-
1
-
-
72449150103
-
The global diabetes epidemic as a consequence of lifestyle- induced low-grade inflammation
-
Kolb, H. and Mandrup-Poulsen, T The global diabetes epidemic as a consequence of lifestyle- induced low-grade inflammation. Diabetologia 53, 10-20 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 10-20
-
-
Kolb, H.1
Mandrup-Poulsen, T.2
-
2
-
-
0031710787
-
Prevalence of insulin resistance in metabolic disorders: The Bruneck study
-
Bonora, E. et al. Prevalence of insulin resistance in metabolic disorders: the Bruneck study. Diabetes 47, 1643-1649 (1998).
-
(1998)
Diabetes
, vol.47
, pp. 1643-1649
-
-
Bonora, E.1
-
3
-
-
0030884698
-
European Group for the Study of Insulin Resistance (EGIR)
-
Ferrannini, E. et al. European Group for the Study of Insulin Resistance (EGIR). J. Clin. Invest. 100, 1166-1173 (1997).
-
(1997)
J. Clin. Invest
, vol.100
, pp. 1166-1173
-
-
Ferrannini, E.1
-
4
-
-
79960226240
-
Characterizing the profile of obese patients who are metabolically healthy
-
Primeau, V et al. Characterizing the profile of obese patients who are metabolically healthy. Int. J. Obes. (Lond.) 35, 971-981 (2011).
-
(2011)
Int. J. Obes. (Lond.)
, vol.35
, pp. 971-981
-
-
Primeau, V.1
-
5
-
-
77957852860
-
Metabolically healthy obesity: Different prevalences using different criteria
-
Velho, S., Paccaud, F., Waeber, G., Vollenweider, P and Marques-Vidal, P. Metabolically healthy obesity: different prevalences using different criteria. Eur. J. Clin. Nutr. 64, 1043-1051 (2010).
-
(2010)
Eur. J. Clin. Nutr
, vol.64
, pp. 1043-1051
-
-
Velho, S.1
Paccaud, F.2
Waeber, G.3
Vollenweider, P.4
Marques-Vidal, P.5
-
7
-
-
79951694160
-
Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: The Cremona study
-
Calori, G. et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona study. Diabetes Care 34, 210-215 (2011).
-
(2011)
Diabetes Care
, vol.34
, pp. 210-215
-
-
Calori, G.1
-
8
-
-
33644749322
-
Mechanisms of pancreatic (3-cell death in type 1 and type 2 diabetes: Many differences, few similarities
-
Cnop, M. et al. Mechanisms of pancreatic 3-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Suppl. 2), 97-107 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 97-107
-
-
Cnop, M.1
-
9
-
-
53549094111
-
Relationship between 3-cell mass and diabetes onset. Diabetes. Obes
-
Matveyenko, A. V. and Butler, P C. Relationship between 3-cell mass and diabetes onset. Diabetes. Obes. Metab. 10 (Suppl. 4), 23-31 (2008).
-
(2008)
Metab
, vol.10
, pp. 23-31
-
-
Matveyenko, A.V.1
Butler, P.C.2
-
10
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
Donath, M. Y and Shoelson, S. E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98-107 (2011).
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
11
-
-
43849111166
-
The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: A 20-year follow-up study
-
Li, G. et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 371, 1783-1789 (2008).
-
(2008)
Lancet
, vol.371
, pp. 1783-1789
-
-
Li, G.1
-
12
-
-
70449517253
-
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study
-
Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 374, 1677-1686 (2009)
-
(2009)
Lancet
, vol.374
, pp. 1677-1686
-
-
-
13
-
-
34250844410
-
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol. Appl
-
Calabrese, E. J. et al. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol. Appl. Pharmacol. 222, 122-128 (2007).
-
(2007)
Pharmacol
, vol.222
, pp. 122-128
-
-
Calabrese, E.J.1
-
14
-
-
0034455878
-
Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes
-
Mohanty, P et al. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J. Clin. Endocrinol. Metab. 85, 2970-2973 (2000).
-
(2000)
J. Clin. Endocrinol. Metab
, vol.85
, pp. 2970-2973
-
-
Mohanty, P.1
-
15
-
-
0037109184
-
Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress
-
Esposito, K. et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106, 2067-2072 (2002).
-
(2002)
Circulation
, vol.106
, pp. 2067-2072
-
-
Esposito, K.1
-
16
-
-
0642307072
-
Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus
-
Esposito, K. et al. Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 78, 1135-1140 (2003).
-
(2003)
Am. J. Clin. Nutr
, vol.78
, pp. 1135-1140
-
-
Esposito, K.1
-
17
-
-
2142827887
-
Increase in intranuclear nuclear factor kB and decrease in inhibitor kB in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect
-
Aljada, A. et al. Increase in intranuclear nuclear factor kB and decrease in inhibitor kB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am. J. Clin. Nutr. 79, 682-690 (2004).
-
(2004)
Am. J. Clin. Nutr
, vol.79
, pp. 682-690
-
-
Aljada, A.1
-
18
-
-
5444256832
-
Activation of leukocytes by postprandial lipemia in healthy volunteers
-
van Oostrom, A. J. et al. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis 177, 175-182 (2004).
-
(2004)
Atherosclerosis
, vol.177
, pp. 175-182
-
-
Van Oostrom, A.J.1
-
19
-
-
43849102129
-
High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome
-
Devaraj, S., Wang-Polagruto, J., Polagruto, J., Keen, C. L. and Jialal, I. High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome. Metabolism 57, 867-870 (2008).
-
(2008)
Metabolism
, vol.57
, pp. 867-870
-
-
Devaraj, S.1
Wang-Polagruto, J.2
Polagruto, J.3
Keen, C.L.4
Jialal, I.5
-
20
-
-
43549113382
-
High-glycemic index carbohydrate increases nuclear factor-KB activation in mononuclear cells of young, lean healthy subjects
-
Dickinson, S., Hancock, D. P., Petocz, P., Ceriello, A., Brand-Miller, J. High-glycemic index carbohydrate increases nuclear factor-KB activation in mononuclear cells of young, lean healthy subjects. Am. J. Clin. Nutr. 87, 1188-1193 (2008).
-
(2008)
Am. J. Clin. Nutr
, vol.87
, pp. 1188-1193
-
-
Dickinson, S.1
Hancock, D.P.2
Petocz, P.3
Ceriello, A.4
Brand-Miller, J.5
-
21
-
-
48749128643
-
Structures of the Toll-like receptor family and its ligand complexes
-
Jin, M. S. and Lee, J. O. Structures of the Toll-like receptor family and its ligand complexes. Immunity 29, 182-191 (2008).
-
(2008)
Immunity
, vol.29
, pp. 182-191
-
-
Jin, M.S.1
Lee, J.O.2
-
22
-
-
17844391306
-
Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4
-
Weatherill, A. R. et al. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J. Immunol. 174, 5390-5397 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 5390-5397
-
-
Weatherill, A.R.1
-
23
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
-
24
-
-
58149310977
-
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-KB pathway in adipocytes links nutritional signalling with innate immunity
-
Schaeffler, A. et al. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-KB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 126, 233-245 (2009).
-
(2009)
Immunology
, vol.126
, pp. 233-245
-
-
Schaeffler, A.1
-
25
-
-
77950888339
-
Nutrient modification of the innate immune response: A novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation. Arterioscler. Thromb. Vasc
-
Schwartz, E. A. et al. Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation. Arterioscler. Thromb. Vasc. Biol. 30, 802-808 (2010).
-
(2010)
Biol
, vol.30
, pp. 802-808
-
-
Schwartz, E.A.1
-
26
-
-
33745945755
-
Tolerance to microbial TLR ligands: Molecular mechanisms and relevance to disease
-
Medvedev, A. E., Sabroe, I., Hasday, J. D. and Vogel, S. N. Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J. Endotoxin. Res. 12, 133-150 (2006).
-
(2006)
J. Endotoxin. Res
, vol.12
, pp. 133-150
-
-
Medvedev, A.E.1
Sabroe, I.2
Hasday, J.D.3
Vogel, S.N.4
-
27
-
-
35748984420
-
Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance
-
Biswas, S. K. et al. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. J. Immunol. 179, 4083-4092 (2007).
-
(2007)
J. Immunol
, vol.179
, pp. 4083-4092
-
-
Biswas, S.K.1
-
28
-
-
70349650125
-
Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-p-dependent pathways and increases expression of negative regulators of TLR signaling
-
Piao, W. et al. Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-p-dependent pathways and increases expression of negative regulators of TLR signaling. J. Leukoc. Biol. 86, 863-875 (2009).
-
(2009)
J. Leukoc. Biol
, vol.86
, pp. 863-875
-
-
Piao, W.1
-
29
-
-
78650671081
-
Inhibition of TLR4-induced IKB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein
-
Ray, M. et al. Inhibition of TLR4-induced IKB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein. J. Immunol. 185, 7309-7316 (2010).
-
(2010)
J. Immunol
, vol.185
, pp. 7309-7316
-
-
Ray, M.1
-
30
-
-
50449086746
-
Obesity and free fatty acids. Endocrinol
-
Boden, G. Obesity and free fatty acids. Endocrinol. Metab. Clin. North Am. 37, 635-646 (2008).
-
(2008)
Metab. Clin. North Am
, vol.37
, pp. 635-646
-
-
Boden, G.1
-
31
-
-
58149333718
-
High glucose induces Toll-like receptor expression in human monocytes: Mechanism of activation
-
Dasu, M. R., Devaraj, S., Zhao, L., Hwang, D. H. and Jialal, I. High glucose induces Toll-like receptor expression in human monocytes: mechanism of activation. Diabetes 57, 3090-3098 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 3090-3098
-
-
Dasu, M.R.1
Devaraj, S.2
Zhao, L.3
Hwang, D.H.4
Jialal, I.5
-
32
-
-
33644757817
-
Natural antibiotics and insulin sensitivity: The role of bactericidal/permeability- increasing protein
-
Gubern, C. et al. Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability- increasing protein. Diabetes 55, 216-224 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 216-224
-
-
Gubern, C.1
-
33
-
-
33947182436
-
Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
-
Creely, S. J. et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 292, E740-E747 (2007).
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.292
, pp. E740-E747
-
-
Creely, S.J.1
-
34
-
-
77950419928
-
Elevated endotoxin levels in non-alcoholic fatty liver disease
-
Harte, A. L. et al. Elevated endotoxin levels in non-alcoholic fatty liver disease. J. Inflamm. (Lond.) 7, 15 (2010).
-
(2010)
J. Inflamm. (Lond.)
, vol.7
, pp. 15
-
-
Harte, A.L.1
-
35
-
-
77953060025
-
Increased Toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
-
Dasu, M. R., Devaraj, S., Park, S. and Jialal, I. Increased Toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 33, 861-868 (2010).
-
(2010)
Diabetes Care
, vol.33
, pp. 861-868
-
-
Dasu, M.R.1
Devaraj, S.2
Park, S.3
Jialal, I.4
-
36
-
-
34848815899
-
Different TNFa expression elicited by glucose in monocytes from type 2 diabetes mellitus patients
-
Chacón, M. R. et al. Different TNFa expression elicited by glucose in monocytes from type 2 diabetes mellitus patients. Atherosclerosis 194, 18-25 (2007).
-
(2007)
Atherosclerosis
, vol.194
, pp. 18-25
-
-
Chacón, M.R.1
-
37
-
-
77955273068
-
Y High interleukin-12 production from stimulated peripheral blood mononuclear cells of type 2 diabetes patients
-
Wu, H. P, Kuo, S. F., Wu, S. Y and Chuang, D. Y High interleukin-12 production from stimulated peripheral blood mononuclear cells of type 2 diabetes patients. Cytokine 51, 298-304 (2010)
-
(2010)
Cytokine
, vol.51
, pp. 298-304
-
-
Wu, H.P.1
Kuo, S.F.2
Wu, S.Y.3
Chuang, D.4
-
38
-
-
79958248856
-
Type 2 diabetes and lipoprotein metabolism affect LPS-induced cytokine and chemokine release in primary human monocytes
-
Bala, M. et al. Type 2 diabetes and lipoprotein metabolism affect LPS-induced cytokine and chemokine release in primary human monocytes. Exp. Clin. Endocrinol. Diabetes 119, 370-376 (2011).
-
(2011)
Exp. Clin. Endocrinol. Diabetes
, vol.119
, pp. 370-376
-
-
Bala, M.1
-
39
-
-
58149359307
-
Elevated Toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects
-
Reyna, S. M. et al. Elevated Toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57, 2595-2602 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2595-2602
-
-
Reyna, S.M.1
-
40
-
-
0036224269
-
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: The Leiden 85- Plus Study
-
van Exel, E. et al. Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85- Plus Study. Diabetes 51, 1088-1092 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 1088-1092
-
-
Van Exel, E.1
-
41
-
-
78650773537
-
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
-
Dasu, M. R., Jialal, I. Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am. J. Physiol. Endocrinol. Metab. 300, 145-154 (2011).
-
(2011)
Am. J. Physiol. Endocrinol. Metab
, vol.300
, pp. 145-154
-
-
Dasu, M.R.1
Jialal, I.2
-
42
-
-
12144290761
-
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
-
Kim, H. J. et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53, 1060-1067 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
-
43
-
-
0037012406
-
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: Role of fat and carbohydrate meals
-
Nappo, F. et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J. Am. Coll. Cardiol. 39, 1145-1150 (2002).
-
(2002)
J. Am. Coll. Cardiol
, vol.39
, pp. 1145-1150
-
-
Nappo, F.1
-
44
-
-
33846821855
-
Postprandial variations of plasma inflammatory markers in abdominally obese men
-
Blackburn, P et al. Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity (Silver Spring) 14, 1747-1754 (2006).
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 1747-1754
-
-
Blackburn, P.1
-
45
-
-
35948940807
-
Prolonged reactive oxygen species generation and nuclear factor-KB activation after a high-fat, high-carbohydrate meal in the obese
-
Patel, C. et al. Prolonged reactive oxygen species generation and nuclear factor-KB activation after a high-fat, high-carbohydrate meal in the obese. J. Clin. Endocrinol. Metab. 92, 4476-4479 (2007).
-
(2007)
J. Clin. Endocrinol. Metab
, vol.92
, pp. 4476-4479
-
-
Patel, C.1
-
46
-
-
33947388389
-
The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression
-
Kempf, K. et al. The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression. J. Mol. Med. 85, 389-396 (2007).
-
(2007)
J. Mol. Med
, vol.85
, pp. 389-396
-
-
Kempf, K.1
-
47
-
-
35648996899
-
Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia
-
Gonzalez, F., Rote, N. S., Minium, J., O’leary, V. B. and Kirwan, J. P Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia. Obesity (Silver Spring) 15, 2436-2444 (2007).
-
(2007)
Obesity (Silver Spring)
, vol.15
, pp. 2436-2444
-
-
Gonzalez, F.1
Rote, N.S.2
Minium, J.3
O’Leary, V.B.4
Kirwan, J.P.5
-
48
-
-
77950290067
-
Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression
-
Zacharioudaki, V. et al. Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression. J. Immunol. 182, 6444-6451 (2009).
-
(2009)
J. Immunol
, vol.182
, pp. 6444-6451
-
-
Zacharioudaki, V.1
-
49
-
-
77955494890
-
The obese healthy paradox: Is inflammation the answer
-
Barbarroja, N. et al. The obese healthy paradox: is inflammation the answer? Biochem. J. 430, 141-149 (2010).
-
(2010)
Biochem. J
, vol.430
, pp. 141-149
-
-
Barbarroja, N.1
-
50
-
-
70349769764
-
Reactive oxygen species production by mitochondria
-
Lambert, A. J. and Brand, M. D. Reactive oxygen species production by mitochondria. Methods Mol. Biol. 554, 165-181 (2009).
-
(2009)
Methods Mol. Biol
, vol.554
, pp. 165-181
-
-
Lambert, A.J.1
Brand, M.D.2
-
51
-
-
73449124480
-
Mitochondrial glutathione, a key survival antioxidant. Antioxid. Redox
-
Mari, M., Morales, A., Colell, A., Garcia-Ruiz, C. and Fernandez-Checa, J. C. Mitochondrial glutathione, a key survival antioxidant. Antioxid. Redox. Signal. 11, 2685-2700 (2009).
-
(2009)
Signal
, vol.11
, pp. 2685-2700
-
-
Mari, M.1
Morales, A.2
Colell, A.3
Garcia-Ruiz, C.4
Fernandez-Checa, J.C.5
-
52
-
-
53349101264
-
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
-
El Osta, A. et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med. 205, 2409-2417 (2008).
-
(2008)
J. Exp. Med
, vol.205
, pp. 2409-2417
-
-
El Osta, A.1
-
53
-
-
48749100078
-
Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells
-
Lambertucci, R. H. et al. Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells. J. Cell Physiol. 216, 796-804 (2008).
-
(2008)
J. Cell Physiol
, vol.216
, pp. 796-804
-
-
Lambertucci, R.H.1
-
54
-
-
34547119919
-
High glucose induces IL-1p expression in human monocytes: Mechanistic insights
-
Dasu, M. R., Devaraj, S. and Jialal, I. High glucose induces IL-1p expression in human monocytes: mechanistic insights. Am. J. Physiol. Endocrinol. Metab. 293, 337-346 (2007).
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.293
, pp. 337-346
-
-
Dasu, M.R.1
Devaraj, S.2
Jialal, I.3
-
55
-
-
0042266366
-
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
-
Short, K. R. et al. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52, 1888-1896 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 1888-1896
-
-
Short, K.R.1
-
56
-
-
66649109663
-
Antioxidants prevent health- promoting effects of physical exercise in humans
-
Ristow, M. et al. Antioxidants prevent health- promoting effects of physical exercise in humans. Proc. Natl Acad. Sci. USA 106, 8665-8670 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 8665-8670
-
-
Ristow, M.1
-
57
-
-
38149131289
-
Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
-
Gomez-Cabrera, M. C. et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am. J. Clin. Nutr. 87, 142-149 (2008).
-
(2008)
Am. J. Clin. Nutr
, vol.87
, pp. 142-149
-
-
Gomez-Cabrera, M.C.1
-
58
-
-
79955423639
-
Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis. Med. Sci
-
Strobel, N. A. et al. Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis. Med. Sci. Sports Exerc. 43, 1017-1024 (2011).
-
(2011)
Sports Exerc
, vol.43
, pp. 1017-1024
-
-
Strobel, N.A.1
-
59
-
-
78650913154
-
Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: A role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxid. Redox
-
Cheng, X., Siow, R. C. and Mann, G. E. Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxid. Redox. Signal. 14, 469-487 (2011).
-
(2011)
Signal
, vol.14
, pp. 469-487
-
-
Cheng, X.1
Siow, R.C.2
Mann, G.E.3
-
60
-
-
79953810587
-
Oltipraz upregulates the nuclear factor (Erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice
-
Yu, Z. et al. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia 54, 922-934 (2011).
-
(2011)
Diabetologia
, vol.54
, pp. 922-934
-
-
Yu, Z.1
-
61
-
-
48449094498
-
AMPK and PPARS agonists are exercise mimetics
-
Narkar, V. A. et al. AMPK and PPARS agonists are exercise mimetics. Cell 134, 405-415 (2008).
-
(2008)
Cell
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
-
62
-
-
77952548782
-
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp
-
Ristow, M. and Zarse, K. How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45, 410-418 (2010).
-
(2010)
Gerontol
, vol.45
, pp. 410-418
-
-
Ristow, M.1
Zarse, K.2
-
63
-
-
62749130586
-
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet
-
Gupte, A. A., Bomhoff, G. L., Swerdlow, R. H. and Geiger, P. C. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes 58, 567-578 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 567-578
-
-
Gupte, A.A.1
Bomhoff, G.L.2
Swerdlow, R.H.3
Geiger, P.C.4
-
64
-
-
77249122068
-
Mild thermotolerance induced at 40 degrees C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide
-
Pallepati, P. and Averill-Bates, D. Mild thermotolerance induced at 40 degrees C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53. Arch. Biochem. Biophys. 495, 97-111 (2010).
-
(2010)
Role of P53. Arch. Biochem. Biophys.
, vol.495
, pp. 97-111
-
-
Pallepati, P.1
Averill-Bates, D.2
-
65
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell
-
Schulz, T. J. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell. Metab. 6, 280-293 (2007).
-
(2007)
Metab
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
-
66
-
-
78650177082
-
Inhibition of respiration extends C. Elegans life span via reactive oxygen species that increase HIF-1 activity
-
Lee, S. J., Hwang, A. B. and Kenyon, C. Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr. Biol. 20, 2131-2136 (2010).
-
(2010)
Curr. Biol
, vol.20
, pp. 2131-2136
-
-
Lee, S.J.1
Hwang, A.B.2
Kenyon, C.3
-
67
-
-
70350365865
-
C. Elegans as model for the study of high glucose-mediated life span reduction
-
Schlotterer, A. et al. C. elegans as model for the study of high glucose-mediated life span reduction. Diabetes 58, 2450-2456 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 2450-2456
-
-
Schlotterer, A.1
-
68
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley, D. E., He, J., Menshikova, E. V. and Ritov, V. B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
69
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R. and Shulman, G. I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350, 664-671 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
70
-
-
33847611885
-
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
-
Boushel, R. et al. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50, 790-796 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 790-796
-
-
Boushel, R.1
-
71
-
-
0942301241
-
Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with type 2 diabetes
-
Bruce, C. R., Kriketos, A. D., Cooney, G. J. and Hawley, J. A. Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with type 2 diabetes. Diabetologia 47, 23-30 (2004).
-
(2004)
Diabetologia
, vol.47
, pp. 23-30
-
-
Bruce, C.R.1
Kriketos, A.D.2
Cooney, G.J.3
Hawley, J.A.4
-
72
-
-
20444466581
-
Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes
-
Hatunic, M., Burns, N., Finucane, F., Mannion, C. and Nolan, J. J. Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes. Diab. Vasc. Dis. Res. 2, 73-75 (2005).
-
(2005)
Diab. Vasc. Dis. Res
, vol.2
, pp. 73-75
-
-
Hatunic, M.1
Burns, N.2
Finucane, F.3
Mannion, C.4
Nolan, J.J.5
-
73
-
-
41449091754
-
Early-onset type 2 diabetes mellitus: An increasing phenomenon of elevated cardiovascular risk. Expert
-
Song, S. H. and Hardisty, C. A. Early-onset type 2 diabetes mellitus: an increasing phenomenon of elevated cardiovascular risk. Expert Rev. Cardiovasc. Ther. 6, 315-322 (2008).
-
(2008)
Rev. Cardiovasc. Ther
, vol.6
, pp. 315-322
-
-
Song, S.H.1
Hardisty, C.A.2
-
74
-
-
77649244994
-
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1a/mitofusin-2 regulatory pathway in response to physical activity
-
Hernandez-Alvarez, M. I. et al. Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1a/mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care 33, 645-651 (2010).
-
(2010)
Diabetes Care
, vol.33
, pp. 645-651
-
-
Hernandez-Alvarez, M.I.1
-
75
-
-
34249945638
-
Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in p cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
-
Burns, N. et al. Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in p cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetologia 50, 1500-1508 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 1500-1508
-
-
Burns, N.1
-
76
-
-
60749137649
-
Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr
-
Babraj, J. A. et al. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr. Disord. 9, 3 (2009).
-
(2009)
Disord
, vol.9
, pp. 3
-
-
Babraj, J.A.1
-
77
-
-
72449181721
-
Improved insulin sensitivity after exercise: Focus on insulin signaling
-
Frosig, C. and Richter, E. A. Improved insulin sensitivity after exercise: focus on insulin signaling. Obesity (Silver Spring) 17 (Suppl. 3), 15-20 (2009).
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 15-20
-
-
Frosig, C.1
Richter, E.A.2
-
78
-
-
79955972054
-
The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes
-
Olsen, D. B., Scheede-Bergdahl, C., Reving, D., Boushel, R. and Dela, F. The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes. Scand. J. Med. Sci. Sports 21, 420-430 (2011).
-
(2011)
Scand. J. Med. Sci. Sports
, vol.21
, pp. 420-430
-
-
Olsen, D.B.1
Scheede-Bergdahl, C.2
Reving, D.3
Boushel, R.4
Dela, F.5
-
79
-
-
77950349827
-
Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
-
Meex, R. C. et al. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes 59, 572-579 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 572-579
-
-
Meex, R.C.1
-
80
-
-
77955508579
-
Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
-
Phielix, E., Meex, R., Moonen-Kornips, E., Hesselink, M. K. and Schrauwen, P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 53, 1714-1721 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 1714-1721
-
-
Phielix, E.1
Meex, R.2
Moonen-Kornips, E.3
Hesselink, M.K.4
Schrauwen, P.5
-
81
-
-
77956013253
-
Minireview: Inflammation and obesity pathogenesis: The hypothalamus heats up
-
Thaler, J. P and Schwartz, M. W. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151, 4109-4115 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 4109-4115
-
-
Thaler, J.P.1
Schwartz, M.W.2
-
82
-
-
77956772446
-
Sensing the fuels: Glucose and lipid signaling in the CNS controlling energy homeostasis
-
Jordan, S. D., Konner, A. C. and Bruning, J. C. Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell. Mol. Life Sci. 67, 3255-3273 (2010).
-
(2010)
Cell. Mol. Life Sci
, vol.67
, pp. 3255-3273
-
-
Jordan, S.D.1
Konner, A.C.2
Bruning, J.C.3
-
83
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Wei, Y, Wang, D., Topczewski, F. and Pagliassotti, M. J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 291, 275-281 (2006).
-
(2006)
Am. J. Physiol. Endocrinol. Metab
, vol.291
, pp. 275-281
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
84
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus. Endocr
-
Eizirik, D. L., Cardozo, A. K. and Cnop, M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 29, 42-61 (2008).
-
(2008)
Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
85
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil, G. S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917 (2010).
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
86
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron, D. and Walter, P Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529 (2007).
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
87
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan, U. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006).
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
-
88
-
-
78650826465
-
Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity- induced myocardial contractile dysfunction
-
Ceylan-Isik, A. F., Sreejayan, N. and Ren, J. Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity- induced myocardial contractile dysfunction. J. Mol. Cell Cardiol. 50, 107-116 (2011).
-
(2011)
J. Mol. Cell Cardiol
, vol.50
, pp. 107-116
-
-
Ceylan-Isik, A.F.1
Sreejayan, N.2
Ren, J.3
-
89
-
-
77955411159
-
Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
-
Kars, M. et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 59, 1899-1905 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 1899-1905
-
-
Kars, M.1
-
90
-
-
79953001199
-
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1
-
Li, J., Wang, J. J. and Zhang, S. X. Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1. J. Biol. Chem. 286, 4912-4921 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 4912-4921
-
-
Li, J.1
Wang, J.J.2
Zhang, S.X.3
-
91
-
-
69849104186
-
A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide- induced inflammatory responses, depending on its capacity to induce the unfolded protein response
-
Harama, D. et al. A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide- induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J. Immunol. 183, 1368-1374 (2009).
-
(2009)
J. Immunol
, vol.183
, pp. 1368-1374
-
-
Harama, D.1
-
92
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U. et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-61 (2004).
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
-
93
-
-
19944430402
-
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
-
Nakatani, Y et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J. Biol. Chem. 280, 847-851 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 847-851
-
-
Nakatani, Y.1
-
94
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun, H. L. et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215 (2009).
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
-
95
-
-
77449096697
-
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance
-
Ye, R. et al. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 59, 6-16 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 6-16
-
-
Ye, R.1
-
96
-
-
79952122987
-
Deletion of Nck1 attenuates hepatic ER stress signaling, improves glucose tolerance and insulin signaling in liver of obese mice
-
Latreille, M., Laberge, M. K., Bourret, G., Yamani, L. and Larose, L. Deletion of Nck1 attenuates hepatic ER stress signaling, improves glucose tolerance and insulin signaling in liver of obese mice. Am. J. Physiol. Endocrinol. Metab. 300, E423-E434 (2011).
-
(2011)
Am. J. Physiol. Endocrinol. Metab
, vol.300
, pp. E423-E434
-
-
Latreille, M.1
Laberge, M.K.2
Bourret, G.3
Yamani, L.4
Larose, L.5
-
97
-
-
79551510124
-
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex. Cell
-
Wu, J. et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex. Cell. Metab. 13, 160-169 (2011).
-
(2011)
Metab
, vol.13
, pp. 160-169
-
-
Wu, J.1
-
98
-
-
77952552782
-
Stress and hormetic regulation of the aging process. Ageing Res
-
Salminen, A. and Kaarniranta, K. ER stress and hormetic regulation of the aging process. Ageing Res. Rev. 9, 211-217 (2010).
-
(2010)
Rev
, vol.9
, pp. 211-217
-
-
Salminen, A.1
Kaarniranta, K.2
-
99
-
-
34547638958
-
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated (3-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
-
Huang, C. J. et al. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated 3-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56, 2016-2027 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 2016-2027
-
-
Huang, C.J.1
-
100
-
-
64649101777
-
Successful versus failed adaptation to high-fat diet-induced insulin resistance the role of IAPP-induced 3-cell endoplasmic reticulum stress
-
Matveyenko, A. V., Gurlo, T., Daval, M., Butler, A. E. and Butler, P. C. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced 3-cell endoplasmic reticulum stress. Diabetes 58, 906-916 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 906-916
-
-
Matveyenko, A.V.1
Gurlo, T.2
Daval, M.3
Butler, A.E.4
Butler, P.C.5
-
101
-
-
0009760791
-
Heat shock protein hsp70 overexpression confers resistance against nitric oxide
-
Bellmann, K., Jaattela, M., Wissing, D., Burkart, V. and Kolb, H. Heat shock protein hsp70 overexpression confers resistance against nitric oxide. FEBS Lett. 391, 185-188 (1996).
-
(1996)
FEBS Lett
, vol.391
, pp. 185-188
-
-
Bellmann, K.1
Jaattela, M.2
Wissing, D.3
Burkart, V.4
Kolb, H.5
-
102
-
-
0030980991
-
Low stress response enhances vulnerability of islet cells in diabetes-prone BB rats
-
Bellmann, K., Hui, L., Radons, J., Burkart, V. and Kolb, H. Low stress response enhances vulnerability of islet cells in diabetes-prone BB rats. Diabetes 46, 232-236 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 232-236
-
-
Bellmann, K.1
Hui, L.2
Radons, J.3
Burkart, V.4
Kolb, H.5
-
103
-
-
0026052415
-
Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 13-induced impaired 3-cell function
-
Margulis, B. A., Sandler, S., Eizirik, D. L., Welsh, N. and Welsh, M. Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 13-induced impaired 3-cell function. Diabetes 40, 1418-1422 (1991).
-
(1991)
Diabetes
, vol.40
, pp. 1418-1422
-
-
Margulis, B.A.1
Sandler, S.2
Eizirik, D.L.3
Welsh, N.4
Welsh, M.5
-
104
-
-
33646533330
-
Interferon-y potentiates endoplasmic reticulum stress- induced death by reducing pancreatic 3 cell defence mechanisms
-
Pirot, P, Eizirik, D. L. and Cardozo, A. K. Interferon-y potentiates endoplasmic reticulum stress- induced death by reducing pancreatic 3 cell defence mechanisms. Diabetologia 49, 1229-1236 (2006).
-
(2006)
Diabetologia
, vol.49
, pp. 1229-1236
-
-
Pirot, P.1
Eizirik, D.L.2
Cardozo, A.K.3
-
105
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic 3-cells
-
Cunha, D. A. et al. Initiation and execution of lipotoxic ER stress in pancreatic 3-cells. J. Cell Sci. 121, 2308-2318 (2008).
-
(2008)
J. Cell Sci
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
-
106
-
-
34147106529
-
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic 3 cells reveals the early degradation of insulin mRNAs
-
Pirot, P. et al. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic 3 cells reveals the early degradation of insulin mRNAs. Diabetologia 50, 1006-1014 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 1006-1014
-
-
Pirot, P.1
-
107
-
-
33751069967
-
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
-
Rutkowski, D. T. et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 4, e374 (2006).
-
(2006)
Plos Biol
, vol.374
, pp. 4
-
-
Rutkowski, D.T.1
-
108
-
-
77952574173
-
ER stress in pancreatic 3 cells: The thin red line between adaptation and failure
-
Eizirik, D. L. and Cnop, M. ER stress in pancreatic 3 cells: the thin red line between adaptation and failure. Sci.Signal. 3, pe7 (2010).
-
(2010)
Sci.Signal
-
-
Eizirik, D.L.1
Cnop, M.2
-
109
-
-
0041853778
-
Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation
-
Hung, C. C., Ichimura, T., Stevens, J. L. and Bonventre, J. V. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J. Biol. Chem. 278, 29317-29326 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29317-29326
-
-
Hung, C.C.1
Ichimura, T.2
Stevens, J.L.3
Bonventre, J.V.4
-
110
-
-
73249116246
-
Glucagon-like peptide-1 agonists protect pancreatic (3-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
-
Cunha, D. A. et al. Glucagon-like peptide-1 agonists protect pancreatic 3-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes 58, 2851-2862 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 2851-2862
-
-
Cunha, D.A.1
-
111
-
-
33750448469
-
GLP-1 receptor activation improves 3 cell function and survival following induction of endoplasmic reticulum stress
-
Yusta, B. et al. GLP-1 receptor activation improves 3 cell function and survival following induction of endoplasmic reticulum stress. Cell. Metab. 4, 391-06 (2006).
-
(2006)
Cell. Metab
, vol.4
, pp. 391-406
-
-
Yusta, B.1
-
112
-
-
72049110972
-
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
-
Johnson, J. D. et al. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant. 18, 833-845 (2009).
-
(2009)
Cell Transplant
, vol.18
, pp. 833-845
-
-
Johnson, J.D.1
-
113
-
-
73349106529
-
The effects of glucagon-like peptide-1 on the 3 cell. Diab. Obes
-
Vilsboll, T. The effects of glucagon-like peptide-1 on the 3 cell. Diab. Obes. Metab. 11 (Suppl. 3), 11-18 (2009).
-
(2009)
Metab
, vol.11
, pp. 11-18
-
-
Vilsboll, T.1
-
114
-
-
77949817711
-
AMPK and SIRT1: A long¬standing partnership
-
Ruderman, N. B. et al. AMPK and SIRT1: a long¬standing partnership? Am. J. Physiol. Endocrinol. Metab. 298, 751-760 (2010).
-
(2010)
Am. J. Physiol. Endocrinol. Metab
, vol.298
, pp. 751-760
-
-
Ruderman, N.B.1
-
115
-
-
78650987216
-
Sirtuin-1 regulation of mammalian metabolism. Trends Mol
-
Gillum, M. P., Erion, D. M. and Shulman, G. I. Sirtuin-1 regulation of mammalian metabolism. Trends Mol. Med. 17, 8-13 (2010).
-
(2010)
Med
, vol.17
, pp. 8-13
-
-
Gillum, M.P.1
Erion, D.M.2
Shulman, G.I.3
-
116
-
-
79953206276
-
Resveratrol potentiates glucose- stimulated insulin secretion in INS-1E 3-cells and human islets through a SIRT1-dependent mechanism
-
Vetterli, L., Brun, T., Giovannoni, L., Bosco, D. and Maechler, P. Resveratrol potentiates glucose- stimulated insulin secretion in INS-1E 3-cells and human islets through a SIRT1-dependent mechanism. J. Biol. Chem. 286, 6049-6060 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 6049-6060
-
-
Vetterli, L.1
Brun, T.2
Giovannoni, L.3
Bosco, D.4
Maechler, P.5
-
117
-
-
0033625664
-
Interleukin-13-induced alteration in a 3-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis
-
Ling, Z., Van de Casteele, M., Eizirik, D. L. and Pipeleers, D. G. Interleukin-13-induced alteration in a 3-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis. Diabetes 49, 340-345 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 340-345
-
-
Ling, Z.1
Van De Casteele, M.2
Eizirik, D.L.3
Pipeleers, D.G.4
-
118
-
-
77749234186
-
Current status of islet cell replacement and regeneration therapy
-
Halban, P. A., German, M. S., Kahn, S. E. and Weir, G. C. Current status of islet cell replacement and regeneration therapy. J. Clin. Endocrinol. Metab. 95, 1034-1043 (2010).
-
(2010)
J. Clin. Endocrinol. Metab
, vol.95
, pp. 1034-1043
-
-
Halban, P.A.1
German, M.S.2
Kahn, S.E.3
Weir, G.C.4
-
119
-
-
79251634527
-
3 cell regeneration in human pancreas. Semin
-
Gianani, R. 3 cell regeneration in human pancreas. Semin. Immunopathol. 33, 23-27 (2011).
-
(2011)
Immunopathol
, vol.33
, pp. 23-27
-
-
Gianani, R.1
-
120
-
-
77955272726
-
Giving and taking: Endothelial and 3-cells in the islets of Langerhans
-
Eberhard, D., Kragl, M. and Lammert, E. ‘Giving and taking’: endothelial and 3-cells in the islets of Langerhans. Trends Endocrinol. Metab. 21, 457-63 (2010).
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 457-463
-
-
Eberhard, D.1
Kragl, M.2
Lammert, E.3
-
121
-
-
77649103802
-
Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits
-
De Silva, N. M. and Frayling, T. M. Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits. Curr. Opin. Lipidol. 21, 44-50 (2010).
-
(2010)
Curr. Opin. Lipidol
, vol.21
, pp. 44-50
-
-
De Silva, N.M.1
Frayling, T.M.2
-
123
-
-
0025600472
-
Hyperglycemia-induced 3 cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background
-
Korsgren, O., Jansson, L., Sandler, S., and Andersson, A. Hyperglycemia-induced 3 cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J. Clin. Invest. 86, 2161-2168 (1990).
-
(1990)
J. Clin. Invest
, vol.86
, pp. 2161-2168
-
-
Korsgren, O.1
Jansson, L.2
Sandler, S.3
Andersson, A.4
-
124
-
-
55749086379
-
Association of SIRT1 gene variation with visceral obesity. Hum
-
Peeters, A. V. et al. Association of SIRT1 gene variation with visceral obesity. Hum. Genet. 124, 431-36 (2008).
-
(2008)
Genet
, vol.124
, pp. 431-436
-
-
Peeters, A.V.1
-
125
-
-
70349974821
-
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: A population-based cohort study
-
van den Berg, S. W. et al. Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. Int. J. Obes. (Lond.) 33, 1143-1152 (2009).
-
(2009)
Int. J. Obes. (Lond.)
, vol.33
, pp. 1143-1152
-
-
Van Den Berg, S.W.1
-
126
-
-
73249152036
-
SIRT1 genetic variation is related to BMI and risk of obesity
-
Zillikens, M. C. et al. SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes 58, 2828-2834 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 2828-2834
-
-
Zillikens, M.C.1
-
127
-
-
58749099124
-
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention—the TULIP Study. BMC Med
-
Weyrich, P. et al. SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention—the TULIP Study. BMC Med. Genet. 9, 100 (2008).
-
(2008)
Genet
, vol.9
, pp. 100
-
-
Weyrich, P.1
-
128
-
-
77949397703
-
The association between the peroxisome proliferator-activated receptor- gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: A HuGE review and meta-analysis
-
Gouda, H. N. et al. The association between the peroxisome proliferator-activated receptor- gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am. J. Epidemiol. 171, 645-655 (2010).
-
(2010)
Am. J. Epidemiol
, vol.171
, pp. 645-655
-
-
Gouda, H.N.1
-
129
-
-
77956922366
-
Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: A HuGE review and meta-analysis
-
Bao, W. et al. Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am. J. Epidemiol. 172, 631-636 (2010).
-
(2010)
Am. J. Epidemiol
, vol.172
, pp. 631-636
-
-
Bao, W.1
-
130
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell
-
Pearson, K. J. et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell. Metab. 8, 157-168 (2008).
-
(2008)
Metab
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
-
131
-
-
79953193036
-
Sensing of energy and nutrients by AMP-activated protein kinase
-
Hardie, D. G. Sensing of energy and nutrients by AMP-activated protein kinase. Am. J. Clin. Nutr. 93, 891-896 (2011).
-
(2011)
Am. J. Clin. Nutr
, vol.93
, pp. 891-896
-
-
Hardie, D.G.1
|