Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

Psychopharmacology

Volumn 155, Issue 1, 2001, Pages 1-10

  Gingrich, Jay A ^a   Hen, René ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Knockout mice; Neuropsychiatric disorder; Serotonin; Single gene mutation

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR;

AFFECT; AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG ABUSE; GENE MUTATION; KNOCKOUT MOUSE; MENTAL DISEASE; MOUSE; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RECEPTOR GENE; REVIEW; SEROTONINERGIC SYSTEM;

ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MENTAL DISORDERS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; RECEPTORS, SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0035073901     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000573     Document Type: Review

References (112)

1. Identifying indoleamine hallucinogens by their preferential action on serotonin autoreceptors
2. Neurotransmitter transporters: Recent progress
3. 1A antagonists
4. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice
5. Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: A double-blind, placebo-controlled trial
6. Molecular physiology of norepinephrine and serotonin transporters
7. Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression
8. 6 receptors stably expressed in HEK293 cells
9. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
10. Treatment of acute migraine with subcutaneous sumatriptan
11. A
12. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: Role of a serotonin excess during the critical period
13. Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs
14. Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder
15. Association of attention-deficit disorder and the dopamine transporter gene
16. Effect of gepirone on increases in tryptophan hydroxylase in response to sound stress
17. Zacopride: Anxiolytic profile in rodent and primate models of anxiety
18. Actions of buspirone in a putative model of anxiety in the mouse
19. 4 receptor-knock-out mice exhibit reduced exploration of novel stimuli
20. 2C receptors
21. Serotonergic mechanisms in anxiety
22. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter
23. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter
24. CNS stimulant potentiation of monoamine oxidase inhibitors in treatment-refractory depression
25. Serotonin-1A anxiolytics: An overview
26. Clinical effects and mechanism of action of sumatriptan in migraine
27. Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice
28. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice
29. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
30. Serotonin receptors and their ligands: A lack of selective agents
31. Serotonin regulation of neurite outgrowth in identified neurons from mature and embryonic Helisoma trivolvis
32. Presynaptic serotonin receptors in the central nervous system
33. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor
34. 3 receptor antagonists. Clinical pharmacology and therapeutic applications
35. Increased stress response and betaphenylethylamine in MAOB-deficient mice
36. Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain
37. 1 receptors
38. 1B/1D antagonist
39. The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin
40. A possible pathophysiologic substrate of attention deficit hyperactivity disorder
41. 1A receptor mutant mice
42. Of mice and flies: Commonalities among 5-HT receptors
43. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission
44. 1B geno-type and receptor binding kinetics in postmortem brain tissue
45. 2 agonists in methamphetamine-sensitized rats
46. Long-term effects of tetrabenazine in hyperkinetic movement disorders
47. Measurement of gastric emptying in dyspeptic patients: Effect of a new gastrokinetic agent (cisapride)
48. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
49. 1C receptor antagonists
50. Tetrabenazine for involuntary movement disorders
51. 1B receptor gene in 2 populations
52. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knockout mice: Gender and brain region differences
53. Reduction of 5-hydroxytryptamine (5-HT) (1A)-mediated temperature and neuroendocrine responses and 5-HT (1A) binding sites in 5-HT transporter knockout mice
54. Phenelzine v imipramine in atypical depression. A preliminary report
55. Reversible and irreversible monoamine oxidase inhibitors in other psychiatric disorders
56. Serotonin, violent behavior and alcohol
57. Critical review of data supporting affective disorder caused by nonpsychotropic medication
58. 1A compounds in mice depends on the anxiety paradigm
59. New players in the 5-HT receptor field: Genes and knockouts
60. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
61. 1A-receptors) as measured by behavioral tests and receptor binding in rats
62. 5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze
63. The structure and signalling properties of 5-HT receptors: An endless diversity?
64. Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates
65. Serotonin-containing cell charged with growth cone arrests
66. The role of serotonin in antipsychotic drug action
67. Para-chlorophenylalanine, serotonin and killing behavior
68. Advances in the molecular characterization of tryptophan hydroxylase
69. Tryptophan depletion and depressive vulnerability
70. Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission
71. Oral ondansetron for the control of cisplatin-induced delayed emesis: A large, multicenter, double-blind, randomized comparative trial of ondansetron versus placebo
72. Serotonin 2B receptor is required for heart development
73. Induction of chronic Fos-related antigens in rat brain by chronic morphine administration
74. Serotonin receptors and animal models of aggressive behavior
75. 1A receptor
76. 1B receptor stimulation enhances cocaine reinforcement
77. A randomised, double-blind, placebo-controlled trial of dexamphetamine in adults with attention deficit hyperactivity disorder
78. Serotonergic and cardiac correlates of aggression in children
79. Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing
80. Autoregulation of serotonin neurons: Role in antidepressant drug action
81. 1D receptor family
82. 1B receptor knock out - Behavioral consequences
83. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
84. Adaptive changes of serotonine 5-HT2A receptors in mice lacking the serotonin transporter
85. Cocaine binding sites related to drug self-administration
86. 1B receptors
87. Cocaine self-administration in dopamine-transporter knockout mice
88. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
89. Two actions are better than one: Avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors
90. 7) activating cAMP formation
91. 5-Hydroxytryptamine receptor subtypes: Molecular and functional diversity
92. 1B receptor
93. Inducible gene targeting in mice using the Cre/lox system
94. 5-HT receptor knockout mice: Pharmacological tools or models of psychiatric disorders
95. Monoamine oxidase: From genes to behavior
96. Role of MAO A and B in neurotransmitter metabolism and behavior
97. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
98. Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the serotonin(1B) receptor
99. Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients
100. Parachlorophenylalanine reversal of tranylcypromine effects in depressed patients
101. Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
102. 1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs?
103. Novel strategies to probe the functions of serotonin receptors
104. Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons
105. VMAT2 knockout mice: Heterozygotes display reduced amphetamine- conditioned reward, enhanced amphetamine locomation, and enhanced MPTP toxicity
106. Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice
107. Brain serotonin, type II alcoholism and impulsive violence
108. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine
109. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver
110. A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination
111. 1B receptors