Behavioral animal models of depression

Neuroscience Bulletin

Volumn 26, Issue 4, 2010, Pages 327-337

  Yan, Hua Cheng ^a   Cao, Xiong ^a   Das, Manas ^a   Zhu, Xin Hong ^a   Gao, Tian Ming ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

animal models; chronic mild stress; depression; forced swimming test; learned helplessness; social defeat; tail suspension test

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; BUSPIRONE; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; MIANSERIN; MONOAMINE OXIDASE INHIBITOR; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL BEHAVIOR; DEPRESSION; DISEASE SEVERITY; ELECTROCONVULSIVE THERAPY; FORCED SWIMMING TEST; HORMONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LEARNED HELPLESSNESS; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PREVALENCE; PROSPECTIVE STUDY; SHORT SURVEY; SOCIAL ISOLATION; STRESS; SUSPENSION;

ANIMALS; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; HELPLESSNESS, LEARNED; HINDLIMB SUSPENSION; HUMANS; SWIMMING;

EID: 77956021637     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-010-0323-7     Document Type: Short Survey

References (89)

1. O. Berton E.J. Nestler 2006 New approaches to antidepressant drug discovery: beyond monoamines Nat Rev Neurosci 7 137 151 10.1038/nrn1846 16429123
2. E.J. Nestler M. Barrot R.J. DiLeone A.J. Eisch S.J. Gold L.M. Monteggia 2002 Neurobiology of depression Neuron 34 13 25 10.1016/S0896-6273(02)00653-0 11931738
3. V. Krishnan E.J. Nestler 2008 The molecular neurobiology of depression Nature 455 894 902 10.1038/nature07455 18923511
4. C.J. Murray A.D. Lopez 1997 Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study Lancet 349 1498 1504 10.1016/S0140-6736(96)07492-2 9167458
5. D. Han E.C. Wang 2005 Remission from depression: a review of venlafaxine clinical and economic evidence Pharmacoeconomics 23 567 581 10.2165/00019053- 200523060-00004 15960553
6. P. Willner P.J. Mitchell 2002 The validity of animal models of predisposition to depression Behav Pharmacol 13 169 188 12122308
7. H. Anisman K. Matheson 2005 Stress, depression, and anhedonia: caveats concerning animal models Neurosci Biobehav Rev 29 525 546 10.1016/j.neubiorev. 2005.03.007 15925696
8. B. Vollmayr M.M. Mahlstedt F.A. Henn 2007 Neurogenesis and depression: what animal models tell us about the link Eur Arch Psychiatry Clin Neurosci 257 300 303 10.1007/s00406-007-0734-2 17401725
9. J.F. Cryan A. Markou I. Lucki 2002 Assessing antidepressant activity in rodents: recent developments and future needs Trends Pharmacol Sci 23 238 245 10.1016/S0165-6147(02)02017-5 12008002
10. A. Urani S. Chourbaji P. Gass 2005 Mutant mouse models of depression: candidate genes and current mouse lines Neurosci Biobehav Rev 29 805 828 10.1016/j.neubiorev.2005.03.020 15925701
11. J.B. Overmier M.E. Seligman 1967 Effects of inescapable shock upon subsequent escape and avoidance responding J Comp Physiol Psychol 63 28 33 10.1037/h0024166 6029715
12. R. Hitzemann 2000 Animal models of psychiatric disorders and their relevance to alcoholism Alcohol Res Health 24 149 158 11199284
13. P. Willner 1984 The validity of animal models of depression Psychopharmacology (Berl) 83 1 16 10.1007/BF00427414
14. M.E. Seligman S.F. Maier 1967 Failure to escape traumatic shock J Exp Psychol 74 1 9 10.1037/h0024514 6032570
15. M.F. O'Neil N.A. Moore 2003 Animal models of depression: are there any? Hum Psychopharmacol 18 239 254 10.1002/hup.496 12766928
16. E.J. Nestler E. Gould H. Manji M. Buncan R.S. Duman H.K. Greshenfeld, et al. 2002 Preclinical models: status of basic research in depression Biol Psychiatry 52 503 528 10.1016/S0006-3223(02)01405-1 12361666
17. R.C. Drugan A.S. Basile J.H. Ha D. Healy R.J. Ferland 1997 Analysis of the importance of controllable versus uncontrollable stress on subsequent behavioral and physiological functioning Brain Res Brain Res Protoc 2 69 74 10.1016/S1385-299X(97)00031-7 9438074
18. R.E. Grahn L.R. Watkins S.F. Maier 2000 Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus Behav Brain Res 112 33 41 10.1016/S0166-4328(00)00161-3 10862933
19. Durgam RC. Rodent models of depression: learned helplessness using a triadic design in rats. Curr Protoc Neurosci 2001, Chapter 8: Unit 8 10B.
20. T. Hajszan A. Dow J.L. Warner-Schmidt K. Szigeti-Buck N.L. Sallam A. Parducz, et al. 2009 Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression Biol Psychiatry 65 392 400 10.1016/j.biopsych.2008.09.031 19006787
21. S. Chourbaji C. Zacher C. Sanchis-Segura C. Dormann B. Vollmayr P. Gass 2005 Learned helplessness: validity and reliability of depressive-like states in mice Brain Res Brain Res Protoc 16 70 78 10.1016/j.brainresprot.2005.09.002 16338640
22. B. Vollmayr F.A. Henn 2001 Learned helplessness in the rat: improvements in validity and reliability Brain Res Brain Res Protoc 8 1 7 10.1016/S1385-299X(01)00067-8 11522522
23. J. Adrien C. Dugovic P. Martin 1991 Sleep-wakefulness patterns in the helpless rat Physiol Behav 49 257 262 10.1016/0031-9384(91)90041-L 2062895
24. N.K. Dess J. Raizer C.D. Chapman J. Garcia 1988 Stressors in the learned helplessness paradigm: effects on body weight and conditioned taste aversion in rats Physiol Behav 44 483 490 10.1016/0031-9384(88)90309-5 2853383
25. L. Greenberg E. Edwards F.A. Henn 1989 Dexamethasone suppression test in helpless rats Biol Psychiatry 26 530 532 10.1016/0006-3223(89)90074-7 2790094
26. F. Henn E. Edwards J. Muneyyirci 1993 Animal models of depression Clin Neurosci 1 152 156
27. B. Vollmayr D. Bachteler V. Vengeliene P. Gass R. Spanagel F. Henn 2004 Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning Behav Brain Res 150 217 221 10.1016/S0166-4328(03)00259-6 15033295
28. A.D. Sherman J.L. Sacquitne F. Petty 1982 Specificity of the learned helplessness model of depression Pharmacol Biochem Behav 16 449 454 10.1016/0091-3057(82)90451-8 7200610
29. W.T. McKinney 1986 Electroconvulsive therapy and animal models of depression Ann N Y Acad Sci 462 65 69 10.1111/j.1749-6632.1986.tb51240.x 3518575
30. B. Vollmayr F.A. Henn 2003 Stress models of depression Clin Neurosci Res 3 245 251 10.1016/S1566-2772(03)00086-0
31. P. Fadda L. Pani A. Porcella W. Fratta 1995 Chronic imipramine, L-sulpiride and mianserin decrease corticotropin releasing factor levels in the rat brain Neurosci Lett 192 121 123 10.1016/0304-3940(95)11612-Z 7675318
32. K. Takamori S. Yoshida S. Okuyama 2001 Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats Pharmacology 63 147 153 10.1159/000056126 11598420
33. S. Ridder S. Chourbaji R. Hellweg A. Urani C. Zacher W. Schmid, et al. 2005 Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions J Neurosci 25 6243 6250 10.1523/JNEUROSCI.0736-05.2005 15987954
34. P.J. Mitchell P.H. Redfern 2005 Animal models of depressive illness: the importance of chronic drug treatment Curr Pharm Des 11 171 203 10.2174/1381612053382250 15638757
35. F.A. Henn B. Vollmayr 2005 Stress models of depression: forming genetically vulnerable strains Neurosci Biobehav Rev 29 799 804 10.1016/j.neubiorev.2005.03.019 15925700
36. Anisman H, Merali Z. Rodent models of depression: learned helplessness induced in mice. Curr Protoc Neurosci 2001, Chapter 8: Unit 8 10C.
37. R.J. Katz K.A. Roth B.J. Carroll 1981 Acute and chronic stress effects on open field activity in the rat: implications for a model of depression Neurosci Biobehav Rev 5 247 251 10.1016/0149-7634(81)90005-1 7196554
38. R.J. Katz K.A. Roth K. Schmaltz 1981 Amphetamine and tranylcypromine in an animal model of depression: pharmacological specificity of the reversal effect Neurosci Biobehav Rev 5 259 264 10.1016/0149-7634(81)90007-5 7196556
39. P. Willner A. Towell D. Sampson S. Sophokleous R. Muscat 1987 Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant Psychopharmacology (Berl) 93 358 364 10.1007/BF00187257
40. P. Willner 1997 Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation Psychopharmacology (Berl) 134 319 329 10.1007/s002130050456
41. R.J. Katz 1982 Animal model of depression: pharmacological sensitivity of a hedonic deficit Pharmacol Biochem Behav 16 965 968 10.1016/0091-3057(82) 90053-3 7202217
42. R.J. Katz G. Baldrighi 1982 A further parametric study of imipramine in an animal model of depression Pharmacol Biochem Behav 16 969 972 10.1016/0091-3057(82)90054-5 7202218
43. R.J. Katz 1981 Animal model of depression: effects of electroconvulsive shock therapy Neurosci Biobehav Rev 5 273 277 10.1016/0149-7634(81)90009-9 7196558
44. P. Willner R. Muscat M. Papp 1992 Chronic mild stress-induced anhedonia: a realistic animal model of depression Neurosci Biobehav Rev 16 525 534 10.1016/S0149-7634(05)80194-0 1480349
45. S. Monleon P. D'Aquila A. Parra V.M. Simon P.F. Brain P. Willner 1995 Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine Psychopharmacology (Berl) 117 453 457 10.1007/BF02246218
46. S. Pothion J.C. Bizot F. Trovero C. Belzung 2004 Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress Behav Brain Res 155 135 146 10.1016/j.bbr.2004.04.008 15325787
47. J. Stemmelin C. Cohen I. Yalcin P. Keane G. Griebel 2010 Implication of [beta]3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress Behav Brain Res 206 310 312 10.1016/j.bbr.2009.09.003 19744528
48. Zhu XH, Yan HC, Qu HD, Chen L, Li SJ, Cao X, et al. Antidepressant effects of intermittent hypoxia by promoting hippocampal neurogenesis in adult rats. Annual Meeting of the Society of Neuroscience 2009, Chicago.
49. P. Willner 2005 Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS Neuropsychobiology 52 90 110 10.1159/000087097 16037678
50. G.W. Brown R. Prudo 1981 Psychiatric disorder in a rural and an urban population: 1. Aetiology of depression Psychol Med 11 581 599 10.1017/S0033291700052880 7267889
51. H.C. Yan H.D. Qu L.R. Sun S.J. Li X. Cao Y.Y. Fang, et al. 2010 Fuzi polysaccharide-1 produces antidepressant-like effects in mice Int J Neuropsychopharmacol 13 623 633 10.1017/S1461145709990733 19796446
52. O. Berton C.A. McClung R.J. Dileone V. Krishnan W. Renthal S.J. Russo, et al. 2006 Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress Science 311 864 868 10.1126/science.1120972 16469931
53. V. Krishnan M.H. Han D.L. Graham O. Berton W. Renthal S.J. Russo, et al. 2007 Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions Cell 131 391 404 10.1016/j.cell.2007.09.018 17956738
54. N.M. Tsankova O. Berton W. Renthal A. Kumar R.L. Neve E.J. Nestler 2006 Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action Nat Neurosci 9 519 525 10.1038/nn1659 16501568
55. B. Buwalda M.H. Kole A.H. Veenema M. Huininga S.F. de Boer S.M. Korte, et al. 2005 Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning Neurosci Biobehav Rev 29 83 97 10.1016/j.neubiorev.2004. 05.005 15652257
56. J.C. Von Frijtag L.G. Reijmers J.E. Van der Harst I.E. Leus R. Van den Bos B.M. Spruijt 2000 Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats Behav Brain Res 117 137 146 10.1016/S0166-4328(00)00300-4
57. P. Meerlo G.J. Overkamp M.A. Benning J.M. Koolhaas R.H. Van den Hoofdakker 1996 Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation Physiol Behav 60 115 119 10.1016/0031-9384(95)02271-6 8804650
58. E. Fuchs M. Kramer B. Hermes P. Netter C. Hiemke 1996 Psychosocial stress in tree shrews: clomipramine counteracts behavioral and endocrine changes Pharmacol Biochem Behav 54 219 228 10.1016/0091-3057(95)02166-3 8728561
59. J.F. Cryan D.A. Slattery 2007 Animal models of mood disorders: Recent developments Curr Opin Psychiatry 20 1 7 10.1097/YCO.0b013e3280117733 17143074
60. A.V. Kalueff D.F. Avgustinovich N.N. Kudryavtseva D.L. Murphy 2006 BDNF in anxiety and depression Science 312 1598 1599 10.1126/science.312.5780.1598 16778038
61. N.N. Kudryavtseva I.V. Bakshtanovskaya L.A. Koryakina 1991 Social model of depression in mice of C57BL/6J strain Pharmacol Biochem Behav 38 315 320 10.1016/0091-3057(91)90284-9 2057501
62. K. Bjorkqvist 2001 Social defeat as a stressor in humans Physiol Behav 73 435 442 10.1016/S0031-9384(01)00490-5 11438372
63. A. Holmes R.J. Yang D.L. Murphy J.N. Crawley 2002 Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter Neuropsychopharmacology 27 914 923 10.1016/S0893-133X(02)00374-3 12464448
64. A.J. Mayorga A. Dalvi M.E. Page S. Zimov-Levinson R. Hen I. Lucki 2001 Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice J Pharmacol Exp Ther 298 1101 1107 11504807
65. N.L. Schramm M.P. McDonald L.E. Limbird 2001 The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety J Neurosci 21 4875 4882 11425914
66. A.M. Pliakas R.R. Carlson R.L. Neve C. Konradi E.J. Nestler W.A. Carlezon Jr 2001 Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens J Neurosci 21 7397 7403 11549750
67. Gourley SL, Taylor JR. Recapitulation and reversal of a persistent depression-like syndrome in rodents. Curr Protoc Neurosci 2009, Chapter 9: Unit 9 32.
68. S.L. Gourley F.J. Wu D.D. Kiraly J.E. Ploski A.T. Kedves R.S. Duman, et al. 2008 Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression Biol Psychiatry 63 353 359 10.1016/j.biopsych.2007.07.016 17889834
69. S.L. Gourley D.D. Kiraly J.L. Howell P. Olausson J.R. Taylor 2008 Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone Biological Psychiatry 64 884 890 10.1016/j.biopsych.2008.06.016 18675955
70. S. Brummelte L.A.M. Galea 2010 Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats Neuroscience 168 680 690 10.1016/j.neuroscience.2010.04.023 20406669
71. R.D. Porsolt M. Le Pichon M. Jalfre 1977 Depression: a new animal model sensitive to antidepressant treatments Nature 266 730 732 10.1038/266730a0 559941
72. R.D. Porsolt A. Bertin M. Jalfre 1977 Behavioral despair in mice: a primary screening test for antidepressants Arch Int Pharmacodyn Ther 229 327 336 596982
73. B. Petit-Demouliere F. Chenu M. Bourin 2005 Forced swimming test in mice: a review of antidepressant activity Psychopharmacology (Berl) 177 245 255 10.1007/s00213-004-2048-7
74. J.F. Cryan C. Mombereau 2004 In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice Mol Psychiatry 9 326 357 10.1038/sj.mp.4001457 14743184
75. I. Lucki 1997 The forced swimming test as a model for core and component behavioral effects of antidepressant drugs Behav Pharmacol 8 523 532 10.1097/00008877-199711000-00010 9832966
76. J.F. Cryan R.J. Valentino I. Lucki 2005 Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test Neurosci Biobehav Rev 29 547 569 10.1016/j.neubiorev.2005.03.008 15893822
77. R.D. Porsolt G. Anton N. Blavet M. Jalfre 1978 Behavioural despair in rats: a new model sensitive to antidepressant treatments Eur J Pharmacol 47 379 391 10.1016/0014-2999(78)90118-8 204499
78. R.D. Porsolt A. Bertin M. Jalfre 1978 "Behavioural despair" in rats and mice: strain differences and the effects of imipramine Eur J Pharmacol 51 291 294 10.1016/0014-2999(78)90414-4 568552
79. I. Lucki A. Dalvi A.J. Mayorga 2001 Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice Psychopharmacology (Berl) 155 315 322 10.1007/s002130100694
80. A. Dalvi I. Lucki 1999 Murine models of depression Psychopharmacology (Berl) 147 14 16 10.1007/s002130051131
81. D.J. David C.E. Renard P. Jolliet M. Hascoet M. Bourin 2003 Antidepressant-like effects in various mice strains in the forced swimming test Psychopharmacology (Berl) 166 373 382
82. L. Steru R. Chermat B. Thierry P. Simon 1985 The tail suspension test: a new method for screening antidepressants in mice Psychopharmacology (Berl) 85 367 370 10.1007/BF00428203
83. J.F. Cryan C. Mombereau A. Vassout 2005 The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice Neurosci Biobehav Rev 29 571 625 10.1016/j.neubiorev. 2005.03.009 15890404
84. F. Bai X. Li M. Clay T. Lindstrom P. Skolnick 2001 Intra- and interstrain differences in models of "behavioral despair" Pharmacol Biochem Behav 70 187 192 10.1016/S0091-3057(01)00599-8 11701187
85. I.Q. Whishaw J. Tomie 1996 Of mice and mazes: similarities between mice and rats on dry land but not water mazes Physiol Behav 60 1191 1197 10.1016/S0031-9384(96)00176-X 8916170
86. S.C. Dulawa R. Hen 2005 Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test Neurosci Biobehav Rev 29 771 783 10.1016/j.neubiorev.2005.03.017 15890403
87. L. Santarelli M. Saxe C. Gross A. Surget F. Battaglia S. Dulawa, et al. 2003 Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 805 809 10.1126/science.1083328 12907793
88. R. Alonso G. Griebel G. Pavone J. Stemmelin G. Le Fur P. Soubrie 2004 Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression Mol Psychiatry 9 278 286 10.1038/sj.mp.4001464 14699428
89. G. Griebel J. Simiand C. Serradeil-Le Gal J. Wagnon M. Pascal B. Scatton, et al. 2002 Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149-415, suggest an innovative approach for the treatment of stressrelated disorders Proc Natl Acad Sci U S A 99 6370 6375 10.1073/pnas.092012099 11959912