2010) Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. Endocrinology 151: 502-512.
-
(2010)
Endocrinology
, vol.151
, pp. 502-512
-
-
Alejandro, E.U.1
Kalynyak, T.B.2
Taghizadeh, F.3
Gwiazda, K.S.4
Rawstron, E.K.5
Jacob, K.J.6
Johnson, J.D.7
-
3
-
-
80355131357
-
Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription
-
Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD (2011) Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J: Official Publication of the Federation of American Societies for Experimental Biology 25: 3884-3895.
-
(2011)
FASEB J: Official Publication of the Federation of American Societies for Experimental Biology
, vol.25
, pp. 3884-3895
-
-
Alejandro, E.U.1
Lim, G.E.2
Mehran, A.E.3
Hu, X.4
Taghizadeh, F.5
Pelipeychenko, D.6
Baccarini, M.7
Johnson, J.D.8
-
4
-
-
0033957476
-
Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction
-
Allison J, Thomas H, Beck D, Brady JL, Lew AM, Elefanty A, Kosaka H, Kay TW, Huang DC, Strasser A (2000) Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction. Int Immunol 12: 9-17.
-
(2000)
Int Immunol
, vol.12
, pp. 9-17
-
-
Allison, J.1
Thomas, H.2
Beck, D.3
Brady, J.L.4
Lew, A.M.5
Elefanty, A.6
Kosaka, H.7
Kay, T.W.8
Huang, D.C.9
Strasser, A.10
-
5
-
-
0037288692
-
Endoplasmic reticulum stress and diabetes mellitus
-
Araki E, Oyadomari S, Mori M (2003) Endoplasmic reticulum stress and diabetes mellitus. Intern Med 42: 7-14.
-
(2003)
Intern Med
, vol.42
, pp. 7-14
-
-
Araki, E.1
Oyadomari, S.2
Mori, M.3
-
6
-
-
67649342203
-
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease
-
Arduino DM, Esteves AR, Cardoso SM, Oliveira CR (2009) Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem Int 55: 341-348.
-
(2009)
Neurochem Int
, vol.55
, pp. 341-348
-
-
Arduino, D.M.1
Esteves, A.R.2
Cardoso, S.M.3
Oliveira, C.R.4
-
7
-
-
55649099025
-
The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis
-
Ariyama Y, Tanaka Y, Shimizu H, Shimomura K, Okada S, Saito T, Yamada E, Oyadomari S, Mori M, Mori M (2008) The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis. Metabolism 57: 1625-1635.
-
(2008)
Metabolism
, vol.57
, pp. 1625-1635
-
-
Ariyama, Y.1
Tanaka, Y.2
Shimizu, H.3
Shimomura, K.4
Okada, S.5
Saito, T.6
Yamada, E.7
Oyadomari, S.8
Mori, M.9
Mori, M.10
-
8
-
-
0035856943
-
Diabetes mellitus and genetically programmed defects in beta-cell function
-
Bell GI, Polonsky KS (2001) Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 414: 788-791.
-
(2001)
Nature
, vol.414
, pp. 788-791
-
-
Bell, G.I.1
Polonsky, K.S.2
-
9
-
-
40049096462
-
2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria
-
2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria. J Physiol 586: 1379-1397.
-
(2008)
J Physiol
, vol.586
, pp. 1379-1397
-
-
Belmonte, S.1
Morad, M.2
-
10
-
-
0030888185
-
The AM and FM of calcium signalling
-
Berridge MJ (1997) The AM and FM of calcium signalling. Nature 386: 759-760.
-
(1997)
Nature
, vol.386
, pp. 759-760
-
-
Berridge, M.J.1
-
12
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
13
-
-
0344825875
-
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
-
Boehning D, Patterson RL, Sedaghat L, Glebova NO, Kurosaki T, Snyder SH (2003) Cytochrome c binds to inositol (1, 4, 5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5: 1051-1061.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 1051-1061
-
-
Boehning, D.1
Patterson, R.L.2
Sedaghat, L.3
Glebova, N.O.4
Kurosaki, T.5
Snyder, S.H.6
-
15
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
16
-
-
67349287016
-
NAADP mobilizes calcium from acidic organelles through two-pore channels
-
Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459: 596-600.
-
(2009)
Nature
, vol.459
, pp. 596-600
-
-
Calcraft, P.J.1
Ruas, M.2
Pan, Z.3
Cheng, X.4
Arredouani, A.5
Hao, X.6
Tang, J.7
Rietdorf, K.8
Teboul, L.9
Chuang, K.T.10
Lin, P.11
Xiao, R.12
Wang, C.13
Zhu, Y.14
Lin, Y.15
Wyatt, C.N.16
Parrington, J.17
Ma, J.18
Evans, A.M.19
Galione, A.20
Zhu, M.X.21
more..
-
17
-
-
77955041880
-
2+ transfer to mitochondria
-
2+ transfer to mitochondria. Cell 142: 270-283.
-
(2010)
Cell
, vol.142
, pp. 270-283
-
-
Cardenas, C.1
Miller, R.A.2
Smith, I.3
Bui, T.4
Molgo, J.5
Muller, M.6
Vais, H.7
Cheung, K.H.8
Yang, J.9
Parker, I.10
Thompson, C.B.11
Birnbaum, M.J.12
Hallows, K.R.13
Foskett, J.K.14
-
18
-
-
78049342172
-
Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition
-
Cerqua C, Anesti V, Pyakurel A, Liu D, Naon D, Wiche G, Baffa R, Dimmer KS, Scorrano L (2010) Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO Rep 11: 854-860.
-
(2010)
EMBO Rep
, vol.11
, pp. 854-860
-
-
Cerqua, C.1
Anesti, V.2
Pyakurel, A.3
Liu, D.4
Naon, D.5
Wiche, G.6
Baffa, R.7
Dimmer, K.S.8
Scorrano, L.9
-
19
-
-
11144243134
-
2+ signaling, which do not depend on their putative pore-forming region
-
2+ signaling, which do not depend on their putative pore-forming region. J Biol Chem 279: 54581-54589.
-
(2004)
J Biol Chem
, vol.279
, pp. 54581-54589
-
-
Chami, M.1
Prandini, A.2
Campanella, M.3
Pinton, P.4
Szabadkai, G.5
Reed, J.C.6
Rizzuto, R.7
-
20
-
-
0033213973
-
Caspase and calpain substrates: roles in synaptic plasticity and cell death
-
Chan SL, Mattson MP (1999) Caspase and calpain substrates: roles in synaptic plasticity and cell death. J Neurosci Res 58: 167-190.
-
(1999)
J Neurosci Res
, vol.58
, pp. 167-190
-
-
Chan, S.L.1
Mattson, M.P.2
-
21
-
-
0034674730
-
Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons
-
Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP (2000) Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275: 18195-18200.
-
(2000)
J Biol Chem
, vol.275
, pp. 18195-18200
-
-
Chan, S.L.1
Mayne, M.2
Holden, C.P.3
Geiger, J.D.4
Mattson, M.P.5
-
22
-
-
3342984659
-
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
-
Chen R, Valencia I, Zhong F, McColl KS, Roderick HL, Bootman MD, Berridge MJ, Conway SJ, Holmes AB, Mignery GA, Velez P, Distelhorst CW (2004) Bcl-2 functionally interacts with inositol 1, 4, 5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1, 4, 5-trisphosphate. J Cell Biol 166: 193-203.
-
(2004)
J Cell Biol
, vol.166
, pp. 193-203
-
-
Chen, R.1
Valencia, I.2
Zhong, F.3
McColl, K.S.4
Roderick, H.L.5
Bootman, M.D.6
Berridge, M.J.7
Conway, S.J.8
Holmes, A.B.9
Mignery, G.A.10
Velez, P.11
Distelhorst, C.W.12
-
23
-
-
33645796667
-
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion
-
Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH (2006) Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol 176: 4590-4599.
-
(2006)
J Immunol
, vol.176
, pp. 4590-4599
-
-
Chen, J.1
Chen, Y.G.2
Reifsnyder, P.C.3
Schott, W.H.4
Lee, C.H.5
Osborne, M.6
Scheuplein, F.7
Haag, F.8
Koch-Nolte, F.9
Serreze, D.V.10
Leiter, E.H.11
-
24
-
-
75949105922
-
The BCL-2 family reunion
-
Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR (2010) The BCL-2 family reunion. Mol Cell 37: 299-310.
-
(2010)
Mol Cell
, vol.37
, pp. 299-310
-
-
Chipuk, J.E.1
Moldoveanu, T.2
Llambi, F.3
Parsons, M.J.4
Green, D.R.5
-
25
-
-
0035430782
-
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
-
Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG (2001) Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50: 1771-1777.
-
(2001)
Diabetes
, vol.50
, pp. 1771-1777
-
-
Cnop, M.1
Hannaert, J.C.2
Hoorens, A.3
Eizirik, D.L.4
Pipeleers, D.G.5
-
26
-
-
0142149115
-
Plasticity of mitochondrial calcium signaling
-
Csordas G, Hajnoczky G (2003) Plasticity of mitochondrial calcium signaling. J Biol Chem 278: 42273-42282.
-
(2003)
J Biol Chem
, vol.278
, pp. 42273-42282
-
-
Csordas, G.1
Hajnoczky, G.2
-
27
-
-
0033521586
-
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
-
Csordas G, Thomas AP, Hajnoczky G (1999) Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J 18: 96-108.
-
(1999)
EMBO J
, vol.18
, pp. 96-108
-
-
Csordas, G.1
Thomas, A.P.2
Hajnoczky, G.3
-
28
-
-
0035163552
-
Calcium signal transmission between ryanodine receptors and mitochondria in cardiac muscle
-
Csordas G, Thomas AP, Hajnoczky G (2001) Calcium signal transmission between ryanodine receptors and mitochondria in cardiac muscle. Trends Cardiovasc Med 11: 269-275.
-
(2001)
Trends Cardiovasc Med
, vol.11
, pp. 269-275
-
-
Csordas, G.1
Thomas, A.P.2
Hajnoczky, G.3
-
29
-
-
33749022800
-
Structural and functional features and significance of the physical linkage between ER and mitochondria
-
Csordas G, Renken C, Varnai P, Walter L, Weaver D, Buttle KF, Balla T, Mannella CA, Hajnoczky G (2006) Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol 174: 915-921.
-
(2006)
J Cell Biol
, vol.174
, pp. 915-921
-
-
Csordas, G.1
Renken, C.2
Varnai, P.3
Walter, L.4
Weaver, D.5
Buttle, K.F.6
Balla, T.7
Mannella, C.A.8
Hajnoczky, G.9
-
30
-
-
57349100367
-
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
-
de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456: 605-610.
-
(2008)
Nature
, vol.456
, pp. 605-610
-
-
de Brito, O.M.1
Scorrano, L.2
-
31
-
-
2342564508
-
Bcl-2 and calcium: controversy beneath the surface
-
Distelhorst CW, Shore GC (2004) Bcl-2 and calcium: controversy beneath the surface. Oncogene 23: 2875-2880.
-
(2004)
Oncogene
, vol.23
, pp. 2875-2880
-
-
Distelhorst, C.W.1
Shore, G.C.2
-
32
-
-
44349157891
-
Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells
-
Dror V, Kalynyak TB, Bychkivska Y, Frey MH, Tee M, Jeffrey KD, Nguyen V, Luciani DS, Johnson JD (2008) Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. J Biol Chem 283: 9909-9916.
-
(2008)
J Biol Chem
, vol.283
, pp. 9909-9916
-
-
Dror, V.1
Kalynyak, T.B.2
Bychkivska, Y.3
Frey, M.H.4
Tee, M.5
Jeffrey, K.D.6
Nguyen, V.7
Luciani, D.S.8
Johnson, J.D.9
-
33
-
-
0037312818
-
Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis
-
Drucker DJ (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17: 161-171.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 161-171
-
-
Drucker, D.J.1
-
37
-
-
0034982387
-
High glucose causes apoptosis in cultured human pancreatic Islets of Langerhans-a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
-
Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LNJL, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F (2001) High glucose causes apoptosis in cultured human pancreatic Islets of Langerhans-a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50: 1290-1301.
-
(2001)
Diabetes
, vol.50
, pp. 1290-1301
-
-
Federici, M.1
Hribal, M.2
Perego, L.3
Ranalli, M.4
Caradonna, Z.5
Perego, C.6
Usellini, L.7
Nano, R.8
Bonini, P.9
Bertuzzi, F.10
Marlier, L.N.J.L.11
Davalli, A.M.12
Carandente, O.13
Pontiroli, A.E.14
Melino, G.15
Marchetti, P.16
Lauro, R.17
Sesti, G.18
Folli, F.19
-
38
-
-
43649083316
-
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway
-
Ferreiro E, Oliveira CR, Pereira CM (2008) The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis 30: 331-342.
-
(2008)
Neurobiol Dis
, vol.30
, pp. 331-342
-
-
Ferreiro, E.1
Oliveira, C.R.2
Pereira, C.M.3
-
39
-
-
70350343033
-
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation
-
Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS (2009) Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem 284: 27664-27673.
-
(2009)
J Biol Chem
, vol.284
, pp. 27664-27673
-
-
Fujimoto, K.1
Hanson, P.T.2
Tran, H.3
Ford, E.L.4
Han, Z.5
Johnson, J.D.6
Schmidt, R.E.7
Green, K.G.8
Wice, B.M.9
Polonsky, K.S.10
-
40
-
-
55249126365
-
2+ release in Aplysia bag cell neurons requires interaction between mitochondrial and endoplasmic reticulum stores
-
2+ release in Aplysia bag cell neurons requires interaction between mitochondrial and endoplasmic reticulum stores. J Neurophysiol 100: 24-37.
-
(2008)
J Neurophysiol
, vol.100
, pp. 24-37
-
-
Geiger, J.E.1
Magoski, N.S.2
-
42
-
-
0038337815
-
The calpain system
-
Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83: 731-801.
-
(2003)
Physiol Rev
, vol.83
, pp. 731-801
-
-
Goll, D.E.1
Thompson, V.F.2
Li, H.3
Wei, W.4
Cong, J.5
-
43
-
-
0019852821
-
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
-
Grankvist K, Marklund SL, Taljedal IB (1981) CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 199: 393-398.
-
(1981)
Biochem J
, vol.199
, pp. 393-398
-
-
Grankvist, K.1
Marklund, S.L.2
Taljedal, I.B.3
-
44
-
-
77649238072
-
RNAi targeting ryanodine receptor 2 protects rat cardiomyocytes from injury caused by simulated ischemia-reperfusion
-
Guo Z, Wang S, Jiao Q, Xu M, Gao F (2010) RNAi targeting ryanodine receptor 2 protects rat cardiomyocytes from injury caused by simulated ischemia-reperfusion. Biomed Pharmacother 64: 184-190.
-
(2010)
Biomed Pharmacother
, vol.64
, pp. 184-190
-
-
Guo, Z.1
Wang, S.2
Jiao, Q.3
Xu, M.4
Gao, F.5
-
45
-
-
38849156952
-
Heart mitochondria: gates of life and death
-
Gustafsson AB, Gottlieb RA (2008) Heart mitochondria: gates of life and death. Cardiovasc Res 77: 334-343.
-
(2008)
Cardiovasc Res
, vol.77
, pp. 334-343
-
-
Gustafsson, A.B.1
Gottlieb, R.A.2
-
48
-
-
24644455527
-
Ryanodine receptors
-
Hamilton SL (2005) Ryanodine receptors. Cell Calcium 38: 253-260.
-
(2005)
Cell Calcium
, vol.38
, pp. 253-260
-
-
Hamilton, S.L.1
-
49
-
-
4043096481
-
Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key
-
Hattersley AT (2004) Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key. J Clin Invest 114: 314-316.
-
(2004)
J Clin Invest
, vol.114
, pp. 314-316
-
-
Hattersley, A.T.1
-
50
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
-
Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312: 572-576.
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
Bernasconi, P.2
Fisher, J.3
Lee, A.H.4
Bassik, M.C.5
Antonsson, B.6
Brandt, G.S.7
Iwakoshi, N.N.8
Schinzel, A.9
Glimcher, L.H.10
Korsmeyer, S.J.11
-
51
-
-
40949143555
-
Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission
-
Hickman JA, Hardwick JM, Kaczmarek LK, Jonas EA (2008) Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. J Neurophysiol 99: 1515-1522.
-
(2008)
J Neurophysiol
, vol.99
, pp. 1515-1522
-
-
Hickman, J.A.1
Hardwick, J.M.2
Kaczmarek, L.K.3
Jonas, E.A.4
-
53
-
-
0033772073
-
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
-
Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26: 163-175.
-
(2000)
Nat Genet
, vol.26
, pp. 163-175
-
-
Horikawa, Y.1
Oda, N.2
Cox, N.J.3
Li, X.4
Orho-Melander, M.5
Hara, M.6
Hinokio, Y.7
Lindner, T.H.8
Mashima, H.9
Schwarz, P.E.10
del Bosque-Plata, L.11
Oda, Y.12
Yoshiuchi, I.13
Colilla, S.14
Polonsky, K.S.15
Wei, S.16
Concannon, P.17
Iwasaki, N.18
Schulze, J.19
Baier, L.J.20
Bogardus, C.21
Groop, L.22
Boerwinkle, E.23
Hanis, C.L.24
Bell, G.I.25
more..
-
54
-
-
0036319111
-
The ryanodine receptor calcium channel of beta-cells: molecular regulation and physiological significance
-
Islam MS (2002) The ryanodine receptor calcium channel of beta-cells: molecular regulation and physiological significance. Diabetes 51: 1299-1309.
-
(2002)
Diabetes
, vol.51
, pp. 1299-1309
-
-
Islam, M.S.1
-
56
-
-
0037087782
-
2+ and sustained opening of the permeability transition pore
-
2+ and sustained opening of the permeability transition pore. J Cell Sci 115: 1175-1188.
-
(2002)
J Cell Sci
, vol.115
, pp. 1175-1188
-
-
Jacobson, J.1
Duchen, M.R.2
-
57
-
-
46149098906
-
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis
-
Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD (2008) Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci USA 105: 8452-8457.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8452-8457
-
-
Jeffrey, K.D.1
Alejandro, E.U.2
Luciani, D.S.3
Kalynyak, T.B.4
Hu, X.5
Li, H.6
Lin, Y.7
Townsend, R.R.8
Polonsky, K.S.9
Johnson, J.D.10
-
58
-
-
16344364156
-
Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons
-
Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF (2005) Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J 24: 1068-1078.
-
(2005)
EMBO J
, vol.24
, pp. 1068-1078
-
-
Jiao, J.1
Huang, X.2
Feit-Leithman, R.A.3
Neve, R.L.4
Snider, W.5
Dartt, D.A.6
Chen, D.F.7
-
60
-
-
0036143325
-
Agonist-specific and sexual stage-dependent inhibition of gonadotropin-releasing hormone-stimulated gonadotropin and growth hormone release by ryanodine: relationship to sexual stage-dependent caffeine-sensitive hormone release
-
Johnson JD, Chang JP (2002) Agonist-specific and sexual stage-dependent inhibition of gonadotropin-releasing hormone-stimulated gonadotropin and growth hormone release by ryanodine: relationship to sexual stage-dependent caffeine-sensitive hormone release. J Neuroendocrinol 14: 144-155.
-
(2002)
J Neuroendocrinol
, vol.14
, pp. 144-155
-
-
Johnson, J.D.1
Chang, J.P.2
-
61
-
-
0037195094
-
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells
-
Johnson JD, Misler S (2002) Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells. Proc Natl Acad Sci USA 99: 14566-14571.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14566-14571
-
-
Johnson, J.D.1
Misler, S.2
-
62
-
-
0034703980
-
2+ stores, regulate gonadotropin secretion
-
2+ stores, regulate gonadotropin secretion. Mol Cell Endocrinol 170: 15-29.
-
(2000)
Mol Cell Endocrinol
, vol.170
, pp. 15-29
-
-
Johnson, J.D.1
Vangoor, F.2
Jobin, R.M.3
Wong, C.J.H.4
Goldberg, J.I.5
Chang, J.P.6
-
63
-
-
0036083948
-
Function-specific calcium stores selectively regulate growth hormone secretion, storage, and mRNA level
-
Johnson JD, Klausen C, Habibi HR, Chang JP (2002) Function-specific calcium stores selectively regulate growth hormone secretion, storage, and mRNA level. Am J Physiol Endocrinol Metab 282: E810-E819.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
-
-
Johnson, J.D.1
Klausen, C.2
Habibi, H.R.3
Chang, J.P.4
-
64
-
-
0242584873
-
+/- mice
-
+/- mice. J Clin Invest 111: 1147-1160.
-
(2003)
J Clin Invest
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
66
-
-
2642520594
-
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
-
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS (2004a) RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem 279: 24794-24802.
-
(2004)
J Biol Chem
, vol.279
, pp. 24794-24802
-
-
Johnson, J.D.1
Han, Z.2
Otani, K.3
Ye, H.4
Zhang, Y.5
Wu, H.6
Horikawa, Y.7
Misler, S.8
Bell, G.I.9
Polonsky, K.S.10
-
67
-
-
2642573270
-
Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion
-
Johnson JD, Kuang S, Misler S, Polonsky KS (2004b) Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. FASEB J 18: 878-880.
-
(2004)
FASEB J
, vol.18
, pp. 878-880
-
-
Johnson, J.D.1
Kuang, S.2
Misler, S.3
Polonsky, K.S.4
-
68
-
-
33750847495
-
Suppressed insulin signaling and increased apoptosis in CD38-null islets
-
Johnson JD, Ford EL, Bernal-Mizrachi E, Kusser KL, Luciani DS, Han Z, Tran H, Randall TD, Lund FE, Polonsky KS (2006) Suppressed insulin signaling and increased apoptosis in CD38-null islets. Diabetes 55: 2737-2746.
-
(2006)
Diabetes
, vol.55
, pp. 2737-2746
-
-
Johnson, J.D.1
Ford, E.L.2
Bernal-Mizrachi, E.3
Kusser, K.L.4
Luciani, D.S.5
Han, Z.6
Tran, H.7
Randall, T.D.8
Lund, F.E.9
Polonsky, K.S.10
-
71
-
-
34547617018
-
Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating
-
Li C, Wang X, Vais H, Thompson CB, Foskett JK, White C (2007) Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1, 4, 5-trisphosphate receptor channel isoform gating. Proc Natl Acad Sci USA 104: 12565-12570.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12565-12570
-
-
Li, C.1
Wang, X.2
Vais, H.3
Thompson, C.B.4
Foskett, J.K.5
White, C.6
-
72
-
-
70349905357
-
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
-
Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I (2009) Role of ERO1-alpha-mediated stimulation of inositol 1, 4, 5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 186: 783-792.
-
(2009)
J Cell Biol
, vol.186
, pp. 783-792
-
-
Li, G.1
Mongillo, M.2
Chin, K.T.3
Harding, H.4
Ron, D.5
Marks, A.R.6
Tabas, I.7
-
73
-
-
53549099939
-
2+ uptake in myocytes from failing hearts restores energy supply and demand matching
-
2+ uptake in myocytes from failing hearts restores energy supply and demand matching. Circ Res 103: 279-288.
-
(2008)
Circ Res
, vol.103
, pp. 279-288
-
-
Liu, T.1
O'Rourke, B.2
-
74
-
-
77953560702
-
2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation
-
2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation. J Biomed Sci 17: 50.
-
(2010)
J Biomed Sci
, vol.17
, pp. 50
-
-
Lu, F.H.1
Tian, Z.2
Zhang, W.H.3
Zhao, Y.J.4
Li, H.L.5
Ren, H.6
Zheng, H.S.7
Liu, C.8
Hu, G.X.9
Tian, Y.10
Yang, B.F.11
Wang, R.12
Xu, C.Q.13
-
75
-
-
63249083149
-
2+ channels in endoplasmic reticulum stress and beta-cell death
-
2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 58: 422-432.
-
(2009)
Diabetes
, vol.58
, pp. 422-432
-
-
Luciani, D.S.1
Gwiazda, K.S.2
Yang, T.L.3
Kalynyak, T.B.4
Bychkivska, Y.5
Frey, M.H.6
Jeffrey, K.D.7
Sampaio, A.V.8
Underhill, T.M.9
Johnson, J.D.10
-
76
-
-
34547830952
-
Functional groups of ryanodine receptors in rat ventricular cells
-
Lukyanenko V, Ziman A, Lukyanenko A, Salnikov V, Lederer WJ (2007) Functional groups of ryanodine receptors in rat ventricular cells. J Physiol 583: 251-269.
-
(2007)
J Physiol
, vol.583
, pp. 251-269
-
-
Lukyanenko, V.1
Ziman, A.2
Lukyanenko, A.3
Salnikov, V.4
Lederer, W.J.5
-
77
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P (2002) Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442.
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
Di Mario, U.13
Del Prato, S.14
Marchetti, P.15
-
78
-
-
34548050205
-
Excitation-contraction coupling and mitochondrial energetics
-
Maack C, O'Rourke B (2007) Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol 102: 369-392.
-
(2007)
Basic Res Cardiol
, vol.102
, pp. 369-392
-
-
Maack, C.1
O'Rourke, B.2
-
79
-
-
0036738398
-
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY (2002) Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110: 851-860.
-
(2002)
J Clin Invest
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
Oberholzer, J.4
Joller-Jemelka, H.I.5
Spinas, G.A.6
Kaiser, N.7
Halban, P.A.8
Donath, M.Y.9
-
80
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1
-
Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E (2003) Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology 144: 335-345.
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
Reig, J.A.4
Cena, V.5
Soria, B.6
Prentki, M.7
Roche, E.8
-
81
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
-
Malhotra JD, Kaufman RJ (2007) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9: 2277-2293.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
82
-
-
0034060699
-
Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells
-
Mariot P, Prevarskaya N, Roudbaraki MM, Le Bourhis X, van Coppenolle F, Vanoverberghe K, Skryma R (2000) Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells. Prostate 43: 205-214.
-
(2000)
Prostate
, vol.43
, pp. 205-214
-
-
Mariot, P.1
Prevarskaya, N.2
Roudbaraki, M.M.3
Le Bourhis, X.4
van Coppenolle, F.5
Vanoverberghe, K.6
Skryma, R.7
-
83
-
-
0001061413
-
Intracellular calcium-release channels: regulators of cell life and death
-
Marks AR (1997) Intracellular calcium-release channels: regulators of cell life and death. Am J Physiol 272: H597-H605.
-
(1997)
Am J Physiol
, vol.272
-
-
Marks, A.R.1
-
84
-
-
0034640113
-
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
-
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (2000) PKA phosphorylation dissociates FKBP12. 6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-376.
-
(2000)
Cell
, vol.101
, pp. 365-376
-
-
Marx, S.O.1
Reiken, S.2
Hisamatsu, Y.3
Jayaraman, T.4
Burkhoff, D.5
Rosemblit, N.6
Marks, A.R.7
-
86
-
-
0035856952
-
beta-Cell death during progression to diabetes
-
Mathis D, Vence L, Benoist C (2001) beta-Cell death during progression to diabetes. Nature 414: 792-798.
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
87
-
-
0034652369
-
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis
-
Mattson MP, Zhu H, Yu J, Kindy MS (2000) Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J Neurosci 20: 1358-1364.
-
(2000)
J Neurosci
, vol.20
, pp. 1358-1364
-
-
Mattson, M.P.1
Zhu, H.2
Yu, J.3
Kindy, M.S.4
-
88
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
89
-
-
0036835665
-
Regulation of mammalian ryanodine receptors
-
Meissner G (2002) Regulation of mammalian ryanodine receptors. Front Biosci 7: d2072-d2080.
-
(2002)
Front Biosci
, vol.7
-
-
Meissner, G.1
-
90
-
-
0036877146
-
2+ signaling and calcium binding chaperones of the endoplasmic reticulum
-
2+ signaling and calcium binding chaperones of the endoplasmic reticulum. Cell Calcium 32: 269-278.
-
(2002)
Cell Calcium
, vol.32
, pp. 269-278
-
-
Michalak, M.1
Robert Parker, J.M.2
Opas, M.3
-
91
-
-
33845912670
-
ER vesicles and mitochondria move and communicate at synapses
-
Mironov SL, Symonchuk N (2006) ER vesicles and mitochondria move and communicate at synapses. J Cell Sci 119: 4926-4934.
-
(2006)
J Cell Sci
, vol.119
, pp. 4926-4934
-
-
Mironov, S.L.1
Symonchuk, N.2
-
93
-
-
0037837821
-
2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6)
-
2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem 278: 11057-11064.
-
(2003)
J Biol Chem
, vol.278
, pp. 11057-11064
-
-
Mitchell, K.J.1
Lai, F.A.2
Rutter, G.A.3
-
96
-
-
0036584585
-
Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression
-
Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M (2002) Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J 16: 745-747.
-
(2002)
FASEB J
, vol.16
, pp. 745-747
-
-
Moritz, W.1
Meier, F.2
Stroka, D.M.3
Giuliani, M.4
Kugelmeier, P.5
Nett, P.C.6
Lehmann, R.7
Candinas, D.8
Gassmann, M.9
Weber, M.10
-
97
-
-
11844284861
-
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
-
Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 102: 105-110.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 105-110
-
-
Oakes, S.A.1
Scorrano, L.2
Opferman, J.T.3
Bassik, M.C.4
Nishino, M.5
Pozzan, T.6
Korsmeyer, S.J.7
-
99
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
100
-
-
0037133051
-
2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors
-
2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors. Proc Natl Acad Sci USA 99: 2380-2385.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2380-2385
-
-
Pacher, P.1
Thomas, A.P.2
Hajnoczky, G.3
-
102
-
-
0038024149
-
Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo
-
Popescu BO, Oprica M, Sajin M, Stanciu CL, Bajenaru O, Predescu A, Vidulescu C, Popescu LM (2002) Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo. J Cell Mol Med 6: 555-569.
-
(2002)
J Cell Mol Med
, vol.6
, pp. 555-569
-
-
Popescu, B.O.1
Oprica, M.2
Sajin, M.3
Stanciu, C.L.4
Bajenaru, O.5
Predescu, A.6
Vidulescu, C.7
Popescu, L.M.8
-
103
-
-
0345161818
-
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction
-
Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV (1999) Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction. Diabetes 48: 1223-1229.
-
(1999)
Diabetes
, vol.48
, pp. 1223-1229
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.2
Strynadka, K.3
Ju, Q.4
Edelstein, D.5
Brownlee, M.6
Korbutt, G.S.7
Rajotte, R.V.8
-
104
-
-
33745234081
-
Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell
-
Robertson RP, Harmon JS (2006) Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radic Biol Med 41: 177-184.
-
(2006)
Free Radic Biol Med
, vol.41
, pp. 177-184
-
-
Robertson, R.P.1
Harmon, J.S.2
-
105
-
-
42549144606
-
Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis
-
Rong Y, Distelhorst CW (2008) Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol 70: 73-91.
-
(2008)
Annu Rev Physiol
, vol.70
, pp. 73-91
-
-
Rong, Y.1
Distelhorst, C.W.2
-
106
-
-
70149105706
-
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
-
Rong YP, Bultynck G, Aromolaran AS, Zhong F, Parys JB, De Smedt H, Mignery GA, Roderick HL, Bootman MD, Distelhorst CW (2009) The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci USA 106: 14397-14402.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14397-14402
-
-
Rong, Y.P.1
Bultynck, G.2
Aromolaran, A.S.3
Zhong, F.4
Parys, J.B.5
de Smedt, H.6
Mignery, G.A.7
Roderick, H.L.8
Bootman, M.D.9
Distelhorst, C.W.10
-
107
-
-
70349829186
-
Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity
-
Ruiz A, Matute C, Alberdi E (2009) Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity. Cell Calcium 46: 273-281.
-
(2009)
Cell Calcium
, vol.46
, pp. 273-281
-
-
Ruiz, A.1
Matute, C.2
Alberdi, E.3
-
108
-
-
77956684691
-
Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins
-
Rutkevich LA, Cohen-Doyle MF, Brockmeier U, Williams DB (2010) Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins. Mol Biol Cell 21: 3093-3105.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 3093-3105
-
-
Rutkevich, L.A.1
Cohen-Doyle, M.F.2
Brockmeier, U.3
Williams, D.B.4
-
109
-
-
0029904237
-
2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity
-
2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc Natl Acad Sci USA 93: 5489-5494.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5489-5494
-
-
Rutter, G.A.1
Burnett, P.2
Rizzuto, R.3
Brini, M.4
Murgia, M.5
Pozzan, T.6
Tavare, J.M.7
Denton, R.M.8
-
112
-
-
33747816795
-
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx
-
Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K (2006) First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx. J Pharmacol Sci 101: 293-302.
-
(2006)
J Pharmacol Sci
, vol.101
, pp. 293-302
-
-
Shigeto, M.1
Katsura, M.2
Matsuda, M.3
Ohkuma, S.4
Kaku, K.5
-
113
-
-
0032482988
-
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
-
Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH (1998a) Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci USA 95: 9558-9561.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9558-9561
-
-
Shimabukuro, M.1
Wang, M.Y.2
Zhou, Y.T.3
Newgard, C.B.4
Unger, R.H.5
-
114
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH (1998b) Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95: 2498-2502.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
115
-
-
20144385980
-
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis
-
Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J 24: 717-729.
-
(2005)
EMBO J
, vol.24
, pp. 717-729
-
-
Simmen, T.1
Aslan, J.E.2
Blagoveshchenskaya, A.D.3
Thomas, L.4
Wan, L.5
Xiang, Y.6
Feliciangeli, S.F.7
Hung, C.H.8
Crump, C.M.9
Thomas, G.10
-
116
-
-
77953725586
-
Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM)
-
Simmen T, Lynes EM, Gesson K, Thomas G (2010) Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM). Biochim et Biophys Acta 1798: 1465-1473.
-
(2010)
Biochim Et Biophys Acta
, vol.1798
, pp. 1465-1473
-
-
Simmen, T.1
Lynes, E.M.2
Gesson, K.3
Thomas, G.4
-
118
-
-
55849096988
-
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
-
Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ (2008) Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118: 3378-3389.
-
(2008)
J Clin Invest
, vol.118
, pp. 3378-3389
-
-
Song, B.1
Scheuner, D.2
Ron, D.3
Pennathur, S.4
Kaufman, R.J.5
-
119
-
-
0037160091
-
Topology of superoxide production from different sites in the mitochondrial electron transport chain
-
St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD (2002) Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 277: 44784-44790.
-
(2002)
J Biol Chem
, vol.277
, pp. 44784-44790
-
-
St-Pierre, J.1
Buckingham, J.A.2
Roebuck, S.J.3
Brand, M.D.4
-
120
-
-
33845692166
-
2+ channels
-
2+ channels. J Cell Biol 175: 901-911.
-
(2006)
J Cell Biol
, vol.175
, pp. 901-911
-
-
Szabadkai, G.1
Bianchi, K.2
Varnai, P.3
de Stefani, D.4
Wieckowski, M.R.5
Cavagna, D.6
Nagy, A.I.7
Balla, T.8
Rizzuto, R.9
-
121
-
-
0033624841
-
2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin
-
2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin. Cell Calcium 27: 43-51.
-
(2000)
Cell Calcium
, vol.27
, pp. 43-51
-
-
Tengholm, A.1
Hellman, B.2
Gylfe, E.3
-
122
-
-
0344897663
-
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance
-
Thomenius MJ, Distelhorst CW (2003) Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance. J Cell Sci 116: 4493-4499.
-
(2003)
J Cell Sci
, vol.116
, pp. 4493-4499
-
-
Thomenius, M.J.1
Distelhorst, C.W.2
-
124
-
-
77949419999
-
Uncoupling protein-2 modulates myocardial excitation-contraction coupling
-
Turner JD, Gaspers LD, Wang G, Thomas AP (2010) Uncoupling protein-2 modulates myocardial excitation-contraction coupling. Circ Res 106: 730-738.
-
(2010)
Circ Res
, vol.106
, pp. 730-738
-
-
Turner, J.D.1
Gaspers, L.D.2
Wang, G.3
Thomas, A.P.4
-
125
-
-
33646351975
-
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
-
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38: 583-588.
-
(2006)
Nat Genet
, vol.38
, pp. 583-588
-
-
Ueki, K.1
Okada, T.2
Hu, J.3
Liew, C.W.4
Assmann, A.5
Dahlgren, G.M.6
Peters, J.L.7
Shackman, J.G.8
Zhang, M.9
Artner, I.10
Satin, L.S.11
Stein, R.12
Holzenberger, M.13
Kennedy, R.T.14
Kahn, C.R.15
Kulkarni, R.N.16
-
126
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM, Croce CM, Alnemri ES, Huang Z (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 97: 7124-7129.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
Shan, S.4
Han, X.5
Srinivasula, S.M.6
Croce, C.M.7
Alnemri, E.S.8
Huang, Z.9
-
127
-
-
27144487808
-
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R
-
White C, Li C, Yang J, Petrenko NB, Madesh M, Thompson CB, Foskett JK (2005) The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol 7: 1021-1028.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 1021-1028
-
-
White, C.1
Li, C.2
Yang, J.3
Petrenko, N.B.4
Madesh, M.5
Thompson, C.B.6
Foskett, J.K.7
-
128
-
-
0032747264
-
Ruthenium red modifies the cardiac and skeletal muscle Ca(2+) release channels (ryanodine receptors) by multiple mechanisms
-
Xu L, Tripathy A, Pasek DA, Meissner G (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca(2+) release channels (ryanodine receptors) by multiple mechanisms. J Biol Chem 274: 32680-32691.
-
(1999)
J Biol Chem
, vol.274
, pp. 32680-32691
-
-
Xu, L.1
Tripathy, A.2
Pasek, D.A.3
Meissner, G.4
-
129
-
-
15144357923
-
A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro
-
Yagui K, Shimada F, Mimura M, Hashimoto N, Suzuki Y, Tokuyama Y, Nata K, Tohgo A, Ikehata F, Takasawa S, Okamoto H, Makino H, Saito Y, Kanatsuka A (1998) A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. Diabetologia 41: 1024-1028.
-
(1998)
Diabetologia
, vol.41
, pp. 1024-1028
-
-
Yagui, K.1
Shimada, F.2
Mimura, M.3
Hashimoto, N.4
Suzuki, Y.5
Tokuyama, Y.6
Nata, K.7
Tohgo, A.8
Ikehata, F.9
Takasawa, S.10
Okamoto, H.11
Makino, H.12
Saito, Y.13
Kanatsuka, A.14
-
130
-
-
67949086707
-
Presenilins are essential for regulating neurotransmitter release
-
Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Sudhof TC, Shen J (2009) Presenilins are essential for regulating neurotransmitter release. Nature 460: 632-636.
-
(2009)
Nature
, vol.460
, pp. 632-636
-
-
Zhang, C.1
Wu, B.2
Beglopoulos, V.3
Wines-Samuelson, M.4
Zhang, D.5
Dragatsis, I.6
Sudhof, T.C.7
Shen, J.8
-
132
-
-
16744368499
-
Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion
-
Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS (2000) Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab 278: E340-E351.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Zhou, Y.P.1
Pena, J.C.2
Roe, M.W.3
Mittal, A.4
Levisetti, M.5
Baldwin, A.C.6
Pugh, W.7
Ostrega, D.8
Ahmed, N.9
Bindokas, V.P.10
Philipson, L.H.11
Hanahan, D.12
Thompson, C.B.13
Polonsky, K.S.14
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