The obese healthy paradox: Is inflammation the answer?

Biochemical Journal

Volumn 430, Issue 1, 2010, Pages 141-149

  Barbarroja, Nuria ^a,b   López Pedrera, Rosario ^c   Mayas, Maria Dolores ^a,b   García Fuentes, Eduardo ^c   Garrido Sánchez, Lourdes ^d   Macias Gonzalez M ^a,b   El Bekay, Rajaa ^a,b   Vidal Puig, Antonio ^e   Tinahones, Francisco J ^a,b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^d HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Inflammation; Insulin resistance; Obesity; Signal transduction

Indexed keywords

ADIPOSE TISSUE; AKT ACTIVATION; C-JUN N-TERMINAL KINASE; COMMON FINDINGS; EXPRESSION LEVELS; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; HEALTHY INDIVIDUALS; IDENTIFICATION OF INDIVIDUALS; INFLAMMATION; INFLAMMATORY RESPONSE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RESISTANCE; INSULIN SIGNALLING; MECHANISTIC LINK; NECROSIS FACTORS; NUCLEAR FACTORS; OBESITY; SIMILAR DEGREE;

ACTIVATION ANALYSIS; BACTERIOPHAGES; ENZYME ACTIVITY; INFRARED DEVICES; MACROPHAGES; METABOLISM; NUTRITION; PATHOLOGY; SIGNAL TRANSDUCTION;

INSULIN;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; I KAPPA B; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ADULT; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; INFLAMMATION; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MACROPHAGE; MALE; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOSYNTHESIS; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MORBID OBESITY; PHYSIOLOGY;

ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTRA-ABDOMINAL FAT; MACROPHAGES; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OBESITY, MORBID; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955494890     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100285     Document Type: Article

References (29)

1. Hotamisligil, G. S. (2006) Inflammation and metabolic disorders. Nature 444, 860-867
2. Hotamisligil, G. S., Shargill, N. S. and Spiegelman, B. M. (1993) Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 97-91
3. Wellen, K. E. and Hotamisligil, G. S. (2005) Inflammation, stress, and diabetes. J. Clin. Invest. 115, 1111-1119
4. Greenberg, A. S. and Obin, M. S. (2006) Obesity and the role of adipose tissue in inflammation and metabolism. Am. J. Clin. Nutr. 83, 461S-465S
5. Pessin, J. E. and Saltiel, A. R. (2000) Signaling pathways in insulin action: molecular targets of insulin resistance. J. Clin. Invest. 106, 165-169
6. 307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277, 1531-1537
7. Gao, Z., Hwang, D., Bataille, F., Lefevre, M., York, D., Quon, M. J. and Ye, J. (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex. J. Biol. Chem. 277, 48115-48121
8. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F. and Spiegelman, B. M. (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science 271, 665-668
9. 2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J. Biol. Chem. 275, 9047-9054
10. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Marin, M. and Hotamisligil, G. S. (2002) A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (Pubitemid 35398190)
11. Engelman, J. A., Berg, A. H., Lewis, R. Y., Lisanti, M. P. and Scherer, P. E. (2000) Tumor necrosis factor α-mediated insulin resistance, but not differentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol. Endocrinol. 14, 1557-1569
12. Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono, H., Abe, M., Shojima, N. et al. (2003) Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol. Endocrinol. 17, 487-497
13. Karelis, A. D., St-Pierre, D. H., Conus, F., Rabasa-Lhoret, R. and Poehlman, E. T. (2004) Metabolic and body composition factors in subgroups of obesity: what do we know? J. Clin. Endocrinol. Metab. 89, 2569-2575
14. Montague, C. T. and O'Rahilly, S. (2000) The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49, 883-888
15. Vignali, D. A. (2000) Multiplexed particle-based flow cytometric assays. J. Immunol. Methods 243, 243-255
16. Gual, P., Le Marchand-Brustel, Y. and Tanti, J. F. (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87, 99-109
17. Saltiel, A. R. and Kahn, C. R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806
18. White, M. F. (2002) IRS proteins and the common path to diabetes. Am. J. Physiol. Endocrinol. Metab. 283, E413-E422
19. Virtue, S. and Vidal-Puig, A. (2010) Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome: an allostatic perspective. Biochim. Biophys. Acta 1801, 338-349
20. Fernández-Veledo, S., Vila-Bedmar, R., Nieto-Vazquez, I. and Lorenzo, M. (2009) c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-α induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists. J. Clin. Endocrinol. Metab. 94, 3583-3593
21. Juge-Aubry, C. E., Somm, E., Chicheportiche, R., Burger, D., Pernin, A., Cuénod-Pittet, B., Quinodoz, P., Giusti, V., Dayer, J. M. and Meier, C. A. (2004) Regulatory effects of interleukin (IL)-1, interferon-β, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J. Clin. Endocrinol. Metab. 89, 2653-2658
22. Fève, B. and Bastard, J. P. (2009) The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 5, 305-311
23. Zick, Y. (2001) Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 11, 437-441 (Pubitemid 33713174)
24. Jager, J., Grémeaux, T., Cormont, M., Le Marchand-Brustel, Y. and Tanti, J. F. (2007) Interleukin-1-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148, 241-251
25. White, M. F. and Kahn, C. R. (1994) The insulin signaling system. J. Biol. Chem. 269, 1-4
26. Carlsen, H., Haugen, F., Zadelaar, S., Kleemann, R., Kooistra, T., Drevon, C. A. and Blomhoff, R. (2009) Diet-induced obesity increases NF-κB signaling in reporter mice. Genes Nutr. 4, 215-222
27. Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P. and Dandona, P. (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110, 1564-1571
28. Sheu, W. H., Chang, T. M., Lee, W. J., Ou, H. C., Wu, C. M., Tseng, L. N., Lang, H. F., Wu, C. S., Wan, C. J. and Lee, I. T. (2008) Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity 16, 1033-1038
29. Chiao, P. J., Miyamoto, S. and Verma, I. M. (1994) Autoregulation of IκBα activity. Proc. Natl. Acad. Sci. U.S.A. 91, 28-32