메뉴 건너뛰기




Volumn , Issue , 2010, Pages 187-229

Role of Natural Products in Drug Discovery

Author keywords

Natural products source of modern medicinal chemistry compounds; Natural products as source of inspiration; Natural products in drug discovery

Indexed keywords


EID: 84860510662     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470584170.ch7     Document Type: Chapter
Times cited : (8)

References (207)
  • 1
    • 0141828545 scopus 로고    scopus 로고
    • The beginnings of drug therapy: ancient mesopotamian medicine
    • Borchart, J. K. (2002). The beginnings of drug therapy: ancient mesopotamian medicine. Drug News Perspective, 15, 187-192.
    • (2002) Drug News Perspective , vol.15 , pp. 187-192
    • Borchart, J.K.1
  • 2
    • 0000931448 scopus 로고
    • Shanidar IV a Neanderthal flower burial in northern Iraq
    • Solecki, R. S. (1975). Shanidar IV, a Neanderthal flower burial in northern Iraq. Science New Series, 190(4217), 880-881.
    • (1975) Science New Series , vol.190 , Issue.4217 , pp. 880-881
    • Solecki, R.S.1
  • 3
    • 2342579565 scopus 로고    scopus 로고
    • The isolation of morphine-first principles in science ethics
    • Huxtable, R. J., Schwarz, S. K. W. (2001). The isolation of morphine-first principles in science and ethics. Molecular Interventions, 1, 189-191.
    • (2001) Molecular Interventions , vol.1 , pp. 189-191
    • Huxtable, R.J.1    Schwarz, S.K.W.2
  • 4
    • 33947451079 scopus 로고
    • Friedrich Wilhelm Sertu rner the discoverer of morphine
    • Lockemann, G. (1951). Friedrich Wilhelm Sertu rner, the discoverer of morphine. Journal of Chemical Education, 28, 277-279.
    • (1951) Journal of Chemical Education , vol.28 , pp. 277-279
    • Lockemann, G.1
  • 5
    • 84886012433 scopus 로고    scopus 로고
    • Alkaloide. Wiley-VCH Weinheim
    • Hesse, M. (2000). Alkaloide. Wiley-VCH, Weinheim.
    • (2000)
    • Hesse, M.1
  • 6
    • 13744263775 scopus 로고    scopus 로고
    • The quest for quinine: those whowon the battles those who won the war. Angewandte Chemie-International Edition
    • Kaufman, T. S., Ru veda, E. A. (2005). The quest for quinine: those whowon the battles and those who won the war. Angewandte Chemie-International Edition, 44, 854-885
    • (2005) , vol.44 , pp. 854-885
    • Kaufman, T.S.1    Ruveda, E.A.2
  • 7
    • 34250761944 scopus 로고    scopus 로고
    • The woodward-doering/rabe-kindler total synthesis of quinine: setting the record straight. Angewandte Chemie-International Edition
    • Jeffrey, I., Seeman, J. I. (2007). The woodward-doering/rabe-kindler total synthesis of quinine: setting the record straight. Angewandte Chemie-International Edition, 46, 1378-1413.
    • (2007) , vol.46 , pp. 1378-1413
    • Jeffrey, I.1    Seeman, J.I.2
  • 8
    • 39849106268 scopus 로고    scopus 로고
    • Rabe rest in peace: confirmation of the rabe-kindler conversion of d-quinotoxine into quinine: experimental affirmation of the woodward-doering formal total synthesis of quinine. Angewandte Chemie- International Edition
    • Smith, A. C., Williams, R. W. (2008). Rabe rest in peace: confirmation of the rabe-kindler conversion of d-quinotoxine into quinine: experimental affirmation of the woodward-doering formal total synthesis of quinine. Angewandte Chemie- International Edition, 47, 1736-1740.
    • (2008) , vol.47 , pp. 1736-1740
    • Smith, A.C.1    Williams, R.W.2
  • 9
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin beyond: the history of the HMG-CoA reductase inhibitors
    • Tobert, J. A. (2003). Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nature Reviews Drug Discovery, 21, 517-526.
    • (2003) Nature Reviews Drug Discovery , vol.21 , pp. 517-526
    • Tobert, J.A.1
  • 10
    • 0017055252 scopus 로고
    • ML-236A ML-236B, ML-236C new inhibitors of cholesterolgenesis produced by Penicillium citrinium
    • Endo, A., Kuroda, M., Tsujita, Y. (1976). ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterolgenesis produced by Penicillium citrinium. Journal of Antibiotics, 29, 1346-1348.
    • (1976) Journal of Antibiotics , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 11
    • 0017754661 scopus 로고    scopus 로고
    • Inhibition of cholesterol synthesis in vitro in vivo by ML-236A ML-236B competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Endo, A., Tsujita, Y., Kuroda, M., Tanzawa, K. (1997). Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. European Journal of Biochemistry, 77, 31-36.
    • (1997) European Journal of Biochemistry , vol.77 , pp. 31-36
    • Endo, A.1    Tsujita, Y.2    Kuroda, M.3    Tanzawa, K.4
  • 12
    • 19744373433 scopus 로고    scopus 로고
    • Best-selling human medicines 2002-2004
    • Maggon, K. (2005). Best-selling human medicines 2002-2004. Drug Discovery Today, 10(11), 739-742.
    • (2005) Drug Discovery Today , vol.10 , Issue.11 , pp. 739-742
    • Maggon, K.1
  • 13
    • 84885978210 scopus 로고    scopus 로고
    • Aspirin the remarkable story of a wonder drug. Bloomsbury Publishing London
    • Jeffreys, D. (2004). Aspirin, the remarkable story of a wonder drug. Bloomsbury Publishing, London.
    • (2004)
    • Jeffreys, D.1
  • 14
    • 0035740794 scopus 로고    scopus 로고
    • Headache in magical medical papyri of Ancient Egypt
    • Karenberg, A., Leitz, C. (2001). Headache in magical and medical papyri of Ancient Egypt. Cephalalgia, 21, 911-916.
    • (2001) Cephalalgia , vol.21 , pp. 911-916
    • Karenberg, A.1    Leitz, C.2
  • 15
    • 84885991835 scopus 로고
    • The papyrus Ebers by B. Ebbell. Isis
    • Temkin, O. (1938). The papyrus Ebers by B. Ebbell. Isis, 28, 126-131.
    • (1938) , vol.28 , pp. 126-131
    • Temkin, O.1
  • 16
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology, 231, 232-235.
    • (1971) Nature New Biology , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 17
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Vane, J., Botting, R. (2003). The mechanism of action of aspirin. Trombosis Research, 110, 255-258.
    • (2003) Trombosis Research , vol.110 , pp. 255-258
    • Vane, J.1    Botting, R.2
  • 18
    • 0016805004 scopus 로고
    • The mechanism of the effect of Aspirin on human platelets: I. Acetylation of a particulate fraction protein
    • Roth, G. J., Majerus, P. W. (1975). The mechanism of the effect of Aspirin on human platelets: I. Acetylation of a particulate fraction protein. Journal of Clinical Investigation, 56, 624-632.
    • (1975) Journal of Clinical Investigation , vol.56 , pp. 624-632
    • Roth, G.J.1    Majerus, P.W.2
  • 19
    • 0026670659 scopus 로고
    • Effects of lowto- high doses of aspirin on platelet aggregability metabolites of thromboxane A2 prostacyclin
    • Tohgi, H., Konno, S., Tamura, K., Kimura, B., Kawano, K. (1992). Effects of lowto- high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin. Stroke, 23, 1400-1403.
    • (1992) Stroke , vol.23 , pp. 1400-1403
    • Tohgi, H.1    Konno, S.2    Tamura, K.3    Kimura, B.4    Kawano, K.5
  • 21
    • 0000378637 scopus 로고
    • On the antibacterial action of cultures of a penicillium with special reference to their use in the isolation of B. Influenzae
    • Fleming, A. (1929). On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. Influenzae. British Journal of Experimental Pathology, 10, 3-13.
    • (1929) British Journal of Experimental Pathology , vol.10 , pp. 3-13
    • Fleming, A.1
  • 23
    • 9544242925 scopus 로고
    • Baterial chemoterapy-the pharmacology of sulfanilamide
    • Marshall, E. K. J. (1939). Baterial chemoterapy-the pharmacology of sulfanilamide. Physiologycal Reviews, 19, 240-269.
    • (1939) Physiologycal Reviews , vol.19 , pp. 240-269
    • Marshall, E.K.J.1
  • 24
    • 0021798830 scopus 로고
    • Carbapenems a new class of beta-lactam antibiotics discovery development of imipenem/cilastatin
    • Birnbaum, J., Kahan, F. M., Kropp, M. A. H., Macdonald, L. S. (1985). Carbapenems, a new class of beta-lactam antibiotics discovery and development of imipenem/cilastatin. The American Journal of Medicine, 78(Suppl 6A), 3.
    • (1985) The American Journal of Medicine , vol.78 , Issue.6 SUPPL , pp. 3
    • Birnbaum, J.1    Kahan, F.M.2    Kropp, M.A.H.3    Macdonald, L.S.4
  • 26
    • 0036488643 scopus 로고    scopus 로고
    • Natural products in cancer chemotherapy: past present future
    • Mann, J. (2002). Natural products in cancer chemotherapy: past, present and future. Nature Reviews Cancer, 2, 143-148.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 143-148
    • Mann, J.1
  • 28
    • 36048953360 scopus 로고    scopus 로고
    • Wirkstoffe auf basis biologisch aktiver Naturstoffe
    • Heilmann, J. (2007). Wirkstoffe auf basis biologisch aktiver Naturstoffe. Chemie in Unserer Zeit, 41, 376-389.
    • (2007) Chemie in Unserer Zeit , vol.41 , pp. 376-389
    • Heilmann, J.1
  • 29
    • 1442285598 scopus 로고    scopus 로고
    • Personal recollections on the early development of Taxol
    • Horwitz, S. B. (2004). Personal recollections on the early development of Taxol. Journal of Natural Products, 67, 136-138.
    • (2004) Journal of Natural Products , vol.67 , pp. 136-138
    • Horwitz, S.B.1
  • 30
    • 0031595885 scopus 로고    scopus 로고
    • Paclitaxel (Taxols): a success story with valuable lessons for natural product drug discovery and development. Medicinal Research Reviews, 18
    • Cragg, G. M. (1998). Paclitaxel (Taxols): a success story with valuable lessons for natural product drug discovery and development. Medicinal Research Reviews, 18, 315-331.
    • (1998) , pp. 315-331
    • Cragg, G.M.1
  • 31
    • 0031682217 scopus 로고    scopus 로고
    • Camptothecin Taxol: discovery to clinic
    • Wall, M. E. (1998). Camptothecin and Taxol: discovery to clinic. Medicinal Research Reviews, 18, 299-314.
    • (1998) Medicinal Research Reviews , vol.18 , pp. 299-314
    • Wall, M.E.1
  • 32
    • 1442310087 scopus 로고    scopus 로고
    • A tale of two tumor targets: topoisomerase i tubulin. The wall wani contribution to cancer chemotherapy
    • Cragg, G. M., Newman, D. J. (2004). A tale of two tumor targets: topoisomerase i and tubulin. The wall and wani contribution to cancer chemotherapy. Journal of Natural Products, 67, 232-244.
    • (2004) Journal of Natural Products , vol.67 , pp. 232-244
    • Cragg, G.M.1    Newman, D.J.2
  • 33
    • 1442334562 scopus 로고    scopus 로고
    • Camptothecin Taxol: historic achievements in natural products research
    • Oberlies, N. H., Kroll, D. J. (2004). Camptothecin and Taxol: historic achievements in natural products research. Journal of Natural Products, 67, 129-135.
    • (2004) Journal of Natural Products , vol.67 , pp. 129-135
    • Oberlies, N.H.1    Kroll, D.J.2
  • 34
    • 33750464876 scopus 로고    scopus 로고
    • Small molecule natural products in the discovery of therapeutic agents: the synthesis connection
    • Wilson, R. M., Danishefsky, S. J. (2006). Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. Journal of Organic Chemistry, 71(22), 8329-8351.
    • (2006) Journal of Organic Chemistry , vol.71 , Issue.22 , pp. 8329-8351
    • Wilson, R.M.1    Danishefsky, S.J.2
  • 37
    • 39149137869 scopus 로고    scopus 로고
    • Plant-derived compounds in clinical trials
    • Saklani, A., Kutty, S. K. (2008). Plant-derived compounds in clinical trials. Drug Discovery Today, 13, 161-171.
    • (2008) Drug Discovery Today , vol.13 , pp. 161-171
    • Saklani, A.1    Kutty, S.K.2
  • 38
    • 14844325717 scopus 로고    scopus 로고
    • The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries
    • Kingston, D. G. I., Newman, D. J. (2005). The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries. Current Opinion in Drug Discovery and Development, 8(2), 207-227.
    • (2005) Current Opinion in Drug Discovery Development , vol.8 , Issue.2 , pp. 207-227
    • Kingston, D.G.I.1    Newman, D.J.2
  • 39
    • 33645801979 scopus 로고    scopus 로고
    • Natural products from marine invertebrates microbes as modulators of antitumor targets
    • Newman, D. J., Cragg, G. M. (2006). Natural products from marine invertebrates and microbes as modulators of antitumor targets. Current Drug Targets, 7(3), 279-304.
    • (2006) Current Drug Targets , vol.7 , Issue.3 , pp. 279-304
    • Newman, D.J.1    Cragg, G.M.2
  • 40
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D. J., Cragg, G. M. (2007). Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70(3), 461-477.
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 41
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products related compounds in clinical advance preclinical trials
    • Newman, D. J., Cragg, G. M. (2004). Marine natural products and related compounds in clinical and advance preclinical trials. Journal of Natural Products, 67, 1216-1238
    • (2004) Journal of Natural Products , vol.67 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 42
    • 42949149681 scopus 로고    scopus 로고
    • Modern natural products chemistry drug discovery
    • Ojima, I. (2008). Modern natural products chemistry and drug discovery. Journal of Medicinal Chemistry, 51, 2587-2588.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 2587-2588
    • Ojima, I.1
  • 44
    • 44249098800 scopus 로고    scopus 로고
    • Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports
    • Butler, M. S. (2008). Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports, 25, 475-516.
    • (2008) , vol.25 , pp. 475-516
    • Butler, M.S.1
  • 46
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Newman, D. J., Cragg, G. M., Snader, K. M. (2003). Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66(7), 1022-1037.
    • (2003) Journal of Natural Products , vol.66 , Issue.7 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 47
    • 4344703950 scopus 로고    scopus 로고
    • The essence of total synthesis. Proceedings of the National Academy of Sciences of the United States of America
    • Nicolaou, K. C., Snyder, S. A. (2004). The essence of total synthesis. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 11929-11936.
    • (2004) , vol.101 , Issue.33 , pp. 11929-11936
    • Nicolaou, K.C.1    Snyder, S.A.2
  • 48
    • 36048953360 scopus 로고    scopus 로고
    • Active substances from biologically active natural products
    • Heilmann, J. (2007). Active substances from biologically active natural products. Chemie in Unserer Zeit, 41(5), 376-389.
    • (2007) Chemie in Unserer Zeit , vol.41 , Issue.5 , pp. 376-389
    • Heilmann, J.1
  • 49
    • 84886064684 scopus 로고    scopus 로고
    • Ethnopharmacology approaches for botanical immunomodulators chemoprotectants in cancer therapy
    • Bhushan, P., Manish, G. (2007). Ethnopharmacology approaches for botanical immunomodulators and chemoprotectants in cancer therapy. Annals of Traditional Chinese Medicine, 3, 255-284.
    • (2007) Annals of Traditional Chinese Medicine , vol.3 , pp. 255-284
    • Bhushan, P.1    Manish, G.2
  • 50
    • 79951738264 scopus 로고    scopus 로고
    • Recent advances in medicinal plants in diabetes treatment. Recent Progress in Medicinal Plants
    • Das, K., Dang, R., Bhaskaran, S., Roopashree, T. S. (2008). Recent advances in medicinal plants in diabetes treatment. Recent Progress in Medicinal Plants, 19, 151-191.
    • (2008) , vol.19 , pp. 151-191
    • Das, K.1    Dang, R.2    Bhaskaran, S.3    Roopashree, T.S.4
  • 51
    • 70349970528 scopus 로고    scopus 로고
    • Rakta kanchan (Bauhinia variegata): chemistry traditional medicinal uses-a review
    • Mali, R. G., Mahajan, S. G., Mehta, A. A. (2007). Rakta kanchan (Bauhinia variegata): chemistry, traditional and medicinal uses-a review. Pharmacognosy Reviews, 1(2), 314-319.
    • (2007) Pharmacognosy Reviews , vol.1 , Issue.2 , pp. 314-319
    • Mali, R.G.1    Mahajan, S.G.2    Mehta, A.A.3
  • 52
    • 43149118590 scopus 로고    scopus 로고
    • Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera)
    • Sangwan, R. S., Chaurasiya, N. D., Lal, P., Misra, L., Tuli, R., Sangwan, N. S. (2008). Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera). Physiologia Plantarum, 133(2), 278-287.
    • (2008) Physiologia Plantarum , vol.133 , Issue.2 , pp. 278-287
    • Sangwan, R.S.1    Chaurasiya, N.D.2    Lal, P.3    Misra, L.4    Tuli, R.5    Sangwan, N.S.6
  • 53
    • 42449109915 scopus 로고    scopus 로고
    • Merger of ayurveda tissue culture-based functional genomics: inspirations from systems biology
    • Deocaris, C. C., Widodo, N., Wadhwa, R., Kaul, S. C. (2008). Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Journal of Translational Medicine, 6.
    • (2008) Journal of Translational Medicine , pp. 6
    • Deocaris, C.C.1    Widodo, N.2    Wadhwa, R.3    Kaul, S.C.4
  • 57
    • 42349104331 scopus 로고    scopus 로고
    • Qinghaosu (Artemisinin): the price of success
    • White, N. J. (2008). Qinghaosu (Artemisinin): the price of success. Science, 320 (5874), 330-334.
    • (2008) Science , vol.320 , Issue.5874 , pp. 330-334
    • White, N.J.1
  • 58
    • 0344194622 scopus 로고
    • From the study of Fructus schizandrae to the discovery of biphenyl dimethyl-dicarboxylate
    • Liu, G. T. (1983). From the study of Fructus schizandrae to the discovery of biphenyl dimethyl-dicarboxylate. Yao xue xue bao = Acta pharmaceutica Sinica, 18(9), 714-720.
    • (1983) Yao xue xue bao = Acta pharmaceutica Sinica , vol.18 , Issue.9 , pp. 714-720
    • Liu, G.T.1
  • 59
    • 34447096207 scopus 로고    scopus 로고
    • Plant natural products: back to the future or into extinction?
    • McChesney, J. D., Venkataraman, S. K., Henri, J. T. (2007). Plant natural products: back to the future or into extinction? Phytochemistry, 68(14), 2015-2022.
    • (2007) Phytochemistry , vol.68 , Issue.14 , pp. 2015-2022
    • McChesney, J.D.1    Venkataraman, S.K.2    Henri, J.T.3
  • 60
    • 0038461995 scopus 로고    scopus 로고
    • Drugs from the deep: marine natural products as drug candidates
    • Haefner, B. (2003). Drugs from the deep: marine natural products as drug candidates. Drug Discovery Today, 8(12), 536-544.
    • (2003) Drug Discovery Today , vol.8 , Issue.12 , pp. 536-544
    • Haefner, B.1
  • 61
    • 34547265714 scopus 로고    scopus 로고
    • Marine natural products. Key advances to the practical application of this resource in drug development
    • Hamann, M. T., Hill, R., Roggo, S. (2007). Marine natural products. Key advances to the practical application of this resource in drug development. Chimia, 61(6), 313-321.
    • (2007) Chimia , vol.61 , Issue.6 , pp. 313-321
    • Hamann, M.T.1    Hill, R.2    Roggo, S.3
  • 62
    • 58949084305 scopus 로고    scopus 로고
    • Deep-sea natural products. Natural Product Reports
    • Skropeta, D. (2008). Deep-sea natural products. Natural Product Reports, 25(6), 1131-1166.
    • (2008) , vol.25 , Issue.6 , pp. 1131-1166
    • Skropeta, D.1
  • 63
    • 0033104653 scopus 로고    scopus 로고
    • Statistical investigation into the structural complementarity of natural products synthetic compounds. Angewandte Chemie International Edition
    • Henkel, T., Brunne, R. M., Muller, H., Reichel, F. (1999). Statistical investigation into the structural complementarity of natural products and synthetic compounds. Angewandte Chemie, International Edition, 38(5), 643-647.
    • (1999) , vol.38 , Issue.5 , pp. 643-647
    • Henkel, T.1    Brunne, R.M.2    Muller, H.3    Reichel, F.4
  • 64
    • 9444229925 scopus 로고    scopus 로고
    • Molecular approaches to discover marine natural product anticancer leads-An update from a drug discovery group collaboration
    • Crews, P., Gerwick, W. H., Schmitz, F. J., France, D., Bair, K. W., Wright, A. E., Hallock, Y. (2003). Molecular approaches to discover marine natural product anticancer leads-An update from a drug discovery group collaboration. Pharmaceutical Biology, 41, 39-52.
    • (2003) Pharmaceutical Biology , vol.41 , pp. 39-52
    • Crews, P.1    Gerwick, W.H.2    Schmitz, F.J.3    France, D.4    Bair, K.W.5    Wright, A.E.6    Hallock, Y.7
  • 65
    • 50149096855 scopus 로고    scopus 로고
    • Wound healing agents: the role of natural non-natural products in drug development
    • de Fatima, A., Modolo, L. V., Sanches, A. C. C., Porto, R. R. (2008). Wound healing agents: the role of natural and non-natural products in drug development. Mini-Reviews in Medicinal Chemistry, 8(9), 879-888.
    • (2008) Mini-Reviews in Medicinal Chemistry , vol.8 , Issue.9 , pp. 879-888
    • de Fatima, A.1    Modolo, L.V.2    Sanches, A.C.C.3    Porto, R.R.4
  • 66
    • 39149098194 scopus 로고    scopus 로고
    • Natural products as leads to anticancer drugs
    • Gordaliza, M. (2007). Natural products as leads to anticancer drugs. Clinical and Translational Oncology, 9(12), 767-776.
    • (2007) Clinical Translational Oncology , vol.9 , Issue.12 , pp. 767-776
    • Gordaliza, M.1
  • 67
    • 0034489957 scopus 로고    scopus 로고
    • Research future trends in the pharmaceutical development of medicinal herbs from Chinese medicine
    • Lee, K. H. (2000). Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine. Public Health Nutrition, 3(4A), 515-522.
    • (2000) Public Health Nutrition , vol.3 , Issue.4 , pp. 515-522
    • Lee, K.H.1
  • 68
    • 0036430152 scopus 로고    scopus 로고
    • Hybrid systems through natural product leads: an approach towards new molecular entities
    • Mehta, G., Singh, V. (2002). Hybrid systems through natural product leads: an approach towards new molecular entities. Chemical Society Reviews, 31(6), 324-334.
    • (2002) Chemical Society Reviews , vol.31 , Issue.6 , pp. 324-334
    • Mehta, G.1    Singh, V.2
  • 69
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
    • Newman, D. J. (2008). Natural products as leads to potential drugs: an old process or the new hope for drug discovery? Journal of Medicinal Chemistry, 51(9), 2589- 2599.
    • (2008) Journal of Medicinal Chemistry , vol.51 , Issue.9 , pp. 2589-2599
    • Newman, D.J.1
  • 70
    • 1642453829 scopus 로고    scopus 로고
    • Mining the microbial metabolome: a new frontier for natural product lead discovery
    • Peric-Concha, N., Long, P. F. (2003). Mining the microbial metabolome: a new frontier for natural product lead discovery. Drug Discovery Today, 8(23), 1078-1084.
    • (2003) Drug Discovery Today , vol.8 , Issue.23 , pp. 1078-1084
    • Peric-Concha, N.1    Long, P.F.2
  • 71
    • 33644817158 scopus 로고    scopus 로고
    • Targeted approaches in natural product lead discovery
    • Potterat, O. (2006). Targeted approaches in natural product lead discovery. Chimia, 60(1-2), 19-22.
    • (2006) Chimia , vol.60 , Issue.1-2 , pp. 19-22
    • Potterat, O.1
  • 72
    • 43049183607 scopus 로고    scopus 로고
    • Natural products as a robust source of new drugs drug leads: past successes present day issues
    • Rishton, G. M. (2008). Natural products as a robust source of new drugs and drug leads: past successes and present day issues. American Journal of Cardiology, 101 (10A), 43D-49D.
    • (2008) American Journal of Cardiology , vol.101 , Issue.10
    • Rishton, G.M.1
  • 74
    • 0001526026 scopus 로고
    • Similarity of the effect of podophyllin colchicine their use in the treatment of condylomata acuminata
    • King, L. S., Sullivan, M. (1946). Similarity of the effect of podophyllin and colchicine and their use in the treatment of condylomata acuminata. Science, 104, 244-245
    • (1946) Science , vol.104 , pp. 244-245
    • King, L.S.1    Sullivan, M.2
  • 75
    • 0003343260 scopus 로고
    • The activity of etoposide (VP16-213) teniposide (VM26) against human lung tumor cells in vitro: cytotoxicity DNA breakage. In: B. F. Issell. F. Muggia. S. K. Carter (eds.). Etoposide (VP 16-213): Current Status New Developments New York: Academic Press
    • Long, B. H., and Brattain, M. G. The activity of etoposide (VP16-213) and teniposide (VM26) against human lung tumor cells in vitro: cytotoxicity and DNA breakage. In: B. F. Issell. F. Muggia. and S. K. Carter (eds.). Etoposide (VP 16-213): Current Status and New Developments, pp. 63-86. New York: Academic Press. 1984.
    • (1984) , pp. 63-86
    • Long, B.H.1    Brattain, M.G.2
  • 76
    • 0021329758 scopus 로고
    • Comparison of cytotoxicity DNA breakage activity of congeners of podophyllotoxin including VP16-213 VM26: a quantitative structure-activity relationship
    • Long, B. H., Musial, S. T., Brattain, M. G. (1984). Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship. Biochemistry, 23(6), 1183-1188.
    • (1984) Biochemistry , vol.23 , Issue.6 , pp. 1183-1188
    • Long, B.H.1    Musial, S.T.2    Brattain, M.G.3
  • 77
    • 0021240783 scopus 로고
    • Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 VM26
    • Minocha, A., Long, B. H. (1984). Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26. Biochemical and Biophysical Research Communications, 122(1), 165-170.
    • (1984) Biochemical Biophysical Research Communications , vol.122 , Issue.1 , pp. 165-170
    • Minocha, A.1    Long, B.H.2
  • 79
    • 0033168569 scopus 로고    scopus 로고
    • Antitumor agents. 194. Synthesis biological evaluations of 4-beta-mono- -di-, -trisubstituted aniline-4u-Odemethyl- podophyllotoxin related compounds with improved pharmacological profiles
    • Zhu, X. K., Guan, J., Tachibana, Y., Bastow, K. F., Cho, S. J., Cheng, H. H., Cheng, Y. C., Gurwith, M., Lee, K. H. (1999). Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4u-Odemethyl- podophyllotoxin and related compounds with improved pharmacological profiles. Journal of Medicinal Chemistry, 42(13), 2441-2446.
    • (1999) Journal of Medicinal Chemistry , vol.42 , Issue.13 , pp. 2441-2446
    • Zhu, X.K.1    Guan, J.2    Tachibana, Y.3    Bastow, K.F.4    Cho, S.J.5    Cheng, H.H.6    Cheng, Y.C.7    Gurwith, M.8    Lee, K.H.9
  • 80
    • 33751102419 scopus 로고    scopus 로고
    • Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound a proposed binding site on tubulin
    • Dabydeen, D. A., Burnett, J. C., Bai, R., Verdier-Pinard, P., Hickford, S. J. H., Pettit, G. R., Blunt, J. W., Munro, M. H. G., Gussio, R., Hamel, E. (2006). Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Molecular Pharmacology, 70(6), 1866-1875.
    • (2006) Molecular Pharmacology , vol.70 , Issue.6 , pp. 1866-1875
    • Dabydeen, D.A.1    Burnett, J.C.2    Bai, R.3    Verdier-Pinard, P.4    Hickford, S.J.H.5    Pettit, G.R.6    Blunt, J.W.7    Munro, M.H.G.8    Gussio, R.9    Hamel, E.10
  • 81
    • 36849083035 scopus 로고    scopus 로고
    • Drug evaluation: eribulin a simplified ketone analog of the tubulin inhibitor halichondrin B for the potential treatment of cancer
    • Newman, S. (2007). Drug evaluation: eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer. Current Opinion in Investigational Drugs, 8(12), 1057-1066.
    • (2007) Current Opinion in Investigational Drugs , vol.8 , Issue.12 , pp. 1057-1066
    • Newman, S.1
  • 84
    • 0022709534 scopus 로고
    • Halichondrins-antitumor polyether macrolides from a marine sponge
    • Hirata, Y., Uemura, D. (1986). Halichondrins-antitumor polyether macrolides from a marine sponge. Pure and Applied Chemistry, 58(5), 701-710.
    • (1986) Pure Applied Chemistry , vol.58 , Issue.5 , pp. 701-710
    • Hirata, Y.1    Uemura, D.2
  • 86
    • 47749155981 scopus 로고    scopus 로고
    • Antibiotics antibiotic resistance genes in natural environments
    • Martinez, J. L. (2008). Antibiotics and antibiotic resistance genes in natural environments. Science, 321(5887), 365-367.
    • (2008) Science , vol.321 , Issue.5887 , pp. 365-367
    • Martinez, J.L.1
  • 88
    • 34249719971 scopus 로고    scopus 로고
    • New strategies for combating multidrugresistant bacteria
    • Wright, G. D., Sutherland, A. D. (2007). New strategies for combating multidrugresistant bacteria. Trends in Molecular Medicine, 13(6), 260-267.
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.6 , pp. 260-267
    • Wright, G.D.1    Sutherland, A.D.2
  • 89
    • 0000383210 scopus 로고
    • Actinonin: an antibiotic substance produced by an actinomycete
    • Gordon, J. J., Kelly, B. K., Miller, G. A. (1962). Actinonin: an antibiotic substance produced by an actinomycete. Nature, 195, 701-702.
    • (1962) Nature , vol.195 , pp. 701-702
    • Gordon, J.J.1    Kelly, B.K.2    Miller, G.A.3
  • 90
  • 92
    • 0016410356 scopus 로고
    • Antibiotic actinonin. II. Total synthesis of actinonin and structural analogs by the isomaleimide method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)
    • Anderson, N. H., Ollis, W. D., Thorpe, J. E., Ward, A. D. (1975). Antibiotic actinonin. II. Total synthesis of actinonin and structural analogs by the isomaleimide method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 9, 825-830.
    • (1975) , vol.9 , pp. 825-830
    • Anderson, N.H.1    Ollis, W.D.2    Thorpe, J.E.3    Ward, A.D.4
  • 93
    • 0016416971 scopus 로고
    • Antibiotic actinonin. IV. Synthesis of structural analogs of actinonin by the mixed anhydride method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)
    • Broughton, B. J., Warren, P. J., Wooldridge, K. R. H., Wright, D. E., Ollis, W. D., Wood, R. J. (1975). Antibiotic actinonin. IV. Synthesis of structural analogs of actinonin by the mixed anhydride method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 9, 842-846.
    • (1975) , vol.9 , pp. 842-846
    • Broughton, B.J.1    Warren, P.J.2    Wooldridge, K.R.H.3    Wright, D.E.4    Ollis, W.D.5    Wood, R.J.6
  • 94
    • 0016414131 scopus 로고
    • Antibiotic actinonin. V. Synthesis of structural analogs of actinonin by the anhydride-ester method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)
    • Devlin, J. P., Ollis, W. D. Thorpe, J. E. (1975). Antibiotic actinonin. V. Synthesis of structural analogs of actinonin by the anhydride-ester method. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 9, 846-848.
    • (1975) , vol.9 , pp. 846-848
    • Devlin, J.P.1    Ollis, W.D.2    Thorpe, J.E.3
  • 99
    • 84885976816 scopus 로고    scopus 로고
    • CRC Dictionary of Natural Products CRC Press 78 318 structural entries June 1996
    • CRC Dictionary of Natural Products, CRC Press, 78, 318 structural entries, June 1996; http://www.crcpress.com/
  • 100
    • 84886040134 scopus 로고    scopus 로고
    • Bioactive Natural Product Database Szenzor Management Consulting Company Budapest (Hungary) (by Berdy) 29 432 entries of natural products with described biological activity (status: July 96).
    • Bioactive Natural Product Database, Szenzor Management Consulting Company, Budapest, (Hungary) (by Berdy), 29, 432 entries of natural products with described biological activity (status: July 96).
  • 101
    • 84885974446 scopus 로고    scopus 로고
    • ACD: Available Chemicals Directory Version 93.2 from Molecular Design Ltd. Information Systems Inc. San Leandro CA USA 182 822 entries.
    • ACD: Available Chemicals Directory, Version 93.2, from Molecular Design Ltd. Information Systems Inc., San Leandro, CA, USA, 182 822 entries.
  • 102
    • 0035347869 scopus 로고    scopus 로고
    • Scaffold architecture pharmacophoric properties of natural products trade drugs: application in the design of natural product-based combinatorial libraries
    • Lee, M. L., Schneider, G. (2001). Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural REFERENCES 221 product-based combinatorial libraries. Journal of Combinatorial Chemistry, 3(3), 284-289.
    • (2001) Journal of Combinatorial Chemistry , vol.3 , Issue.3 , pp. 284-289
    • Lee, M.L.1    Schneider, G.2
  • 103
    • 0031024171 scopus 로고    scopus 로고
    • Experimental computational approaches to estimate solubility permeability in drug discovery development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., Feeney, P. J. (1997). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 23(1-3), 3-25.
    • (1997) Advanced Drug Delivery Reviews , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 104
    • 0035289779 scopus 로고    scopus 로고
    • Experimental computational approaches to estimate solubility permeability in drug discovery development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., Feeney, P. J. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 46(1-3), 3-26.
    • (2001) Advanced Drug Delivery Reviews , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 105
    • 0037208308 scopus 로고    scopus 로고
    • Property distributions: differences between drugs natural products, molecules from combinatorial chemistry
    • Feher, M., Schmidt, J. M. (2003). Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. Journal of Chemical Information and Computer Sciences, 43(1), 218-227.
    • (2003) Journal of Chemical Information Computer Sciences , vol.43 , Issue.1 , pp. 218-227
    • Feher, M.1    Schmidt, J.M.2
  • 106
    • 34547265045 scopus 로고    scopus 로고
    • Properties architecture of drugs natural products revisited
    • Grabowski, K., Schneider, G. (2007). Properties and architecture of drugs and natural products revisited. Current Chemical Biology, 1(1), 115-127.
    • (2007) Current Chemical Biology , vol.1 , Issue.1 , pp. 115-127
    • Grabowski, K.1    Schneider, G.2
  • 107
    • 84886011458 scopus 로고    scopus 로고
    • Cheminformatics analysis of natural products. Lessons from nature inspiring the design of new drugs. In: Petersen F. Amstutz R. eds. Natural products as drugs. Birkhaeuser Verlag Basel CH
    • Ertl, P., Schuffenhauer, A. (2007). Cheminformatics analysis of natural products. Lessons from nature inspiring the design of new drugs. In: Petersen, F., Amstutz, R., eds., Natural products as drugs. Birkhaeuser Verlag, Basel, CH.
    • (2007)
    • Ertl, P.1    Schuffenhauer, A.2
  • 108
    • 15444377930 scopus 로고    scopus 로고
    • What can a chemist learn from nature's macrocycles? A brief conceptual view
    • Wessjohann, L. A., Ruijter, E., Garcia-Rivera, D., Brandt, W. (2005). What can a chemist learn from nature's macrocycles? A brief, conceptual view. Molecular Diversity, 9(1-3), 171-186.
    • (2005) Molecular Diversity , vol.9 , Issue.1-3 , pp. 171-186
    • Wessjohann, L.A.1    Ruijter, E.2    Garcia-Rivera, D.3    Brandt, W.4
  • 109
    • 84984763696 scopus 로고    scopus 로고
    • Chemical space
    • Kirkpatrick, P., Ellis, C. (2004). Chemical space. Nature, 432(7019), 823.
    • (2004) Nature , vol.432 , Issue.7019 , pp. 823
    • Kirkpatrick, P.1    Ellis, C.2
  • 110
    • 0030039619 scopus 로고    scopus 로고
    • The art practice of structure-based drug design: a molecular modeling perspective
    • Bohacek, R. S., McMartin, C., Guida, W. C. (1996). The art and practice of structure-based drug design: a molecular modeling perspective. Medicinal Research Reviews, 16(1), 3-50.
    • (1996) Medicinal Research Reviews , vol.16 , Issue.1 , pp. 3-50
    • Bohacek, R.S.1    McMartin, C.2    Guida, W.C.3
  • 111
    • 84886017394 scopus 로고    scopus 로고
    • Dictionary of Natural Products Version 17.1 Chapmann & Hall/CRC Informa
    • Dictionary of Natural Products, Version 17.1 (2008) Chapmann & Hall/CRC Informa; http://www.crcpress.com/
    • (2008)
  • 112
    • 19644393308 scopus 로고    scopus 로고
    • Bioactive microbial metabolites: a personal view
    • Berdy, J. (2005). Bioactive microbial metabolites: a personal view. Journal of Antibiotics, 58(1), 1-26.
    • (2005) Journal of Antibiotics , vol.58 , Issue.1 , pp. 1-26
    • Berdy, J.1
  • 114
    • 0042202919 scopus 로고    scopus 로고
    • Chemography: the art of navigating in chemical space
    • Oprea, T. I., Gottfries, J. (2001). Chemography: the art of navigating in chemical space. Journal of Combinatorial Chemistry, 3(2), 157-166.
    • (2001) Journal of Combinatorial Chemistry , vol.3 , Issue.2 , pp. 157-166
    • Oprea, T.I.1    Gottfries, J.2
  • 115
    • 0034351503 scopus 로고    scopus 로고
    • Chemical information management in drug discovery: optimizing the computational combinatorial chemistry interfaces
    • Oprea, T. I., Gottfries, J., Sherbukhin, V., Svensson, P., Kuhler, T. C. (2000). Chemical information management in drug discovery: optimizing the computational and combinatorial chemistry interfaces. Journal of Molecular Graphics and Modelling, 18(4/5), 512-524.
    • (2000) Journal of Molecular Graphics Modelling , vol.18 , Issue.4-5 , pp. 512-524
    • Oprea, T.I.1    Gottfries, J.2    Sherbukhin, V.3    Svensson, P.4    Kuhler, T.C.5
  • 116
    • 0012286670 scopus 로고    scopus 로고
    • Pharmacokinetically based mapping device for chemical space navigation
    • Oprea, T. I., Zamora, I., Ungell, A.-L. (2002). Pharmacokinetically based mapping device for chemical space navigation. Journal of Combinatorial Chemistry, 4(4), 258-266.
    • (2002) Journal of Combinatorial Chemistry , vol.4 , Issue.4 , pp. 258-266
    • Oprea, T.I.1    Zamora, I.2    Ungell, A.-L.3
  • 118
    • 34250779428 scopus 로고    scopus 로고
    • ChemGPS-NP: tuned for navigation in biologically relevant chemical space
    • Larsson, J., Gottfries, J., Muresan, S., Backlund, A. (2007). ChemGPS-NP: tuned for navigation in biologically relevant chemical space. Journal of Natural Products, 70(5), 789-794.
    • (2007) Journal of Natural Products , vol.70 , Issue.5 , pp. 789-794
    • Larsson, J.1    Gottfries, J.2    Muresan, S.3    Backlund, A.4
  • 119
    • 28444498830 scopus 로고    scopus 로고
    • Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proceedings of the National Academy of Sciences of the United States of America
    • Koch, M. A., Schuffenhauer, A., Scheck, M., Wetzel, S., Casaulta, M., Odermatt, A., Ertl, P., Waldmann, H. (2005). Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proceedings of the National Academy of Sciences of the United States of America, 102(48), 17272-17277.
    • (2005) , vol.102 , Issue.48 , pp. 17272-17277
    • Koch, M.A.1    Schuffenhauer, A.2    Scheck, M.3    Wetzel, S.4    Casaulta, M.5    Odermatt, A.6    Ertl, P.7    Waldmann, H.8
  • 121
    • 3042799070 scopus 로고    scopus 로고
    • A planning strategy for diversity-oriented synthesis
    • Angewandte Chemie International Edition
    • Burke, M. D., Schreiber, S. L. (2004). A planning strategy for diversity-oriented synthesis. Angewandte Chemie, International Edition, 43(1), 46-58.
    • (2004) , vol.43 , Issue.1 , pp. 46-58
    • Burke, M.D.1    Schreiber, S.L.2
  • 122
    • 0032572816 scopus 로고    scopus 로고
    • A scoring scheme for discriminating between drugs nondrugs
    • Sadowski, J., Kubinyi, H. (1998). A scoring scheme for discriminating between drugs and nondrugs. Journal of Medicinal Chemistry, 41(18), 3325-3329.
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.18 , pp. 3325-3329
    • Sadowski, J.1    Kubinyi, H.2
  • 123
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented diversity-oriented organic synthesis in drug discovery
    • Schreiber, S. L. (2000). Target-oriented and diversity-oriented organic synthesis in drug discovery. Science, 287(5460), 1964-1969.
    • (2000) Science , vol.287 , Issue.5460 , pp. 1964-1969
    • Schreiber, S.L.1
  • 124
    • 0032572819 scopus 로고    scopus 로고
    • Can we learn to distinguish between ''drug-like'' ''nondrug-like'' molecules?
    • Shah, A. V., Walters, W. P., Murcko, M. A. (1998). Can we learn to distinguish between ''drug-like'' and ''nondrug-like'' molecules? Journal ofMedicinal Chemistry, 41(18), 3314-3324.
    • (1998) Journal ofMedicinal Chemistry , vol.41 , Issue.18 , pp. 3314-3324
    • Shah, A.V.1    Walters, W.P.2    Murcko, M.A.3
  • 126
    • 35748973556 scopus 로고    scopus 로고
    • A decade of drug-likeness
    • Anon (2007). A decade of drug-likeness. Nature Reviews Drug Discovery, 6(11), 853.
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 853
    • Anon1
  • 127
    • 49949152506 scopus 로고    scopus 로고
    • Lead discovery the concepts of complexity lead-likeness in the evolution of drug candidates
    • Hann, M. M., Leach, A. R., Burrows, J. N., Griffen, E. (2006). Lead discovery and the concepts of complexity and lead-likeness in the evolution of drug candidates. Comprehensive Medicinal Chemistry II, 4, 435-458.
    • (2006) Comprehensive Medicinal Chemistry II , vol.4 , pp. 435-458
    • Hann, M.M.1    Leach, A.R.2    Burrows, J.N.3    Griffen, E.4
  • 129
    • 33750994920 scopus 로고    scopus 로고
    • Bridging chemical biological space: ''Target Fishing'' using two- threedimensionalmolecular descriptors
    • Nettles, J. H., Jenkins, J. L., Bender, A., Deng, Z., Davies, J. W., Glick, M. (2006). Bridging chemical and biological space: ''Target Fishing'' using two- and threedimensionalmolecular descriptors. Journal of Medicinal Chemistry, 49(23), 6802-6810.
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.23 , pp. 6802-6810
    • Nettles, J.H.1    Jenkins, J.L.2    Bender, A.3    Deng, Z.4    Davies, J.W.5    Glick, M.6
  • 130
    • 84886029334 scopus 로고    scopus 로고
    • Pursuing leadlikeness in pharmaceutical research. Joint Meeting on Medicinal Chemistry Proceedings Vienna Austria June 20-23 1-4.
    • Oprea, T. I. (2005). Pursuing leadlikeness in pharmaceutical research. Joint Meeting on Medicinal Chemistry, Proceedings, Vienna, Austria, June 20-23, 1-4.
    • (2005)
    • Oprea, T.I.1
  • 131
    • 0037439447 scopus 로고    scopus 로고
    • Nonleadlikeness leadlikeness in biochemical screening
    • Rishton, G. M. (2002). Nonleadlikeness and leadlikeness in biochemical screening. Drug Discovery Today, 8(2), 86-96.
    • (2002) Drug Discovery Today , vol.8 , Issue.2 , pp. 86-96
    • Rishton, G.M.1
  • 132
    • 49949151887 scopus 로고    scopus 로고
    • Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    • Rishton, G. M. (2008). Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening. Current Opinion in Chemical Biology 12(3), 340-351.
    • (2008) Current Opinion in Chemical Biology , vol.12 , Issue.3 , pp. 340-351
    • Rishton, G.M.1
  • 134
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates: natural products as guiding principles in the design synthesis of compound libraries
    • Angewandte Chemie International Edition
    • Breinbauer, R., Vetter, I. R., Waldmann, H. (2002). From protein domains to drug candidates: natural products as guiding principles in the design and synthesis of compound libraries. Angewandte Chemie, International Edition, 41(16), 2878-2890.
    • (2002) , vol.41 , Issue.16 , pp. 2878-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 136
    • 0042121318 scopus 로고    scopus 로고
    • Medicinal chemistry of target family-directed masterkeys. Drug Discovery Today
    • Mueller, G. (2003). Medicinal chemistry of target family-directed masterkeys. Drug Discovery Today, 8(15), 681-691.
    • (2003) , vol.8 , Issue.15 , pp. 681-691
    • Mueller, G.1
  • 137
    • 10044253102 scopus 로고    scopus 로고
    • Compound library development guided by protein structure similarity clustering natural product structure. Proceedings of the National Academy of Sciences of the United States of America
    • Koch, M. A., Wittenberg, L.-O., Basu, S., Jeyaraj, D. A., Gourzoulidou, E., Reinecke, K., Odermatt, A., Waldmann, H. (2004). Compound library development guided by protein structure similarity clustering and natural product structure. Proceedings of the National Academy of Sciences of the United States of America, 101(48), 16721-16726.
    • (2004) , vol.101 , Issue.48 , pp. 16721-16726
    • Koch, M.A.1    Wittenberg, L.-O.2    Basu, S.3    Jeyaraj, D.A.4    Gourzoulidou, E.5    Reinecke, K.6    Odermatt, A.7    Waldmann, H.8
  • 139
    • 0037362041 scopus 로고    scopus 로고
    • Cheminformatics analysis of organic substituents: identification of the most common substituents calculation of substituent properties, automatic identification of drug-like bioisosteric groups
    • Ertl, P. (2003). Cheminformatics analysis of organic substituents: identification of the most common substituents, calculation of substituent properties, and automatic identification of drug-like bioisosteric groups. Journal of Chemical Information and Computer Sciences, 43(2), 374-380.
    • (2003) Journal of Chemical Information Computer Sciences , vol.43 , Issue.2 , pp. 374-380
    • Ertl, P.1
  • 141
    • 34247194965 scopus 로고    scopus 로고
    • Virtual exploration of the chemical universe up to atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery
    • Fink, T., Reymond, J.-L. (2007). Virtual exploration of the chemical universe up to atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery. Journal of Chemical Information and Modeling, 47(2), 342-353.
    • (2007) Journal of Chemical Information and Modeling , vol.47 , Issue.2 , pp. 342-353
    • Fink, T.1    Reymond, J.-L.2
  • 142
  • 143
    • 18344363754 scopus 로고    scopus 로고
    • Prospective exploration of synthetically feasible medicinally relevant chemical space
    • Schuerer, S. C., Tyagi, P., Muskal, S. M. (2005). Prospective exploration of synthetically feasible, medicinally relevant chemical space. Journal of Chemical Information and Modeling, 45(2), 239-248.
    • (2005) Journal of Chemical Information Modeling , vol.45 , Issue.2 , pp. 239-248
    • Schuerer, S.C.1    Tyagi, P.2    Muskal, S.M.3
  • 144
    • 33846973035 scopus 로고    scopus 로고
    • Intellectual property protection in the natural product drug discovery traditional herbal medicine herbal medicinal products
    • Kartal, M. (2007). Intellectual property protection in the natural product drug discovery, traditional herbal medicine and herbal medicinal products. Phytotherapy Research, 21, 113-119.
    • (2007) Phytotherapy Research , vol.21 , pp. 113-119
    • Kartal, M.1
  • 145
    • 0029883966 scopus 로고    scopus 로고
    • The position of intellectual property rights in drug discovery development from natural products
    • Boyd, M. R. (1996). The position of intellectual property rights in drug discovery and development from natural products. Journal of Ethnopharmacology, 51, 17-27.
    • (1996) Journal of Ethnopharmacology , vol.51 , pp. 17-27
    • Boyd, M.R.1
  • 146
    • 0000650941 scopus 로고    scopus 로고
    • Access to genetic resources protection of traditional knowledge in the territories of indigenous peoples
    • Aguilar, G. (2001). Access to genetic resources and protection of traditional knowledge in the territories of indigenous peoples. Environmental Science and Policy, 4, 241-256.
    • (2001) Environmental Science Policy , vol.4 , pp. 241-256
    • Aguilar, G.1
  • 147
    • 84886077068 scopus 로고    scopus 로고
    • Convention on Biological Diversity
    • Convention on Biological Diversity; http://www.cbd.int/ (29 August).
  • 150
    • 84871493253 scopus 로고    scopus 로고
    • Bioprospecting ethics benefits A model for effective benefit-sharing
    • Christoffersen, L. P., Mathur, E. J. (2005). Bioprospecting ethics and benefits A model for effective benefit-sharing. Industrial Biotechnology, 1, 255-259.
    • (2005) Industrial Biotechnology , vol.1 , pp. 255-259
    • Christoffersen, L.P.1    Mathur, E.J.2
  • 152
    • 84885990659 scopus 로고    scopus 로고
    • Natural products isolation 2nd edn Vol. 20 Humana Press Totowa NJ
    • Sarker, S. D., Latif, Z., Gray, A. I. (2005). Natural products isolation, 2nd edn, Vol. 20, Humana Press, Totowa, NJ.
    • (2005)
    • Sarker, S.D.1    Latif, Z.2    Gray, A.I.3
  • 153
    • 74049120308 scopus 로고    scopus 로고
    • Hyphenated techniques. In: Sarker S. D. Latif Z. Gray A. I. eds. Natural products isolation
    • Sarker, S. D., Nahar, L. (2005). Hyphenated techniques. In: Sarker, S. D., Latif, Z., Gray, A. I. eds. Natural products isolation, Vol. 20, pp. 233-267, Humana Press, Totowa, NJ.
    • (2005) , vol.20 , pp. 233-267
    • Sarker, S.D.1    Nahar, L.2
  • 156
    • 34547568170 scopus 로고    scopus 로고
    • Highthroughput microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction
    • Kwon, S. J., Lee, M.-Y., Ku, B., Sherman, D. H., Dordick, J. S. (2007). Highthroughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction. ACS Chemical Biology, 2, 419-425.
    • (2007) ACS Chemical Biology , vol.2 , pp. 419-425
    • Kwon, S.J.1    Lee, M.-Y.2    Ku, B.3    Sherman, D.H.4    Dordick, J.S.5
  • 157
    • 0037305949 scopus 로고    scopus 로고
    • Forward chemical genetics: progress obstacles on the path to a new pharmacopoeia. Current Opinion in Chemical Biology
    • Lokey, R. S. (2003). Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia. Current Opinion in Chemical Biology, 7(1), 91-96.
    • (2003) , vol.7 , Issue.1 , pp. 91-96
    • Lokey, R.S.1
  • 158
    • 33745726644 scopus 로고    scopus 로고
    • Chemical genetics
    • Walsh, D. P., Chang, Y. T. (2006). Chemical genetics. Chemical Reviews, 106(6), 2476-2530.
    • (2006) Chemical Reviews , vol.106 , Issue.6 , pp. 2476-2530
    • Walsh, D.P.1    Chang, Y.T.2
  • 159
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation structure of Taxol a novel antileukemic antitumor agent from Taxus breoifolia
    • Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P., McPhail, A. T. (1971). Plant antitumor agents. VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus breoifolia. Journal of the American Chemical Society, 93, 2325-2327.
    • (1971) Journal of the American Chemical Society , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 160
    • 17544369960 scopus 로고    scopus 로고
    • Arzneimittel aus der natur die biologie der taxane. Pharmazie in Unserer Zeit
    • Leistner, E. (2005). Arzneimittel aus der natur die biologie der taxane. Pharmazie in Unserer Zeit, 34, 98-103.
    • (2005) , vol.34 , pp. 98-103
    • Leistner, E.1
  • 161
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by Taxol
    • Schiff, P. B., Fant, J., Horwitz, S. B. (1979). Promotion of microtubule assembly in vitro by Taxol. Nature, 277, 665-667.
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 163
    • 0027430002 scopus 로고
    • The Taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer anti-HIV agents
    • Cragg, G. M., Schepartz, S. A., Suffness, M., Grever, M. R. (1993). The Taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. Journal of Natural Products, 56, 1657-1668.
    • (1993) Journal of Natural Products , vol.56 , pp. 1657-1668
    • Cragg, G.M.1    Schepartz, S.A.2    Suffness, M.3    Grever, M.R.4
  • 172
    • 84885995336 scopus 로고    scopus 로고
    • Preparation of paclitaxel. 96- US10228 9640667 19960607
    • Sisti, N. J., Swindell, C. S., Chander, M. C. (1996). Preparation of paclitaxel. 96- US10228 9640667, 19960607.
    • (1996)
    • Sisti, N.J.1    Swindell, C.S.2    Chander, M.C.3
  • 173
    • 84886034692 scopus 로고    scopus 로고
    • Paclitaxel synthesis from protected precursor compounds. 95-483082 5948919 19950607
    • Sisti, N. J., Swindell, C. S., Chander, M. C. (1999). Paclitaxel synthesis from protected precursor compounds. 95-483082 5948919, 19950607.
    • (1999)
    • Sisti, N.J.1    Swindell, C.S.2    Chander, M.C.3
  • 174
    • 84886050961 scopus 로고    scopus 로고
    • US 20006020507
    • Gibson, F. S. (2000). US 20006020507.
    • (2000)
    • Gibson, F.S.1
  • 175
    • 84886032468 scopus 로고    scopus 로고
    • Agency U.E.P. Greener synthetic pathways award
    • Agency, U. E. P. (2004). Greener synthetic pathways award; http://www.epa.gov/ greenchemistry/pubs/pgcc/winners/gspa04.html (29 August).
    • (2004)
  • 176
    • 0025160288 scopus 로고
    • Discodermolide-a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
    • Gunasekera, S. P., Gunasekera, M., Longley, R. E., Schulte, G. K. (1990). Discodermolide-a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. Journal of Organic Chemistry, 55, 4912-4915.
    • (1990) Journal of Organic Chemistry , vol.55 , pp. 4912-4915
    • Gunasekera, S.P.1    Gunasekera, M.2    Longley, R.E.3    Schulte, G.K.4
  • 177
    • 33751498972 scopus 로고
    • Discodermolide-a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta-correction
    • Gunasekera, S. P., Gunasekera, M., Longley, R. E., Schulte, G. K. (1991). Discodermolide-a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta-correction. Journal of Organic Chemistry, 56, 1346.
    • (1991) Journal of Organic Chemistry , vol.56 , pp. 1346
    • Gunasekera, S.P.1    Gunasekera, M.2    Longley, R.E.3    Schulte, G.K.4
  • 182
    • 0034677179 scopus 로고    scopus 로고
    • Total synthesis of the antimicrotubule agent (+)discodermolide using boron-mediated aldol reactions of chiral ketones
    • Paterson, I., Florence, G. J., Gerlach, K., Scott, J. P. (2000). Total synthesis of the antimicrotubule agent (+)discodermolide using boron-mediated aldol reactions of chiral ketones. Angewandte Chemie-International Edition, 39, 377-380.
    • (2000) Angewandte Chemie-International Edition , vol.39 , pp. 377-380
    • Paterson, I.1    Florence, G.J.2    Gerlach, K.3    Scott, J.P.4
  • 190
    • 33644839988 scopus 로고    scopus 로고
    • Diversity-oriented synthesis: exploring intersections between chemistry biology
    • Tan, D. S. (2005). Diversity-oriented synthesis: exploring intersections between chemistry and biology. Nature Chemical Biology, 1(2), 74-84.
    • (2005) Nature Chemical Biology , vol.1 , Issue.2 , pp. 74-84
    • Tan, D.S.1
  • 191
    • 58149346448 scopus 로고    scopus 로고
    • Synthesis of natural-product-like molecules with over eighty distinct scaffolds. Angewandte Chemie-International Edition
    • Morton, D., Leach, S., Cordier, C., Warriner, S., Nelson, A. (2009). Synthesis of natural-product-like molecules with over eighty distinct scaffolds. Angewandte Chemie-International Edition, 48(1), 104-109.
    • (2009) , vol.48 , Issue.1 , pp. 104-109
    • Morton, D.1    Leach, S.2    Cordier, C.3    Warriner, S.4    Nelson, A.5
  • 193
    • 0347123565 scopus 로고    scopus 로고
    • Synthesis biological evaluation of an indomethacin library revaels a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie- International Edition
    • Rosenbaum, C., Baumhof, P., Mazitschek, R., Mu ller, O., Giannis, A., Waldmann, H. (2004). Synthesis and biological evaluation of an indomethacin library revaels a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie- International Edition, 43, 224-228.
    • (2004) , vol.43 , pp. 224-228
    • Rosenbaum, C.1    Baumhof, P.2    Mazitschek, R.3    Muller, O.4    Giannis, A.5    Waldmann, H.6
  • 195
    • 46749131522 scopus 로고    scopus 로고
    • Divergent synthesis of a pochonin library targeting HSP90 in vivo efficacy of an identified inhibitor. Angewandte Chemie-International Edition
    • Barluenga, S., Wang, C., Fontaine, J. G., Aouadi, K., Beebe, K., Tsutsumi, S., Neckers, L., Winssinger, N. (2008). Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor. Angewandte Chemie-International Edition, 47, 4432-4435.
    • (2008) , vol.47 , pp. 4432-4435
    • Barluenga, S.1    Wang, C.2    Fontaine, J.G.3    Aouadi, K.4    Beebe, K.5    Tsutsumi, S.6    Neckers, L.7    Winssinger, N.8
  • 196
    • 0037108448 scopus 로고    scopus 로고
    • BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
    • Gorre, M. E., Ellwood-Yen, K., Chiosis, G., Rosen, N., Sawyers, C. L. (2002). BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood, 100, 3041-3044.
    • (2002) Blood , vol.100 , pp. 3041-3044
    • Gorre, M.E.1    Ellwood-Yen, K.2    Chiosis, G.3    Rosen, N.4    Sawyers, C.L.5
  • 197
    • 34547137932 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia suppresses leukemic stem cells
    • Peng, C., Brain, J., Hu, Y., Goodrich, A., Kong, L., Grayzel, D., Pak, R., Read, M., Li, S. (2007). Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells. Blood, 110, 678-685.
    • (2007) Blood , vol.110 , pp. 678-685
    • Peng, C.1    Brain, J.2    Hu, Y.3    Goodrich, A.4    Kong, L.5    Grayzel, D.6    Pak, R.7    Read, M.8    Li, S.9
  • 198
    • 0038404927 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function down-regulates Akt kinase sensitizes tumors to Taxol
    • Solit, D. B., Basso, A. D., Olshen, A. B., Scher, H. I., Rosen, N. (2003). Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Research, 63, 2139-2144.
    • (2003) Cancer Research , vol.63 , pp. 2139-2144
    • Solit, D.B.1    Basso, A.D.2    Olshen, A.B.3    Scher, H.I.4    Rosen, N.5
  • 199
    • 34547183507 scopus 로고    scopus 로고
    • Roles of heat-shock protein 90 in maintaining facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America
    • Luo, W., Dou, F., Rodina, A., Chip, S., Kim, J., Zhao, Q., Moulick, K., Aguirre, J., Wu, N., Greengard, P., Chiosis, G. (2007). Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America, 104, 9511-9516.
    • (2007) , vol.104 , pp. 9511-9516
    • Luo, W.1    Dou, F.2    Rodina, A.3    Chip, S.4    Kim, J.5    Zhao, Q.6    Moulick, K.7    Aguirre, J.8    Wu, N.9    Greengard, P.10    Chiosis, G.11
  • 200
    • 3042685847 scopus 로고    scopus 로고
    • New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. Journal of the American Chemical Society, 126
    • Yang, Z.-Q., Geng, X., Solit, D., Pratilas, C. A., Rosen, N., Danishefsky, S. J. (2004). New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. Journal of the American Chemical Society, 126, 7881-7889.
    • (2004) , pp. 7881-7889
    • Yang, Z.-Q.1    Geng, X.2    Solit, D.3    Pratilas, C.A.4    Rosen, N.5    Danishefsky, S.J.6
  • 201
    • 0036836678 scopus 로고    scopus 로고
    • Halohydrin oxime derivatives of radicicol: Synthesis antitumor activities Bioorganic Medicinal Chemistry
    • Agatsuma, T., Ogawa, H., Akasaka, K., Asai, A., Yamashita, Y., Mizukami, T., Akinaga, S., Saitoh, Y. (2002). Halohydrin and oxime derivatives of radicicol: Synthesis and antitumor activities Bioorganic and Medicinal Chemistry, 10, 3445-3454.
    • (2002) , vol.10 , pp. 3445-3454
    • Agatsuma, T.1    Ogawa, H.2    Akasaka, K.3    Asai, A.4    Yamashita, Y.5    Mizukami, T.6    Akinaga, S.7    Saitoh, Y.8
  • 202
    • 52449134189 scopus 로고    scopus 로고
    • Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction. Angewandte Chemie-International Edition
    • Waldmann, H., Khedkar, V., Du ckert, H., Schu rmann, S., Oppel, I. M., Kumar, K. (2008). Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction. Angewandte Chemie-International Edition, 47, 6869-6872.
    • (2008) , vol.47 , pp. 6869-6872
    • Waldmann, H.1    Khedkar, V.2    Duckert, H.3    Schurmann, S.4    Oppel, I.M.5    Kumar, K.6
  • 204
    • 42349112550 scopus 로고    scopus 로고
    • The use of polymer-assisted solution-phase synthesis automation for the high-throughput preparation of biologically active compounds
    • Ley, S. V., Ladlow, M., Vickerstaffe, E. (2006). The use of polymer-assisted solution-phase synthesis and automation for the high-throughput preparation of biologically active compounds. Exploiting Chemical Diversity for Drug Discovery, 3-32.
    • (2006) Exploiting Chemical Diversity for Drug Discovery , pp. 3-32
    • Ley, S.V.1    Ladlow, M.2    Vickerstaffe, E.3
  • 205
    • 34347212838 scopus 로고    scopus 로고
    • Combinatorial solid-phase natural product chemistry
    • Mentel, M., Breinbauer, R. (2007). Combinatorial solid-phase natural product chemistry. Topics in Current Chemistry, 278, 209-241.
    • (2007) Topics in Current Chemistry , vol.278 , pp. 209-241
    • Mentel, M.1    Breinbauer, R.2
  • 206
    • 0036691029 scopus 로고    scopus 로고
    • New tools concepts for modern organic synthesis
    • Ley, S. V., Baxendale, I. R. (2002). New tools and concepts for modern organic synthesis. Nature Reviews Drug Discovery, 1(8), 573-586.
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.8 , pp. 573-586
    • Ley, S.V.1    Baxendale, I.R.2
  • 207
    • 42349099366 scopus 로고    scopus 로고
    • The changing face of organic synthesis
    • Ley, S. V., Baxendale, I. R. (2008). The changing face of organic synthesis. Chimia, 62(3), 162-168
    • (2008) Chimia , vol.62 , Issue.3 , pp. 162-168
    • Ley, S.V.1    Baxendale, I.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.