Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture

Experimental Dermatology

Volumn 19, Issue 2, 2010, Pages 137-144

  Wagner, Anika E ^a   Ernst, Insa ^a   Iori, Renato ^b   Desel, Christine ^a   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Human keratinocytes; Nrf2; Phase 2 enzymes; Sulforaphane

Indexed keywords

ASCORBIC ACID; ASCORBIGEN; GLUCOSINOLATE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE 3 CARBINOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; TRANSACTIVATION;

ANTICARCINOGENIC AGENTS; ASCORBIC ACID; CELLS, CULTURED; GENE EXPRESSION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; INDOLES; KERATINOCYTES; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; NF-KAPPA B; RNA, MESSENGER; THIOCYANATES;

EID: 74949124720     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00928.x     Document Type: Article

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