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Volumn 52, Issue 11-12, 2012, Pages 2177-2185

Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane

Author keywords

4 Hydroxynonenal; Chemoprevention; Free radicals; Glutathione S transferases; Isothiocyanates; Lipid peroxidation; Sulforaphane

Indexed keywords

4 HYDROXYNONENAL; CARCINOGEN; CYTOCHROME P450; DRUG METABOLIZING ENZYME; ISOTHIOCYANIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

EID: 84861535838     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.04.012     Document Type: Review
Times cited : (18)

References (139)
  • 1
    • 53049089942 scopus 로고    scopus 로고
    • Cancer is a preventable disease that requires major lifestyle changes
    • P. Anand, A.B. Kunnumakkara, and A.B. Kunnumakara Cancer is a preventable disease that requires major lifestyle changes Pharm. Res. 25 2008 2097 2116
    • (2008) Pharm. Res. , vol.25 , pp. 2097-2116
    • Anand, P.1    Kunnumakkara, A.B.2    Kunnumakara, A.B.3
  • 2
    • 37049019076 scopus 로고    scopus 로고
    • Lifestyle-related factors and environmental agents causing cancer: An overview
    • P. Irigaray, J.A. Newby, and R. Clapp Lifestyle-related factors and environmental agents causing cancer: an overview Biomed. Pharmacother. 61 2007 640 658
    • (2007) Biomed. Pharmacother. , vol.61 , pp. 640-658
    • Irigaray, P.1    Newby, J.A.2    Clapp, R.3
  • 3
    • 0347379799 scopus 로고    scopus 로고
    • Epigenetic theories of cancer initiation
    • L.F. Jaffe Epigenetic theories of cancer initiation Adv. Cancer Res. 90 2003 209 230
    • (2003) Adv. Cancer Res. , vol.90 , pp. 209-230
    • Jaffe, L.F.1
  • 4
    • 77649135478 scopus 로고    scopus 로고
    • A new view of carcinogenesis and an alternative approach to cancer therapy
    • M. López-Lázaro A new view of carcinogenesis and an alternative approach to cancer therapy Mol. Med 16 2010 144 153
    • (2010) Mol. Med , vol.16 , pp. 144-153
    • López-Lázaro, M.1
  • 6
    • 0032418162 scopus 로고    scopus 로고
    • The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: Suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue
    • T. Ikegami, Y. Matsuzaki, and J. Shoda The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue Cancer Lett. 134 1998 129 139
    • (1998) Cancer Lett. , vol.134 , pp. 129-139
    • Ikegami, T.1    Matsuzaki, Y.2    Shoda, J.3
  • 8
    • 17844392872 scopus 로고    scopus 로고
    • Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population
    • L.I. Wang, E.L. Giovannucci, D. Hunter, D. Neuberg, L. Su, and D.C. Christiani Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population Cancer Causes Control 15 2004 977 985
    • (2004) Cancer Causes Control , vol.15 , pp. 977-985
    • Wang, L.I.1    Giovannucci, E.L.2    Hunter, D.3    Neuberg, D.4    Su, L.5    Christiani, D.C.6
  • 11
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • J.W. Fahey, Y. Zhang, and P. Talalay Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Proc. Natl. Acad. Sci. USA 94 1997 10367 10372
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3
  • 12
  • 13
    • 34248547027 scopus 로고    scopus 로고
    • Sulforaphane as a promising molecule for fighting cancer
    • C. Fimognari, and P. Hrelia Sulforaphane as a promising molecule for fighting cancer Mutat. Res. 635 2007 90 104
    • (2007) Mutat. Res. , vol.635 , pp. 90-104
    • Fimognari, C.1    Hrelia, P.2
  • 14
    • 0028326168 scopus 로고
    • Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
    • Y. Zhang, and P. Talalay Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms Cancer Res. 54 1994 1976s 1981s
    • (1994) Cancer Res. , vol.54
    • Zhang, Y.1    Talalay, P.2
  • 15
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Y. Zhang, P. Talalay, C.G. Cho, and G.H. Posner A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure Proc. Natl. Acad. Sci. USA 89 1992 2399 2403
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4
  • 16
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • C. Xu, M.T. Huang, G. Shen, X. Yuan, W. Lin, T.O. Khor, A.H. Conney, and A.N. Kong Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 Cancer Res. 66 2006 8293 8296
    • (2006) Cancer Res. , vol.66 , pp. 8293-8296
    • Xu, C.1    Huang, M.T.2    Shen, G.3    Yuan, X.4    Lin, W.5    Khor, T.O.6    Conney, A.H.7    Kong, A.N.8
  • 17
    • 0034601232 scopus 로고    scopus 로고
    • Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane
    • K. Singletary, and C. MacDonald Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane Cancer Lett 155 2000 47 54
    • (2000) Cancer Lett , vol.155 , pp. 47-54
    • Singletary, K.1    MacDonald, C.2
  • 18
    • 0026589840 scopus 로고
    • Rapid detection of inducers of enzymes that protect against carcinogens
    • H.J. Prochaska, A.B. Santamaria, and P. Talalay Rapid detection of inducers of enzymes that protect against carcinogens Proc. Natl. Acad. Sci. USA 89 1992 2394 2398
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2394-2398
    • Prochaska, H.J.1    Santamaria, A.B.2    Talalay, P.3
  • 19
    • 0035094701 scopus 로고    scopus 로고
    • Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates
    • Y. Zhang Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates Carcinogenesis 22 2001 425 431
    • (2001) Carcinogenesis , vol.22 , pp. 425-431
    • Zhang, Y.1
  • 21
    • 0035987188 scopus 로고    scopus 로고
    • Isothiocyanates as cancer chemopreventive agents: Their biological activities and metabolism in rodents and humans
    • C.C. Conaway, Y.M. Yang, and F.L. Chung Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans Curr. Drug Metab. 3 2002 233 255
    • (2002) Curr. Drug Metab. , vol.3 , pp. 233-255
    • Conaway, C.C.1    Yang, Y.M.2    Chung, F.L.3
  • 22
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • J.W. Fahey, X. Haristoy, P.M. Dolan, T.W. Kensler, I. Scholtus, K.K. Stephenson, P. Talalay, and A. Lozniewski Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors Proc. Natl. Acad. Sci. USA 99 2002 7610 7615
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3    Kensler, T.W.4    Scholtus, I.5    Stephenson, K.K.6    Talalay, P.7    Lozniewski, A.8
  • 23
    • 58749089692 scopus 로고    scopus 로고
    • Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane
    • M.C. Ramirez, and K. Singletary Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane J. Nutr. Biochem. 20 2009 195 201
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 195-201
    • Ramirez, M.C.1    Singletary, K.2
  • 24
    • 34547795788 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    • B.S. Cornblatt, L. Ye, and A.T. Dinkova-Kostova Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast Carcinogenesis 28 2007 1485 1490
    • (2007) Carcinogenesis , vol.28 , pp. 1485-1490
    • Cornblatt, B.S.1    Ye, L.2    Dinkova-Kostova, A.T.3
  • 25
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Y.J. Surh Cancer chemoprevention with dietary phytochemicals Nat. Rev. Cancer 3 2003 768 780
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 26
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • F.L. Chung, C.C. Conaway, C.V. Rao, and B.S. Reddy Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate Carcinogenesis 21 2000 2287 2291
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 27
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
    • A.V. Singh, D. Xiao, K.L. Lew, R. Dhir, and S.V. Singh Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo Carcinogenesis 25 2004 83 90
    • (2004) Carcinogenesis , vol.25 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 28
    • 0036511358 scopus 로고    scopus 로고
    • Chemoprevention by sulforaphane: Its metabolites mediate growth arrest and apoptosis in human prostate cancer cells
    • J.W. Chiao, F.L. Chung, R. Kancherla, T. Ahmed, A. Mittelman, and C.C. Conaway Chemoprevention by sulforaphane: its metabolites mediate growth arrest and apoptosis in human prostate cancer cells Int. J. Oncol. 20 2002 631 636
    • (2002) Int. J. Oncol. , vol.20 , pp. 631-636
    • Chiao, J.W.1    Chung, F.L.2    Kancherla, R.3    Ahmed, T.4    Mittelman, A.5    Conaway, C.C.6
  • 29
    • 0033605676 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide: Implications for oxygen sensing and signaling
    • L.E. Huang, W.G. Willmore, J. Gu, M.A. Goldberg, and H.F. Bunn Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide: implications for oxygen sensing and signaling J. Biol. Chem. 274 1999 9038 9044
    • (1999) J. Biol. Chem. , vol.274 , pp. 9038-9044
    • Huang, L.E.1    Willmore, W.G.2    Gu, J.3    Goldberg, M.A.4    Bunn, H.F.5
  • 31
    • 49749150144 scopus 로고    scopus 로고
    • Sulforaphane inhibited expression of hypoxia-inducible factor-1α in human tongue squamous cancer cells and prostate cancer cells
    • H. Yao, H. Wang, Z. Zhang, B.H. Jiang, J. Luo, and X. Shi Sulforaphane inhibited expression of hypoxia-inducible factor-1α in human tongue squamous cancer cells and prostate cancer cells Int. J. Cancer 15 2008 1255 1261
    • (2008) Int. J. Cancer , vol.15 , pp. 1255-1261
    • Yao, H.1    Wang, H.2    Zhang, Z.3    Jiang, B.H.4    Luo, J.5    Shi, X.6
  • 32
    • 67649417900 scopus 로고    scopus 로고
    • Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-κB-DNA-binding activity in human bladder T24 cells
    • Y. Shan, K. Wu, W. Wang, S. Wang, N. Lin, R. Zhao, A. Cassidy, and Y. Bao Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-κB-DNA-binding activity in human bladder T24 cells Int. J. Oncol. 34 2009 1129 1134
    • (2009) Int. J. Oncol. , vol.34 , pp. 1129-1134
    • Shan, Y.1    Wu, K.2    Wang, W.3    Wang, S.4    Lin, N.5    Zhao, R.6    Cassidy, A.7    Bao, Y.8
  • 33
    • 0034662433 scopus 로고    scopus 로고
    • Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro
    • K. Xu, and P.J. Thornalley Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro Biochem. Pharmacol 60 2000 221 231
    • (2000) Biochem. Pharmacol , vol.60 , pp. 221-231
    • Xu, K.1    Thornalley, P.J.2
  • 34
    • 3543117254 scopus 로고    scopus 로고
    • Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
    • L. Tang, and Y. Zhang Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells J. Nutr. 134 2004 2004 2010
    • (2004) J. Nutr. , vol.134 , pp. 2004-2010
    • Tang, L.1    Zhang, Y.2
  • 35
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • C.C. Conaway, C.X. Wang, B. Pittman, Y.M. Yang, J.E. Schwartz, D. Tian, E.J. McIntee, S.S. Hecht, and F.L. Chung Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice Cancer Res. 65 2005 8548 8557
    • (2005) Cancer Res. , vol.65 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3    Yang, Y.M.4    Schwartz, J.E.5    Tian, D.6    McIntee, E.J.7    Hecht, S.S.8    Chung, F.L.9
  • 36
    • 33646201718 scopus 로고    scopus 로고
    • Antimetastatic activity of sulforaphane
    • P. Thejass, and G. Kuttan Antimetastatic activity of sulforaphane Life Sci. 78 2006 3043 3050
    • (2006) Life Sci. , vol.78 , pp. 3043-3050
    • Thejass, P.1    Kuttan, G.2
  • 38
    • 27744435860 scopus 로고    scopus 로고
    • Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells
    • P. Rose, Q. Huang, C.N. Ong, and M. Whiteman Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells Toxicol. Appl. Pharmacol. 209 2005 105 113
    • (2005) Toxicol. Appl. Pharmacol. , vol.209 , pp. 105-113
    • Rose, P.1    Huang, Q.2    Ong, C.N.3    Whiteman, M.4
  • 39
    • 33645472584 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    • E. Bertl, H. Bartsch, and C. Gerhauser Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention Mol. Cancer Ther 5 2006 575 585
    • (2006) Mol. Cancer Ther , vol.5 , pp. 575-585
    • Bertl, E.1    Bartsch, H.2    Gerhauser, C.3
  • 40
    • 0034490852 scopus 로고    scopus 로고
    • Chemoprotection against cancer by induction of phase 2 enzymes
    • P. Talalay Chemoprotection against cancer by induction of phase 2 enzymes Biofactors 12 2000 5 11
    • (2000) Biofactors , vol.12 , pp. 5-11
    • Talalay, P.1
  • 41
    • 0002989036 scopus 로고
    • Xenobiotic metabolism: Mammalian aspects
    • J.A. Caldwell Xenobiotic metabolism: mammalian aspects ACS Symp. Ser. Am. Chem. Soc 299 1986 2 28
    • (1986) ACS Symp. Ser. Am. Chem. Soc , vol.299 , pp. 2-28
    • Caldwell, J.A.1
  • 42
    • 0029879994 scopus 로고    scopus 로고
    • CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
    • S. Barcelo, J.M. Gardiner, A. Gescher, and J.K. Chipman CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane Carcinogenesis 17 1996 277 282
    • (1996) Carcinogenesis , vol.17 , pp. 277-282
    • Barcelo, S.1    Gardiner, J.M.2    Gescher, A.3    Chipman, J.K.4
  • 43
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes
    • K. Maheo, F. Morel, S. Langouet, H. Kramer, E. Le Ferrec, B. Ketterer, and A. Guillouzo Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes Cancer Res. 57 1997 3649 3652
    • (1997) Cancer Res. , vol.57 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouet, S.3    Kramer, H.4    Le Ferrec, E.5    Ketterer, B.6    Guillouzo, A.7
  • 44
    • 0032543382 scopus 로고    scopus 로고
    • Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane
    • S. Barcelo, K. Mace, A.M. Pfeifer, and J.K. Chipman Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f] quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane Mutat. Res 402 1998 111 120
    • (1998) Mutat. Res , vol.402 , pp. 111-120
    • Barcelo, S.1    MacE, K.2    Pfeifer, A.M.3    Chipman, J.K.4
  • 45
    • 26444561456 scopus 로고    scopus 로고
    • Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity
    • V. Yoxall Kentish, P., Coldham, N., Kuhnert, N., Sauer, M. J., Ioannides, C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: implications for its chemopreventive activity Int. J. Cancer 117 2005 356 362
    • (2005) Int. J. Cancer , vol.117 , pp. 356-362
    • Yoxall, V.1    Kentish, P.2    Coldham, N.3    Kuhnert, N.4    Sauer, M.J.5    Ioannides, C.6
  • 47
    • 1842588301 scopus 로고    scopus 로고
    • Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds
    • R. Munday, and C.M. Munday Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds J. Agric. Food Chem 52 2004 1867 1871
    • (2004) J. Agric. Food Chem , vol.52 , pp. 1867-1871
    • Munday, R.1    Munday, C.M.2
  • 49
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by sulforaphane
    • J.D. Brooks, V.G. Paton, and G. Vidanes Potent induction of phase 2 enzymes in human prostate cells by sulforaphane Cancer Epidemiol. Biomarkers Prev 10 2001 949 954
    • (2001) Cancer Epidemiol. Biomarkers Prev , vol.10 , pp. 949-954
    • Brooks, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 50
    • 12744278308 scopus 로고    scopus 로고
    • Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
    • Y. Zhang, J.R. Marshall, and C.B. Ambrosone Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk Nutr. Cancer 50 2004 206 213
    • (2004) Nutr. Cancer , vol.50 , pp. 206-213
    • Zhang, Y.1    Marshall, J.R.2    Ambrosone, C.B.3
  • 51
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • N. Juge, R.F. Mithen, and M. Traka Molecular basis for chemoprevention by sulforaphane: a comprehensive review Cell. Mol. Life Sci. 64 2007 1105 1127
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 52
    • 33846153232 scopus 로고    scopus 로고
    • Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    • Y. Zhang, R. Munday, H.E. Jobson, C.M. Munday, C. Lister, P. Wilson, J.W. Fahey, and P. Mhawech-Fauceglia Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts J. Agric. Food Chem. 54 2006 9370 9376
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 9370-9376
    • Zhang, Y.1    Munday, R.2    Jobson, H.E.3    Munday, C.M.4    Lister, C.5    Wilson, P.6    Fahey, J.W.7    Mhawech-Fauceglia, P.8
  • 53
    • 0036045433 scopus 로고    scopus 로고
    • Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells
    • G.P. Basten, Y. Bao, and G. Williamson Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells Carcinogenesis 23 2002 1399 1404
    • (2002) Carcinogenesis , vol.23 , pp. 1399-1404
    • Basten, G.P.1    Bao, Y.2    Williamson, G.3
  • 54
    • 0038647564 scopus 로고    scopus 로고
    • Enhancement of glutathione and γ-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant derived food and beverage components in the human hepatoma cell line HepG2
    • G. Scharf, S. Prustomersky, S. Knasmuller, R. Schulte-Hermann, and W.W. Huber Enhancement of glutathione and γ-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant derived food and beverage components in the human hepatoma cell line HepG2 Nutr. Cancer 45 2003 74 83
    • (2003) Nutr. Cancer , vol.45 , pp. 74-83
    • Scharf, G.1    Prustomersky, S.2    Knasmuller, S.3    Schulte-Hermann, R.4    Huber, W.W.5
  • 55
    • 0034125712 scopus 로고    scopus 로고
    • Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
    • Y. Zhang Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells Carcinogenesis 21 2000 1175 1182
    • (2000) Carcinogenesis , vol.21 , pp. 1175-1182
    • Zhang, Y.1
  • 56
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, Y. Katoh, M. Yamamoto, and P. Talalay Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc. Natl. Acad. Sci. USA 99 2002 11908 11913
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6    Yamamoto, M.7    Talalay, P.8
  • 57
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • G.K. McWalter, L.G. Higgins, L.I. McLellan, C.J. Henderson, L. Song, P.J. Thornalley, K. Itoh, M. Yamamoto, and J.D. Hayes Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates J. Nutr. 134 2004 3499S 3506S
    • (2004) J. Nutr. , vol.134
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 58
    • 0037418625 scopus 로고    scopus 로고
    • Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers
    • Z.Q. Jiang, C. Chen, B. Yang, V. Hebbar, and A.N. Kong Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers Life Sci. 72 2003 2243 2253
    • (2003) Life Sci. , vol.72 , pp. 2243-2253
    • Jiang, Z.Q.1    Chen, C.2    Yang, B.3    Hebbar, V.4    Kong, A.N.5
  • 59
    • 33645213057 scopus 로고    scopus 로고
    • Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells
    • A.S. Keck, and J.W. Finley Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells Food Chem. Toxicol 44 2006 695 703
    • (2006) Food Chem. Toxicol , vol.44 , pp. 695-703
    • Keck, A.S.1    Finley, J.W.2
  • 60
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by sulforaphane
    • J.D. Brooks, V.G. Paton, and G. Vidanes Potent induction of phase 2 enzymes in human prostate cells by sulforaphane Cancer Epidemiol. Biomarkers Prev 10 2001 949 954
    • (2001) Cancer Epidemiol. Biomarkers Prev , vol.10 , pp. 949-954
    • Brooks, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 61
    • 33846153232 scopus 로고    scopus 로고
    • Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    • Y. Zhang, R. Munday, H.E. Jobson, C.M. Munday, C. Lister, P. Wilson, J.W. Fahey, and P. Mhawech-Fauceglia Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts J. Agric. Food Chem. 54 2006 9370 9376
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 9370-9376
    • Zhang, Y.1    Munday, R.2    Jobson, H.E.3    Munday, C.M.4    Lister, C.5    Wilson, P.6    Fahey, J.W.7    Mhawech-Fauceglia, P.8
  • 62
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239 247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 63
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • H.U. Simon, A. Haj-Yehia, and F. Levi-Schaffer Role of reactive oxygen species (ROS) in apoptosis induction Apoptosis 5 2000 415 418
    • (2000) Apoptosis , vol.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 64
    • 7444229836 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    • N.A. Pham, J.W. Jacobberger, A.D. Schimmer, P. Cao, M. Gronda, and D.W. Hedley The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice Mol. Cancer Ther. 3 2004 1239 1248
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1239-1248
    • Pham, N.A.1    Jacobberger, J.W.2    Schimmer, A.D.3    Cao, P.4    Gronda, M.5    Hedley, D.W.6
  • 66
    • 51749118898 scopus 로고    scopus 로고
    • Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
    • W.Y. Choi, B.T. Choi, W.H. Lee, and Y.H. Choi Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells Biomed. Pharmacother. 62 2008 637 644
    • (2008) Biomed. Pharmacother. , vol.62 , pp. 637-644
    • Choi, W.Y.1    Choi, B.T.2    Lee, W.H.3    Choi, Y.H.4
  • 67
    • 16444382033 scopus 로고    scopus 로고
    • Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent
    • S. Choi, and S.V. Singh Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent Cancer Res 65 2005 2035 2043
    • (2005) Cancer Res , vol.65 , pp. 2035-2043
    • Choi, S.1    Singh, S.V.2
  • 69
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • M. McMahon, K. Itoh, M. Yamamoto, and J.D. Hayes Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression J. Biol. Chem 278 2003 21592 21600
    • (2003) J. Biol. Chem , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 70
    • 33644649421 scopus 로고    scopus 로고
    • Nrf2: A potential molecular target for cancer chemoprevention by natural compounds
    • W.S. Jeong, M. Jun, and A.N. Kong Nrf2: a potential molecular target for cancer chemoprevention by natural compounds Antioxid. Redox Signaling 8 2006 99 106
    • (2006) Antioxid. Redox Signaling , vol.8 , pp. 99-106
    • Jeong, W.S.1    Jun, M.2    Kong, A.N.3
  • 71
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 13 1999 76 86
    • (1999) Genes Dev. , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 72
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    • R. Hu, C. Xu, G. Shen, M.R. Jain, T.O. Khor, A. Gopalkrishnan, W. Lin, B. Reddy, J.Y. Chan, and A.N. Kong Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice Cancer Lett. 243 2006 170 192
    • (2006) Cancer Lett. , vol.243 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3    Jain, M.R.4    Khor, T.O.5    Gopalkrishnan, A.6    Lin, W.7    Reddy, B.8    Chan, J.Y.9    Kong, A.N.10
  • 73
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • R.K. Thimmulappa, K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray Cancer Res. 62 2002 5196 5203
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 74
    • 37848999061 scopus 로고    scopus 로고
    • 4-Hydroxynonenal self limits Fas-mediated DISC independent apoptosis by promoting export of Daxx from nucleus to cytosol and its binding to Fas
    • R. Sharma, A. Sharma, S. Dwivedi, P. Zimniak, S. Awasthi, and Y.C. Awasthi 4-Hydroxynonenal self limits Fas-mediated DISC independent apoptosis by promoting export of Daxx from nucleus to cytosol and its binding to Fas Biochemistry 47 2008 143 156
    • (2008) Biochemistry , vol.47 , pp. 143-156
    • Sharma, R.1    Sharma, A.2    Dwivedi, S.3    Zimniak, P.4    Awasthi, S.5    Awasthi, Y.C.6
  • 77
    • 79953182004 scopus 로고    scopus 로고
    • Role of Alpha class glutathione transferases in chemoprevention: Human leukemia (HL60) cells overexpressing GSTA1 and GSTA4 resist sulphorphane and curcumin induced cytotoxicity
    • R. Sharma, B. Ellis, and A. Sharma Role of Alpha class glutathione transferases in chemoprevention: human leukemia (HL60) cells overexpressing GSTA1 and GSTA4 resist sulphorphane and curcumin induced cytotoxicity Phytother. Res 25 2011 563 568
    • (2011) Phytother. Res , vol.25 , pp. 563-568
    • Sharma, R.1    Ellis, B.2    Sharma, A.3
  • 81
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • B.N. Ames, M.K. Shigenaga, and T.M. Hagen Oxidants, antioxidants, and the degenerative diseases of aging Proc. Natl. Acad. Sci. USA 90 1993 7915 7922
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 82
    • 2342518836 scopus 로고    scopus 로고
    • Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
    • R. Sharma, D. Brown, S. Awasthi, Y. Yang, A. Sharma, B. Patrick, M.K. Saini, S.P. Singh, P. Zimniak, S.V. Singh, and Y.C. Awasthi Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells Eur. J. Biochem. 271 2004 1690 1701
    • (2004) Eur. J. Biochem. , vol.271 , pp. 1690-1701
    • Sharma, R.1    Brown, D.2    Awasthi, S.3    Yang, Y.4    Sharma, A.5    Patrick, B.6    Saini, M.K.7    Singh, S.P.8    Zimniak, P.9    Singh, S.V.10    Awasthi, Y.C.11
  • 83
    • 79451476147 scopus 로고    scopus 로고
    • Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells
    • R. Vatsyayan, P. Chaudhary, A. Sharma, R. Sharma, P.C. Rao Lelsani, S. Awasthi, and Y.C. Awasthi Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells Exp. Eye Res. 92 2011 147 154
    • (2011) Exp. Eye Res. , vol.92 , pp. 147-154
    • Vatsyayan, R.1    Chaudhary, P.2    Sharma, A.3    Sharma, R.4    Rao Lelsani, P.C.5    Awasthi, S.6    Awasthi, Y.C.7
  • 84
    • 30144437735 scopus 로고    scopus 로고
    • Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases
    • Y.C. Awasthi, G.A. Ansari, and S. Awasthi Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases Methods Enzymol. 401 2005 379 407
    • (2005) Methods Enzymol. , vol.401 , pp. 379-407
    • Awasthi, Y.C.1    Ansari, G.A.2    Awasthi, S.3
  • 85
    • 0035798564 scopus 로고    scopus 로고
    • Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress
    • J.Z. Cheng, R. Sharma, Y. Yang, S.S. Singhal, A. Sharma, M.K. Saini, S.V. Singh, P. Zimniak, S. Awasthi, and Y.C. Awasthi Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress J. Biol. Chem. 276 2001 41213 41223
    • (2001) J. Biol. Chem. , vol.276 , pp. 41213-41223
    • Cheng, J.Z.1    Sharma, R.2    Yang, Y.3    Singhal, S.S.4    Sharma, A.5    Saini, M.K.6    Singh, S.V.7    Zimniak, P.8    Awasthi, S.9    Awasthi, Y.C.10
  • 86
    • 0035374455 scopus 로고    scopus 로고
    • Role of glutathione S-transferases in protection against lipid peroxidation: Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation
    • Y. Yang, J.Z. Cheng, S.S. Singhal, M. Saini, U. Pandya, S. Awasthi, and Y.C. Awasthi Role of glutathione S-transferases in protection against lipid peroxidation: overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation J. Biol. Chem. 276 2001 19220 19230
    • (2001) J. Biol. Chem. , vol.276 , pp. 19220-19230
    • Yang, Y.1    Cheng, J.Z.2    Singhal, S.S.3    Saini, M.4    Pandya, U.5    Awasthi, S.6    Awasthi, Y.C.7
  • 87
    • 0036351376 scopus 로고    scopus 로고
    • Role of Alpha class glutathione S-transferases as antioxidant enzymes in rodent tissues
    • Y. Yang, R. Sharma, P. Zimniak, and Y.C. Awasthi Role of Alpha class glutathione S-transferases as antioxidant enzymes in rodent tissues Toxicol. Appl. Pharmacol. 182 2002 105 115
    • (2002) Toxicol. Appl. Pharmacol. , vol.182 , pp. 105-115
    • Yang, Y.1    Sharma, R.2    Zimniak, P.3    Awasthi, Y.C.4
  • 88
    • 0042023468 scopus 로고    scopus 로고
    • Transport of glutathione-conjugates and chemotherapeutic drugs by RLIP76 (RalBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance
    • S. Awasthi, S.S. Singhal, R. Sharma, P. Zimniak, and Y.C. Awasthi Transport of glutathione-conjugates and chemotherapeutic drugs by RLIP76 (RalBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance Int. J. Cancer 106 2003 635 646
    • (2003) Int. J. Cancer , vol.106 , pp. 635-646
    • Awasthi, S.1    Singhal, S.S.2    Sharma, R.3    Zimniak, P.4    Awasthi, Y.C.5
  • 91
    • 33644530955 scopus 로고    scopus 로고
    • Regression of melanoma in a murine model by RLIP76 depletion
    • S.S. Singhal, Y.C. Awasthi, and S. Awasthi Regression of melanoma in a murine model by RLIP76 depletion Cancer Res. 66 2006 2354 2360
    • (2006) Cancer Res. , vol.66 , pp. 2354-2360
    • Singhal, S.S.1    Awasthi, Y.C.2    Awasthi, S.3
  • 92
    • 34249322665 scopus 로고    scopus 로고
    • Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1)
    • S.S. Singhal, J. Singhal, S. Yadav, S. Dwivedi, P.J. Boor, Y.C. Awasthi, and S. Awasthi Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1) Cancer Res. 67 2007 4382 4389
    • (2007) Cancer Res. , vol.67 , pp. 4382-4389
    • Singhal, S.S.1    Singhal, J.2    Yadav, S.3    Dwivedi, S.4    Boor, P.J.5    Awasthi, Y.C.6    Awasthi, S.7
  • 95
    • 68849109631 scopus 로고    scopus 로고
    • Signaling pathways involved in Phase II gene induction by alpha beta unsaturated aldehydes
    • H. Zhang, and H.J. Forman Signaling pathways involved in Phase II gene induction by alpha beta unsaturated aldehydes Toxicol. Ind. Health 4-5 2009 269 278
    • (2009) Toxicol. Ind. Health , vol.4-5 , pp. 269-278
    • Zhang, H.1    Forman, H.J.2
  • 96
    • 0031939472 scopus 로고    scopus 로고
    • Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro
    • L. Gamet-Payrastre, S. Lumeau, N. Gasc, G. Cassar, P. Rollin, and J. Tulliez Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro Anticancer Drugs 9 1998 141 148
    • (1998) Anticancer Drugs , vol.9 , pp. 141-148
    • Gamet-Payrastre, L.1    Lumeau, S.2    Gasc, N.3    Cassar, G.4    Rollin, P.5    Tulliez, J.6
  • 97
    • 0034162822 scopus 로고    scopus 로고
    • Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
    • L. Gamet-Payrastre, P. Li, S. Lumeau, G. Cassar, M.A. Dupont, S. Chevolleau, N. Gasc, J. Tulliez, and F. Terce Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells Cancer Res. 60 2000 1426 1433
    • (2000) Cancer Res. , vol.60 , pp. 1426-1433
    • Gamet-Payrastre, L.1    Li, P.2    Lumeau, S.3    Cassar, G.4    Dupont, M.A.5    Chevolleau, S.6    Gasc, N.7    Tulliez, J.8    Terce, F.9
  • 99
    • 0034662433 scopus 로고    scopus 로고
    • Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro
    • K. Xu, and P.J. Thornalley Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro Biochem. Pharmacol 60 2000 221 231
    • (2000) Biochem. Pharmacol , vol.60 , pp. 221-231
    • Xu, K.1    Thornalley, P.J.2
  • 100
    • 0036252496 scopus 로고    scopus 로고
    • Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane
    • C. Fimognari, M. Nusse, R. Cesari, R. Iori, G. Cantelli-Forti, and P. Hrelia Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane Carcinogenesis 23 2002 581 586
    • (2002) Carcinogenesis , vol.23 , pp. 581-586
    • Fimognari, C.1    Nusse, M.2    Cesari, R.3    Iori, R.4    Cantelli-Forti, G.5    Hrelia, P.6
  • 101
    • 3543117254 scopus 로고    scopus 로고
    • Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
    • L. Tang, and Y. Zhang Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells J. Nutr. 134 2004 2004 2010
    • (2004) J. Nutr. , vol.134 , pp. 2004-2010
    • Tang, L.1    Zhang, Y.2
  • 102
    • 33745282435 scopus 로고    scopus 로고
    • Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    • A. Herman-Antosiewicz, D.E. Johnson, and S.V. Singh Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells Cancer Res 66 2006 5828 5835
    • (2006) Cancer Res , vol.66 , pp. 5828-5835
    • Herman-Antosiewicz, A.1    Johnson, D.E.2    Singh, S.V.3
  • 103
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • C.J. Sherr Cancer cell cycles Science 274 1996 1672 1677
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 104
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev. 13 1999 1501 1512
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 105
    • 33644841610 scopus 로고    scopus 로고
    • P53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1
    • G. Shen, C. Xu, C. Chen, V. Hebbar, and A.N. Kong p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1 Cancer Chemother. Pharmacol 57 2006 317 327
    • (2006) Cancer Chemother. Pharmacol , vol.57 , pp. 317-327
    • Shen, G.1    Xu, C.2    Chen, C.3    Hebbar, V.4    Kong, A.N.5
  • 107
    • 34247622975 scopus 로고    scopus 로고
    • Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells
    • Y. Shan, C. Sun, X. Zhao, K. Wu, A. Cassidy, and Y. Bao Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells Int. J. Oncol. 29 2006 883 888
    • (2006) Int. J. Oncol. , vol.29 , pp. 883-888
    • Shan, Y.1    Sun, C.2    Zhao, X.3    Wu, K.4    Cassidy, A.5    Bao, Y.6
  • 108
    • 33845593776 scopus 로고    scopus 로고
    • Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
    • S.J. Jackson, K.W. Singletary, and R.C. Venema Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization Vasc. Pharmacol 46 2006 77 84
    • (2006) Vasc. Pharmacol , vol.46 , pp. 77-84
    • Jackson, S.J.1    Singletary, K.W.2    Venema, R.C.3
  • 109
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • M.C. Myzak, P.A. Karplus, F.L. Chung, and R.H. Dashwood A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase Cancer Res. 64 2004 5767 5774
    • (2004) Cancer Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 110
    • 79959742774 scopus 로고    scopus 로고
    • Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
    • J. Clarke, A. Hsu, Z. Yu, R. Dashwood, and E. Ho Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells Mol. Nutr. Foods Res 55 2011 999 1009
    • (2011) Mol. Nutr. Foods Res , vol.55 , pp. 999-1009
    • Clarke, J.1    Hsu, A.2    Yu, Z.3    Dashwood, R.4    Ho, E.5
  • 112
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • A. Pledgie-Tracy, M. Sobolewski, and N. Davidson Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines Mol. Cancer Ther. 6 2007 1013 1021
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.2    Davidson, N.3
  • 113
    • 0034861275 scopus 로고    scopus 로고
    • 4-Hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release
    • C. Ji, V. Amarnath, J. Pietenpol, and L. Marnett 4-Hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release Chem. Res. Toxicol. 14 2001 1090 1096
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1090-1096
    • Ji, C.1    Amarnath, V.2    Pietenpol, J.3    Marnett, L.4
  • 115
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    • S. Meeran, S. Patel, and T. Tollefsbol Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines PLoS One 5 2010 e11457
    • (2010) PLoS One , vol.5 , pp. 11457
    • Meeran, S.1    Patel, S.2    Tollefsbol, T.3
  • 118
    • 72249122960 scopus 로고    scopus 로고
    • Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    • E. Ho, J. Clarke, and R. Dashwood Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention J. Nutr. 139 2009 2393 2396
    • (2009) J. Nutr. , vol.139 , pp. 2393-2396
    • Ho, E.1    Clarke, J.2    Dashwood, R.3
  • 119
    • 79953706274 scopus 로고    scopus 로고
    • Potential health benefits of sulforaphane: A review of the experimental, clinical and epidemiological evidences and underlying mechanisms
    • E. Fawzy, and E. Nehad Potential health benefits of sulforaphane: a review of the experimental, clinical and epidemiological evidences and underlying mechanisms J. Med. Plants Res 5 2011 473 484
    • (2011) J. Med. Plants Res , vol.5 , pp. 473-484
    • Fawzy, E.1    Nehad, E.2
  • 120
    • 74949124720 scopus 로고    scopus 로고
    • Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture
    • A. Wagner, I. Ernst, R. Iori, C. Desel, and G. Rimbach Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture Exp. Dermatol 19 2010 137 144
    • (2010) Exp. Dermatol , vol.19 , pp. 137-144
    • Wagner, A.1    Ernst, I.2    Iori, R.3    Desel, C.4    Rimbach, G.5
  • 121
    • 29644437160 scopus 로고    scopus 로고
    • 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
    • Z. Chen, Y. Saito, Y. Yoshida, A. Sekine, N. Noguchi, and E. Niki 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2 J. Biol. Chem. 280 2005 41921 41927
    • (2005) J. Biol. Chem. , vol.280 , pp. 41921-41927
    • Chen, Z.1    Saito, Y.2    Yoshida, Y.3    Sekine, A.4    Noguchi, N.5    Niki, E.6
  • 122
    • 36348938843 scopus 로고    scopus 로고
    • Heat shock factor 1 attenuates 4-hydroxynonenal-mediated apoptosis: Critical role for heat shock protein 70 induction and stabilization of Bcl-XL
    • A. Jacobs, and L. Marnett Heat shock factor 1 attenuates 4-hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL J. Biol. Chem 282 2007 33412 33420
    • (2007) J. Biol. Chem , vol.282 , pp. 33412-33420
    • Jacobs, A.1    Marnett, L.2
  • 123
    • 0036845841 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is proapoptotic: The role of hydrogen peroxide
    • S. Wang, S. Kotamraju, E. Konorev, S. Kalivendi, J. Joseph, and B. Kalyanaraman Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is proapoptotic: the role of hydrogen peroxide Biochem. J. 367 2002 729 740
    • (2002) Biochem. J. , vol.367 , pp. 729-740
    • Wang, S.1    Kotamraju, S.2    Konorev, E.3    Kalivendi, S.4    Joseph, J.5    Kalyanaraman, B.6
  • 124
    • 0035947678 scopus 로고    scopus 로고
    • κb kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal
    • C. Ji, K. Kozak, and L.I. Marnett κB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal J. Biol. Chem. 276 2001 18223 18228
    • (2001) J. Biol. Chem. , vol.276 , pp. 18223-18228
    • Ji, C.1    Kozak, K.2    Marnett, L.I.3
  • 125
    • 77958081965 scopus 로고    scopus 로고
    • HNE-induced 5-LO expression is regulated by NF-κB/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages
    • S. Lee, C. Kim, K. Seo, and C. Kim HNE-induced 5-LO expression is regulated by NF-κB/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages Cardiovasc. Res 88 2010 352 359
    • (2010) Cardiovasc. Res , vol.88 , pp. 352-359
    • Lee, S.1    Kim, C.2    Seo, K.3    Kim, C.4
  • 126
    • 33846818874 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes
    • P. Malone, and M. Hernandez 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes Exp. Eye Res 84 2007 444 454
    • (2007) Exp. Eye Res , vol.84 , pp. 444-454
    • Malone, P.1    Hernandez, M.2
  • 127
    • 66149118221 scopus 로고    scopus 로고
    • HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins
    • A. Jacobs, and L. Marnett HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins J. Biol. Chem 284 2009 9176 9183
    • (2009) J. Biol. Chem , vol.284 , pp. 9176-9183
    • Jacobs, A.1    Marnett, L.2
  • 128
    • 78149260516 scopus 로고    scopus 로고
    • Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
    • N. Gan, Y. Wu, C. Brunet, F. Chung, C. Dai, and L. Mi Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27 J. Biol. Chem. 285 2010 35528 35536
    • (2010) J. Biol. Chem. , vol.285 , pp. 35528-35536
    • Gan, N.1    Wu, Y.2    Brunet, C.3    Chung, F.4    Dai, C.5    Mi, L.6
  • 129
    • 10044241543 scopus 로고    scopus 로고
    • Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-κB activation and proinflammatory cytokine release in alveolar epithelial cells
    • F. Moodie, J. Marwick, C. Anderson, P. Szulakowski, S. Biswas, M. Bauter, I. Kilty, and I. Rahman Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-κB activation and proinflammatory cytokine release in alveolar epithelial cells FASEB J 18 2004 1897 1899
    • (2004) FASEB J , vol.18 , pp. 1897-1899
    • Moodie, F.1    Marwick, J.2    Anderson, C.3    Szulakowski, P.4    Biswas, S.5    Bauter, M.6    Kilty, I.7    Rahman, I.8
  • 130
    • 33745104461 scopus 로고    scopus 로고
    • 4-Hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress: Is this the whole truth about it or can 4-HNE also exert protective effects?
    • Z. Chen, and E. Niki 4-Hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress: is this the whole truth about it or can 4-HNE also exert protective effects? IUBMB Life 58 2006 372 373
    • (2006) IUBMB Life , vol.58 , pp. 372-373
    • Chen, Z.1    Niki, E.2
  • 131
    • 77955843950 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity
    • S. Pizzimenti, E. Menegatti, D. Berardi, C. Toaldo, P. Pettazzoni, R. Minelli, B. Giglioni, A. Cerbone, M. Dianzani, C. Ferretti, and G. Barrera 4-Hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity J. Nutr. Biochem. 21 2010 818 826
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 818-826
    • Pizzimenti, S.1    Menegatti, E.2    Berardi, D.3    Toaldo, C.4    Pettazzoni, P.5    Minelli, R.6    Giglioni, B.7    Cerbone, A.8    Dianzani, M.9    Ferretti, C.10    Barrera, G.11
  • 132
    • 77954032493 scopus 로고    scopus 로고
    • Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway
    • D. Moon, S. Kang, K. Kim, M. Kim, Y. Choi, and G. Kim Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway Cancer Lett. 295 2010 260 266
    • (2010) Cancer Lett. , vol.295 , pp. 260-266
    • Moon, D.1    Kang, S.2    Kim, K.3    Kim, M.4    Choi, Y.5    Kim, G.6
  • 134
    • 33645815069 scopus 로고    scopus 로고
    • Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis
    • L. Gamet-Payrastre Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis Curr. Cancer Drug Targets 6 2006 135 145
    • (2006) Curr. Cancer Drug Targets , vol.6 , pp. 135-145
    • Gamet-Payrastre, L.1
  • 137
    • 79955559726 scopus 로고    scopus 로고
    • Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death
    • B. Kaminski, A. Weigert, B. Brüne, M. Schumacher, U. Wenzel, D. Steinhilber, J. Stein, and S. Ulrich Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death Cancer Chemother. Pharmacol. 67 2011 1167 1178
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , pp. 1167-1178
    • Kaminski, B.1    Weigert, A.2    Brüne, B.3    Schumacher, M.4    Wenzel, U.5    Steinhilber, D.6    Stein, J.7    Ulrich, S.8
  • 138
    • 0035426001 scopus 로고    scopus 로고
    • Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells
    • C. Anuradha, S. Kanno, and S. Hirano Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells Free Radic. Biol. Med 31 2001 367 373
    • (2001) Free Radic. Biol. Med , vol.31 , pp. 367-373
    • Anuradha, C.1    Kanno, S.2    Hirano, S.3
  • 139
    • 0035808553 scopus 로고    scopus 로고
    • The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    • J.W. Fahey, A.T. Zalcmann, and P. Talalay The chemical diversity and distribution of glucosinolates and isothiocyanates among plants Phytochemistry 56 2001 5 51
    • (2001) Phytochemistry , vol.56 , pp. 5-51
    • Fahey, J.W.1    Zalcmann, A.T.2    Talalay, P.3


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