-
1
-
-
0039910769
-
Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid
-
Alcazar O, Qiu-yue Z, Gine E, Tamarit-Rodriguez J. Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. Diabetes 46: 1153-1158, 1997. (Pubitemid 27271076)
-
(1997)
Diabetes
, vol.46
, Issue.7
, pp. 1153-1158
-
-
Alcazar, O.1
Qiu-yue, Z.2
Gine, E.3
Tamarit-Rodriguez, J.4
-
2
-
-
38349109606
-
Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis
-
Alejandro EU, Johnson JD. Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis. J Biol Chem 283: 2407-2417, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 2407-2417
-
-
Alejandro, E.U.1
Johnson, J.D.2
-
3
-
-
0037838892
-
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
-
DOI 10.1074/jbc.M211495200
-
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278: 11303-11311, 2003. (Pubitemid 36792687)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11303-11311
-
-
Briscoe, C.P.1
Tadayyon, M.2
Andrews, J.L.3
Benson, W.G.4
Chambers, J.K.5
Eilert, M.M.6
Ellis, C.7
Elshourbagy, N.A.8
Goetz, A.S.9
Minnick, D.T.10
Murdock, P.R.11
Sauls Jr., H.R.12
Shabon, U.13
Spinage, L.D.14
Strum, J.C.15
Szekeres, P.G.16
Tan, K.B.17
Way, J.M.18
Ignar, D.M.19
Wilson, S.20
Muir, A.I.21
more..
-
4
-
-
0037219411
-
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
DOI 10.2337/diabetes.52.1.102
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003. (Pubitemid 36042113)
-
(2003)
Diabetes
, vol.52
, Issue.1
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
5
-
-
19944432792
-
2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 54: 452-461, 2005.
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
Van Eylen, F.7
Mandrup-Poulsen, T.8
Herchuelz, A.9
Eizirik, D.L.10
-
6
-
-
34250174228
-
2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death
-
2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death. Mol Cell Endocrinol 272: 50-62, 2007.
-
(2007)
Mol Cell Endocrinol
, vol.272
, pp. 50-62
-
-
Choi, S.E.1
Kim, H.E.2
Shin, H.C.3
Jang, H.J.4
Lee, K.W.5
Kim, Y.6
Kang, S.S.7
Chun, J.8
Kang, Y.9
-
8
-
-
33947510911
-
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
-
DOI 10.1074/jbc.M607627200
-
Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem 282: 3989-3997, 2007. (Pubitemid 47084497)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.6
, pp. 3989-3997
-
-
Cnop, M.1
Ladriere, L.2
Hekerman, P.3
Ortis, F.4
Cardozo, A.K.5
Dogusan, Z.6
Flamez, D.7
Boyce, M.8
Yuan, J.9
Eizirik, D.L.10
-
9
-
-
0014594153
-
Stimulation of insulin secretion by infusion of free fatty acids
-
Crespin SR, Greenough WB 3rd, Steinberg D. Stimulation of insulin secretion by infusion of free fatty acids. J Clin Invest 48: 1934-1943, 1969.
-
(1969)
J Clin Invest
, vol.48
, pp. 1934-1943
-
-
Crespin, S.R.1
Greenough III, W.B.2
Steinberg, D.3
-
10
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
-
Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci 121: 2308-2318, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham, M.C.6
Moore, F.7
Rasschaert, J.8
Cardozo, A.K.9
Bellomo, E.10
Overbergh, L.11
Mathieu, C.12
Lupi, R.13
Hai, T.14
Herchuelz, A.15
Marchetti, P.16
Rutter, G.A.17
Eizirik, D.L.18
Cnop, M.19
-
11
-
-
0034737731
-
Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI β-cells)
-
DOI 10.1074/jbc.275.13.9363
-
Deeney JT, Gromada J, Hoy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE. Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem 275: 9363-9368, 2000. (Pubitemid 30185160)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.13
, pp. 9363-9368
-
-
Deeney, J.T.1
Gromada, J.2
Hoy, M.3
Olsen, H.L.4
Rhodes, C.J.5
Prentki, M.6
Berggren, P.-O.7
Corkey, B.E.8
-
12
-
-
34547888676
-
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells
-
DOI 10.1677/JOE-07-0082
-
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG. Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol 194: 283-291, 2007. (Pubitemid 47249667)
-
(2007)
Journal of Endocrinology
, vol.194
, Issue.2
, pp. 283-291
-
-
Diakogiannaki, E.1
Dhayal, S.2
Childs, C.E.3
Calder, P.C.4
Welters, H.J.5
Morgan, N.G.6
-
13
-
-
0041828484
-
Inflammatory mediators and islet β-cell failure: A link between type 1 and type 2 diabetes
-
DOI 10.1007/s00109-003-0450-y
-
Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81: 455-470, 2003. (Pubitemid 37070198)
-
(2003)
Journal of Molecular Medicine
, vol.81
, Issue.8
, pp. 455-470
-
-
Donath, M.Y.1
Storling, J.2
Maedler, K.3
Mandrup-Poulsen, T.4
-
14
-
-
35848969322
-
Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells
-
DOI 10.1007/s00125-007-0835-5
-
Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia 50: 2504-2515, 2007. (Pubitemid 350060652)
-
(2007)
Diabetologia
, vol.50
, Issue.12
, pp. 2504-2515
-
-
Dror, V.1
Nguyen, V.2
Walia, P.3
Kalynyak, T.B.4
Hill, J.A.5
Johnson, J.D.6
-
15
-
-
0036924861
-
Different role of saturated and unsaturated fatty acids in β-cell apoptosis
-
DOI 10.1016/S0006-291X(02)02752-3, PII S0006291X02027523
-
Eitel K, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Haring HU, Kellerer M. Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. Biochem Biophys Res Commun 299: 853-856, 2002. (Pubitemid 36034564)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.299
, Issue.5
, pp. 853-856
-
-
Eitel, K.1
Staiger, H.2
Brendel, M.D.3
Brandhorst, D.4
Bretzel, R.G.5
Haring, H.-U.6
Kellerer, M.7
-
16
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29: 42-61, 2008.
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
17
-
-
33846327180
-
GPR40 is expressed in glucagon producing cells and affects glucagon secretion
-
DOI 10.1016/j.bbrc.2006.12.193, PII S0006291X06028671
-
Flodgren E, Olde B, Meidute-Abaraviciene S, Winzell MS, Ahren B, Salehi A. GPR40 is expressed in glucagon producing cells and affects glucagon secretion. Biochem Biophys Res Commun 354: 240-245, 2007. (Pubitemid 46123225)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.1
, pp. 240-245
-
-
Flodgren, E.1
Olde, B.2
Meidute-Abaraviciene, S.3
Winzell, M.S.4
Ahren, B.5
Salehi, A.6
-
20
-
-
40849099994
-
Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y
-
Furstova V, Kopska T, James RF, Kovar J. Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic beta-cell line NES2Y. Life Sci 82: 684-691, 2008.
-
(2008)
Life Sci
, vol.82
, pp. 684-691
-
-
Furstova, V.1
Kopska, T.2
James, R.F.3
Kovar, J.4
-
21
-
-
0030890812
-
2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell
-
2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell. Biochem J 323: 445-450, 1997.
-
(1997)
Biochem J
, vol.323
, pp. 445-450
-
-
Guest, P.C.1
Bailyes, E.M.2
Hutton, J.C.3
-
22
-
-
34247603072
-
Rhythm of the β-cell oscillator is not governed by a single regulator: Multiple systems contribute to oscillatory behavior
-
DOI 10.1152/ajpendo.00648.2006
-
Heart E, Smith PJ. Rhythm of the beta-cell oscillator is not governed by a single regulator: multiple systems contribute to oscillatory behavior. Am J Physiol Endocrinol Metab 292: E1295-E1300, 2007. (Pubitemid 46684597)
-
(2007)
American Journal of Physiology - Endocrinology and Metabolism
, vol.292
, Issue.5
-
-
Heart, E.1
Smith, P.J.S.2
-
23
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
-
DOI 10.1038/nature01478
-
Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422: 173-176, 2003. (Pubitemid 36362750)
-
(2003)
Nature
, vol.422
, Issue.6928
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
Kobayashi, M.4
Fujii, R.5
Fukusumi, S.6
Ogi, K.7
Hosoya, M.8
Tanaka, Y.9
Uejima, H.10
Tanaka, H.11
Maruyama, M.12
Satoh, R.13
Okubo, S.14
Kizawa, H.15
Komatsu, H.16
Matsumura, F.17
Noguchi, Y.18
Shinohara, T.19
Hinuma, S.20
Fujisawa, Y.21
Fujino, M.22
more..
-
24
-
-
46149098906
-
Carboxypeptidase e mediates palmitate-induced beta-cell ER stress and apoptosis
-
Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD. Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci USA 105: 8452-8457, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8452-8457
-
-
Jeffrey, K.D.1
Alejandro, E.U.2
Luciani, D.S.3
Kalynyak, T.B.4
Hu, X.5
Li, H.6
Lin, Y.7
Townsend, R.R.8
Polonsky, K.S.9
Johnson, J.D.10
-
25
-
-
0242584873
-
+/- mice
-
DOI 10.1172/JCI200316537
-
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS. Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 111: 1147-1160, 2003. (Pubitemid 36519932)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.8
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
27
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
DOI 10.1210/en.2005-1494
-
Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147: 3398-3407, 2006. (Pubitemid 43901131)
-
(2006)
Endocrinology
, vol.147
, Issue.7
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
28
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
-
DOI 10.1210/en.2004-0478
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145: 5087-5096, 2004. (Pubitemid 39551129)
-
(2004)
Endocrinology
, vol.145
, Issue.11
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
29
-
-
0026593276
-
Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity
-
Kiekens R, In't Veld P, Mahler T, Schuit F, Van De Winkel M, Pipeleers D. Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity. J Clin Invest 89: 117-125, 1992.
-
(1992)
J Clin Invest
, vol.89
, pp. 117-125
-
-
Kiekens, R.1
In't Veld, P.2
Mahler, T.3
Schuit, F.4
Van De Winkel, M.5
Pipeleers, D.6
-
30
-
-
0037423719
-
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
-
DOI 10.1016/S0006-291X(02)03064-4
-
Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301: 406-410, 2003. (Pubitemid 36279253)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.301
, Issue.2
, pp. 406-410
-
-
Kotarsky, K.1
Nilsson, N.E.2
Flodgren, E.3
Owman, C.4
Olde, B.5
-
31
-
-
40449106191
-
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
-
Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab 294: E540-E550, 2008.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Lai, E.1
Bikopoulos, G.2
Wheeler, M.B.3
Rozakis-Adcock, M.4
Volchuk, A.5
-
32
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50: 752-763, 2007.
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
Biankin, A.V.6
Biden, T.J.7
-
34
-
-
63249083149
-
2+ channels in endoplasmic reticulum stress and beta-cell death
-
2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 58: 422-432, 2009.
-
(2009)
Diabetes
, vol.58
, pp. 422-432
-
-
Luciani, D.S.1
Gwiazda, K.S.2
Yang, T.L.3
Kalynyak, T.B.4
Bychkivska, Y.5
Frey, M.H.6
Jeffrey, K.D.7
Sampaio, A.V.8
Underhill, T.M.9
Johnson, J.D.10
-
35
-
-
24344498300
-
Acute effects of insulin on beta-cells from transplantable human islets
-
Luciani DS, Johnson JD. Acute effects of insulin on beta-cells from transplantable human islets. Mol Cell Endocrinol 241: 88-98, 2005.
-
(2005)
Mol Cell Endocrinol
, vol.241
, pp. 88-98
-
-
Luciani, D.S.1
Johnson, J.D.2
-
36
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
Di Mario, U.13
Del Prato, S.14
Marchetti, P.15
-
37
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
-
DOI 10.2337/diabetes.52.3.726
-
Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52: 726-733, 2003. (Pubitemid 36323580)
-
(2003)
Diabetes
, vol.52
, Issue.3
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
38
-
-
0035156817
-
Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
-
Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 50: 69-76, 2001. (Pubitemid 32047983)
-
(2001)
Diabetes
, vol.50
, Issue.1
, pp. 69-76
-
-
Maedler, K.1
Spinas, G.A.2
Dyntar, D.3
Moritz, W.4
Kaiser, N.5
Donath, M.Y.6
-
39
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
DOI 10.1007/s00125-007-0816-8
-
Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50: 2486-2494, 2007. (Pubitemid 350060637)
-
(2007)
Diabetologia
, vol.50
, Issue.12
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliani, M.2
Lupi, R.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Filipponi, F.7
Weir, G.C.8
Eizirik, D.L.9
Cnop, M.10
-
40
-
-
0025281303
-
Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
-
Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132, 1990. (Pubitemid 20228111)
-
(1990)
Endocrinology
, vol.127
, Issue.1
, pp. 126-132
-
-
Miyazaki, J.-I.1
Araki, K.2
Yamato, E.3
Ikegami, H.4
Asano, T.5
Shibasaki, Y.6
Oka, Y.7
Yamamura, K.-I.8
-
41
-
-
33845517309
-
Fatty acid signaling in the beta-cell and insulin secretion
-
Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M. Fatty acid signaling in the beta-cell and insulin secretion. Diabetes 55, Suppl 2: S16-S23, 2006.
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 2
-
-
Nolan, C.J.1
Madiraju, M.S.2
Delghingaro-Augusto, V.3
Peyot, M.L.4
Prentki, M.5
-
42
-
-
3242670708
-
2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells
-
2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol 557: 935-948, 2004.
-
(2004)
J Physiol
, vol.557
, pp. 935-948
-
-
Olofsson, C.S.1
Salehi, A.2
Holm, C.3
Rorsman, P.4
-
43
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461, 2004. (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
44
-
-
33646570865
-
2+ indicators based on computationally redesigned calmodulin-peptide pairs
-
2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol 13: 521-530, 2006.
-
(2006)
Chem Biol
, vol.13
, pp. 521-530
-
-
Palmer, A.E.1
Giacomello, M.2
Kortemme, T.3
Hires, S.A.4
Lev-Ram, V.5
Baker, D.6
Tsien, R.Y.7
-
46
-
-
34347230164
-
Measuring calcium signaling using genetically targetable fluorescent indicators
-
Palmer AE, Tsien RY. Measuring calcium signaling using genetically targetable fluorescent indicators. Nat Protoc 1: 1057-1065, 2006.
-
(2006)
Nat Protoc
, vol.1
, pp. 1057-1065
-
-
Palmer, A.E.1
Tsien, R.Y.2
-
47
-
-
0242367268
-
Palmitate potentiation of glucose-induced insulin release: A study using 2-bromopalmitate
-
DOI 10.1016/S0026-0495(03)00279-8
-
Parker SM, Moore PC, Johnson LM, Poitout V. Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metabolism 52: 1367-1371, 2003. (Pubitemid 37351107)
-
(2003)
Metabolism: Clinical and Experimental
, vol.52
, Issue.10
, pp. 1367-1371
-
-
Parker, S.M.1
Moore P, P.C.2
Johnson, L.M.3
Poitout, V.4
-
48
-
-
0036797785
-
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress
-
DOI 10.1053/meta.2002.35200
-
Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51: 1340-1347, 2002. (Pubitemid 35174157)
-
(2002)
Metabolism: Clinical and Experimental
, vol.51
, Issue.10
, pp. 1340-1347
-
-
Piro, S.1
Anello, M.2
Di Pietro, C.3
Lizzio, M.N.4
Patane, G.5
Rabuazzo, A.M.6
Vigneri, R.7
Purrello, M.8
Purrello, F.9
-
49
-
-
20244370455
-
2+-signaling in pancreatic beta-cells
-
2+-signaling in pancreatic beta-cells. Mol Cell Endocrinol 212: 1-9, 2003.
-
(2003)
Mol Cell Endocrinol
, vol.212
, pp. 1-9
-
-
Remizov, O.1
Jakubov, R.2
Dufer, M.3
Krippeit Drews, P.4
Drews, G.5
Waring, M.6
Brabant, G.7
Wienbergen, A.8
Rustenbeck, I.9
Schofl, C.10
-
50
-
-
33748958993
-
Use of analogs and inhibitors to study the functional signifi- Cance of protein palmitoylation
-
Resh MD. Use of analogs and inhibitors to study the functional signifi- cance of protein palmitoylation. Methods 40: 191-197, 2006.
-
(2006)
Methods
, vol.40
, pp. 191-197
-
-
Resh, M.D.1
-
51
-
-
0027275837
-
Interactions of long-chain fatty acids and albumin: Determination of free fatty acid levels using the fluorescent probe ADIFAB
-
Richieri GV, Anel A, Kleinfeld AM. Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32: 7574-7580, 1993. (Pubitemid 23232334)
-
(1993)
Biochemistry
, vol.32
, Issue.29
, pp. 7574-7580
-
-
Richieri, G.V.1
Anel, A.2
Kleinfeld, A.M.3
-
52
-
-
0036163156
-
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
-
DOI 10.1007/s125-002-8248-z
-
Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45: 85-96, 2002. (Pubitemid 34118546)
-
(2002)
Diabetologia
, vol.45
, Issue.1
, pp. 85-96
-
-
Sakuraba, H.1
Mizukami, H.2
Yagihashi, N.3
Wada, R.4
Hanyu, C.5
Yagihashi, S.6
-
53
-
-
27944449329
-
1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion
-
1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Cell Tissue Res 322: 207-215, 2005.
-
(2005)
Cell Tissue Res
, vol.322
, pp. 207-215
-
-
Salehi, A.1
Flodgren, E.2
Nilsson, N.E.3
Jimenez-Feltstrom, J.4
Miyazaki, J.5
Owman, C.6
Olde, B.7
-
54
-
-
33751520308
-
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40
-
Schnell S, Schaefer M, Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol Cell Endocrinol 263: 173-180, 2007.
-
(2007)
Mol Cell Endocrinol
, vol.263
, pp. 173-180
-
-
Schnell, S.1
Schaefer, M.2
Schofl, C.3
-
55
-
-
22244446505
-
The mammalian unfolded protein response
-
DOI 10.1146/annurev.biochem.73.011303.074134
-
Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005. (Pubitemid 40995523)
-
(2005)
Annual Review of Biochemistry
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
56
-
-
0032478314
-
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
-
DOI 10.1073/pnas.95.5.2498
-
Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95: 2498-2502, 1998. (Pubitemid 28145970)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.5
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.-T.2
Levi, M.3
Unger, R.H.4
-
57
-
-
0016866225
-
Fatty acids, platelets, and microcirculatory obstruction
-
Spector AA, Hoak JC. Fatty acids, platelets, and microcirculatory obstruction. Science 190: 490-492, 1975.
-
(1975)
Science
, vol.190
, pp. 490-492
-
-
Spector, A.A.1
Hoak, J.C.2
-
58
-
-
47549113634
-
Differential modulation of L-type calcium channel subunits by oleate
-
Tian Y, Corkey RF, Yaney GC, Goforth PB, Satin LS, Moitoso de Vargas L. Differential modulation of L-type calcium channel subunits by oleate. Am J Physiol Endocrinol Metab 294: E1178-E1186, 2008.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Tian, Y.1
Corkey, R.F.2
Yaney, G.C.3
Goforth, P.B.4
Satin, L.S.5
Moitoso De Vargas, L.6
-
59
-
-
0028051811
-
Amino-acid responsiveness in beta cell subpopulations with different sensitivity to glucose
-
DOI 10.1006/bbrc.1994.2486
-
Van Schravendijk CF, Kiekens R, Heylen L, Pipeleers DG. Amino-acid responsiveness in beta cell subpopulations with different sensitivity to glucose. Biochem Biophys Res Commun 204: 490-497, 1994. (Pubitemid 24343947)
-
(1994)
Biochemical and Biophysical Research Communications
, vol.204
, Issue.2
, pp. 490-497
-
-
Vanschravendijk, C.F.H.1
Kiekens, R.2
Heylen, L.3
Pipeleers, D.G.4
-
60
-
-
0026803423
-
Pancreatic beta cell heterogeneity in glucose-induced insulin secretion
-
Van Schravendijk CF, Kiekens R, Pipeleers DG. Pancreatic beta cell heterogeneity in glucose-induced insulin secretion. J Biol Chem 267: 21344-21348, 1992.
-
(1992)
J Biol Chem
, vol.267
, pp. 21344-21348
-
-
Van Schravendijk, C.F.1
Kiekens, R.2
Pipeleers, D.G.3
-
62
-
-
0028221978
-
Mechanisms of the stimulation of insulin release by saturated fatty acids: A study of palmitate effects in mouse β-cells
-
Warnotte C, Gilon P, Nenquin M, Henquin JC. Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes 43: 703-711, 1994. (Pubitemid 24138785)
-
(1994)
Diabetes
, vol.43
, Issue.5
, pp. 703-711
-
-
Warnotte, C.1
Gilon, P.2
Nenquin, M.3
Henquin, J.-C.4
-
63
-
-
0033587626
-
Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion
-
DOI 10.1016/S0303-7207(99)00069-6, PII S0303720799000696
-
Warnotte C, Nenquin M, Henquin JC. Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. Mol Cell Endocrinol 153: 147-153, 1999. (Pubitemid 29339165)
-
(1999)
Molecular and Cellular Endocrinology
, vol.153
, Issue.1-2
, pp. 147-153
-
-
Warnotte, C.1
Nenquin, M.2
Henquin, J.-C.3
-
64
-
-
26444442450
-
Endoplasmic reticulum stress: Cell life and death decisions
-
DOI 10.1172/JCI26373
-
Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005. (Pubitemid 41434389)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2656-2664
-
-
Xu, C.1
Bailly-Maitre, B.2
Reed, J.C.3
-
65
-
-
0038707331
-
Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea
-
DOI 10.1210/jc.2002-020735
-
Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88: 2300-2308, 2003. (Pubitemid 36549911)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.5
, pp. 2300-2308
-
-
Yoon, K.H.1
Ko, S.H.2
Cho, J.H.3
Lee, J.M.4
Ahn, Y.B.5
Song, K.H.6
Yoo, S.J.7
Kang, M.I.8
Cha, B.Y.9
Lee, K.W.10
Son, H.Y.11
Kang, S.K.12
Kim, H.S.13
Lee, I.K.14
Bonner-Weir, S.15
-
66
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870-876, 1994.
-
(1994)
J Clin Invest
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
|