Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-β-lactamases

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 1880-1886

  Payne, David J ^a   Hueso Rodríguez, Juan Antonio ^a   Boyd, Helen ^a   Concha, Néstor O ^a   Janson, Cheryl A ^a   Gilpin, Martin ^a   Bateson, John H ^a   Cheever, Christy ^a   Niconovich, Nancy L ^a   Pearson, Stewart ^a   Rittenhouse, Stephen ^a   Tew, David ^a   Díez, Emilio ^a   Pérez, Paloma ^a   De la Fuente, Jesus ^a   Rees, Michael ^a   Rivera Sagredo, Alfonso ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BETA LACTAMASE INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE; MEROPENEM; NATURAL PRODUCT; SB 236049; SB 236050; SB 238569; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACTEROIDES FRAGILIS; CHAETOMIUM; CHAETOMIUM FUNICOLA; DRUG ISOLATION; DRUG POTENTIATION; DRUG PURIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION;

BACILLUS; BACILLUS CEREUS; BETA-LACTAMASES; BINDING SITES; CHAETOMIUM; DRUG SYNERGISM; ENZYME INHIBITORS; FERMENTATION; HETEROCYCLIC COMPOUNDS, 3-RING; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; THIENAMYCINS;

EID: 0036096423     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.1880-1886.2002     Document Type: Article

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