-
1
-
-
0031459980
-
Extrachromosomal rDNA circles: A cause of aging in yeast
-
Sinclair DA, Guarente L. Extrachromosomal rDNA circles: a cause of aging in yeast. Cell 1997;91:1033-1042
-
(1997)
Cell
, vol.91
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
2
-
-
3943054839
-
The Sir2 family of protein deacetylases
-
Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004;73:417-435
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 417-435
-
-
Blander, G.1
Guarente, L.2
-
3
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000;289:2126-2128
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
4
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 2004;101:15998-16003
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
5
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang Y, Tissenbaum HA. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev 2006;127:48-56
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
6
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000;273:793-798
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
7
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001;107:137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
8
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
Hu, L.S.11
Cheng, H.L.12
Jedrychowski, M.P.13
Gygi, S.P.14
Sinclair, D.A.15
Alt, F.W.16
Greenberg, M.E.17
-
9
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004;305:1010-1013
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
10
-
-
8844247034
-
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
-
Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 2004;95:971-980
-
(2004)
Circ Res
, vol.95
, pp. 971-980
-
-
Alcendor, R.R.1
Kirshenbaum, L.A.2
Imai, S.3
Vatner, S.F.4
Sadoshima, J.5
-
11
-
-
16844375290
-
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
-
Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, Catoire H, Neri C. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet 2005;37:349-350
-
(2005)
Nat Genet
, vol.37
, pp. 349-350
-
-
Parker, J.A.1
Arango, M.2
Abderrahmane, S.3
Lambert, E.4
Tourette, C.5
Catoire, H.6
Neri, C.7
-
12
-
-
30044443515
-
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity
-
Pillai JB, Isbatan A, Imai S, Gupta MP. Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J Biol Chem 2005;280:43121-43130
-
(2005)
J Biol Chem
, vol.280
, pp. 43121-43130
-
-
Pillai, J.B.1
Isbatan, A.2
Imai, S.3
Gupta, M.P.4
-
13
-
-
33745166337
-
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
-
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isono M, Isshiki K, Uzu T, Kashiwagi A, Koya D. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radic Biol Med 2006;40:2175-2182
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 2175-2182
-
-
Kume, S.1
Haneda, M.2
Kanasaki, K.3
Sugimoto, T.4
Araki, S.5
Isono, M.6
Isshiki, K.7
Uzu, T.8
Kashiwagi, A.9
Koya, D.10
-
14
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004;429:771-776
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
15
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005;434:113-118
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
16
-
-
20144365700
-
Nuclear trapping of the forkhead transcrip-tion factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
-
Frescas D, Valenti L, Accili D. Nuclear trapping of the forkhead transcrip-tion factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 2005;280:20589-20595
-
(2005)
J Biol Chem
, vol.280
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
17
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Meneur C, Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab 2005;2:105-117
-
(2005)
Cell Metab
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Meneur, C.6
Permutt, M.A.7
Imai, S.8
-
18
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006;4:e31
-
(2006)
PLoS Biol
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
Easlon, E.J.11
Lin, S.J.12
Guarente, L.13
-
19
-
-
33746419647
-
Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
-
Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, Smith SR, Alfonso A, Ravussin E. Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006;29:1337-1344
-
(2006)
Diabetes Care
, vol.29
, pp. 1337-1344
-
-
Larson-Meyer, D.E.1
Heilbronn, L.K.2
Redman, L.M.3
Newcomer, B.R.4
Frisard, M.I.5
Anton, S.6
Smith, S.R.7
Alfonso, A.8
Ravussin, E.9
-
20
-
-
60649110218
-
Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
-
Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis 2008;203:206-213
-
(2008)
Atherosclerosis
, vol.203
, pp. 206-213
-
-
Lefevre, M.1
Redman, L.M.2
Heilbronn, L.K.3
Smith, J.V.4
Martin, C.K.5
Rood, J.C.6
Greenway, F.L.7
Williamson, D.A.8
Smith, S.R.9
Ravussin, E.10
-
21
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004;305:390-392
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de Cabo, R.9
Sinclair, D.A.10
-
22
-
-
45549102566
-
Regulation of SIRT1 protein levels by nutrient availability
-
Kanfi Y, Peshti V, Gozlan YM, Rathaus M, Gil R, Cohen HY. Regulation of SIRT1 protein levels by nutrient availability. FEBS Lett 2008;582:2417-2423
-
(2008)
FEBS Lett
, vol.582
, pp. 2417-2423
-
-
Kanfi, Y.1
Peshti, V.2
Gozlan, Y.M.3
Rathaus, M.4
Gil, R.5
Cohen, H.Y.6
-
23
-
-
49549105992
-
Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
-
Pedersen SB, Olholm J, Paulsen SK, Bennetzen MF, Richelsen B. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women. Int J Obes (Lond) 2008;32:1250-1255
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 1250-1255
-
-
Pedersen, S.B.1
Olholm, J.2
Paulsen, S.K.3
Bennetzen, M.F.4
Richelsen, B.5
-
24
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
de Cabo, R.26
Sinclair, D.A.27
more..
-
25
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
27
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 2006;66:4368-4377
-
(2006)
Cancer Res
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
Schuler, A.D.3
Posakony, J.4
Li, H.5
Goehle, S.6
Kollipara, R.7
Depinho, R.A.8
Gu, Y.9
Simon, J.A.10
Bedalov, A.11
-
28
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 2008;22:1753-1757
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
29
-
-
45549096918
-
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
-
Li Y, Xu W, McBurney MW, Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 2008;8:38-48
-
(2008)
Cell Metab
, vol.8
, pp. 38-48
-
-
Li, Y.1
Xu, W.2
McBurney, M.W.3
Longo, V.D.4
-
30
-
-
55749086379
-
Association of SIRT1 gene variation with visceral obesity
-
Peeters AV, Beckers S, Verrijken A, Mertens I, Roevens P, Peeters PJ, Van Hul W, Van Gaal LF. Association of SIRT1 gene variation with visceral obesity. Hum Genet 2008;124:431-436
-
(2008)
Hum Genet
, vol.124
, pp. 431-436
-
-
Peeters, A.V.1
Beckers, S.2
Verrijken, A.3
Mertens, I.4
Roevens, P.5
Peeters, P.J.6
Van Hul, W.7
Van Gaal, L.F.8
-
31
-
-
58749099124
-
SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention: The TULIP study
-
Weyrich P, Machicao F, Reinhardt J, Machann J, Schick F, Tschritter O, Stefan N, Fritsche A, Haring HU. SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention: the TULIP study. BMC Med Genet 2008;9:100
-
(2008)
BMC Med Genet
, vol.9
, pp. 100
-
-
Weyrich, P.1
Machicao, F.2
Reinhardt, J.3
Machann, J.4
Schick, F.5
Tschritter, O.6
Stefan, N.7
Fritsche, A.8
Haring, H.U.9
-
33
-
-
36148941777
-
The Rotterdam Study: Objectives and design update
-
Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, Tiemeier H, Uitterlinden AG, Vingerling JR, Witteman JC. The Rotterdam Study: objectives and design update. Eur J Epidemiol 2007;22:819-829
-
(2007)
Eur J Epidemiol
, vol.22
, pp. 819-829
-
-
Hofman, A.1
Breteler, M.M.2
van Duijn, C.M.3
Krestin, G.P.4
Pols, H.A.5
Stricker, B.H.6
Tiemeier, H.7
Uitterlinden, A.G.8
Vingerling, J.R.9
Witteman, J.C.10
-
34
-
-
0036314246
-
A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands
-
Vaessen N, Heutink P, Houwing-Duistermaat JJ, Snijders PJ, Rademaker T, Testers L, Batstra MR, Sandkuijl LA, van Duijn CM, Oostra BA. A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands. Diabetes 2002;51:856-859
-
(2002)
Diabetes
, vol.51
, pp. 856-859
-
-
Vaessen, N.1
Heutink, P.2
Houwing-Duistermaat, J.J.3
Snijders, P.J.4
Rademaker, T.5
Testers, L.6
Batstra, M.R.7
Sandkuijl, L.A.8
van Duijn, C.M.9
Oostra, B.A.10
-
35
-
-
27644568866
-
Heritability of the function and structure of the arterial wall: Findings of the Erasmus Rucphen Family (ERF) study
-
Sayed-Tabatabaei FA, van Rijn MJ, Schut AF, Aulchenko YS, Croes EA, Zillikens MC, Pols HA, Witteman JC, Oostra BA, van Duijn CM. Heritability of the function and structure of the arterial wall: findings of the Erasmus Rucphen Family (ERF) study. Stroke 2005;36:2351-2356
-
(2005)
Stroke
, vol.36
, pp. 2351-2356
-
-
Sayed-Tabatabaei, F.A.1
van Rijn, M.J.2
Schut, A.F.3
Aulchenko, Y.S.4
Croes, E.A.5
Zillikens, M.C.6
Pols, H.A.7
Witteman, J.C.8
Oostra, B.A.9
van Duijn, C.M.10
-
36
-
-
33644832531
-
Heritability of fasting glucose levels in a young genetically isolated population
-
Santos RL, Zillikens MC, Rivadeneira FR, Pols HA, Oostra BA, van Duijn CM, Aulchenko YS. Heritability of fasting glucose levels in a young genetically isolated population. Diabetologia 2006;49:667-672
-
(2006)
Diabetologia
, vol.49
, pp. 667-672
-
-
Santos, R.L.1
Zillikens, M.C.2
Rivadeneira, F.R.3
Pols, H.A.4
Oostra, B.A.5
van Duijn, C.M.6
Aulchenko, Y.S.7
-
37
-
-
73249130225
-
-
Raymond M, Rousset F. GENEPOP version 1.2, population genetics software for exact tests and ecumenicism. J Heredity 1995;86:248-249
-
Raymond M, Rousset F. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Heredity 1995;86:248-249
-
-
-
-
38
-
-
0035071957
-
A new statistical method for haplotype reconstruction from population data
-
Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-989
-
(2001)
Am J Hum Genet
, vol.68
, pp. 978-989
-
-
Stephens, M.1
Smith, N.J.2
Donnelly, P.3
-
40
-
-
47949104798
-
The role of exercise and PGC1alpha in inflammation and chronic disease
-
Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 2008;454:463-469
-
(2008)
Nature
, vol.454
, pp. 463-469
-
-
Handschin, C.1
Spiegelman, B.M.2
-
41
-
-
26244436281
-
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
-
Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 2005;16:4623-4635
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
Park, J.Y.2
Burneskis, J.M.3
Barrett, J.C.4
Horikawa, I.5
-
42
-
-
47549088250
-
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 2008;134:329-340
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
Kaluzova, M.2
Grimaldi, B.3
Sahar, S.4
Hirayama, J.5
Chen, D.6
Guarente, L.P.7
Sassone-Corsi, P.8
-
43
-
-
47749140333
-
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 2008;134:317-328
-
(2008)
Cell
, vol.134
, pp. 317-328
-
-
Asher, G.1
Gatfield, D.2
Stratmann, M.3
Reinke, H.4
Dibner, C.5
Kreppel, F.6
Mostoslavsky, R.7
Alt, F.W.8
Schibler, U.9
-
44
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
-
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai SI, Bass J. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 2009;324:651-654
-
(2009)
Science
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
Yoshino, J.2
Brace, C.S.3
Abrassart, D.4
Kobayashi, Y.5
Marcheva, B.6
Hong, H.K.7
Chong, J.L.8
Buhr, E.D.9
Lee, C.10
Takahashi, J.S.11
Imai, S.I.12
Bass, J.13
-
45
-
-
43049121395
-
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
-
Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 2008;14:661-673
-
(2008)
Dev Cell
, vol.14
, pp. 661-673
-
-
Fulco, M.1
Cen, Y.2
Zhao, P.3
Hoffman, E.P.4
McBurney, M.W.5
Sauve, A.A.6
Sartorelli, V.7
-
46
-
-
42349112088
-
Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
-
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-369
-
(2008)
Nat Rev Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
Ioannidis, J.P.6
Hirschhorn, J.N.7
-
47
-
-
25444484672
-
Small molecule regulation of Sir2 protein deacetylases
-
Grubisha O, Smith BC, Denu JM. Small molecule regulation of Sir2 protein deacetylases. FEBS J 2005;272:4607-4616
-
(2005)
FEBS J
, vol.272
, pp. 4607-4616
-
-
Grubisha, O.1
Smith, B.C.2
Denu, J.M.3
-
48
-
-
33746862126
-
Resveratrol inhibits insulin responses in a SirT1-independent pathway
-
Zhang J. Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem J 2006;397:519-527
-
(2006)
Biochem J
, vol.397
, pp. 519-527
-
-
Zhang, J.1
-
49
-
-
20344407841
-
Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
-
de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 2005;49:405-430
-
(2005)
Mol Nutr Food Res
, vol.49
, pp. 405-430
-
-
de la Lastra, C.A.1
Villegas, I.2
-
50
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007;450:712-716
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
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