메뉴 건너뛰기




Volumn 751, Issue 1, 2012, Pages 29-35

ATM and DNA-PKcs make a complementary couple in DNA double strand break repair

Author keywords

ATM; DNA PKcs; DSB repair; Illegitimate repair; Residual DSBs

Indexed keywords

ATM PROTEIN; DEOXYRIBONUCLEIC ACID DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; PROTEIN KINASE; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84862219438     PISSN: 13835742     EISSN: 13882139     Source Type: Journal    
DOI: 10.1016/j.mrrev.2011.12.006     Document Type: Review
Times cited : (17)

References (97)
  • 2
    • 38049125555 scopus 로고    scopus 로고
    • The endless tale of non-homologous end-joining
    • Weterings E., Chen D.J. The endless tale of non-homologous end-joining. Cell Res. 2008, 18:114-124.
    • (2008) Cell Res. , vol.18 , pp. 114-124
    • Weterings, E.1    Chen, D.J.2
  • 3
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney B.L., Meek K., Lees-miller S.P. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 2009, 417:639-650.
    • (2009) Biochem. J. , vol.417 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-miller, S.P.3
  • 4
    • 34249945536 scopus 로고    scopus 로고
    • DNA double-strand break repair: from mechanistic understanding to cancer treatment
    • (Replication Fork Repair Processes)
    • Helleday T., Lo J., van Gent D.C., Engelward B.P. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair 2007, 6:923-935. (Replication Fork Repair Processes).
    • (2007) DNA Repair , vol.6 , pp. 923-935
    • Helleday, T.1    Lo, J.2    van Gent, D.C.3    Engelward, B.P.4
  • 6
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 7
    • 3242708425 scopus 로고    scopus 로고
    • Regulation of DNA replication by ATR: signaling in response to DNA intermediates
    • Shechter D., Costanzo V., Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair 2004, 3:901-908.
    • (2004) DNA Repair , vol.3 , pp. 901-908
    • Shechter, D.1    Costanzo, V.2    Gautier, J.3
  • 8
    • 34247507469 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
    • Chen B.P.C., Uematsu N., Kobayashi J., Lerenthal Y., Krempler A., Yajima H., Löbrich M., Shiloh Y., Chen D.J. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J. Biol. Chem. 2007, 282:6582-6587.
    • (2007) J. Biol. Chem. , vol.282 , pp. 6582-6587
    • Chen, B.P.C.1    Uematsu, N.2    Kobayashi, J.3    Lerenthal, Y.4    Krempler, A.5    Yajima, H.6    Löbrich, M.7    Shiloh, Y.8    Chen, D.J.9
  • 9
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: taking shape
    • Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem. Sci. 2006, 31:402-410.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 10
    • 33646106590 scopus 로고    scopus 로고
    • [gamma]H2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes
    • Stucki M., Jackson S.P. [gamma]H2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair 2006, 5:534-543.
    • (2006) DNA Repair , vol.5 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 11
    • 39149100653 scopus 로고    scopus 로고
    • DNA protein kinase dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells
    • Arlander S.J.H., Greene B.T., Innes C.L., Paules R.S. DNA protein kinase dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells. Cancer Res. 2008, 68:89-97.
    • (2008) Cancer Res. , vol.68 , pp. 89-97
    • Arlander, S.J.H.1    Greene, B.T.2    Innes, C.L.3    Paules, R.S.4
  • 12
    • 38349177265 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-d-arabino-pentofuranosylcytosine
    • Liu X., Matsuda A., Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-d-arabino-pentofuranosylcytosine. Mol. Cancer Ther. 2008, 7:133-142.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 133-142
    • Liu, X.1    Matsuda, A.2    Plunkett, W.3
  • 14
    • 0034025078 scopus 로고    scopus 로고
    • The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
    • Jhappan C., Yusufzai T.M., Anderson S., Anver M.R., Merlino G. The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol. Cell. Biol. 2000, 20:4075-4083.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4075-4083
    • Jhappan, C.1    Yusufzai, T.M.2    Anderson, S.3    Anver, M.R.4    Merlino, G.5
  • 16
    • 0031025079 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
    • Rathmell W.K., Kaufmann W.K., Hurt J.C., Byrd L.L., Chu G. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res. 1997, 57:68-74.
    • (1997) Cancer Res. , vol.57 , pp. 68-74
    • Rathmell, W.K.1    Kaufmann, W.K.2    Hurt, J.C.3    Byrd, L.L.4    Chu, G.5
  • 17
    • 58049083839 scopus 로고    scopus 로고
    • DNA-PK suppresses a p53-independent apoptotic response to DNA damage
    • Gurley K.E., Moser R., Gu Y., Hasty P., Kemp C.J. DNA-PK suppresses a p53-independent apoptotic response to DNA damage. EMBO Rep. 2009, 10:87-93.
    • (2009) EMBO Rep. , vol.10 , pp. 87-93
    • Gurley, K.E.1    Moser, R.2    Gu, Y.3    Hasty, P.4    Kemp, C.J.5
  • 18
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • (BRIDGE OVER BROKEN ENDS - The Cellular Response to DNA Breaks in Health and Disease)
    • Burma S., Chen D.J. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair 2004, 3:909-918. (BRIDGE OVER BROKEN ENDS - The Cellular Response to DNA Breaks in Health and Disease).
    • (2004) DNA Repair , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 19
    • 28544448011 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
    • Cui X., Yu Y., Gupta S., Cho Y.-M., Lees-Miller S.P., Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol. Cell. Biol. 2005, 25:10842-10852.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10842-10852
    • Cui, X.1    Yu, Y.2    Gupta, S.3    Cho, Y.-M.4    Lees-Miller, S.P.5    Meek, K.6
  • 20
    • 79956220705 scopus 로고    scopus 로고
    • Choosing the right path: Does DNA-PK help make the decision?
    • Neal J.A., Meek K. Choosing the right path: Does DNA-PK help make the decision?. Mutat. Res. 2011, 711(1-2):73-86.
    • (2011) Mutat. Res. , vol.711 , Issue.1-2 , pp. 73-86
    • Neal, J.A.1    Meek, K.2
  • 21
    • 14844292557 scopus 로고    scopus 로고
    • DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks
    • Drouet J., Delteil C., Lefrançois J., Concannon P., Salles B., Calsou P. DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks. J. Biol. Chem. 2005, 280:7060-7069.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7060-7069
    • Drouet, J.1    Delteil, C.2    Lefrançois, J.3    Concannon, P.4    Salles, B.5    Calsou, P.6
  • 23
    • 0030009738 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
    • Chan D.W., Lees-Miller S.P. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem. 1996, 271:8936-8941.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8936-8941
    • Chan, D.W.1    Lees-Miller, S.P.2
  • 24
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan D.W., Chen B.P.-C., Prithivirajsingh S., Kurimasa A., Story M.D., Qin J., Chen D.J. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 2002, 16:2333-2338.
    • (2002) Genes Dev. , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.-C.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 26
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma G.C., Custer R.P., Bosma M.J. A severe combined immunodeficiency mutation in the mouse. Nature 1983, 301:527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 27
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
    • Peterson S.R., Kurimasa A., Oshimura M., Dynan W.S., Bradbury E.M., Chen D.J. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Nat. Acad. Sci. 1995, 92:3171-3174.
    • (1995) Proc. Nat. Acad. Sci. , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 29
    • 0015792544 scopus 로고
    • Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder
    • McGuire T.C., Poppie M.J. Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder. Infect. Immun. 1973, 8:272-277.
    • (1973) Infect. Immun. , vol.8 , pp. 272-277
    • McGuire, T.C.1    Poppie, M.J.2
  • 33
    • 0037250083 scopus 로고    scopus 로고
    • Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J
    • Virsik-Köpp P., Rave-Fränk M., Hofman-Hüther H., Schmidberger H. Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J. Int. J. Radiat. Biol. 2003, 79:61-68.
    • (2003) Int. J. Radiat. Biol. , vol.79 , pp. 61-68
    • Virsik-Köpp, P.1    Rave-Fränk, M.2    Hofman-Hüther, H.3    Schmidberger, H.4
  • 35
    • 53549118024 scopus 로고    scopus 로고
    • The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells
    • Ruis B.L., Fattah K.R., Hendrickson E.A. The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol. Cell. Biol. 2008, 28:6182-6195.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 6182-6195
    • Ruis, B.L.1    Fattah, K.R.2    Hendrickson, E.A.3
  • 38
    • 77951977063 scopus 로고    scopus 로고
    • Gene amplification, radiation sensitivity and DNA double-strand breaks
    • Mondello C., Smirnova A., Giulotto E. Gene amplification, radiation sensitivity and DNA double-strand breaks. Mut. Res./Rev. Mut. Res. 2010, 704:29-37.
    • (2010) Mut. Res./Rev. Mut. Res. , vol.704 , pp. 29-37
    • Mondello, C.1    Smirnova, A.2    Giulotto, E.3
  • 39
    • 28544432416 scopus 로고    scopus 로고
    • Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts
    • Martín M., Genesca A., Latre L., Jaco I., Taccioli G.E., Egozcue J., Blasco M.A., Iliakis G., Tusell L. Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts. Cancer Res. 2005, 65:10223-10232.
    • (2005) Cancer Res. , vol.65 , pp. 10223-10232
    • Martín, M.1    Genesca, A.2    Latre, L.3    Jaco, I.4    Taccioli, G.E.5    Egozcue, J.6    Blasco, M.A.7    Iliakis, G.8    Tusell, L.9
  • 40
    • 0030446964 scopus 로고    scopus 로고
    • P53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice
    • Gurley K.E., Kemp C.J. p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice. Carcinogenesis 1996, 17:2537-2542.
    • (1996) Carcinogenesis , vol.17 , pp. 2537-2542
    • Gurley, K.E.1    Kemp, C.J.2
  • 41
    • 34247602569 scopus 로고    scopus 로고
    • Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
    • Costantini S., Woodbine L., Andreoli L., Jeggo P.A., Vindigni A. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair 2007, 6:712-722.
    • (2007) DNA Repair , vol.6 , pp. 712-722
    • Costantini, S.1    Woodbine, L.2    Andreoli, L.3    Jeggo, P.A.4    Vindigni, A.5
  • 42
    • 34047153762 scopus 로고    scopus 로고
    • Functions and regulation of human artemis in double strand break repair
    • Dahm K. Functions and regulation of human artemis in double strand break repair. J. Cell. Biochem. 2007, 100:1346-1351.
    • (2007) J. Cell. Biochem. , vol.100 , pp. 1346-1351
    • Dahm, K.1
  • 43
    • 22044445683 scopus 로고    scopus 로고
    • DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining
    • Douglas P., Gupta S., Morrice N., Meek K., Lees-Miller S.P. DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair 2005, 4:1006-1018.
    • (2005) DNA Repair , vol.4 , pp. 1006-1018
    • Douglas, P.1    Gupta, S.2    Morrice, N.3    Meek, K.4    Lees-Miller, S.P.5
  • 45
    • 0242268028 scopus 로고    scopus 로고
    • DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
    • Yu Y., Wang W., Ding Q., Ye R., Chen D., Merkle D., Schriemer D., Meek K., Lees-Miller S.P. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair 2003, 2:1239-1252.
    • (2003) DNA Repair , vol.2 , pp. 1239-1252
    • Yu, Y.1    Wang, W.2    Ding, Q.3    Ye, R.4    Chen, D.5    Merkle, D.6    Schriemer, D.7    Meek, K.8    Lees-Miller, S.P.9
  • 46
    • 16444384872 scopus 로고    scopus 로고
    • Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM
    • Peng Y., Woods R.G., Beamish H., Ye R., Lees-Miller S.P., Lavin M.F., Bedford J.S. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005, 65:1670-1677.
    • (2005) Cancer Res. , vol.65 , pp. 1670-1677
    • Peng, Y.1    Woods, R.G.2    Beamish, H.3    Ye, R.4    Lees-Miller, S.P.5    Lavin, M.F.6    Bedford, J.S.7
  • 47
    • 0026071588 scopus 로고
    • Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
    • Biedermann K.A., Sun J.R., Giaccia A.J., Tosto L.M., Brown J.M. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:1394-1397.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 1394-1397
    • Biedermann, K.A.1    Sun, J.R.2    Giaccia, A.J.3    Tosto, L.M.4    Brown, J.M.5
  • 48
    • 0027512522 scopus 로고
    • Brown characterization of the DNA double strand break repair defect in scid mice
    • Chang C., Biedermann K.A., Mezzina M., Martin J. Brown characterization of the DNA double strand break repair defect in scid mice. Cancer Res. 1993, 53:1244-1248.
    • (1993) Cancer Res. , vol.53 , pp. 1244-1248
    • Chang, C.1    Biedermann, K.A.2    Mezzina, M.3    Martin, J.4
  • 49
    • 0028859586 scopus 로고
    • Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line
    • Allalunis-Turner M.J., Zia P.K., Barron G.M., Mirzayans R.R., Day r. Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line. Radiat. Res. 1995, 144:288-293.
    • (1995) Radiat. Res. , vol.144 , pp. 288-293
    • Allalunis-Turner, M.J.1    Zia, P.K.2    Barron, G.M.3    Mirzayans, R.R.4    Day, R.5
  • 50
    • 0030926490 scopus 로고    scopus 로고
    • The scid defect results in much slower repair of DNA double-strand breaks but not high levels of residual breaks
    • Nevaldine B., Longo J.A., Hahn P.J. The scid defect results in much slower repair of DNA double-strand breaks but not high levels of residual breaks. Radiat. Res. 1997, 147:535-540.
    • (1997) Radiat. Res. , vol.147 , pp. 535-540
    • Nevaldine, B.1    Longo, J.A.2    Hahn, P.J.3
  • 51
    • 0034162719 scopus 로고    scopus 로고
    • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    • DiBiase S.J., Zeng Z.-C., Chen R., Hyslop T., Curran W.J., Iliakis G. DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res. 2000, 60:1245-1253.
    • (2000) Cancer Res. , vol.60 , pp. 1245-1253
    • DiBiase, S.J.1    Zeng, Z.-C.2    Chen, R.3    Hyslop, T.4    Curran, W.J.5    Iliakis, G.6
  • 52
    • 0030067159 scopus 로고    scopus 로고
    • Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation
    • Evans J.W., Liu X.F., Kirchgessner C.U., Brown J.M. Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation. Radiat. Res. 1996, 145:39-46.
    • (1996) Radiat. Res. , vol.145 , pp. 39-46
    • Evans, J.W.1    Liu, X.F.2    Kirchgessner, C.U.3    Brown, J.M.4
  • 53
    • 0035872477 scopus 로고    scopus 로고
    • Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks
    • Rothkamm K., Kuhne M., Jeggo P.A., Lobrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res. 2001, 61:3886-3893.
    • (2001) Cancer Res. , vol.61 , pp. 3886-3893
    • Rothkamm, K.1    Kuhne, M.2    Jeggo, P.A.3    Lobrich, M.4
  • 54
    • 73349098442 scopus 로고    scopus 로고
    • Limiting the persistence of a chromosome break diminishes its mutagenic potential
    • Bennardo N., Gunn A., Cheng A., Hasty P., Stark J.M. Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet. 2009, 5:e1000683.
    • (2009) PLoS Genet. , vol.5
    • Bennardo, N.1    Gunn, A.2    Cheng, A.3    Hasty, P.4    Stark, J.M.5
  • 58
    • 0008158443 scopus 로고
    • Radiosensitivity in ataxia-telangiectasia: a new explanation
    • Painter R., Young B. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. U.S.A. 1980, 77:7315-7317.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 7315-7317
    • Painter, R.1    Young, B.2
  • 60
    • 0021978722 scopus 로고
    • On the nature of a defect in cells from individuals with ataxia-telangiectasia
    • Cornforth M.N., Bedford J. On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science 1985, 29:1589-1591.
    • (1985) Science , vol.29 , pp. 1589-1591
    • Cornforth, M.N.1    Bedford, J.2
  • 61
    • 0030750923 scopus 로고    scopus 로고
    • Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks
    • Foray N., Priestley A., Alsbeih G., Badie C., Capulas E.P., Arlett C.F., Malaise E.P. Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol. 1997, 72:271-283.
    • (1997) Int. J. Radiat. Biol. , vol.72 , pp. 271-283
    • Foray, N.1    Priestley, A.2    Alsbeih, G.3    Badie, C.4    Capulas, E.P.5    Arlett, C.F.6    Malaise, E.P.7
  • 62
    • 0344286677 scopus 로고    scopus 로고
    • Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts
    • Löbrich M., Kühne M., Wetzel J., Rothkamm K. Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts. Genes Chromosomes Cancer 2000, 27:59-68.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 59-68
    • Löbrich, M.1    Kühne, M.2    Wetzel, J.3    Rothkamm, K.4
  • 63
    • 68549110557 scopus 로고    scopus 로고
    • Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells
    • Martín M., Terradas M., Iliakis G., Tusell L., Genescà A. Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells. Genes Chromosomes Cancer 2009, 48:745-759.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 745-759
    • Martín, M.1    Terradas, M.2    Iliakis, G.3    Tusell, L.4    Genescà, A.5
  • 64
    • 1642556817 scopus 로고    scopus 로고
    • A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
    • Kühne M., Riballo E., Rief N., Rothkamm K., Jeggo P.A., Lobrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res. 2004, 64:500-508.
    • (2004) Cancer Res. , vol.64 , pp. 500-508
    • Kühne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Lobrich, M.6
  • 66
    • 0037964269 scopus 로고    scopus 로고
    • Radiation-induced chromosome aberrations in ataxia telangiectasia cells: high frequency of deletions and misrejoining detected by fluorescence in situ hybridization
    • Kawata T., Ito H., George K., Wu H., Uno T., Isobe K., Cucinotta F.A. Radiation-induced chromosome aberrations in ataxia telangiectasia cells: high frequency of deletions and misrejoining detected by fluorescence in situ hybridization. Radiat. Res. 2003, 597-603.
    • (2003) Radiat. Res. , pp. 597-603
    • Kawata, T.1    Ito, H.2    George, K.3    Wu, H.4    Uno, T.5    Isobe, K.6    Cucinotta, F.A.7
  • 68
    • 25444502657 scopus 로고    scopus 로고
    • Artemis links ATM to double strand break rejoining
    • Jeggo a.P., Löbrich M. Artemis links ATM to double strand break rejoining. Cell Cycle 2005, 4:359-362.
    • (2005) Cell Cycle , vol.4 , pp. 359-362
    • Jeggo, A.1    Löbrich, M.2
  • 69
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma Y., Pannicke U., Schwarz K., Lieber M.R. Hairpin opening and overhang processing by an artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 2002, 108:781-794.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 71
    • 33748872519 scopus 로고    scopus 로고
    • Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends
    • Drouet J., Frit P., Delteil C., de Villartay J.-P., Salles B., Calsou P. Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends. J. Biol. Chem. 2006, 281:27784-27793.
    • (2006) J. Biol. Chem. , vol.281 , pp. 27784-27793
    • Drouet, J.1    Frit, P.2    Delteil, C.3    de Villartay, J.-P.4    Salles, B.5    Calsou, P.6
  • 73
    • 33646090620 scopus 로고    scopus 로고
    • Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin
    • Soubeyrand S., Pope L., De Chasseval R., Gosselin D., Dong F., de Villartay J.-P., Haché R.J.G. Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin. J. Mol. Biol. 2006, 358:1200-1211.
    • (2006) J. Mol. Biol. , vol.358 , pp. 1200-1211
    • Soubeyrand, S.1    Pope, L.2    De Chasseval, R.3    Gosselin, D.4    Dong, F.5    de Villartay, J.-P.6    Haché, R.J.G.7
  • 74
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi A.A., Noon A.T., Deckbar D., Ziv Y., Shiloh Y., Löbrich M., Jeggo P.A. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 2008, 31:167-177.
    • (2008) Mol. Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Löbrich, M.6    Jeggo, P.A.7
  • 75
    • 0025945545 scopus 로고
    • Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia
    • Brito-Babapulle V., Catovsky D. Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. Cancer Genet. Cytogenet. 1991, 55:1-9.
    • (1991) Cancer Genet. Cytogenet. , vol.55 , pp. 1-9
    • Brito-Babapulle, V.1    Catovsky, D.2
  • 76
    • 0023225454 scopus 로고
    • Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11. A model for other T cell neoplasia
    • Hollis R., Kennaugh A., Butterworth S., Taylor A. Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11. A model for other T cell neoplasia. Hum. Genet. 1987, 76:389-395.
    • (1987) Hum. Genet. , vol.76 , pp. 389-395
    • Hollis, R.1    Kennaugh, A.2    Butterworth, S.3    Taylor, A.4
  • 77
    • 84862190364 scopus 로고    scopus 로고
    • OMIM-AT ATAXIA-TELANGIECTASIA; AT, OMIM MIM ID #208900.
    • OMIM-AT ATAXIA-TELANGIECTASIA; AT, OMIM MIM ID #208900.
  • 78
    • 0024263107 scopus 로고
    • Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32. 1 distal breakpoint
    • Stern M., Zhang F., Thomas G., Griscelli C., Aurias A. Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32. 1 distal breakpoint. Hum. Genet. 1988, 81:18-22.
    • (1988) Hum. Genet. , vol.81 , pp. 18-22
    • Stern, M.1    Zhang, F.2    Thomas, G.3    Griscelli, C.4    Aurias, A.5
  • 79
    • 0023858598 scopus 로고
    • Molecular characterization of different ataxia telangiectasia T-cell clones. I. A common breakpoint at the 14q11. 2 band splits the T-cell receptor alpha-chain gene
    • Stern M.H., Zhang F.R., Griscelli C., Thomas G., Aurias A. Molecular characterization of different ataxia telangiectasia T-cell clones. I. A common breakpoint at the 14q11. 2 band splits the T-cell receptor alpha-chain gene. Hum. Genet. 1988, 78:33-36.
    • (1988) Hum. Genet. , vol.78 , pp. 33-36
    • Stern, M.H.1    Zhang, F.R.2    Griscelli, C.3    Thomas, G.4    Aurias, A.5
  • 80
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Ann. Rev. Biochem. 2010, 79:181-211.
    • (2010) Ann. Rev. Biochem. , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 81
    • 41149099048 scopus 로고    scopus 로고
    • DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
    • Franco S., Murphy M.M., Li G., Borjeson T., Boboila C., Alt F.W. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J. Exp. Med. 2008, 205:557-564.
    • (2008) J. Exp. Med. , vol.205 , pp. 557-564
    • Franco, S.1    Murphy, M.M.2    Li, G.3    Borjeson, T.4    Boboila, C.5    Alt, F.W.6
  • 82
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    • Manis J.P., Dudley D., Kaylor L., Alt F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 2002, 16:607-617.
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 83
    • 33846256163 scopus 로고    scopus 로고
    • Primary immunodeficiency syndromes associated with defective DNA double-strand break repair
    • Gennery A.R. Primary immunodeficiency syndromes associated with defective DNA double-strand break repair. Br. Med. Bull. 2006, 77-78:71-85.
    • (2006) Br. Med. Bull. , pp. 71-85
    • Gennery, A.R.1
  • 85
    • 0022930677 scopus 로고
    • Inverted duplication of JH associated with chromosome 14 translocation and T-cell leukemia in ataxia-telangiectasia
    • Johnson J.P., Gatti R.A., Sears T.S., White R.L. Inverted duplication of JH associated with chromosome 14 translocation and T-cell leukemia in ataxia-telangiectasia. Am. J. Hum. Genet. 1986, 39:787-796.
    • (1986) Am. J. Hum. Genet. , vol.39 , pp. 787-796
    • Johnson, J.P.1    Gatti, R.A.2    Sears, T.S.3    White, R.L.4
  • 90
    • 53149091313 scopus 로고    scopus 로고
    • Aberrant V(D)J ecombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining
    • Bredemeyer A.L., Huang C.-Y., Walker L.M., Bassing C.H., Sleckman B.P. Aberrant V(D)J ecombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. J. Immunol. 2008, 181:2620-2625.
    • (2008) J. Immunol. , vol.181 , pp. 2620-2625
    • Bredemeyer, A.L.1    Huang, C.-Y.2    Walker, L.M.3    Bassing, C.H.4    Sleckman, B.P.5
  • 94
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M., De Haro L.P., Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 2008, 18:134-147.
    • (2008) Cell Res. , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 95
    • 52049098230 scopus 로고    scopus 로고
    • Comparison of nonhomologous end joining and homologous recombination in human cells
    • Mao Z., Bozzella M., Seluanov A., Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair 2008, 7:1765-1771.
    • (2008) DNA Repair , vol.7 , pp. 1765-1771
    • Mao, Z.1    Bozzella, M.2    Seluanov, A.3    Gorbunova, V.4
  • 96
    • 23744447715 scopus 로고    scopus 로고
    • Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
    • Kim J.-S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M.R., Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 2005, 170:341-347.
    • (2005) J. Cell Biol. , vol.170 , pp. 341-347
    • Kim, J.-S.1    Krasieva, T.B.2    Kurumizaka, H.3    Chen, D.J.4    Taylor, A.M.R.5    Yokomori, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.