Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic β-cell apoptosis

Journal of Biological Chemistry

Volumn 283, Issue 4, 2008, Pages 2407-2417

  Alejandro, Emilyn U ^a   Johnson, James D ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b 2350 Health Sciences Mall ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME ACTIVITY; ENZYME INHIBITION; MUTAGENS; PHOSPHORYLATION;

DNA LADDERING; PROPIDIUM IODIDE; THREONINE KINASE RAF-1;

CELL DEATH;

DNA; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MOUSE; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DEPLETION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; CELL DEATH; CELL LINE; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN-SECRETING CELLS; MAP KINASE KINASE KINASES; MICE; MUTATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION;

EID: 38349109606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703612200     Document Type: Article

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