Antitumor agents. 194. Synthesis and biological evaluations of 4-β- mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles

Journal of Medicinal Chemistry

Volumn 42, Issue 13, 1999, Pages 2441-2446

  Zhu, X K ^a   Guan, J ^a   Tachibana, Y ^a   Bastow, K F ^a   Sung Jin Cho, ^a   Cheng H , H ^a   Cheng, Y C ^a   Gurwith, M ^a   Lee, K H ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' O DEMETHYL 4BETA [4'' (BENZIMIDAZOLE 2'' YL)ANILINO] 4 DESOXYPODOPHYLLOTOXIN; ETOPOSIDE; PODOPHYLLOTOXIN DERIVATIVE; TENIPOSIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; TISSUE CULTURE; TUMOR CELL LINE; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ETOPOSIDE; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA P388; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033168569     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990055f     Document Type: Article

References (18)