Nutrient modification of the innate immune response: A novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 4, 2010, Pages 802-808

  Schwartz, Eric A ^a,b   Zhang, Wei Yang ^a   Karnik, Sheetal K ^a   Borwege, Sabine ^a   Anand, Vijay R ^a   Laine, Phyllis S ^a   Su, Yali ^c   Reaven, Peter D ^a,d  

^a CARL T HAYDEN VA MEDICAL CENTER   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c Kronos Science Laboratories   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Ceramide; Mitogen activated protein kinase; Monocytes; Protein kinase C; Toll like receptor

Indexed keywords

CERAMIDE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C THETA; SATURATED FATTY ACID; TOLL LIKE RECEPTOR 4; AUTACOID; FATTY ACID; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C ZETA; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TLR4 PROTEIN, HUMAN;

ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; ENZYME ACTIVATION; FATTY ACID METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; INSULIN RESISTANCE; MACROPHAGE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRIENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; TIME;

CELL LINE; CERAMIDES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FATTY ACIDS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; TIME FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 77950888339     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.201681     Document Type: Article

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