메뉴 건너뛰기




Volumn 235, Issue 2, 2012, Pages 402-418

Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

Author keywords

Alzheimer; HITS CLIP; Method; Non coding RNA; PAR CLIP; Post transcriptional; Predictors; RIP Chip

Indexed keywords

ARGONAUTE PROTEIN; MICRORNA;

EID: 84860386287     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.12.043     Document Type: Review
Times cited : (39)

References (206)
  • 4
    • 7044285911 scopus 로고    scopus 로고
    • Probing microRNAs with microarrays: tissue specificity and functional inference
    • Babak T., Zhang W., Morris Q., Blencowe B.J., Hughes T.R. Probing microRNAs with microarrays: tissue specificity and functional inference. RNA 2004, 10:1813-1819.
    • (2004) RNA , vol.10 , pp. 1813-1819
    • Babak, T.1    Zhang, W.2    Morris, Q.3    Blencowe, B.J.4    Hughes, T.R.5
  • 5
    • 79960455119 scopus 로고    scopus 로고
    • A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing
    • Babiarz J.E., Hsu R., Melton C., Thomas M., Ullian E.M., Blelloch R. A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing. RNA 2011, 17:1489-1501.
    • (2011) RNA , vol.17 , pp. 1489-1501
    • Babiarz, J.E.1    Hsu, R.2    Melton, C.3    Thomas, M.4    Ullian, E.M.5    Blelloch, R.6
  • 7
    • 79960676808 scopus 로고    scopus 로고
    • Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons
    • Bailey J.A., Ray B., Greig N.H., Lahiri D.K. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 2011, 6:e21954.
    • (2011) PLoS One , vol.6
    • Bailey, J.A.1    Ray, B.2    Greig, N.H.3    Lahiri, D.K.4
  • 8
    • 79959425811 scopus 로고    scopus 로고
    • Specific and sensitive quantitative RT-PCR of miRNAs with DNA primers
    • Balcells I., Cirera S., Busk P.K. Specific and sensitive quantitative RT-PCR of miRNAs with DNA primers. BMC Biotechnol. 2011, 11:70.
    • (2011) BMC Biotechnol. , vol.11 , pp. 70
    • Balcells, I.1    Cirera, S.2    Busk, P.K.3
  • 9
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 10
    • 13944260434 scopus 로고    scopus 로고
    • Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
    • Baskerville S., Bartel D.P. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005, 11:241-247.
    • (2005) RNA , vol.11 , pp. 241-247
    • Baskerville, S.1    Bartel, D.P.2
  • 11
    • 78650203665 scopus 로고    scopus 로고
    • Why so few drugs for Alzheimer's disease? Are methods failing drugs?
    • Becker R.E., Greig N.H. Why so few drugs for Alzheimer's disease? Are methods failing drugs?. Curr. Alzheimer Res. 2010, 7:642-651.
    • (2010) Curr. Alzheimer Res. , vol.7 , pp. 642-651
    • Becker, R.E.1    Greig, N.H.2
  • 13
    • 0033790843 scopus 로고    scopus 로고
    • Use of high specific activity StarFire oligonucleotide probes to visualize low-abundance pre-mRNA splicing intermediates in S. pombe
    • Behlke M.A., Dames S.A., McDonald W.H., Gould K.L., Devor E.J., Walder J.A. Use of high specific activity StarFire oligonucleotide probes to visualize low-abundance pre-mRNA splicing intermediates in S. pombe. Biotechniques 2000, 29:892-897.
    • (2000) Biotechniques , vol.29 , pp. 892-897
    • Behlke, M.A.1    Dames, S.A.2    McDonald, W.H.3    Gould, K.L.4    Devor, E.J.5    Walder, J.A.6
  • 14
    • 37649021046 scopus 로고    scopus 로고
    • Identification of human microRNA targets from isolated argonaute protein complexes
    • Beitzinger M., Peters L., Zhu J.Y., Kremmer E., Meister G. Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol. 2007, 4:76-84.
    • (2007) RNA Biol. , vol.4 , pp. 76-84
    • Beitzinger, M.1    Peters, L.2    Zhu, J.Y.3    Kremmer, E.4    Meister, G.5
  • 15
    • 77649201708 scopus 로고    scopus 로고
    • Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available
    • Benes V., Castoldi M. Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available. Methods 2010, 50:244-249.
    • (2010) Methods , vol.50 , pp. 244-249
    • Benes, V.1    Castoldi, M.2
  • 16
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: back to the future
    • Bertram L., Lill C.M., Tanzi R.E. The genetics of Alzheimer disease: back to the future. Neuron 2010, 68:270-281.
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 18
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • Betel D., Koppal A., Agius P., Sander C., Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol. 2010, 11:R90.
    • (2010) Genome Biol. , vol.11
    • Betel, D.1    Koppal, A.2    Agius, P.3    Sander, C.4    Leslie, C.5
  • 19
    • 84857823520 scopus 로고    scopus 로고
    • Pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns
    • doi:10.1093/nar/gkr903
    • Burroughs A.M., Kawano M., Ando Y., Daub C.O., Hayashizaki Y. pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns. Nucleic Acids Res. 2011, doi:10.1093/nar/gkr903.
    • (2011) Nucleic Acids Res.
    • Burroughs, A.M.1    Kawano, M.2    Ando, Y.3    Daub, C.O.4    Hayashizaki, Y.5
  • 21
  • 22
  • 23
    • 70349453924 scopus 로고    scopus 로고
    • Active turnover modulates mature microRNA activity in Caenorhabditis elegans
    • Chatterjee S., Grosshans H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 2009, 461:546-549.
    • (2009) Nature , vol.461 , pp. 546-549
    • Chatterjee, S.1    Grosshans, H.2
  • 26
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi S.W., Zang J.B., Mele A., Darnell R.B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 2009, 460:479-486.
    • (2009) Nature , vol.460 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 27
    • 35348914716 scopus 로고    scopus 로고
    • Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    • Choi W.-Y., Giraldez A.J., Schier A.F. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 2007, 318:271-274.
    • (2007) Science , vol.318 , pp. 271-274
    • Choi, W.-Y.1    Giraldez, A.J.2    Schier, A.F.3
  • 30
    • 33748310866 scopus 로고    scopus 로고
    • Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
    • Deo M., Yu J.-Y., Chung K.-H., Tippens M., Turner D.L. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev. Dyn. 2006, 235:2538-2548.
    • (2006) Dev. Dyn. , vol.235 , pp. 2538-2548
    • Deo, M.1    Yu, J.-Y.2    Chung, K.-H.3    Tippens, M.4    Turner, D.L.5
  • 31
    • 34447521718 scopus 로고    scopus 로고
    • Isolation of microRNA targets by miRNP immunopurification
    • Easow G., Teleman A.A., Cohen S.M. Isolation of microRNA targets by miRNP immunopurification. RNA 2007, 13:1198-1204.
    • (2007) RNA , vol.13 , pp. 1198-1204
    • Easow, G.1    Teleman, A.A.2    Cohen, S.M.3
  • 32
    • 78149303249 scopus 로고    scopus 로고
    • MicroRNA sponges: progress and possibilities
    • Ebert M.S., Sharp P.A. MicroRNA sponges: progress and possibilities. RNA 2010, 16:2043-2050.
    • (2010) RNA , vol.16 , pp. 2043-2050
    • Ebert, M.S.1    Sharp, P.A.2
  • 33
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
    • Ebert M.S., Neilson J.R., Sharp P.A. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 2007, 4:721-726.
    • (2007) Nat. Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 39
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat. Rev. Genet. 2008, 9:102-114.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 40
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman R.C., Farh K.K., Burge C.B., Bartel D.P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009, 19:92-105.
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 42
    • 4544288083 scopus 로고    scopus 로고
    • Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region
    • Ge Y.-W., Ghosh C., Song W., Maloney B., Lahiri D.K. Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. J. Neurochem. 2004, 90:1432-1444.
    • (2004) J. Neurochem. , vol.90 , pp. 1432-1444
    • Ge, Y.-W.1    Ghosh, C.2    Song, W.3    Maloney, B.4    Lahiri, D.K.5
  • 43
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • Gehrke S., Imai Y., Sokol N., Lu B. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 2010, 466:637-641.
    • (2010) Nature , vol.466 , pp. 637-641
    • Gehrke, S.1    Imai, Y.2    Sokol, N.3    Lu, B.4
  • 44
    • 77951190661 scopus 로고    scopus 로고
    • Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression
    • Git A., Dvinge H., Salmon-Divon M., Osborne M., Kutter C., Hadfield J., Bertone P., Caldas C. Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression. RNA 2010, 16:991-1006.
    • (2010) RNA , vol.16 , pp. 991-1006
    • Git, A.1    Dvinge, H.2    Salmon-Divon, M.3    Osborne, M.4    Kutter, C.5    Hadfield, J.6    Bertone, P.7    Caldas, C.8
  • 46
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010, 466:835-840.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 51
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han J., Lee Y., Yeom K.-H., Kim Y.-K., Jin H., Kim V.N. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 2004, 18:3016-3027.
    • (2004) Genes Dev. , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3    Kim, Y.-K.4    Jin, H.5    Kim, V.N.6
  • 52
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 53
    • 70350707749 scopus 로고    scopus 로고
    • Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets
    • Hausser J., Landthaler M., Jaskiewicz L., Gaidatzis D., Zavolan M. Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets. Genome Res. 2009, 19:2009-2020.
    • (2009) Genome Res. , vol.19 , pp. 2009-2020
    • Hausser, J.1    Landthaler, M.2    Jaskiewicz, L.3    Gaidatzis, D.4    Zavolan, M.5
  • 58
    • 47749154078 scopus 로고    scopus 로고
    • Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance
    • Hendrickson D.G., Hogan D.J., Herschlag D., Ferrell J.E., Brown P.O. Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One 2008, 3:e2126.
    • (2008) PLoS One , vol.3
    • Hendrickson, D.G.1    Hogan, D.J.2    Herschlag, D.3    Ferrell, J.E.4    Brown, P.O.5
  • 60
    • 53949088050 scopus 로고    scopus 로고
    • Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
    • Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 2008, 32:276-284.
    • (2008) Mol. Cell , vol.32 , pp. 276-284
    • Heo, I.1    Joo, C.2    Cho, J.3    Ha, M.4    Han, J.5    Kim, V.N.6
  • 61
    • 68749102148 scopus 로고    scopus 로고
    • TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
    • Heo I., Joo C., Kim Y.-K., Ha M., Yoon M.-J., Cho J., Yeom K.-H., Han J., Kim V.N. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 2009, 138:696-708.
    • (2009) Cell , vol.138 , pp. 696-708
    • Heo, I.1    Joo, C.2    Kim, Y.-K.3    Ha, M.4    Yoon, M.-J.5    Cho, J.6    Yeom, K.-H.7    Han, J.8    Kim, V.N.9
  • 62
    • 70349293700 scopus 로고    scopus 로고
    • Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
    • Hong X., Hammell M., Ambros V., Cohen S.M. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:15085-15090.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 15085-15090
    • Hong, X.1    Hammell, M.2    Ambros, V.3    Cohen, S.M.4
  • 63
    • 79960945068 scopus 로고    scopus 로고
    • Performing the Labeled microRNA pull-down (LAMP) assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs
    • Hsu R.-J., Tsai H.-J. Performing the Labeled microRNA pull-down (LAMP) assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs. Methods Mol. Biol. 2011, 764:241-247.
    • (2011) Methods Mol. Biol. , vol.764 , pp. 241-247
    • Hsu, R.-J.1    Tsai, H.-J.2
  • 64
    • 67249160019 scopus 로고    scopus 로고
    • Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs
    • Hsu R.-J., Yang H.-J., Tsai H.-J. Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs. Nucleic Acids Res. 2009, 37:e77.
    • (2009) Nucleic Acids Res. , vol.37
    • Hsu, R.-J.1    Yang, H.-J.2    Tsai, H.-J.3
  • 65
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvágner G., McLachlan J., Pasquinelli A.E., Bálint E., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001, 293:834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvágner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Bálint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 68
    • 33751348560 scopus 로고    scopus 로고
    • Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody
    • Ikeda K., Satoh M., Pauley K.M., Fritzler M.J., Reeves W.H., Chan E.K.L. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J. Immunol. Methods 2006, 317:38-44.
    • (2006) J. Immunol. Methods , vol.317 , pp. 38-44
    • Ikeda, K.1    Satoh, M.2    Pauley, K.M.3    Fritzler, M.J.4    Reeves, W.H.5    Chan, E.K.L.6
  • 70
    • 78349312100 scopus 로고    scopus 로고
    • Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes
    • Jørgensen S., Baker A., Møller S., Nielsen B.S. Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes. Methods 2010, 52:375-381.
    • (2010) Methods , vol.52 , pp. 375-381
    • Jørgensen, S.1    Baker, A.2    Møller, S.3    Nielsen, B.S.4
  • 71
    • 77449131843 scopus 로고    scopus 로고
    • MicroRNA assassins: factors that regulate the disappearance of miRNAs
    • Kai Z.S., Pasquinelli A.E. MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat. Struct. Mol. Biol. 2010, 17:5-10.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 5-10
    • Kai, Z.S.1    Pasquinelli, A.E.2
  • 73
    • 61449186404 scopus 로고    scopus 로고
    • Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2
    • Katoh T., Sakaguchi Y., Miyauchi K., Suzuki T., Kashiwabara S.-I., Baba T., Suzuki T. Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev. 2009, 23:433-438.
    • (2009) Genes Dev. , vol.23 , pp. 433-438
    • Katoh, T.1    Sakaguchi, Y.2    Miyauchi, K.3    Suzuki, T.4    Kashiwabara, S.-I.5    Baba, T.6    Suzuki, T.7
  • 74
    • 34748821761 scopus 로고    scopus 로고
    • The role of site accessibility in microRNA target recognition
    • Kertesz M., Iovino N., Unnerstall U., Gaul U., Segal E. The role of site accessibility in microRNA target recognition. Nat. Genet. 2007, 39:1278-1284.
    • (2007) Nat. Genet. , vol.39 , pp. 1278-1284
    • Kertesz, M.1    Iovino, N.2    Unnerstall, U.3    Gaul, U.4    Segal, E.5
  • 79
    • 56649095991 scopus 로고    scopus 로고
    • Opportunities and challenges in the discovery of new central nervous system drugs
    • Krause J.E., Chenard B.L. Opportunities and challenges in the discovery of new central nervous system drugs. Ann. N. Y. Acad. Sci. 2008, 1144:243-250.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1144 , pp. 243-250
    • Krause, J.E.1    Chenard, B.L.2
  • 81
    • 0141631876 scopus 로고    scopus 로고
    • A microRNA array reveals extensive regulation of microRNAs during brain development
    • Krichevsky A.M., King K.S., Donahue C.P., Khrapko K., Kosik K.S. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 2003, 9:1274-1281.
    • (2003) RNA , vol.9 , pp. 1274-1281
    • Krichevsky, A.M.1    King, K.S.2    Donahue, C.P.3    Khrapko, K.4    Kosik, K.S.5
  • 85
    • 0036567147 scopus 로고    scopus 로고
    • Design of antisense oligonucleotides stabilized by locked nucleic acids
    • Kurreck J., Wyszko E., Gillen C., Erdmann V.A. Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res. 2002, 30:1911-1918.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1911-1918
    • Kurreck, J.1    Wyszko, E.2    Gillen, C.3    Erdmann, V.A.4
  • 86
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001, 294:853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 87
    • 79951760462 scopus 로고    scopus 로고
    • Application of a multidisciplinary approach to Alzheimer's disease to develop novel drug targets by integrating biomarkers, imaging, genetic and molecular strategies
    • Lahiri D.K. Application of a multidisciplinary approach to Alzheimer's disease to develop novel drug targets by integrating biomarkers, imaging, genetic and molecular strategies. Curr. Alzheimer Res. 2011, 8:1-3.
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 1-3
    • Lahiri, D.K.1
  • 88
    • 0029114162 scopus 로고
    • Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
    • Lahiri D.K., Nall C. Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Brain Res. Mol. Brain Res. 1995, 32:233-240.
    • (1995) Brain Res. Mol. Brain Res. , vol.32 , pp. 233-240
    • Lahiri, D.K.1    Nall, C.2
  • 89
    • 0025967258 scopus 로고
    • The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences
    • Lahiri D.K., Robakis N.K. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Res. Mol. Brain Res. 1991, 9:253-257.
    • (1991) Brain Res. Mol. Brain Res. , vol.9 , pp. 253-257
    • Lahiri, D.K.1    Robakis, N.K.2
  • 91
    • 16344379032 scopus 로고    scopus 로고
    • Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease
    • Lahiri D.K., Ge Y.-W., Maloney B. Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease. FASEB J. 2005, 19:653-655.
    • (2005) FASEB J. , vol.19 , pp. 653-655
    • Lahiri, D.K.1    Ge, Y.-W.2    Maloney, B.3
  • 92
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
    • Lahiri D.K., Maloney B., Zawia N.H. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Mol. Psychiatry 2009, 14:992-1003.
    • (2009) Mol. Psychiatry , vol.14 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 93
    • 78649663246 scopus 로고    scopus 로고
    • A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax)
    • Lam L.T., Lu X., Zhang H., Lesniewski R., Rosenberg S., Semizarov D. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). Mol. Cancer Ther. 2010, 9:2943-2950.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2943-2950
    • Lam, L.T.1    Lu, X.2    Zhang, H.3    Lesniewski, R.4    Rosenberg, S.5    Semizarov, D.6
  • 95
    • 78449310037 scopus 로고    scopus 로고
    • MRNA turnover rate limits siRNA and microRNA efficacy
    • Larsson E., Sander C., Marks D. mRNA turnover rate limits siRNA and microRNA efficacy. Mol. Syst. Biol. 2010, 6:433.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 433
    • Larsson, E.1    Sander, C.2    Marks, D.3
  • 96
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau N.C., Lim L.P., Weinstein E.G., Bartel D.P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001, 294:858-862.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 97
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001, 294:862-864.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 98
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 101
    • 77955469975 scopus 로고    scopus 로고
    • A direct comparison of anti-microRNA oligonucleotide potency
    • Lennox K.A., Behlke M.A. A direct comparison of anti-microRNA oligonucleotide potency. Pharm. Res. 2010, 27:1788-1799.
    • (2010) Pharm. Res. , vol.27 , pp. 1788-1799
    • Lennox, K.A.1    Behlke, M.A.2
  • 103
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 108
    • 84855806746 scopus 로고    scopus 로고
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
    • Liu W., Liu C., Zhu J., Shu P., Yin B., Gong Y., Qiang B., Yuan J., Peng X. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol. Aging 2010, 10.1016/j.neurobiolaging.2010.04.034.
    • (2010) Neurobiol. Aging
    • Liu, W.1    Liu, C.2    Zhu, J.3    Shu, P.4    Yin, B.5    Gong, Y.6    Qiang, B.7    Yuan, J.8    Peng, X.9
  • 109
    • 79961041751 scopus 로고    scopus 로고
    • A novel microRNA interaction relevant to Alzheimer's disease pathogenesis and drug target discovery: miR-346 induces expression of amyloid precursor protein
    • Long J.M., Lahiri D.K. A novel microRNA interaction relevant to Alzheimer's disease pathogenesis and drug target discovery: miR-346 induces expression of amyloid precursor protein. Alzheimers Dement. 2011, 7:S566-S567.
    • (2011) Alzheimers Dement. , vol.7
    • Long, J.M.1    Lahiri, D.K.2
  • 110
    • 79961045911 scopus 로고    scopus 로고
    • Current drug targets for modulating Alzheimer's amyloid precursor protein: role of specific micro-RNA species
    • Long J.M., Lahiri D.K. Current drug targets for modulating Alzheimer's amyloid precursor protein: role of specific micro-RNA species. Curr. Med. Chem. 2011, 18:3314-3321.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 3314-3321
    • Long, J.M.1    Lahiri, D.K.2
  • 111
    • 79151483332 scopus 로고    scopus 로고
    • MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed
    • Long J.M., Lahiri D.K. MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochem. Biophys. Res. Commun. 2011, 404:889-895.
    • (2011) Biochem. Biophys. Res. Commun. , vol.404 , pp. 889-895
    • Long, J.M.1    Lahiri, D.K.2
  • 112
    • 69049086730 scopus 로고    scopus 로고
    • Imaging individual microRNAs in single mammalian cells in situ
    • Lu J., Tsourkas A. Imaging individual microRNAs in single mammalian cells in situ. Nucleic Acids Res. 2009, 37:e100.
    • (2009) Nucleic Acids Res. , vol.37
    • Lu, J.1    Tsourkas, A.2
  • 113
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • Lukiw W.J. Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 2007, 18:297-300.
    • (2007) Neuroreport , vol.18 , pp. 297-300
    • Lukiw, W.J.1
  • 116
    • 9444239191 scopus 로고    scopus 로고
    • Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease
    • Maloney B., Ge Y.-W., Greig N., Lahiri D.K. Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease. FASEB J. 2004, 18:1288-1290.
    • (2004) FASEB J. , vol.18 , pp. 1288-1290
    • Maloney, B.1    Ge, Y.-W.2    Greig, N.3    Lahiri, D.K.4
  • 120
    • 68749113985 scopus 로고    scopus 로고
    • Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
    • Mayr C., Bartel D.P. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 2009, 138:673-684.
    • (2009) Cell , vol.138 , pp. 673-684
    • Mayr, C.1    Bartel, D.P.2
  • 121
    • 0034121074 scopus 로고    scopus 로고
    • A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins
    • Mbella E.G., Bertrand S., Huez G., Octave J.N. A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins. Mol. Cell. Biol. 2000, 20:4572-4579.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4572-4579
    • Mbella, E.G.1    Bertrand, S.2    Huez, G.3    Octave, J.N.4
  • 124
    • 33748587841 scopus 로고    scopus 로고
    • A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes
    • Miranda K.C., Huynh T., Tay Y., Ang Y.-S., Tam W.-L., Thomson A.M., Lim B., Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 2006, 126:1203-1217.
    • (2006) Cell , vol.126 , pp. 1203-1217
    • Miranda, K.C.1    Huynh, T.2    Tay, Y.3    Ang, Y.-S.4    Tam, W.-L.5    Thomson, A.M.6    Lim, B.7    Rigoutsos, I.8
  • 127
    • 79957745817 scopus 로고    scopus 로고
    • Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs)
    • Mortensen R.D., Serra M., Steitz J.A., Vasudevan S. Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc. Natl. Acad. Sci. U. S. A. 2011, 108:8281-8286.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 8281-8286
    • Mortensen, R.D.1    Serra, M.2    Steitz, J.A.3    Vasudevan, S.4
  • 129
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study
    • Nelson P.T., Wang W.-X. MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J. Alzheimers Dis. 2010, 21:75-79.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 75-79
    • Nelson, P.T.1    Wang, W.-X.2
  • 130
    • 70350212463 scopus 로고    scopus 로고
    • In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain
    • Nelson P.T., Wilfred B.R. In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain. Neurosci. Lett. 2009, 466:69-72.
    • (2009) Neurosci. Lett. , vol.466 , pp. 69-72
    • Nelson, P.T.1    Wilfred, B.R.2
  • 132
    • 34748880173 scopus 로고    scopus 로고
    • A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells
    • Nelson P.T., De Planell-Saguer M., Lamprinaki S., Kiriakidou M., Zhang P., O'Doherty U., Mourelatos Z. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA 2007, 13:1787-1792.
    • (2007) RNA , vol.13 , pp. 1787-1792
    • Nelson, P.T.1    De Planell-Saguer, M.2    Lamprinaki, S.3    Kiriakidou, M.4    Zhang, P.5    O'Doherty, U.6    Mourelatos, Z.7
  • 133
    • 55049129890 scopus 로고    scopus 로고
    • Technical variables in high-throughput miRNA expression profiling: much work remains to be done
    • Nelson P.T., Wang W.-X., Wilfred B.R., Tang G. Technical variables in high-throughput miRNA expression profiling: much work remains to be done. Biochim. Biophys. Acta 2008, 1779:758-765.
    • (2008) Biochim. Biophys. Acta , vol.1779 , pp. 758-765
    • Nelson, P.T.1    Wang, W.-X.2    Wilfred, B.R.3    Tang, G.4
  • 134
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
    • Nelson P.T., Braak H., Markesbery W.R. Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J. Neuropathol. Exp. Neurol. 2009, 68:1-14.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 135
    • 77952675690 scopus 로고    scopus 로고
    • High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain
    • Nelson P.T., Kiriakidou M., Mourelatos Z., Tan G.S., Jennings M.H., Xie K., Wang W.-X. High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain. Brain Res. 2010, 1338:122-130.
    • (2010) Brain Res. , vol.1338 , pp. 122-130
    • Nelson, P.T.1    Kiriakidou, M.2    Mourelatos, Z.3    Tan, G.S.4    Jennings, M.H.5    Xie, K.6    Wang, W.-X.7
  • 136
    • 80053208703 scopus 로고    scopus 로고
    • Deep sequencing of microRNA precursors reveals extensive 3' end modification
    • Newman M.A., Mani V., Hammond S.M. Deep sequencing of microRNA precursors reveals extensive 3' end modification. RNA 2011, 17:1795-1803.
    • (2011) RNA , vol.17 , pp. 1795-1803
    • Newman, M.A.1    Mani, V.2    Hammond, S.M.3
  • 138
    • 77953312769 scopus 로고    scopus 로고
    • Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation
    • Nunez-Iglesias J., Liu C.C., Morgan T.E., Finch C.E., Zhou X.J. Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One 2010, 5:e8898.
    • (2010) PLoS One , vol.5
    • Nunez-Iglesias, J.1    Liu, C.C.2    Morgan, T.E.3    Finch, C.E.4    Zhou, X.J.5
  • 140
    • 37349059288 scopus 로고    scopus 로고
    • In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations
    • Nuovo G.J. In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations. Methods 2008, 44:39-46.
    • (2008) Methods , vol.44 , pp. 39-46
    • Nuovo, G.J.1
  • 141
    • 61449254438 scopus 로고    scopus 로고
    • A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets
    • Nuovo G.J., Elton T.S., Nana-Sinkam P., Volinia S., Croce C.M., Schmittgen T.D. A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets. Nat. Protoc. 2009, 4:107-115.
    • (2009) Nat. Protoc. , vol.4 , pp. 107-115
    • Nuovo, G.J.1    Elton, T.S.2    Nana-Sinkam, P.3    Volinia, S.4    Croce, C.M.5    Schmittgen, T.D.6
  • 143
    • 34250777057 scopus 로고    scopus 로고
    • Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections
    • Obernosterer G., Martinez J., Alenius M. Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections. Nat. Protoc. 2007, 2:1508-1514.
    • (2007) Nat. Protoc. , vol.2 , pp. 1508-1514
    • Obernosterer, G.1    Martinez, J.2    Alenius, M.3
  • 144
    • 34548671165 scopus 로고    scopus 로고
    • Isolation of microRNA targets using biotinylated synthetic microRNAs
    • Orom U.A., Lund A.H. Isolation of microRNA targets using biotinylated synthetic microRNAs. Methods 2007, 43:162-165.
    • (2007) Methods , vol.43 , pp. 162-165
    • Orom, U.A.1    Lund, A.H.2
  • 145
    • 33646027887 scopus 로고    scopus 로고
    • LNA-modified oligonucleotides mediate specific inhibition of microRNA function
    • Ørom U.A., Kauppinen S., Lund A.H. LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene 2006, 372:137-141.
    • (2006) Gene , vol.372 , pp. 137-141
    • Ørom, U.A.1    Kauppinen, S.2    Lund, A.H.3
  • 146
    • 43449090367 scopus 로고    scopus 로고
    • MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation
    • Ørom U.A., Nielsen F.C., Lund A.H. MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol. Cell 2008, 30:460-471.
    • (2008) Mol. Cell , vol.30 , pp. 460-471
    • Ørom, U.A.1    Nielsen, F.C.2    Lund, A.H.3
  • 148
    • 34249810892 scopus 로고    scopus 로고
    • Argonaute proteins: mediators of RNA silencing
    • Peters L., Meister G. Argonaute proteins: mediators of RNA silencing. Mol. Cell 2007, 26:611-623.
    • (2007) Mol. Cell , vol.26 , pp. 611-623
    • Peters, L.1    Meister, G.2
  • 149
    • 0026507460 scopus 로고
    • The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter
    • Pollwein P., Masters C.L., Beyreuther K. The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter. Nucleic Acids Res. 1992, 20:63-68.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 63-68
    • Pollwein, P.1    Masters, C.L.2    Beyreuther, K.3
  • 151
    • 67650519133 scopus 로고    scopus 로고
    • The RNA-induced silencing complex: a versatile gene-silencing machine
    • Pratt A.J., MacRae I.J. The RNA-induced silencing complex: a versatile gene-silencing machine. J. Biol. Chem. 2009, 284:17897-17901.
    • (2009) J. Biol. Chem. , vol.284 , pp. 17897-17901
    • Pratt, A.J.1    MacRae, I.J.2
  • 152
    • 0026806977 scopus 로고
    • The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain
    • Quitschke W.W., Goldgaber D. The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. J. Biol. Chem. 1992, 267:17362-17368.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17362-17368
    • Quitschke, W.W.1    Goldgaber, D.2
  • 153
    • 41049111771 scopus 로고    scopus 로고
    • Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline
    • Raina P., Santaguida P., Ismaila A., Patterson C., Cowan D., Levine M., Booker L., Oremus M. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann. Intern. Med. 2008, 148:379-397.
    • (2008) Ann. Intern. Med. , vol.148 , pp. 379-397
    • Raina, P.1    Santaguida, P.2    Ismaila, A.3    Patterson, C.4    Cowan, D.5    Levine, M.6    Booker, L.7    Oremus, M.8
  • 154
    • 79954415024 scopus 로고    scopus 로고
    • Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model
    • Ray B., Chauhan N.B., Lahiri D.K. Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. J. Neurochem. 2011, 117:388-402.
    • (2011) J. Neurochem. , vol.117 , pp. 388-402
    • Ray, B.1    Chauhan, N.B.2    Lahiri, D.K.3
  • 155
    • 79959407483 scopus 로고    scopus 로고
    • Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker
    • Ray B., Long J.M., Sokol D.K., Lahiri D.K. Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. PLoS One 2011, 6:e20405.
    • (2011) PLoS One , vol.6
    • Ray, B.1    Long, J.M.2    Sokol, D.K.3    Lahiri, D.K.4
  • 157
    • 0033525735 scopus 로고    scopus 로고
    • Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
    • Rogers J.T., Leiter L.M., McPhee J., Cahill C.M., Zhan S.S., Potter H., Nilsson L.N. Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J. Biol. Chem. 1999, 274:6421-6431.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6421-6431
    • Rogers, J.T.1    Leiter, L.M.2    McPhee, J.3    Cahill, C.M.4    Zhan, S.S.5    Potter, H.6    Nilsson, L.N.7
  • 159
    • 33845436047 scopus 로고    scopus 로고
    • Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    • Ruby J.G., Jan C., Player C., Axtell M.J., Lee W., Nusbaum C., Ge H., Bartel D.P. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 2006, 127:1193-1207.
    • (2006) Cell , vol.127 , pp. 1193-1207
    • Ruby, J.G.1    Jan, C.2    Player, C.3    Axtell, M.J.4    Lee, W.5    Nusbaum, C.6    Ge, H.7    Bartel, D.P.8
  • 161
    • 46249092601 scopus 로고    scopus 로고
    • Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites
    • Sandberg R., Neilson J.R., Sarma A., Sharp P.A., Burge C.B. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science 2008, 320:1643-1647.
    • (2008) Science , vol.320 , pp. 1643-1647
    • Sandberg, R.1    Neilson, J.R.2    Sarma, A.3    Sharp, P.A.4    Burge, C.B.5
  • 165
  • 166
    • 78651295101 scopus 로고    scopus 로고
    • Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative
    • Schneider L.S., Insel P.S., Weiner M.W. Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative. Arch. Neurol. 2011, 68:58-66.
    • (2011) Arch. Neurol. , vol.68 , pp. 58-66
    • Schneider, L.S.1    Insel, P.S.2    Weiner, M.W.3
  • 169
    • 1942494040 scopus 로고    scopus 로고
    • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    • Sempere L.F., Freemantle S., Pitha-Rowe I., Moss E., Dmitrovsky E., Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004, 5:R13.
    • (2004) Genome Biol. , vol.5
    • Sempere, L.F.1    Freemantle, S.2    Pitha-Rowe, I.3    Moss, E.4    Dmitrovsky, E.5    Ambros, V.6
  • 170
    • 65749093295 scopus 로고    scopus 로고
    • Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex
    • Sethi P., Lukiw W.J. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 2009, 459:100-104.
    • (2009) Neurosci. Lett. , vol.459 , pp. 100-104
    • Sethi, P.1    Lukiw, W.J.2
  • 172
    • 30344456035 scopus 로고    scopus 로고
    • Facile means for quantifying microRNA expression by real-time PCR
    • Shi R., Chiang V.L. Facile means for quantifying microRNA expression by real-time PCR. Biotechniques 2005, 39:519-525.
    • (2005) Biotechniques , vol.39 , pp. 519-525
    • Shi, R.1    Chiang, V.L.2
  • 174
    • 38449091863 scopus 로고    scopus 로고
    • Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification
    • Silahtaroglu A.N., Nolting D., Dyrskjøt L., Berezikov E., Møller M., Tommerup N., Kauppinen S. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat. Protoc. 2007, 2:2520-2528.
    • (2007) Nat. Protoc. , vol.2 , pp. 2520-2528
    • Silahtaroglu, A.N.1    Nolting, D.2    Dyrskjøt, L.3    Berezikov, E.4    Møller, M.5    Tommerup, N.6    Kauppinen, S.7
  • 175
    • 0034609681 scopus 로고    scopus 로고
    • Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR
    • Simpson D.A., Feeney S., Boyle C., Stitt A.W. Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol. Vis. 2000, 6:178-183.
    • (2000) Mol. Vis. , vol.6 , pp. 178-183
    • Simpson, D.A.1    Feeney, S.2    Boyle, C.3    Stitt, A.W.4
  • 176
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • Siomi H., Siomi M.C. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 2010, 38:323-332.
    • (2010) Mol. Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 177
    • 80051733474 scopus 로고    scopus 로고
    • A sensitive alternative for microRNA in situ hybridizations using probes of 2'-O-methyl RNA + LNA
    • Søe M.J., Møller T., Dufva M., Holmstrøm K. A sensitive alternative for microRNA in situ hybridizations using probes of 2'-O-methyl RNA + LNA. J. Histochem. Cytochem. 2011, 59:661-672.
    • (2011) J. Histochem. Cytochem. , vol.59 , pp. 661-672
    • Søe, M.J.1    Møller, T.2    Dufva, M.3    Holmstrøm, K.4
  • 178
    • 79954627454 scopus 로고    scopus 로고
    • Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links
    • Sokol D.K., Maloney B., Long J.M., Ray B., Lahiri D.K. Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Neurology 2011, 76:1344-1352.
    • (2011) Neurology , vol.76 , pp. 1344-1352
    • Sokol, D.K.1    Maloney, B.2    Long, J.M.3    Ray, B.4    Lahiri, D.K.5
  • 179
    • 0032517094 scopus 로고    scopus 로고
    • Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein
    • Song W., Lahiri D.K. Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein. Gene 1998, 217:165-176.
    • (1998) Gene , vol.217 , pp. 165-176
    • Song, W.1    Lahiri, D.K.2
  • 181
    • 16344383409 scopus 로고    scopus 로고
    • Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs
    • Sun Y., Koo S., White N., Peralta E., Esau C., Dean N.M., Perera R.J. Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs. Nucleic Acids Res. 2004, 32:e188.
    • (2004) Nucleic Acids Res. , vol.32
    • Sun, Y.1    Koo, S.2    White, N.3    Peralta, E.4    Esau, C.5    Dean, N.M.6    Perera, R.J.7
  • 182
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 183
    • 84925564551 scopus 로고    scopus 로고
    • Why are drug trials in Alzheimer's disease failing?
    • The Lancet
    • The Lancet Why are drug trials in Alzheimer's disease failing?. Lancet 2010, 376:658.
    • (2010) Lancet , vol.376 , pp. 658
  • 184
    • 34548682763 scopus 로고    scopus 로고
    • Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes
    • Thompson R.C., Deo M., Turner D.L. Analysis of microRNA expression by in situ hybridization with RNA oligonucleotide probes. Methods 2007, 43:153-161.
    • (2007) Methods , vol.43 , pp. 153-161
    • Thompson, R.C.1    Deo, M.2    Turner, D.L.3
  • 185
    • 16544365954 scopus 로고    scopus 로고
    • Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
    • Válóczi A., Hornyik C., Varga N., Burgyán J., Kauppinen S., Havelda Z. Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res. 2004, 32:e175.
    • (2004) Nucleic Acids Res. , vol.32
    • Válóczi, A.1    Hornyik, C.2    Varga, N.3    Burgyán, J.4    Kauppinen, S.5    Havelda, Z.6
  • 186
    • 79251581020 scopus 로고    scopus 로고
    • The art of microRNA research
    • van Rooij E. The art of microRNA research. Circ. Res. 2011, 108:219-234.
    • (2011) Circ. Res. , vol.108 , pp. 219-234
    • van Rooij, E.1
  • 187
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3:1-12.
    • (2002) Genome Biol. , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 188
    • 34548691422 scopus 로고    scopus 로고
    • Detection of microRNAs by Northern blot analyses using LNA probes
    • Várallyay E., Burgyán J., Havelda Z. Detection of microRNAs by Northern blot analyses using LNA probes. Methods 2007, 43:140-145.
    • (2007) Methods , vol.43 , pp. 140-145
    • Várallyay, E.1    Burgyán, J.2    Havelda, Z.3
  • 189
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: microRNAs can up-regulate translation
    • Vasudevan S., Tong Y., Steitz J.A. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007, 318:1931-1934.
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 191
    • 77953319294 scopus 로고    scopus 로고
    • MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
    • Vilardo E., Barbato C., Ciotti M., Cogoni C., Ruberti F. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. J. Biol. Chem. 2010, 285:18344-18351.
    • (2010) J. Biol. Chem. , vol.285 , pp. 18344-18351
    • Vilardo, E.1    Barbato, C.2    Ciotti, M.3    Cogoni, C.4    Ruberti, F.5
  • 192
    • 77949497597 scopus 로고    scopus 로고
    • A nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression
    • Vostrov A.A., Taheny M.J., Izkhakov N., Quitschke W.W. A nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression. BMC Res. Notes 2010, 3:4.
    • (2010) BMC Res. Notes , vol.3 , pp. 4
    • Vostrov, A.A.1    Taheny, M.J.2    Izkhakov, N.3    Quitschke, W.W.4
  • 193
    • 77953625037 scopus 로고    scopus 로고
    • High-performance quantification of mature microRNAs by real-time RT-PCR using deoxyuridine-incorporated oligonucleotides and hemi-nested primers
    • Wan G., Lim Q.E., Too H.-P. High-performance quantification of mature microRNAs by real-time RT-PCR using deoxyuridine-incorporated oligonucleotides and hemi-nested primers. RNA 2010, 16:1436-1445.
    • (2010) RNA , vol.16 , pp. 1436-1445
    • Wan, G.1    Lim, Q.E.2    Too, H.-P.3
  • 194
    • 33845876339 scopus 로고    scopus 로고
    • Direct and sensitive miRNA profiling from low-input total RNA
    • Wang H., Ach R.A., Curry B. Direct and sensitive miRNA profiling from low-input total RNA. RNA 2007, 13:151-159.
    • (2007) RNA , vol.13 , pp. 151-159
    • Wang, H.1    Ach, R.A.2    Curry, B.3
  • 195
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • Wang W.X., Rajeev B.W., Stromberg A.J., Ren N., Tang G., Huang Q., Rigoutsos I., Nelson P.T. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 2008, 28:1213-1223.
    • (2008) J. Neurosci. , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 196
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang Y., Sheng G., Juranek S., Tuschl T., Patel D.J. Structure of the guide-strand-containing argonaute silencing complex. Nature 2008, 456:209-213.
    • (2008) Nature , vol.456 , pp. 209-213
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 197
    • 75149163985 scopus 로고    scopus 로고
    • Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes
    • Wang W.-X., Wilfred B.R., Hu Y., Stromberg A.J., Nelson P.T. Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA 2010, 16:394-404.
    • (2010) RNA , vol.16 , pp. 394-404
    • Wang, W.-X.1    Wilfred, B.R.2    Hu, Y.3    Stromberg, A.J.4    Nelson, P.T.5
  • 199
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 200
    • 81255176919 scopus 로고    scopus 로고
    • Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
    • Winter J., Diederichs S. Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol. 2011, 8.
    • (2011) RNA Biol. , vol.8
    • Winter, J.1    Diederichs, S.2
  • 201
    • 79959936612 scopus 로고    scopus 로고
    • Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation
    • Yeom K.-H., Heo I., Lee J., Hohng S., Kim V.N., Joo C. Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation. EMBO Rep. 2011, 12:690-696.
    • (2011) EMBO Rep. , vol.12 , pp. 690-696
    • Yeom, K.-H.1    Heo, I.2    Lee, J.3    Hohng, S.4    Kim, V.N.5    Joo, C.6
  • 202
    • 0028061197 scopus 로고
    • Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region
    • Zaidi S.H., Malter J.S. Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region. J. Biol. Chem. 1994, 269:24007-24013.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24007-24013
    • Zaidi, S.H.1    Malter, J.S.2
  • 203
    • 0028096546 scopus 로고
    • Multiple proteins interact at a unique cis-element in the 3'-untranslated region of amyloid precursor protein mRNA
    • Zaidi S.H., Denman R., Malter J.S. Multiple proteins interact at a unique cis-element in the 3'-untranslated region of amyloid precursor protein mRNA. J. Biol. Chem. 1994, 269:24000-24006.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24000-24006
    • Zaidi, S.H.1    Denman, R.2    Malter, J.S.3
  • 204
    • 79960230895 scopus 로고    scopus 로고
    • Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data
    • Zhang C., Darnell R.B. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat. Biotechnol. 2011, 29:607-614.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 607-614
    • Zhang, C.1    Darnell, R.B.2
  • 205
    • 33750447604 scopus 로고    scopus 로고
    • Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray
    • Zhao J.-J., Hua Y.-J., Sun D.-G., Meng X.-X., Xiao H.-S., Ma X. Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray. Childs Nerv. Syst. 2006, 22:1419-1425.
    • (2006) Childs Nerv. Syst. , vol.22 , pp. 1419-1425
    • Zhao, J.-J.1    Hua, Y.-J.2    Sun, D.-G.3    Meng, X.-X.4    Xiao, H.-S.5    Ma, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.