Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet β cell

Free Radical Biology and Medicine

Volumn 41, Issue 2, 2006, Pages 177-184

  Robertson, R Paul ^a   Harmon, Jamie S ^a  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

Diabetes; Free radicals; Glucotoxicity; Insulin gene expression; MafA; Oxidative stress; Pancreatic islet cell; PDX 1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 ISOPROSTAGLANDIN F2 ALPHA; ACETYLCYSTEINE; AMINOGUANINE; ANTIDIABETIC AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; CATALASE; CYTOKINE; ENZYME; GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE; GUANINE DERIVATIVE; HYDROPEROXIDE; INSULIN; KONINGIC ACID; MANNOHEPTULOSE; REACTIVE OXYGEN METABOLITE; SULFONYLUREA DERIVATIVE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

APOPTOSIS; BLOOD GLUCOSE MONITORING; CELL DEATH; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE COURSE; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS NECROSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

ANIMALS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

ANIMALIA;

EID: 33745234081     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.04.030     Document Type: Review

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