Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 15, 2003, Pages 3335-3357

  Mínguez, José M ^a   Kim, Sun Young ^a   Giuliano, Kenneth A ^b   Balachandran, Raghavan ^c   Madiraju, Charitha ^c   Day, Billy W ^a   Curran, Dennis P ^a  

^a Chevron Science Center   (United States)

^b Cellomics Inc   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(1 TERT BUTYLDIMETHYLSILANYLOXY) 2,4 DIMETHYLHEX 5 EN 3 OL; 1 (TERT BUTYLDIMETHYLSILANYLOXY) 2,4 DIMETHYL 5 EN 3 OL TERT BUTYLDIMETHYLSILYL ETHER; 1 (TERT BUTYLDIMETHYLSILANYLOXY) 3 (4 METHOXYBENZYLOXY) 2,4 DIMETHYLHEX 5 ENE; 1,6 BIS(TERT BUTYLDIMETHYLSILANYLOXY) 5,7 DIMETHYLNON 8 EN 4 OL; 1,6 BIS(TERT BUTYLDIMETHYLSILANYLOXY) 5,7 DIMETHYLNON 8 EN 4 OL 4 METHOXYBENZYL ETHER; 1,6 BIS(TERT BUTYLDIMETHYLSILANYLOXY) 5,7 DIMETHYLUNDECA 8,10 DIEN 4 OL 4 METHOXYBENZYL ETHER; 11 IODO 8 (4 METHOXYBENZYLOXY) 5,7 DIMETHYLUNDECA 1,3 DIEN 6 OL TERT BUTYLDIMETHYLSILYL ETHER; 13 ACETOXY 7,15 DIHYDROXY 6,8,14,16 TETRAMETHYLEICOSA 4,9,17,19 TETRAENYL ESTER; 13 CARBAMOYLOXY 7,15 DIHYDROXY 6,8,14,16 TETRAMETHYLEICOSA 4,9,17,19 TETRAENYL ESTER; 15 (TERT BUTYLDIMETHYLSILANYLOXY) 7,13 BIS(4 METHOXYBENZYLOXY) 6,8,14,16 TETRAMETHYLEICOSA 4,9,17,19 TETRAEN 1 OL TETRAHYDROPYRAN 2 YL ETHER; 15 ACETOXY 7,13 DIHYDROXY 6,8,14,16 TETRAMETHYLEICOSA 4,9,17,19 TETRAENYL ESTER; 15 CARBAMOYLOXY 7,13 DIHYDROXY 6,8,14,16 TETRAMETHYLEICOSA 4,9,17,19 TETRAENYL ESTER; 15 HYDROXY 3,9 BIS(4 METHOXYBENZYLOXY) 2,8,10 TRIMETHYL 1 (1 METHYLPENTA 2,4 DIENYL)PENTADECA 6,11 DIENYL ESTER; 3 (4 METHOXYBENZYLOXY) 2,4 DIMETHYL 9 (TETRAHYDROPYRAN 2 YLOXY)NON 5 EN 1 OL; 3 (4 METHOXYBENZYLOXY) 2,4 DIMETHYL 9 (TETRAHYDROPYRAN 2 YLOXY)NON 5 EN 1 OL TERT BUTYLDIMETHYLSILYL ETHER; 3 (4 METHOXYBENZYLOXY) 2,4 DIMETHYL 9 (TETRAHYDROPYRAN 2 YLOXY)NON 5 ENAL; 3 (TERT BUTYLDIMETHYLSILANYLOXY) 2,4 DIMETHYLHEX 5 EN 1 OL; 3 (TERT BUTYLDIMETHYLSILANYLOXY) 2,4 DIMETHYLHEX 5 ENAL; 3,8 BIS(TERT BUTYLDIMETHYLSILANYLOXY) 5 (4 METHOXYBENZYLOXY) 2,4 DIMETHYLOCTANAL; 3,9 BIS(4 METHOXYBENZYLOXY) 2,8,10 TRIMETHYL 1 (1 METHYLPENTA 2,4 DIENYL) 15 (TETRAHYDROPYRAN 2 YLOXY)PENTADECA 6,11 DIENYL ESTER; 4 (TETRAHYDROPYRAN 2 YLOXY)BUTYLTRIPHENYLPHOSPHONIUM IODIDE; 5 (TERT BUTYLDIMETHYLSILANYLOXY) 3 (4 METHOXYBENZYLOXY) 2,4 DIMETHYLPENTANAL; 8,14 BIS(4 METHOXYBENZYLOXY) 5,7,13,15 TETRAMETHYL 20 (TETRAHYDROPYRAN 2 YLOXY)EICOSA 1,3,11,16 TETRAEN 6 OL; ALKANE; ANTIMITOTIC AGENT; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; LACTONE; UNCLASSIFIED DRUG; [6 (TERT BUTYLDIMETHYLSILANYLOXY) 4 (4 METHOXYBENZYLOXY) 5,7 DIMETHYLUNDECA 8,10 DIENYL]TRIPHENYLPHOSPHONIUM IODIDE;

ARTICLE; BINDING SITE; BIOASSAY; CARCINOMA CELL; CELL PROLIFERATION; CELL SCREENING; CHEMISTRY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; TUMOR CELL LINE; WITTIG REACTION;

EID: 0038354572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00186-X     Document Type: Article

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