메뉴 건너뛰기




Volumn 8, Issue 1, 2009, Pages 19-28

Enhanced gene amplification in human cells knocked down for DNA-PKcs

Author keywords

DNA PKcs; Double minutes; Gene amplification; Human cells; shRNA

Indexed keywords

DIHYDROFOLATE REDUCTASE; DOUBLE STRANDED DNA; METHOTREXATE; PROTEIN KINASE C; SHORT HAIRPIN RNA;

EID: 56549095215     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.08.015     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • Albertson D.G. Gene amplification in cancer. Trends Genet. 22 (2006) 447-455
    • (2006) Trends Genet. , vol.22 , pp. 447-455
    • Albertson, D.G.1
  • 2
    • 0024411328 scopus 로고
    • Recent progress in understanding mechanisms of mammalian DNA amplification
    • Stark G.R., Debatisse M., Giulotto E., and Wahl G.M. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell 57 (1989) 901-908
    • (1989) Cell , vol.57 , pp. 901-908
    • Stark, G.R.1    Debatisse, M.2    Giulotto, E.3    Wahl, G.M.4
  • 3
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone L.R., White A., Sprouse J., Livanos E., Jacks T., and Tlsty T.D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70 (1992) 923-935
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 4
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y., Tainsky M.A., Bischoff F.Z., Strong L.C., and Wahl G.M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70 (1992) 937-948
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 5
    • 0023620862 scopus 로고
    • Hamster cells with increased rates of DNA amplification, a new phenotype
    • Giulotto E., Knights C., and Stark G.R. Hamster cells with increased rates of DNA amplification, a new phenotype. Cell 48 (1987) 485-837
    • (1987) Cell , vol.48 , pp. 485-837
    • Giulotto, E.1    Knights, C.2    Stark, G.R.3
  • 6
    • 30144431670 scopus 로고    scopus 로고
    • Manifestation, mechanisms and mysteries of gene amplifications
    • Myllykangas S., and Knuutila S. Manifestation, mechanisms and mysteries of gene amplifications. Cancer Lett. 232 (2006) 79-89
    • (2006) Cancer Lett. , vol.232 , pp. 79-89
    • Myllykangas, S.1    Knuutila, S.2
  • 7
    • 0026018901 scopus 로고
    • A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration
    • Windle B., Draper B.W., Yin Y.X., O'Gorman S., and Wahl G.M. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 5 (1991) 160-174
    • (1991) Genes Dev. , vol.5 , pp. 160-174
    • Windle, B.1    Draper, B.W.2    Yin, Y.X.3    O'Gorman, S.4    Wahl, G.M.5
  • 8
    • 0026645532 scopus 로고
    • Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification
    • Toledo F., Le Roscouet D., Buttin G., and Debatisse M. Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 11 (1992) 2665-2673
    • (1992) EMBO J. , vol.11 , pp. 2665-2673
    • Toledo, F.1    Le Roscouet, D.2    Buttin, G.3    Debatisse, M.4
  • 9
    • 0028172912 scopus 로고
    • Telomeric and nontelomeric (TTAGGG)n sequences in gene amplification and chromosome stability
    • Bertoni L., Attolini C., Tessera L., Mucciolo E., and Giulotto E. Telomeric and nontelomeric (TTAGGG)n sequences in gene amplification and chromosome stability. Genomics 24 (1994) 53-62
    • (1994) Genomics , vol.24 , pp. 53-62
    • Bertoni, L.1    Attolini, C.2    Tessera, L.3    Mucciolo, E.4    Giulotto, E.5
  • 10
    • 0034608950 scopus 로고    scopus 로고
    • Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks
    • Singer M.J., Mesner L.D., Friedman C.L., Trask B.J., and Hamlin J.L. Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. Proc. Natl. Acad. Sci. USA 97 (2000) 7921-7926
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7921-7926
    • Singer, M.J.1    Mesner, L.D.2    Friedman, C.L.3    Trask, B.J.4    Hamlin, J.L.5
  • 12
    • 33845604556 scopus 로고    scopus 로고
    • DNA double-strand break repair: all's well that ends well
    • Wyman C., and Kanaar R. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 40 (2006) 363-383
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 363-383
    • Wyman, C.1    Kanaar, R.2
  • 13
    • 33748173811 scopus 로고    scopus 로고
    • Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability
    • Jeggo P.A., and Löbrich M. Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair 5 (2006) 1192-1198
    • (2006) DNA Repair , vol.5 , pp. 1192-1198
    • Jeggo, P.A.1    Löbrich, M.2
  • 14
    • 33750006616 scopus 로고    scopus 로고
    • The role of DNA damage response proteins at telomeres-an "integrative" model
    • Slijepcevic P. The role of DNA damage response proteins at telomeres-an "integrative" model. DNA Repair 5 (2006) 1299-1306
    • (2006) DNA Repair , vol.5 , pp. 1299-1306
    • Slijepcevic, P.1
  • 18
    • 0035023139 scopus 로고    scopus 로고
    • The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • Goytisolo F.A., Samper E., Edmonson S., Taccioli G.E., and Blasco M.A. The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell Biol. 21 (2001) 3642-3651
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3642-3651
    • Goytisolo, F.A.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 20
    • 0345599233 scopus 로고    scopus 로고
    • Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit
    • Rebuzzini P., Lisa A., Giulotto E., and Mondello C. Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit. Cancer Lett. 203 (2004) 79-86
    • (2004) Cancer Lett. , vol.203 , pp. 79-86
    • Rebuzzini, P.1    Lisa, A.2    Giulotto, E.3    Mondello, C.4
  • 21
    • 28544432416 scopus 로고    scopus 로고
    • Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts
    • Martín M., Genescà A., Latre L., Jaco I., Taccioli G.E., Egozcue J., Blasco M.A., Iliakis G., and Tusell L. Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts. Cancer Res. 65 (2005) 10223-10232
    • (2005) Cancer Res. , vol.65 , pp. 10223-10232
    • Martín, M.1    Genescà, A.2    Latre, L.3    Jaco, I.4    Taccioli, G.E.5    Egozcue, J.6    Blasco, M.A.7    Iliakis, G.8    Tusell, L.9
  • 22
    • 0035361714 scopus 로고    scopus 로고
    • Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit
    • Mondello C., Rebuzzini P., Dolzan M., Edmonson S., Taccioli G.E., and Giulotto E. Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit. Cancer Res. 61 (2001) 4520-4525
    • (2001) Cancer Res. , vol.61 , pp. 4520-4525
    • Mondello, C.1    Rebuzzini, P.2    Dolzan, M.3    Edmonson, S.4    Taccioli, G.E.5    Giulotto, E.6
  • 23
    • 0035132526 scopus 로고    scopus 로고
    • Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants
    • Mondello C., Faravelli M., Pipitone L., Rollier A., Di Leonardo A., and Giulotto E. Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants. Carcinogenesis 22 (2001) 141-145
    • (2001) Carcinogenesis , vol.22 , pp. 141-145
    • Mondello, C.1    Faravelli, M.2    Pipitone, L.3    Rollier, A.4    Di Leonardo, A.5    Giulotto, E.6
  • 24
    • 34047157163 scopus 로고    scopus 로고
    • Inhibition of gene amplification in telomerase deficient immortalized mouse embryonic fibroblasts
    • Rebuzzini P., Martinelli P., Blasco M., Giulotto E., and Mondello C. Inhibition of gene amplification in telomerase deficient immortalized mouse embryonic fibroblasts. Carcinogenesis 28 (2007) 553-559
    • (2007) Carcinogenesis , vol.28 , pp. 553-559
    • Rebuzzini, P.1    Martinelli, P.2    Blasco, M.3    Giulotto, E.4    Mondello, C.5
  • 25
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp T.R., Bernards R., and Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296 (2002) 550-553
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 26
    • 0037198145 scopus 로고    scopus 로고
    • DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint
    • Lee S.H., and Kim C.H. DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint. Mol. Cell 13 (2002) 159-166
    • (2002) Mol. Cell , vol.13 , pp. 159-166
    • Lee, S.H.1    Kim, C.H.2
  • 27
    • 25444499420 scopus 로고    scopus 로고
    • Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles
    • Zhang Q., Williams E.S., Askin K.F., Peng Y., Bedford J.S., Liber H.L., and Bailey S.M. Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles. Radiat. Res. 164 (2005) 497-504
    • (2005) Radiat. Res. , vol.164 , pp. 497-504
    • Zhang, Q.1    Williams, E.S.2    Askin, K.F.3    Peng, Y.4    Bedford, J.S.5    Liber, H.L.6    Bailey, S.M.7
  • 28
    • 34547122924 scopus 로고    scopus 로고
    • Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones
    • Biard D.S. Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones. Nucleic Acids Res. 35 (2007) 3535-3550
    • (2007) Nucleic Acids Res. , vol.35 , pp. 3535-3550
    • Biard, D.S.1
  • 29
    • 0037112422 scopus 로고    scopus 로고
    • Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines
    • Sak A., Stuschke M., Wurm R., Schroeder G., Sinn B., Wolf G., and Budach V. Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines. Cancer Res. 62 (2002) 6621-6624
    • (2002) Cancer Res. , vol.62 , pp. 6621-6624
    • Sak, A.1    Stuschke, M.2    Wurm, R.3    Schroeder, G.4    Sinn, B.5    Wolf, G.6    Budach, V.7
  • 30
    • 18144399248 scopus 로고    scopus 로고
    • More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit
    • Dip R., and Naegeli R.H. More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit. FASEB J. 19 (2005) 704-715
    • (2005) FASEB J. , vol.19 , pp. 704-715
    • Dip, R.1    Naegeli, R.H.2
  • 31
    • 0037133699 scopus 로고    scopus 로고
    • DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
    • Allen C., Kurimasa A., Brenneman M.A., Chen D.J., and Nickoloff J.A. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. USA 99 (2002) 3758-3763
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3758-3763
    • Allen, C.1    Kurimasa, A.2    Brenneman, M.A.3    Chen, D.J.4    Nickoloff, J.A.5
  • 32
    • 3142685133 scopus 로고    scopus 로고
    • Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions
    • Dip R., and Naegeli H. Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions. Biochem. J. 381 (2004) 165-174
    • (2004) Biochem. J. , vol.381 , pp. 165-174
    • Dip, R.1    Naegeli, H.2
  • 33
    • 0036245743 scopus 로고    scopus 로고
    • Expanding small RNA interference
    • Tuschl T. Expanding small RNA interference. Nat. Biotechnol. 20 (2002) 446-448
    • (2002) Nat. Biotechnol. , vol.20 , pp. 446-448
    • Tuschl, T.1
  • 34
    • 0037112508 scopus 로고    scopus 로고
    • Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation
    • Peng Y., Zhang Q., Nagasawa H., Okayasu R., Liber H.L., and Bedford J.S. Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res. 62 (2002) 6400-6404
    • (2002) Cancer Res. , vol.62 , pp. 6400-6404
    • Peng, Y.1    Zhang, Q.2    Nagasawa, H.3    Okayasu, R.4    Liber, H.L.5    Bedford, J.S.6
  • 35
    • 16244403037 scopus 로고    scopus 로고
    • New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining
    • Rebuzzini P., Khoriauli L., Azzalin C.M., Magnani E., Mondello C., and Giulotto E. New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining. DNA Repair 4 (2005) 546-555
    • (2005) DNA Repair , vol.4 , pp. 546-555
    • Rebuzzini, P.1    Khoriauli, L.2    Azzalin, C.M.3    Magnani, E.4    Mondello, C.5    Giulotto, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.