Brain-derived neurotrophic factor and neuropsychiatric disorders

Pharmacological Reviews

Volumn 64, Issue 2, 2012, Pages 238-258

  Autry, Anita E ^a   Monteggia, Lisa M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYFLAVONE; AMPHETAMINE; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; CHLORPROMAZINE; CLOZAPINE; DIAMORPHINE; DOPAMINE; DOPAMINE TRANSPORTER; FLUOXETINE; HALOPERIDOL; KETAMINE; MESSENGER RNA; METHYLAZOXYMETHANOL ACETATE; MONOAMINE OXIDASE INHIBITOR; MORPHINE; NERVE GROWTH FACTOR; NEUROLEPTIC AGENT; NORADRENALIN UPTAKE INHIBITOR; OLANZAPINE; OPIATE; RACLOPRIDE; RISPERIDONE; ROTTLERIN; SEROTONIN UPTAKE INHIBITOR; SOMATOMEDIN; TRICYCLIC ANTIDEPRESSANT AGENT; TYROSINE 3 MONOOXYGENASE; UNINDEXED DRUG;

ADDICTION; ALCOHOLISM; ANOREXIA NERVOSA; ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; BIPOLAR DISORDER; BULIMIA; EATING DISORDER; ELECTROCONVULSIVE THERAPY; GENE DISRUPTION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HYPERPHAGIA; LONG TERM POTENTIATION; MAJOR DEPRESSION; MENTAL DISEASE; MOOD DISORDER; MORPHINE ADDICTION; NERVOUS SYSTEM DEVELOPMENT; NEUROCHEMISTRY; NEUROMODULATION; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETT SYNDROME; REVIEW; RUBINSTEIN SYNDROME; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TOBACCO DEPENDENCE; WERNICKE KORSAKOFF SYNDROME;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; NEURONAL PLASTICITY;

EID: 84858165817     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.111.005108     Document Type: Review

References (228)

1. Adachi M, Autry AE, Covington HE 3rd, and Monteggia LM (2009) MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome. J Neurosci 29:4218-4227.
2. Adachi M, Barrot M, Autry AE, Theobald D, and Monteggia LM (2008) Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63:642-649.
3. Advani T, Koek W, and Hensler JG (2009) Gender differences in the enhanced vulnerability of BDNF+/- mice to mild stress. Int J Neuropsychopharmacol 12: 583-588
4. Aid T, Kazantseva A, Piirsoo M, Palm K, and Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85:525-535.
5. Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, et al. (2002) Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci 22:4153-4162.
6. Altar CA, Whitehead RE, Chen R, Wörtwein G, and Madsen TM (2003) Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry 54:703-709.
7. Amaral MD, Chapleau CA, and Pozzo-Miller L (2007) Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther 113:394-409.
8. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, and Zoghbi HY (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2. Nat Genet 23:185-188.
9. Andero R, Heldt SA, Ye K, Liu X, Armario A, and Ressler KJ (2011) Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry 168:163-172.
10. Anderson KD, Alderson RF, Altar CA, DiStefano PS, Corcoran TL, Lindsay RM, and Wiegand SJ (1995) Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors. J Comp Neurol 357:296-317.
11. Angelucci F, Gruber SH, El Khoury A, Tonali PA, and Mathé AA (2007a) Chronic amphetamine treatment reduces NGF and BDNF in the rat brain. Eur Neuropsychopharmacol 17:756-762.
12. Angelucci F, Ricci V, Pomponi M, Conte G, Mathé AA, Attilio Tonali P, and Bria P (2007b) Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. J Psychopharmacol 21:820-825.
13. Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, and Eisch AJ (2009) Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience 159:1003-1010.
14. Autry AE, Adachi M, Cheng P, and Monteggia LM (2009) Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66:84-90.
15. Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, and Monteggia LM (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475:91-95.
16. Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, and Lucki I (2008) Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res 1211:37-43.
17. Barde YA, Edgar D, and Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1:549-553.
18. Becker AE, Grinspoon SK, Klibanski A, and Herzog DB (1999) Eating disorders. N Engl J Med 340:1092-1098.
19. Becker JB, Monteggia LM, Perrot-Sinal TS, Romeo RD, Taylor JR, Yehuda R, and Bale TL (2007) Stress and disease: is being female a predisposing factor? J Neurosci 27:11851-11855.
20. Berhow MT, Hiroi N, and Nestler EJ (1996) Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J Neurosci 16:4707-4715.
21. Berhow MT, Russell DS, Terwilliger RZ, Beitner-Johnson D, Self DW, Lindsay RM, and Nestler EJ (1995) Influence of neurotrophic factors on morphine- and cocaineinduced biochemical changes in the mesolimbic dopamine system. Neuroscience 68:969-979.
22. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, and Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351-354.
23. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, et al. (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868.
24. Beuten J, Ma JZ, Payne TJ, Dupont RT, Lou XY, Crews KM, Elston RC, and Li MD (2007) Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. Biol Psychiatry 61:48-55.
25. Beuten J, Ma JZ, Payne TJ, Dupont RT, Quezada P, Huang W, Crews KM, and Li MD (2005) Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. Am J Med Genet B Neuropsychiatr Genet 139B:73-80.
26. Blum R, Kafitz KW, and Konnerth A (2002) Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature 419:687-693.
27. Boos HB, Aleman A, Cahn W, Hulshoff Pol H, and Kahn RS (2007) Brain volumes in relatives of patients with schizophrenia: a meta-analysis. Arch Gen Psychiatry 64:297-304.
28. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, and Charney DS (2000) Hippocampal volume reduction in major depression. Am J Psychiatry 157: 115-118.
29. Büttner A (2011) Review: the neuropathology of drug abuse. Neuropathol Appl Neurobiol 37:118-134.
30. Castrén E (2004) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4:58-64.
31. Castrén E and Rantamäki T (2010) The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol 70:289-297.
32. Castrén E, Võikar V, and Rantamäki T (2007) Role of neurotrophic factors in depression. Curr Opin Pharmacol 7:18-21.
33. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, and Zoghbi HY (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320:1224-1229.
34. Chang Q, Khare G, Dani V, Nelson S, and Jaenisch R (2006) The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49:341-348.
35. Chao MV, Rajagopal R, and Lee FS (2006) Neurotrophin signalling in health and disease. Clin Sci (Lond) 110:167-173.
36. Chapleau CA, Calfa GD, Lane MC, Albertson AJ, Larimore JL, Kudo S, Armstrong DL, Percy AK, and Pozzo-Miller L (2009) Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rettassociated MECP2 mutations. Neurobiol Dis 35:219-233.
37. Charney DS and Manji HK (2004) Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci STKE 2004:re5.
38. Chen G and Manji HK (2006) The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers. Curr Opin Psychiatry 19:313-323.
39. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, and Greenberg ME (2003a) Derepression of BDNF transcription involves calciumdependent phosphorylation of MeCP2. Science 302:885-889.
40. Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, and Greenberg ME (2003b) Upstream stimulatory factors are mediators of Ca2 - responsive transcription in neurons. J Neurosci 23:2572-2581.
41. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, et al. (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140-143.
42. Chourbaji S, Hellweg R, Brandis D, Zörner B, Zacher C, Lang UE, Henn FA, Hörtnagl H, and Gass P (2004) Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain Res Mol Brain Res 121:28-36.
43. Chu NN, Zuo YF, Meng L, Lee DY, Han JS, and Cui CL (2007) Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats. Brain Res 1182:90-98.
44. Corominas M, Roncero C, Ribases M, Castells X, and Casas M (2007) Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction. Neuropsychobiology 55:2-13.
45. Cowansage KK, LeDoux JE, and Monfils MH (2010) Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr Mol Pharmacol 3:12-29.
46. Czubak A, Nowakowska E, Kus K, Burda K, Metelska J, Baer-Dubowska W, and Cichocki M (2009) Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF). Pharmacol Rep 61:1017-1023.
47. Dardennes RM, Zizzari P, Tolle V, Foulon C, Kipman A, Romo L, Iancu-Gontard D, Boni C, Sinet PM, Thérese Bluet M, et al. (2007) Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. Psychoneuroendocrinology 32:106-113.
48. Davis MI (2008) Ethanol-BDNF interactions: still more questions than answers. Pharmacol Ther 118:36-57.
49. Daws LC, Munn JL, Valdez MF, Frosto-Burke T, and Hensler JG (2007) Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient mice. J Neurochem 101:641-651.
50. Deltheil T, Guiard BP, Cerdan J, David DJ, Tanaka KF, Repérant C, Guilloux JP, Coudoré F, Hen R, and Gardier AM (2008a) Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology 55:1006-1014.
51. Deltheil T, Guiard BP, Guilloux JP, Nicolas L, Deloménie C, Repérant C, Le Maitre E, Leroux-Nicollet I, Benmansour S, Coudoré F, et al. (2008b) Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacol Biochem Behav 90:174-183.
52. Di Luca M, Caputi A, and Cattabeni F (1994) Synaptic protein phosphorylation changes in animals exposed to neurotoxicants during development. Neurotoxicology 15:525-532.
53. Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, et al. (2010) A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatmentresistant bipolar depression. Arch Gen Psychiatry 67:793-802.
54. Dluzen DE, Gao X, Story GM, Anderson LI, Kucera J, and Walro JM (2001) Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice. Exp Neurol 170:121-128.
55. Dmitrzak-Weglarz M, Skibinska M, Slopien A, Szczepankiewicz A, Rybakowski F, Kramer L, Hauser J, and Rajewski A (2007) BDNF Met66 allele is associated with anorexia nervosa in the Polish population. Psychiatr Genet 17:245-246.
56. Drevets WC and Furey ML (2010) Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial. Biol Psychiatry 67:432-438.
57. Duman RS and Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59:1116-1127.
58. Duman RS, Nakagawa S, and Malberg J (2001) Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology 25:836-844.
59. Durany N, Michel T, Zöchling R, Boissl KW, Cruz-Sánchez FF, Riederer P, and Thome J (2001) Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res 52:79-86.
60. Durany N and Thome J (2004) Neurotrophic factors and the pathophysiology of schizophrenic psychoses. Eur Psychiatry 19:326-337.
61. Dwivedi Y (2010) Brain-derived neurotrophic factor and suicide pathogenesis. Ann Med 42:87-96.
62. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, and Pandey GN (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804-815.
63. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, et al. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269.
64. Ellison G (1994) Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. Brain Res Brain Res Rev 19:223-239.
65. Ernfors P, Lee KF, and Jaenisch R (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:147-150.
66. Featherstone RE, Kapur S, and Fletcher PJ (2007) The amphetamine-induced sensitized state as a model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 31:1556-1571.
67. Fiore M, Korf J, Antonelli A, Talamini L, and Aloe L (2002) Long-lasting effects of prenatal MAM treatment on water maze performance in rats: associations with altered brain development and neurotrophin levels. Neurotoxicol Teratol 24:179-191.
68. Fletcher JM, Morton CJ, Zwar RA, Murray SS, O'Leary PD, and Hughes RA (2008) Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor. J Biol Chem 283:33375-33383.
69. Friedel S, Horro FF, Wermter AK, Geller F, Dempfle A, Reichwald K, Smidt J, Brönner G, Konrad K, Herpertz-Dahlmann B, et al. (2005) Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 132B:96-99.
70. Frielingsdorf H, Bath KG, Soliman F, Difede J, Casey BJ, and Lee FS (2010) Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder. Ann NY Acad Sci 1208:150-157.
71. Frodl T, Meisenzahl E, Zetzsche T, Bottlender R, Born C, Groll C, Jäger M, Leinsinger G, Hahn K, and Möller HJ (2002) Enlargement of the amygdala in patients with a first episode of major depression. Biol Psychiatry 51:708-714.
72. Frustaci A, Pozzi G, Gianfagna F, Manzoli L, and Boccia S (2008) Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology 58: 163-170.
73. Furey ML and Drevets WC (2006) Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. Arch Gen Psychiatry 63:1121-1129.
74. Gardier AM (2009) Mutant mouse models and antidepressant drug research: focus on serotonin and brain-derived neurotrophic factor. Behav Pharmacol 20:18-32.
75. Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR, Gordon E, Kemp AH, and Williams LM (2009) Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 14:681-695.
76. Gingrich JA and Hen R (2001) Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology (Berl) 155: 1-10.
77. Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA, and Mirnics K (2006) Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood. Mol Psychiatry 11:633-648.
78. Goghari VM, Sponheim SR, and MacDonald AW III (2010) The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. Neurosci Biobehav Rev 34(3):468-486.
79. Gorski JA, Balogh SA, Wehner JM, and Jones KR (2003) Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121:341-354.
80. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, and Self DW (2007) Dynamic BDNF activity in nucleus accumbens with cocaine use increases selfadministration and relapse. Nat Neurosci 10:1029-1037.
81. Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, et al. (2009) Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry 65:696-701.
82. Grzywacz A, Samochowiec A, Ciechanowicz A, and Samochowiec J (2010) Familybased study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence. Pharmacol Rep 62:938-941.
83. Hagberg B, Aicardi J, Dias K, and Ramos O (1983) A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann Neurol 14:471-479.
84. Hallam TM and Bourtchouladze R (2006) Rubinstein-Taybi syndrome: molecular findings and therapeutic approaches to improve cognitive dysfunction. Cell Mol Life Sci 63:1725-1735.
85. Hashimoto K, Koizumi H, Nakazato M, Shimizu E, and Iyo M (2005a) Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications. Prog Neuropsychopharmacol Biol Psychiatry 29: 499-504.
86. Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, and Chuang DM (2002) Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology 43:1173-1179.
87. Hashimoto T, Bergen SE, Nguyen QL, Xu B, Monteggia LM, Pierri JN, Sun Z, Sampson AR, and Lewis DA (2005b) Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25:372-383.
88. Heinz A and Schlagenhauf F (2010) Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophr Bull 36:472-485.
89. Heldt SA, Stanek L, Chhatwal JP, and Ressler KJ (2007) Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 12:656-670.
90. Hennekam RC (2006) Rubinstein-Taybi syndrome. Eur J Hum Genet 14:981-985.
91. Hensler JG, Advani T, and Monteggia LM (2007) Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone. Biol Psychiatry 62:521-529.
92. Heymach JV Jr, Krüttgen A, Suter U, and Shooter EM (1996) The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cells. J Biol Chem 271:25430-25437.
93. Hill JJ, Kolluri N, Hashimoto T, Wu Q, Sampson AR, Monteggia LM, and Lewis DA (2005) Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57:932-934.
94. Hohn A, Leibrock J, Bailey K, and Barde YA (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341.
95. Holick KA, Lee DC, Hen R, and Dulawa SC (2008) Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor. Neuropsychopharmacology 33:406-417.
96. Hoshaw BA, Malberg JE, and Lucki I (2005) Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res 1037:204-208.
97. Hovatta I and Barlow C (2008) Molecular genetics of anxiety in mice and men. Ann Med 40:92-109.
98. Hu Y and Russek SJ (2008) BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J Neurochem 105:1-17.
99. Ibarguen-Vargas Y, Surget A, Vourc'h P, Leman S, Andres CR, Gardier AM, and Belzung C (2009) Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress. Behav Brain Res 202:245-251.
100. Iritani S, Niizato K, Nawa H, Ikeda K, and Emson PC (2003) Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains. Prog Neuropsychopharmacol Biol Psychiatry 27:801-807.
101. Ivarsson T, Råstam M, Wentz E, Gillberg IC, and Gillberg C (2000) Depressive disorders in teenage-onset anorexia nervosa: a controlled longitudinal, partly community-based study. Compr Psychiatry 41:398-403.
102. Jacobsen JP and Mørk A (2006) Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain Res 1110:221-225.
103. Janecka A, Fichna J, and Janecki T (2004) Opioid receptors and their ligands. Curr Top Med Chem 4:1-17.
104. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, et al. (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107:2687-2692.
105. Javitt DC (2010) Glutamatergic theories of schizophrenia. Isr J Psychiatry Relat Sci 47:4-16.
106. Joe KH, Kim YK, Kim TS, Roh SW, Choi SW, Kim YB, Lee HJ, and Kim DJ (2007) Decreased plasma brain-derived neurotrophic factor levels in patients with alcohol dependence. Alcohol Clin Exp Res 31:1833-1838.
107. Jönsson EG, Edman-Ahlbom B, Sillén A, Gunnar A, Kulle B, Frigessi A, Vares M, Ekholm B, Wode-Helgodt B, Schumacher J, et al. (2006) Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Prog Neuropsychopharmacol Biol Psychiatry 30:924-933.
108. Kang H and Schuman EM (1996) A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science 273:1402-1406.
109. Kernie SG, Liebl DJ, and Parada LF (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290-1300.
110. Kessler RC, Chiu WT, Demler O, Merikangas KR, and Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617-627.
111. Klein DA and Walsh BT (2004) Eating disorders: clinical features and pathophysiology. Physiol Behav 81:359-374.
112. Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, and Torrey EF (2004) Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatr 9:609-620.
113. Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S, Koike K, Okamura N, Matsushita S, Suzuki K, et al. (2004) Association between the brainderived neurotrophic factor 196G/A polymorphism and eating disorders. Am J Med Genet B Neuropsychiatr Genet 127B:125-127.
114. Koop CE and Luoto J (2006) "The health consequences of smoking: cancer," overview of a report of the Surgeon General. 1982. Public Health Rep 121 (Suppl 1):269-275; discussion 268.
115. Kossel AH, Cambridge SB, Wagner U, and Bonhoeffer T (2001) A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation. Proc Natl Acad Sci USA 98:14702-14707.
116. Kovalchuk Y, Holthoff K, and Konnerth A (2004) Neurotrophin action on a rapid timescale. Curr Opin Neurobiol 14:558-563.
117. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, et al. (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131: 391-404.
118. Kuntz-Melcavage KL, Brucklacher RM, Grigson PS, Freeman WM, and Vrana KE (2009) Gene expression changes following extinction testing in a heroin behavioral incubation model. BMC Neurosci 10:95.
119. Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, and Gallinat J (2007a) Molecular mechanisms of schizophrenia. Cell Physiol Biochem 20:687-702.
120. Lang UE, Sander T, Lohoff FW, Hellweg R, Bajbouj M, Winterer G, and Gallinat J (2007b) Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking. Psychopharmacology (Berl) 190:433-439.
121. Lee R, Kermani P, Teng KK, and Hempstead BL (2001) Regulation of cell survival by secreted proneurotrophins. Science 294:1945-1948.
122. Lessmann V, Gottmann K, and Malcangio M (2003) Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69:341-374.
123. Levi-Montalcini R (1966) The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect 60:217-259.
124. Levine ES, Crozier RA, Black IB, and Plummer MR (1998) Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing Nmethyl-D-aspartic acid receptor activity. Proc Natl Acad Sci USA 95:10235-10239.
125. Levine ES, Dreyfus CF, Black IB, and Plummer MR (1995) Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci USA 92:8074-8077.
126. Lewis JD, Meehan RR, Henzel WJ, Maurer-Fogy I, Jeppesen P, Klein F, and Bird A (1992) Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69:905-914.
127. Li MD, Lou XY, Chen G, Ma JZ, and Elston RC (2008) Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry 64:951-957.
128. Lippmann M, Bress A, Nemeroff CB, Plotsky PM, and Monteggia LM (2007) Longterm behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 25:3091-3098.
129. Liu IY, Lyons WE, Mamounas LA, and Thompson RF (2004) Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci 24:7958-7963.
130. Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, and Uhl GR (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067:1-12.
131. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, and Uhl GR (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet 134B:93-103.
132. Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, et al. (2010) Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390.
133. Lodge DJ and Grace AA (2008) Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia. Neurotox Res 14:97-104.
134. Lohof AM, Ip NY, and Poo MM (1993) Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 363:350-353.
135. Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, and Berrettini WH (2005) Confirmation of association between the Val66Met polymorphism in the brainderived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet 139B(1):51-53.
136. Lu Y, Christian K, and Lu B (2008) BDNF: a key regulator for protein synthesisdependent LTP and long-term memory? Neurobiol Learn Mem 89:312-323.
137. Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, and Tessarollo L (1999) Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci USA 96:15239-15244.
138. Malberg JE and Blendy JA (2005) Antidepressant action: to the nucleus and beyond. Trends Pharmacol Sci 26:631-638.
139. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, and Sun YE (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302:890-893.
140. Martinowich K, Manji H, and Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10:1089-1093.
141. Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, and Barde YA (2008) Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 11:131-133.
142. Mattson MP (2008) Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 1144:97-112.
143. McEwen BS (2005) Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 54 (5 Suppl 1):20-23.
144. McEwen BS and Magarinos AM (1997) Stress effects on morphology and function of the hippocampus. Ann NY Acad Sci 821:271-284.
145. Merlio JP, Ernfors P, Jaber M, and Persson H (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience 51:513-532.
146. Mokdad AH, Marks JS, Stroup DF, and Gerberding JL (2004) Actual causes of death in the United States, 2000. JAMA 291:1238-1245.
147. Montag C, Basten U, Stelzel C, Fiebach CJ, and Reuter M (2010) The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. Psychiatry Res 179:86-90.
148. Monteggia LM (2011) Toward neurotrophin-based therapeutics. Am J Psychiatry 168:114-116.
149. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW, and Nestler EJ (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 101: 10827-10832.
150. Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, Parada LF, and Nestler EJ (2007) Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61:187-197.
151. Mössner R, Daniel S, Albert D, Heils A, Okladnova O, Schmitt A, and Lesch KP (2000) Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochem Int 36:197-202.
152. Mueser KT and McGurk SR (2004) Schizophrenia. Lancet 363:2063-2072.
153. Nagappan G and Lu B (2005) Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci 28:464-471.
154. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, and Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389.
155. Nanko S, Kunugi H, Hirasawa H, Kato N, Nabika T, and Kobayashi S (2003) Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62:281-283.
156. Naoe Y, Shinkai T, Hori H, Fukunaka Y, Utsunomiya K, Sakata S, Matsumoto C, Shimizu K, Hwang R, Ohmori O, et al. (2007) No association between the brainderived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis. Neurosci Lett 415:108-112.
157. Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, and Kennedy JL (2002) The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71:651-655.
158. Nibuya M, Morinobu S, and Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539-7547.
159. Numan S, Lane-Ladd SB, Zhang L, Lundgren KH, Russell DS, Seroogy KB, and Nestler EJ (1998) Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J Neurosci 18:10700-10708.
160. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Ohta K, Kinouchi S, Shibuya-Tayoshi S, Tayoshi S, Aono M, et al. (2006) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett 401:1-5.
161. Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, and Dwivedi Y (2008) Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol 11: 1047-1061.
162. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, and Kandel ER (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145.
163. Pillai A (2008) Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia. Neurosignals 16:183-193.
164. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:24-32.
165. Price RB, Nock MK, Charney DS, and Mathew SJ (2009) Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry 66:522-526.
166. Price RD, Milne SA, Sharkey J, and Matsuoka N (2007) Advances in small molecules promoting neurotrophic function. Pharmacol Ther 115:292-306.
167. Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, Chao MV, Männistö PT, and Castrén E (2007) Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharmacology 32:2152-2162.
168. Rask-Andersen M, Olszewski PK, Levine AS, and Schiöth HB (2010) Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake. Brain Res Rev 62:147-164.
169. Rattiner LM, Davis M, French CT, and Ressler KJ (2004) Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdaladependent fear conditioning. J Neurosci 24:4796-4806.
170. Regier DA, Narrow WE, Rae DS, Manderscheid RW, Locke BZ, and Goodwin FK (1993) The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services. Arch Gen Psychiatry 50:85-94.
171. Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M, Cavallini MC, Cellini E, Di Bella D, Erzegovesi S, et al. (2004) Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet 13:1205-1212.
172. Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M, Cristina Cavallini M, Cellini E, Di Bella D, Erzegovesi S, et al. (2005) Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet 13:428-434.
173. Richtand NM, Taylor B, Welge JA, Ahlbrand R, Ostrander MM, Burr J, Hayes S, Coolen LM, Pritchard LM, Logue A, et al. (2006) Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology 31:77-89.
174. Robinson TE and Kolb B (1999) Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur J Neurosci 11:1598-1604.
175. Roelfsema JH and Peters DJ (2007) Rubinstein-Taybi syndrome: clinical and molecular overview. Expert Rev Mol Med 9:1-16.
176. Rose CR, Blum R, Kafitz KW, Kovalchuk Y, and Konnerth A (2004) From modulator to mediator: rapid effects of BDNF on ion channels. Bioessays 26:1185-1194.
177. Roux PP and Barker PA (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 67:203-233.
178. Rueter LE, Ballard ME, Gallagher KB, Basso AM, Curzon P, and Kohlhaas KL (2004) Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia. Psychopharmacology (Berl) 176:312-319.
179. Russo SJ, Mazei-Robison MS, Ables JL, and Nestler EJ (2009) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56 (Suppl 1):73-82.
180. Rybakowski F, Dmitrzak-Weglarz M, Szczepankiewicz A, Skibinska M, Slopien A, Rajewski A, and Hauser J (2007) Brain derived neurotrophic factor gene Val66Met and 270C/T polymorphisms and personality traits predisposing to anorexia nervosa. Neuro Endocrinol Lett 28:153-158.
181. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, et al. (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 23:349-357.
182. Sanacora G (2008) New understanding of mechanisms of action of bipolar medications. J Clin Psychiatry 69 (Suppl 5):22-27.
183. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
184. Saylor AJ and McGinty JF (2008) Amphetamine-induced locomotion and gene expression are altered in BDNF heterozygous mice. Genes Brain Behav 7:906-914.
185. Schmitt KC and Reith ME (2010) Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. Ann N Y Acad Sci 1187:316-340.
186. Schuman EM (1999) Neurotrophin regulation of synaptic transmission. Curr Opin Neurobiol 9:105-109.
187. Seeman P (2002) Atypical antipsychotics: mechanism of action. Can J Psychiatry 47:27-38.
188. Sen S, Duman R, and Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 64:527-532.
189. Serres F and Carney SL (2006) Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. Brain Res 1101:36-42.
190. Shaltiel G, Chen G, and Manji HK (2007) Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol 7:22-26.
191. Shelton RC (2007) The molecular neurobiology of depression. Psychiatr Clin North Am 30:1-11.
192. Shieh PB, Hu SC, Bobb K, Timmusk T, and Ghosh A (1998) Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20:727-740.
193. Shirayama Y, Chen AC, Nakagawa S, Russell DS, and Duman RS (2002) Brainderived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251-3261.
194. Sklair-Tavron L, Shi WX, Lane SB, Harris HW, Bunney BS, and Nestler EJ (1996) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci USA 93:11202-11207.
195. Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G, Schaffner S, Kirov G, Jones I, Owen M, et al. (2002) Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 7:579-593.
196. Soliman F, Glatt CE, Bath KG, Levita L, Jones RM, Pattwell SS, Jing D, Tottenham N, Amso D, Somerville LH, et al. (2010) A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327:863-866.
197. Steen RG, Mull C, McClure R, Hamer RM, and Lieberman JA (2006) Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 188:510-518.
198. Sun D, Huang W, Hwang YY, Zhang Y, Zhang Q, and Li MD (2007) Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions. Neuropsychopharmacology 32:110-116.
199. Szczepankiewicz A, Skibinska M, Czerski PM, Kapelski P, Leszczynska-Rodziewicz A, Slopien A, Dmitrzak-Weglarz M, Rybakowski F, Rybakowski J, and Hauser J (2005) No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia. Schizophr Res 76:187-193.
200. Szekeres G, Juhász A, Rimanóczy A, Kéri S, and Janka Z (2003) The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res 65:15-18.
201. Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, and Tsuda M (2002) Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J Biol Chem 277:35920-35931.
202. Takahashi M, Shirakawa O, Toyooka K, Kitamura N, Hashimoto T, Maeda K, Koizumi S, Wakabayashi K, Takahashi H, Someya T, et al. (2000) Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol Psychiatry 5:293-300.
203. Tamminga CA and Holcomb HH (2005) Phenotype of schizophrenia: a review and formulation. Mol Psychiatry 10:27-39.
204. Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, and Greenberg ME (1998) Ca2 influx regulates BDNF transcription by a CREB family transcription factordependent mechanism. Neuron 20:709-726.
205. Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G, and Popoli M (2006) Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 58:115-134.
206. Tebartz van Elst L, Woermann F, Lemieux L, and Trimble MR (2000) Increased amygdala volumes in female and depressed humans. A quantitative magnetic resonance imaging study. Neurosci Lett 281:103-106.
207. Thompson Ray M, Weickert CS, Wyatt E, and Webster MJ (2011) Decreased BDNF, trkB-TK and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci 36:195-203.
208. Thornton LM, Dellava JE, Root TL, Lichtenstein P, and Bulik CM (2011) Anorexia nervosa and generalized anxiety disorder: further explorations of the relation between anxiety and body mass index. J Anxiety Disord 25:727-730.
209. Tordjman S, Drapier D, Bonnot O, Graignic R, Fortes S, Cohen D, Millet B, Laurent C, and Roubertoux PL (2007) Animal models relevant to schizophrenia and autism: validity and limitations. Behav Genet 37:61-78.
210. Tseng KY, Chambers RA, and Lipska BK (2009) The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res 204:295-305.
211. Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK, and Pozzo-Miller L (2006) BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J Physiol 574: 787-803.
212. van Haren NE, Bakker SC, and Kahn RS (2008) Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry 21:161-167.
213. Volk DW, Austin MC, Pierri JN, Sampson AR, and Lewis DA (2000) Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry 57:237-245.
214. Watanabe Y, Muratake T, Kaneko N, Nunokawa A, and Someya T (2006) No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Schizophr Res 84:29-35.
215. Watanabe Y, Nunokawa A, Kaneko N, and Someya T (2007) Meta-analysis of case-control association studies between the C270T polymorphism of the brainderived neurotrophic factor gene and schizophrenia. Schizophr Res 95:250-252.
216. Waterhouse EG and Xu B (2009) New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Mol Cell Neurosci 42:81-89.
217. Weickert CS, Hyde TM, Lipska BK, Herman MM, Weinberger DR, and Kleinman JE (2003) Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry 8:592-610.
218. Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behaviouralneurobiological concordance in the effects of CMS. Neuropsychobiology 52:90-110.
219. Wittert G, Hope P, and Pyle D (1996) Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commun 218:877-881.
220. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, and Lu B (2005) Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8:1069-1077.
221. Xu MQ, St Clair D, Ott J, Feng GY, and He L (2007) Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res 91:6-13.
222. Yan HC, Cao X, Das M, Zhu XH, and Gao TM (2010) Behavioral animal models of depression. Neurosci Bull 26:327-337.
223. Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, et al. (2009) Neuronal release of proBDNF. Nat Neurosci 12:113-115.
224. Yang T, Yin W, Derevyanny VD, Moore LA, and Longo FM (2005) Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth. Eur J Neurosci 22:2159-2170.
225. Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, and Lasalle JM (2007) Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci USA 104:19416-19421.
226. Yoshii A and Constantine-Paton M (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol 70:304-322.
227. Yu H and Chen ZY (2011) The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin 32:3-11.
228. Zarate CA, Jr., Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, and Manji HK (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856-864.