The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

Molecular Cancer Therapeutics

Volumn 4, Issue 7, 2005, Pages 1086-1095

  Jordan, Mary Ann ^a   Kamath, Kathryn ^a   Manna, Tapas ^a   Okouneva, Tatiana ^a   Miller, Herbert P ^a   Davis, Celia ^a   Littlefield, Bruce A ^b   Wilson, Leslie ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EISAI RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINO 2 HYDROXYPROPYL)HEXACOSAHYDRO 3 METHOXY 26 METHYL 20,27 BIS(METHYLENE) 11,15:18,21:24.28 TRIEPOXY 7,9 ETHANO 12,15 METHANO 9H,15H FURO[3,2 I]FURO[2',3':5,6]PYRANO[4,3 B][1,4]DIOXACYCLOPENTACOSIN 5 (4H) ONE; ANTIMITOTIC AGENT; E 7389; ER 086526; HALICHONDRIN B; MICROTUBULE PROTEIN; NCS 707389; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

ANAPHASE; ARTICLE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; DRUG TARGETING; ELECTRON MICROSCOPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; METAPHASE; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN AGGREGATION; STEADY STATE; TUMOR CELL;

ANIMALS; ANTIMITOTIC AGENTS; BREAST NEOPLASMS; CATTLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FURANS; HUMANS; INTERPHASE; KETONES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; TUBULIN; TUMOR CELLS, CULTURED;

EID: 23144433687     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0345     Document Type: Article

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