RLIP76 and Cancer

Clinical Cancer Research

Volumn 14, Issue 14, 2008, Pages 4372-4384

  Awasthi, Sanjay ^a   Singhal, Sharad S ^a   Awasthi, Yogesh C ^a   Martin, Bryan ^b   Woo, Jung Hee ^b   Cunningham, C Casey ^c   Frankel, Arthur E ^b,d  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c Terapio Inc

^d Cancer Research Institute

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CISPLATIN; CLATHRIN; DAUNORUBICIN; DOXORUBICIN; MELPHALAN; MEMBRANE PROTEIN; MITOMYCIN C; NAVELBINE; PROTEIN RLIP76; RLIP76 ANTIBODY; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE; ABC TRANSPORTER; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RALBP1 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CENTROMERE; COMBINATION CHEMOTHERAPY; CYTOSOL; ENDOCYTOSIS; HUMAN; LIVER CANCER; LUNG CARCINOMA; MELANOMA; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; TUMOR; GENETICS; METABOLISM; NEOPLASM; OXIDATIVE STRESS; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ATP-BINDING CASSETTE TRANSPORTERS; GTPASE-ACTIVATING PROTEINS; HUMANS; NEOPLASMS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 51649103801     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-0145     Document Type: Article

References (51)

1. Ishii N, Ishii T, Hartman PS. The role of the electron transport SDHC gene on lifespan and cancer. Mitochondrion 2007;7:24-8.
2. Okada F. Beyond foreign-body-induced carcinogenesis: impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression. Int J Cancer 2007;121:2364-72.
3. Irminger-Finger I. Science of cancer and aging. J Clin Oncol 2007;25:1844-51.
4. Davies KJ. An overview of oxidative stress. IUBMB Life 2000;50:241-4.
5. Wallace DC. Mitochondria and cancer: Warburg addressed. Cold Spring Harbor Symp Quant Biol 2005;70:363-74.
6. Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 2007; 121:2381-6.
7. Sheehan D, Meade G. Foley VM, Dowd CA. Structure, function, and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J 2001; 360:1-16.
8. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11: 81-128.
9. Jullien-FloresV, Dorseuil 0, Romero F, et al. Bridging Ral GTPase to Rho Pathways. RLIP76, a Ral Effector with Cdc42/Rac GTPase-Activating Protein Activity. J Biol Chem 1995;270:22473-7.
10. Park SH, Weinberg RA. A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene1995;11:2349-55.
11. Awasthi S, Cheng J, Singhal SS, et al. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry 2000;39:9327-34.
12. Mirey G, Balakireva M, L'Hoste S, Rosse C, Voegeling S, Camonis J. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol 2003; 23:1112-24.
13. Labelle EF, Singh SV, Srivastava SK, Awasthi YC. Dinitrophenyl glutathione efflux from human erythrocytes is a primary active ATP.dependent transport. Biochem J 1986;238:443-9.
14. Labelle EF, Singh SV, Ahmad H, Woronski L, Srivastava SK, Awasthi YC. A novel dinitrophenylglutathione stimulated ATPase is present in human erythrocyte membranes. FEBS Lett 1988;228:53-6.
15. Sharma R, Gupta S, Singh SV, et al. Purification and characterization of dinitrophenylglutathione ATPase of human erythrocytes and its expression in other tissues. Biochem Biophys Res Commun 1990; 171:155-61.
16. Awasthi S, Singhal SS, Srivastava SK, et al. Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. J Clin Invest 1994;93:958-65.
17. Awasthi S, Singhal SS, Srivastava SK, et al ATP-dependent human erythrocyte glutathione conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity Biochemistry 1998;37:5231-8.
18. Awasthi S, Singhal SS, Pikula S, et al. ATP-dependent human erythrocyte glutathione conjugate transporter II Functional reconstitution of transport activity. Biochemistry 1998;37:5239-48.
19. Awasthi S, Cheng JZ, Singhal SS, et al Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76: identification of ATP binding sequences. Biochemistry 2001; 40:4159-68.
20. Awasthi YC, Singhal SS, Gupta S, et al Purification and characterization of an ATPase from human liver which catalyzes ATP hydrolysis in presence of the conjugates of bilirubin, bile acids and glutathione Biochem Biophys Res Commun 1991;175:1090-6.
21. Saxena M, Singhal SS, Awasthi S, et al. Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes. Arch Biochem Biophys 1992:298 231-7
22. Awasthi S, Singhal SS, Pandya U, et al ATP-dependent colchicine transport by Human erythrocyte glutathione conjugate transporter Toxicol Appl Pharmacol 1999;155:215-26.
23. Singhal SS, Sharma R, Gupta S, et al The anionic conjugates of bilirubin and bile acids stimulate ATP hydrolysis by S- (Dinitrophenyl) glutathione ATPase of human erythrocyte. FEBS Lett 1991;281:255-7
24. Sharma R, Singhal SS, Wickramarachchi D, Awasthi YC, Awasthi S. RLIP76 (RALBP1) mediated transport of leukotrienes C4 (LTC4) in cancer cells: Implications in drug resistance. Int J Cancer 2004;112:934-42
25. Awasthi YC, Sharma R, Yadav S, Dwivedi S, Sharma A. Awasthi S. The non-ABC drug transporter (RALBP-1) plays a major rote in the mechanisms of drug resistance Curr Drug Metab 2007;8:315-23.
26. Sharma R, Singhal SS, Cheng J, et al. RLIP76 is the major ATP-dependent transporter of glutathioneconjugates and doxorubicin in human erythrocytes. Arch Biochem Biophys 2001;391:171-9.
27. Singhal SS, Singhal J, Sharma R, et al. Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int J Oncol 2003;22:365-75.
28. Awasthi S, Singhal SS, Sharma R, Zimniak P, Awasthi YC. Transport of glutathione-conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int J Cancer 2003;106:635-46.
29. Singhal SS, Yadav S, Singhal J, et al. Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol 2005;70:481-8.
30. Singhal SS, Yadav S, Singhal J, Drake K, Awasthi YC, Awasthi S. The Role of PKCα and RLIP76 inTransportmediated Doxorubicin-resistance in Lung Cancer. FEBS Lett 2005;579:4635-41.
31. Stuckler D, Singhal J, Singhal SS, Yadav S, Awasthi YC, Awasthi S. RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Res 2005;65:991-8.
32. Awasthi S, Singhal SS, Yadav S, et al. RLIP76 is a major determinant of radiation sensitivity. Cancer Res 2005;65:6022-8.
33. Singhal SS, Wickramarachchi D, Singhal J, Yadav S, Awasthi YC, Awasthi S. Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett 2006;580:2258-64.
34. Singhal SS, SinghalJ, Nair MP, Lacko AG, Awasthi YC, Awasthi S. Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol 2007; 30:717-25.
35. Singhal SS, Yadav S, SinghalJ, Awasthi YC, Awasthi S. Mitogenic and drug-resistance mediating effects of PKC α require RLIP76. Biochem Biophys Res Commun 2006;348:722-7.
36. Yadav S, Singhal SS, Singhal J, et al. Identification of membrane-anchoring domains of RLIP76 using deletion mutant analysis. Biochemistry 2004;43: 16243-53.
37. Yadav S, Zajac E, Singhal SS, Awasthi S. Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Rev 2007;26:59-69.
38. HuY, Mivechi NF. HSF-1 interacts with Ral binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo. J Biol Chem 2003;278:17299-306.
39. Rosse C, L'Hoste S, Offner N, Picard A, Camonis J. RLIP, an effector of the Ral GTPase, is a platform for CDK1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem 2003;278: 30597-604.
40. Yadav S, Zajac E, Singhal SS, et al. POB1 overexpression inhibits RLIP76-mediated transport of glutathione conjugates and drugs and promotes apoptosis. Biochem Biophys Res Commun 2005;328: 1003-9.
41. Nadkar A, Pungaliya C, Drake K, Zajac E, Singhal SS, Awasthi S. Therapeutic resistance in lung cancer. Exp Opin Drug MetabToxicol 2006;2:753-77.
42. Boissel L, Houssin N, Chikh A, Rynditch A, Van Hove L, Moreau J. Recruitment of cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation. Dev Biol 2007;312:331-43.
43. Bodemann BO, White MA. Ral GTPase and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer 2008;8:133-40.
44. Tang Y, Olufemi L, Wang MT, Nie D. Role of Rho GTPases in breast cancer. Front Biosci 2008;13: 759-76.
45. Awasthi S, Hallene KL, Fazio V, et al. RLIP76, a non- ABC transporter, and drug resistance in epilepsy. BMC Neurosci 2005;6:61.
46. Singhal SS, Awasthi YC, Awasthi S. Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res 2006;66:2354-60.
47. Singhal SS, Singhal J, Yadav S, et al. Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res 2007;67:4382-9.
48. Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int J Oncol 2003;22: 721-32.
49. Drake KJ, Singhal J, Yadav S, et al. RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol 2007;30: 139-44.
50. Gressett SM, Stanford BL, Hardwicke F. Management of hand-foot syndrome induced by capecitabine. J Oncol Pharm Pract 2006;12:131-141.
51. Werner-Wasik M. Treatment-related esophagitis. Semin Oncol 2005;32:S60-6.