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Volumn 43, Issue 2, 2003, Pages 224-228

Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis-Related Kinase Inhibitors

Author keywords

Angiogenesis; Combinatorial chemistry; Indomethacin; Kinase inhibitors; Medicinal chemistry

Indexed keywords

ANGIOGRAPHY; BIOSYNTHESIS;

EID: 0347123565     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352582     Document Type: Article
Times cited : (47)

References (41)
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    • For reviews on the indole ring as a privileged structure and combinatorial syntheses of indole-based compound libraries, see: a) D. A. Horton, G. T. Bourne, M. L. Smythe, Chem. Rev. 2003, 103, 893-930;
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    • note
    • The structure-activity relationship apparent from the selected 134 compounds and comparison with the structures of the remaining 63 compounds indicated that biochemical investigation of the latter would not reveal more potent inhibitors. Therefore, 63 of the library compounds were not screened.
  • 39
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    • (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 309-315
    • Cohen, P.1
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    • (2001) Chem. Rev. , vol.101 , pp. 2541-2571
    • Bridges, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.