Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

European Journal of Biochemistry

Volumn 77, Issue 1, 1977, Pages 31-36

  ENDO, Akira ^a   TSUJITA, Yoshio ^a   KURODA, Masao ^a   TANZAWA, Kazuhiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIGITONIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; ML 236 B; ML 236A; STEROL; UNCLASSIFIED DRUG;

ACETIC ACID C 14; IN VITRO STUDY; LIVER; LIVER SLICE; MEVALONIC ACID C 14; MOUSE; OCTANOIC ACID C 14; ORAL DRUG ADMINISTRATION; RAT; THEORETICAL STUDY;

ACETATES; ANIMAL; BINDING, COMPETITIVE; CAPRYLATES; CHOLESTEROL; FATTY ACIDS; GALLBLADDER; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IN VITRO; KIDNEY; KINETICS; LACTONES; LIVER; MALE; MEVALONIC ACID; MICE; NAPHTHALENES; ORGAN SPECIFICITY; PYRANS; RATS; STEROLS;

EID: 0017754661     PISSN: 00142956     EISSN: 14321033     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1977.tb11637.x     Document Type: Article

References (9)

1. Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues* *This research was supported by U. S. Public Health Service Grants CA-08501, CA-05200, and Research Career Award HE-01958, and by the Damon Runyon Memorial Fund Award No. 747.