Unlocking the secrets of the pancreatic β cell: Man and mouse provide the key

Journal of Clinical Investigation

Volumn 114, Issue 3, 2004, Pages 314-316

  Hattersley, Andrew T ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROTEIN; TRANSCRIPTION FACTOR;

ALLELE; CELL COUNT; GENE; GENE MUTATION; HUMAN; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ANIMALS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENOMIC IMPRINTING; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC;

EID: 4043096481     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200422506     Document Type: Review

References (10)

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2. Yamagata, K., et al. 1996. Mutations in the hepatocyte nuclear factor 4 alpha gene in maturity-onset diabetes of the young (MODY1). Nature. 384:458-460.
3. Servitja, J.M., and Ferrer, J. 2004. Transcriptional networks controlling pancreatic development and beta cell function (review). Diabetologia. 47:597-613.
4. Silander, K., et al. 2004. Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes. 53:1141-1149.
5. Love-Gregory, L.D., et al. 2004. A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes. 53:1134-1140.
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7. Shield, J.P., et al. 2001. Variable evidence of pancreatic insufficiency in those children with transient neonatal diabetes in remission [abstract]. Pediatr. Res. 49:P2-619.
8. Temple, I.K., et al. 1995. An imprinted gene(s) for diabetes? Nat. Genet. 9:110-112.
9. Kamiya, M., et al. 2000. The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes. Hum. Mol. Genet. 9:453-460.
10. Ma, D., et al. 2004. Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J. Clin. Invest. 114:339-348. doi:10.1172/JCI200419876.