Neurotrophic factors and the pathophysiology of schizophrenic psychoses

European Psychiatry

Volumn 19, Issue 6, 2004, Pages 326-337

  Durany, Nuria ^a   Thome, Johannes ^b  

^a UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antipsychotic drugs; BDNF; CNTF; Maldevelopment; Neurogenesis; Neuroleptics; NGF; NT 3; NTF

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CLOZAPINE; HALOPERIDOL; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; NERVE GROWTH FACTOR; NEUROLEPTIC AGENT; NEUROTROPHIC FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN 6; NEUROTROPHIN RECEPTOR; OLANZAPINE; ONCOSTATIN M; RISPERIDONE;

BRAIN REGION; CEREBROSPINAL FLUID; CORRELATION ANALYSIS; DATA BASE; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; ELECTROCONVULSIVE THERAPY; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; HISTOPATHOLOGY; HUMAN; MEDICAL LITERATURE; NEUROIMAGING; PATHOPHYSIOLOGY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; THEORY;

EID: 4444320149     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2004.06.020     Document Type: Short Survey

References (157)

1. Agerman K., and Ernfors P. Differential influence of BDNF and NT-3 on the expression of calcium binding proteins and neuropeptide Y in vivo Neuroreport 14 2003 2183 2187
2. Akbarian S., Bunney W.E., Potkin S.G., Wigal S.B., Hagman J.O., and Sandman C.A. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development Arch Gen Psychiatry 50 1993 169 177
3. Alderson R.F., Alterman A.L., Barde Y.A., and Lindsay R.M. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture Neuron 5 1990 297 306
4. Aloe L., Iannitelli A., Angelucci F., Bersani G., and Fiore M. Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia-like disorders Behav Pharmacol 11 2000 235 242
5. Altar C.A., Criden M.R., Lindsay R.M., and DiStefano P.S. Characterization and topography of high affinity 125I-neurotrophin-3 binding to mammalian brain J Neurosci 13 1993 733 743
6. Altar C.A., Cai N., Bliven T., Juhasz M., Conner J.M., and Acheson A.L. Anterograde transport of brain-derived neurotrophic factor and its role in the brain Nature 389 1997 856 860
7. Andersson H., Lindqvist E., and Olson L. Down regulation of brain-derived neurotrophic factor mRNA in adult rat brain after acute administration of methylmercury Mol Chem Neuropathol 31 1997 225 233
8. Angelucci F., Mathe A.A., and Aloe L. Brain-derived neurotrophic factor and tyrosine kinase receptor trkB in rat brain are significantly altered after haloperidol and risperidone administration J Neurosci Res 60 2000 783 794
9. Apfel S.C. Neurotrophic factors in peripheral neuropathies: therapeutic implications Brain Pathol 9 1999 393 413
10. Arinami T., and Toru M. No evidence for association between CNTF null mutant and schizophrenia Br J Psychiatry 169 1996 253
11. Arinami T., Takekoshi K., Itokawa M., Hamaguchi H., and Toru M. Failure to find association of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia Psychiatr Genet 6 1996 13 15
12. Arnold S.E., Hyman B.T., van Hoesen G.W., and Damasio A.R. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia Arch Gen Psychiatry 48 1991 625 632
13. Arnold S.E., Franz B.R., Gur R.C., Gur R.E., Shapiro R.M., and Moberg P.J. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions Am J Psychiatry 152 1995 738 748
14. Ashe P.C., Berry M.D., and Boulton A.A. Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents Prog Neuro-Psychopharmacol Biol Psychiatry 25 2001 691 707
15. Barbacid M. Neurotrophic factors and their receptors Curr Opin Cell Biol 7 1995 148 155
16. Barde Y.A. Trophic factors and neuronal survival Neuron 2 1989 1525 1534
17. Barres B.A., Burne J.F., Holtmann B., Thoenen H., Sendtner M., and Raff M.C. Ciliary neurotrophic factor enhances the rate of oligodendrocyte generation Mol Cell Neurosci 8 1996 146 156
18. Bartrup J.T., Moorman J.M., and Newberry N.R. BDNF enhances neuronal growth and synaptic activity in hippocampal cell cultures Neuroreport 8 1997 3791 3794
19. Benes F.M., Sorensen I., and Bird D.E. Reduced neuronal size in posterior hippocampus of schizophrenic patients Schizophr Bull 17 1991 597 608
20. Bernstein H.G., Krell D., Baumann B., Danos P., Falkai P., and Diekmann S. Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia Schizophr Res 33 1998 125 132
21. Birling M.C., and Price J. Influence of growth factors on neuronal differentiation Curr Opin Cell Biol 7 1995 878 884
22. Bogerts B., Lieberman J.A., Ashtari M., Bilder R.M., Degreef G., and Lerner G. Hippocampus-amygdale volumes and psychopathology in chronic schizophrenia Biol Psychiatry 33 1993 236 246
23. Boris-Moller F., Kamme F., and Wieloch T. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia Mol Brain Res 63 1998 163 173
24. Bourque M.J., and Trudeau L.E. GDNF enhances the synaptic efficacy of dopaminergic neurons in culture Eur J Neurosci 12 2000 3172 3180
25. Buchanan R.W., Vladar K., Barta P.E., and Pearlson G.D. Structural evaluation of the prefrontal cortex in schizophrenia Am J Psychiatry 155 1998 1049 1055
26. Caldwell M.A., He X., Wilkie N., Pollack S., Marshall G., and Wafford K.A. Growth factors regulate the survival and fate of cells derived from human neurospheres Nat Biotechnol 19 2001 475 479
27. Cassacia-Bonnefil P., Gu C., and Chao M.V. Neurotrophins in cell survival/death decisions Adv Exp Med Biol 468 1999 275 282
28. Castren E., da Penha Berzaghi M., Lindholm D., and Thoenen H. Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain Exp Neurol 122 1993 244 252
29. Chao M.V. Neurotrophins and their receptors: a convergence point for many signaling pathways Nat Rev Neurosci 4 2003 299 309
30. Chao M.V., and Hempstead B.L. p75 and trk: a two-receptor system Trends Neurosci 18 1995 321 326
31. Chen B., Dowlatshahi D., MacQueen G.M., Wang J.F., and Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication Biol Psychiatry 50 2001 260 265
32. Cheng B., and Mattson M.P. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults Brain Res 640 1994 56 67
33. Clary D.O., and Reichardt L.F. An alternatively spliced form of the nerve growth factor receptor trkA confers an enhanced response to neurotrophin-3 Proc Natl Acad Sci USA 91 1994 11133 11137
34. Cohen B.M., and Wan W. The thalamus as a site of action of antipsychotic drugs Am J Psychiatry 153 1996 104 106
35. Conover J.C., Erickson J.T., Katz D.M., Bianchi L.M., Poueymirou W.T., and McClain J. Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT-4 Nature 375 1995 235 241
36. Corey-Bloom J., Jernigan T., Archibald S., Harris M.J., and Jeste D.V. Quantitative magnetic resonance imaging of the brain in late-life schizophrenia Am J Psychiatry 152 1995 447 449
37. Dawson E., Powell J.F., Shan P.C., Nothen M., Crocq M.A., and Propping P. An association study of a neurotrophin-3 (NT-3) gene polymorphism with schizophrenia Acta Psychiatr Scand 92 1995 425 428
38. Dechant G., Rodrguez-Tbar A., and Barde Y.A. Neurotrophin receptors Prog Neurobiol 42 1994 347 352
39. Decker K.P., Roy-Byrne P.P., and Merchant K.M. Effect of muscimol on haloperidol-induced alteration of neurotensin gene expression in the striatum and nucleus accumbens in rat Brain Res 691 1995 9 17
40. Durany N., Michel T., Zöchling R., Boissl K.W., Cruz-Sanchez F.F., and Riederer P. Brain-derived neurotrophic factor and neurotrophin-3 in schizophrenic psychoses Schizophr Res 52 2001 79 86
41. Franzek E., and Beckmann H. A study of genetic heterogeneity in schizophrenia Int Psychiatry Today 4 1995 9 12
42. Friedman W.J., Ernfors P., and Persson H. Transient and persistent expression of NT-3/BDNF mRNA in the rat brain during post-natal development J Neurosci 11 1991 1577 1584
43. Gelernter J., van Dyck C., van Kammen D.P., Malison R., Price L.H., and Cubells J.F. Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease Am J Med Genet 74 1997 497 500
44. Gill M., Hawi Z., O'Neill F.A., Walsh D., Straub R.E., and Kendler K.S. Neurotrophin-3 gene polymorphism and schizophrenia: no evidence for linkage or association Psychiatr Genet 6 1996 183 186
45. Gilmore J.H., Jarskog L.F., Lindgren J.C., McEvoy J.P., and Xiao H. Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness Psychiatry Res 73 1997 109 113
46. Hattori M., and Nanko S. Association of neurotrophin-3 gene variant with severe forms of schizophrenia Biochem Biophys Res Co 209 1995 513 518
47. Hattori M., Kuwata S., Fukuda R., Sasaki T., Shibata Y., and Kazamatsuri H. Dinucleotide repeat polymorphism in the promoter region of neurotrophin-3 gene (NT-3) Hum Mol Genet 2 1993 1511
48. Hattori M., Kunugi H., Akahane A., Tanaka H., Ishida S., and Hirose T. Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their association with schizophrenia Am J Med Genet 114 2002 304 309
49. Hawi Z., Straub R.E., O'Neill A., Kendler K.S., Walsh D., and Gill M. No linkage or linkage disequilibrium between brain-derived neurotrophic factor (BDNF) dinucleotide repeat polymorphism and schizophrenia in Irish families Psychiatry Res 81 1998 111 116
50. Heckers S., Rauch S.L., Goff D., Savage C.R., Schacter D.L., and Fischman A.J. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia Nat Neurosci 1 1998 266 267
51. Heuckeroth R.O., Lampe P.A., Johnson E.M., and Milbrandt J. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro Dev Biol 200 1998 116 129
52. Hofer M., Pagliusi S.R., Hohn A., Leibrock J., and Barde Y.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain EMBO J 9 1990 1459 1464
53. Horton A.R., Davis A.M., Buj-Bello A., Bartlett P., and Murphy M. Leukemia inhibitory factor and ciliary neurotrophic factor in sensory neuron development Perspect Dev Neurobiol 4 1996 358
54. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., and Squinto S.P. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra Nature 350 1991 230 232
55. Ip N.Y., Li Y., Yancopoulos G.D., and Lindsay R.M. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF J Neurosci 13 1993 394 405
56. Ip N.Y., McClain J., Barrezueta N.X., Aldrich T.H., Pan L., and Li Y. The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development Neuron 10 1993 89 102
57. Iritani S., Niizato K., Nawa H., Ikedas K., and Emsoon P.C. Immnohistochemical study of brain-derived neurotrophic factor and its receptor, trkB, in the hippocampal formation of schizophrenic brains Prog Neuro-Psychopharmacol Biol Psychiatry 27 2003 801 807
58. Jacobsen L.K., Giedd J.N., Rajapakse J.C., Hamburger S.D., Vaituzis A.C., and Frazier J.A. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia Psychiatry Res 68 1997 77 86
59. Jakob H., and Beckmann H. Prenatal development disturbances in the limbic allocortex in schizophrenics J Neural Transm 65 1986 303 326
60. Jerningan T.L., Zisook S., Heaton R.K., Moranville J.T., Hesselink J.R., and Braff D.L. Magnetic resonance imaging abnormalities in lenticular and cerebral cortex in schizophrenia Arch Gen Psychiatry 48 1991 881 890
61. Jockers-Scherubl M.C., Matthies U., Danker-Hopfe H., Lang U.E., Mahlberg R., and Hellweg R. Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients J Psychopharmacol 17 2003 439 445
62. Jones P., and Murray R.M. The genetics of schizophrenia is the genetics of neurodevelopment Br J Psychiatry 158 1991 615 623
63. Jönsson E., Brene S., Zhang X.R., Nimgaonkar V.L., Tylec A., and Schalling M. Schizophrenia and neurotrophin-3 alleles Acta Psychiatr Scand 95 1997 414 419
64. Kaisho Y., Shintani A., Nishida M., Fukumoto H., and Igarashi K. Developmental changes of neurotrophini-3 level in the mouse brain detected by a highly sensitive enzyme immunoassay Brain Res 666 1994 143 146
65. Kinon B.J., and Lieberman J.A. Mechanisms of action of atypical antipsychotic drugs: a critical analysis Psychopharmacology 1996 2 34
66. Kirsch M., and Hofmann H.D. Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system Neurosci Lett 180 1994 163 166
67. Klyushnik T.P., Danilovskaya E.V., Vatolkina O.E., Turkova I.L., Tsutsul'kovskaya M.Y., and Orlova V.A. Changes in the serum levels of autoantibody to nerve growth factor in patients with schizophrenia Neurosci Behav Physiol 29 1999 355 357
68. Knipper M., Berzaghi M.P., Blöchl A., Breer H., Thoenen H., and Lindholm D. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus Eur J Neurosci 6 1994 668 671
69. Kokaia Z., Metsis M., Kokaia M., Elmer E., and Lindvall O. Co-expression of trkB and trkC receptors in CNS neurons suggests regulation by multiple neurotrophins Neuroreport 6 1995 769 772
70. Konradi C., and Heckers S. Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein Neuroscience 65 1995 1051 1061
71. Konradi C., and Heckers S. Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia Biol Psychiatry 50 2001 729 742
72. Kornhuber J., and Weller M. Aktueller Stand der biochemischen Hypothesen zur Pathogenese der Schizophrenien Nervenartz 65 1994 741 754
73. Kornhuber J., Mack-Burkhardt F., Riederer P., Hebenstreit G.F., Reynolds G.P., and Andrews H.B. [3H]MK-801 binding sites in post-mortem brain regions of schizophrenic patients J Neural Transm 77 1989 231 236
74. Korsching S. The neurotrophic factor concept: a reexamination J Neurosci 13 1993 2739 2748
75. Krebs M.O., Guillin O., Bourdell M.C., Schwartz J.C., Olie J.P., and Poirier M.F. Brain-derived neurotrophic factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia Mol Psychiatry 5 2000 558 562
76. Kumar S., Pena L.A., and de Vellis J. CNS glial cells express neurotrophin receptors whose levels are regulated by NGF Mol Brain Res 17 1993 163 168
77. Laudiero L.B., Aloe L., Levi-Montaleini R., Buttineilli C., Schilter D., and Gillessen S. Multiple sclerosis patients express increased levels of B-nerve growth factor in cerebrospinal fluid Neurosci Lett 147 1992 9 12
78. Lauer M., Beckmann H., and Senitz D. Increased frequency of dentate granule cells with basal dendrites in the hippocampal formation of schizophrenics Psychiatry Res 122 2003 89 97
79. Lee K., Kunugi H., and Nanko S. Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis Psychiatry Res 104 2001 11 17
80. Lev A.A., Rosen D.R., Kos C., Clifford E., Landes G., and Hauser S.L. Human ciliary neurotrophic factor: localization to the proximal region of the long arm of chromosome 11 and association with CA/GT dinucleotide repeat Genomics 16 1993 539 541
81. Leveque J.C., Macias W., Rajadhyaksha A., Carlson R.R., Barczak A., and Kang S. Intracellular modulation of NMDA receptor function by antipsychotic drugs J Neurosci 20 2000 4011 4020
82. Li T., Vallada H., Bell R., Liu X., Xie T., and Collier D.A. CNTF and psychiatric disorders Nat Genet 13 1996 143 144
83. Lindholm D., Hamner S., and Zirrgiebel U. Neurotrophins and cerebellar development Perspect Dev Neurobiol 5 1997 83 94
84. Lindsay R.M., Wiegand S.J., Altar C.A., and DiStefano P.S. Neurotrophic factors: from molecule to man TINS 17 1994 182 189
85. Lipska B.K., Khaing Z.Z., Weickert C.S., and Weinberger D.R. BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs Eur J Neurosci 14 2001 135 144
86. Lo D.C. A central role for ciliary neurotrophic factor? Proc Natl Acad Sci USA 90 1993 2557 2558
87. Luts A., Jonsson S.A., Guldberg-Kjaer N., and Brun A. Uniform abnormalities in the hippocampus of five chronic schizophrenic men compared with age-matched controls Acta Psychiatr Scand 98 1998 60 64
88. Mac Lennan A.J., Gaskin A.A., and Lado D.C. CNTF receptor alpha mRNA expression in rodent cell lines and developing rat Brain Res Mol Brain Res 25 1994 251 256
89. Maisonpierre P.C., Belluscio L., Friedman B., Alderson R.F., Wiegand S.J., and Furth M.E. NT-3, BDNF and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression Neuron 5 1990 501 509
90. Maness L.M., Kastin A.J., Weber J.T., Banks W.A., Beckman B.S., and Zadina J.E. The neurotrophins and their receptors: structure, function and neuropathology Neurosci Biobehav Rev 18 1994 143 159
91. Marty S., Carroll P., Cellerion A., Castren E., Staiger V., and Thoenen H. Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures J Neurosci 16 1996 675 687
92. McGuffin P., Owen M.J., and Farmer A.E. Genetic basis of schizophrenia Lancet 346 1995 678 682
93. Meredith G.E., Switzer R.C., and Napier T.C. Short-term D2-receptor blockade induces synaptic degeneration, reduces levels of tyrosine hydroxylase and brain-derived neurotrophic factor, and enhances D2-meidated firing in the ventral pallidum Brian Res 995 2004 14 22
94. Muglia P., Vicente A.M., Verga M., King N., Macciardi F., and Kennedy J.L. Association between the BDNF gene and schizophrenia Mol Psychiatry 8 2003 146 147
95. Muragaki Y., Timothy N., Leight S., Hempstead B.L., Chao M.V., and Trojanowski J.Q. Expression of trk receptors in the developing and adult human central and peripheral nervous system J Comp Neurol 356 1995 387 397
96. Murase K., Igarashi K., and Hayashi K. Neurotrophin-3 levels in the developing rat nervous system and in human samples Clin Chim Acta 227 1994 23 26
97. Murray R.M. Neurodevelopmental schizophrenia: the rediscovery of dementia praecox Br J Psychiatry [Suppl] 25 1994 6 12
98. Nanko S., Hattori M., Kuwata S., Sasaki T., Fukuda R., and Dai X.Y. Neurotrophin-3 gene polymorphism associated with schizophrenia Acta Psychiatr Scand 89 1994 390 392
99. Nawa H., Takahashi M., and Patterson P.H. Cytokine and growth factor involvement in schizophrenia-support for the developmental model Mol Psychiatry 5 2000 594 603
100. Nawa H., Futamura T., Mizuno M., Takahashi M., Toyooka K., and Someya T. Contribution of neurotrophic factors and cytokines to schizophrenia Nippon Rinsho 61 2003 521 528
101. Nibuya M., Morinobu S., and Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neurosci 15 1995 7539 7547
102. Nimgaonkar V.L., Zhang X.R., Brar J.S., DeLeo M., and Ganguli R. Lack of association of schizophrenia with the neurotrophin-3 gene locus Acta Psychiatr Scand 92 1995 464 466
103. Nothen M.M., Cichon S., Eggermann K., Propping P., Knapp M., and Maier W. CNTF and psychiatric disorders Nat Genet 12 1996 123
104. Numan S., Lane-Ladd S.B., Zhang L., Lundgren K.H., Russell D.S., and Seroogy K.B. Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal J Neurosci 18 1998 10700 10708
105. Obrien J.S., Carson G.S., Seo H.C., Hiraiwa M., and Kishimoto Y. Identification of prosaposin as a neurotrophic factor Proc Natl Acad Sci USA 91 1994 9593 9596
106. Ockel M., and Barde Y.A. Neurotrophine: Überlebensfaktoren für Nervenzellen Neuroforum 3 1995 31 35
107. Okazawa H., Murata M., Watanabe M., Kamei M., and Kanazawa I. Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum FEBS Lett 313 1992 138 142
108. Oyesiku N.M., Evans C.O., Houston S., Darrell R.S., Smith J.S., and Fulop Z.L. Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain Brain Res 833 1999 161 172
109. Pennica D., Shaw K.J., Swanson T.A., Moose M.W., Shelton D.L., and Lioncheck K.A. Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex J Biol Chem 270 1995 10915 10922
110. Pennica D., Swanson T.A., Shaw K.J., Kuang W.J., Gray C.L., and Beatty B.G. Human cardiotrophin 1: protein and gene structure, biological and binding activities and chromosomal localisation Cytokine 8 1996 183 189
111. Perez-Polo J.R., Westlund K., Hall K., and Livingston K. Levels of serum nerve growth factor in schizophrenia Birth Defects 14 1978 311 321
112. Pierce R.C., and Bari A.A. The role of neurotrophic factors in psychostimulant-induced behavioural and neuronal plasticity Res Neurosci 12 2001 95 110
113. Prakash N., Cohen-Cory S., and Fros R.D. Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo Nature 381 1996 702 706
114. Pröschel M., Saunders A., Roses A.D., and Müller C.R. Dinucleotide repeat polymorphism at the human gene for the brain-derived neurotrophic factor (BDNF) Hum Mol Genet 1 1992 353
115. Raedler T.J., Knable M.B., and Weinberger D.R. Schizophrenia as a developmental disorder of the cerebral cortex Curr Opin Neurobiol 8 1998 157 161
116. Reynolds G.P. Antipsychotic drug mechanism and neurotransmitter systems in schizophrenia Acta Psychiatr Scand [Suppl] 380 1994 36 40
117. Rodríguez-Tébar A., Dechant G., Götz R., and Barde Y.A. Binding of neurotrophic-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor EMBO J 11 1992 917 922
118. Sakai T., Sasaki T., Tatsumi M., Kunugi H., Hattori M., and Nanko S. Schizophrenia and the ciliary neurotrophic factor (CNTF) gene: no evidence for association Psychiatry Res 71 1997 7 10
119. Sasaki T., Dai X.Y., Kuwata S., Fukuda R., Kunigi H., and Hattori M. Brain-derived neurotrophic factor gene and schizophrenia in Japanese subjects Am J Med Genet 74 1997 443 444
120. Schramm M., Falkai P., Feldmann N., Knable M.B., and Bayer T.A. Reduced tyrosine kinase receptor C mRNA levels in the frontal cortex of patients with schizophrenia Neurosci Lett 257 1998 65 68
121. Schröder J., Essig M., Baudendistel K., Jahn T., Gerdsen I., and Stockert A. Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: a study with functional magnetic resonance imaging Neuroimage 9 1999 81 87
122. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., and Wible C.G. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study New Engl J Med 327 1992 604 612
123. Shimizu E., Hashimoto K., Watanabe H., Komatsu N., Okamura N., and Koike K. Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls Neurosci Lett 351 2003 111 114
124. Snider W.D. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us Cell 77 1994 627 638
125. Snider W.D., and Johnson E.M. Neurotrophic molecules Ann Neurol 26 1989 489 506
126. Soderström S., and Ebendal T. The levels of neurotrophin-3 protein in the rat brain determined by enzyme immunoassay show a pattern distinct from nerve growth factor Neurosci Lett 189 1995 5 8
127. Spence S.A., Hirsch S.R., Brooks D.J., and Grasby P.M. Prefrontal cortex activity in people with schizophrenia and control subjects. Evidence from positron emission tomography for remission of 'hypofrontality' with recovery from acute schizophrenia Br J Psychiatry 172 1998 316 323
128. Staecker H., Liu W., Hartnick C., Lefebvre P., Malgrange B., and Moonen G. NT-3 combined with CNTF promotes survival of neurons in modulus-spiral ganglion explants Neuroreport 6 1995 1533 1537
129. Szekeres G., Juhasz A., Rimanoczy A., Keri S., and Janka Z. The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia Schizophr Res 65 2003 15 18
130. Takahashi M. The GDNF/RET signaling pathway and human diseases Cytokine Growth Factor Rev 12 2001 361 373
131. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., and Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases Nat Genet 7 1994 79 84
132. Takahashi M., Shirakawa O., Toyooka K., Kitamura N., Hashimoto T., and Maeda K. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients Mol Psychiatry 5 2000 293 300
133. Talamini L.M., Koch T., Luiten P.G., Koolhaas J.M., and Korf J. Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders Brain Res 857 1999 105 120
134. Tanaka Y., Ujike H., Fujiwara Y., Takeda T., Takehisa Y., and Kodama M. Schizophrenic psychoses and the CNTF null mutation Neuroreport 9 1998 981 983
135. Thoenen H. The changing scene of neurotrophic factors Trends Neuroci 14 1991 165 170
136. Thoenen H. Neurotrophins and neuronal plasticity Science 270 1996 593 598
137. Thome J., Baumer A., Hársanyi A., Foley P., Kornhuber J., and Wiesbeck G.A. The Gly-Glu bi-allele polymorphism of the neurotrophin-3 (NT-3) gene: allele frequencies in a Caucasian population and relevance for psychiatric disorders Neuroreport 7 1996 2123 2126
138. Thome J., Durany N., Harsányi A., Foley P., Palomo A., and Kornhuber J. A null mutation allele in the CNTF gene and schizophrenic psychoses Neuroreport 7 1996 1413 1416
139. Thome J., Nara K., Foley P., Michel T., Gsell W., and Retz W. Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin-3 (NT-3) concentration in human post-mortem brain tissue J Hirnforsch 38 1997 443 451
140. Thome J., Durany N., Palomo A., Foley P., Harsányi A., and Baumer A. Variants in neurotrophic factor genes (CNTF, NT-3) and schizophrenic psychoses: no associations in a Spanish population Psychiatry Res 71 1997 1 5
141. Thome J., Jonsson E., Foley P., Harsanyi A., Sedvall G., and Riederer P. Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population Psychiatry Res 7 1997 79 82
142. Thome J., Foley P., and Riederer P. Neurotrophic factors and the maldevelopment hypothesis of schizophrenic psychosis J Neural Transm 105 1998 85 100
143. Thome J., Sakai N., Shin K.H., Steffen C., Zhang Y.J., and Impey S. cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment J Neurosci 20 2000 4030 4036
144. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., and Someya T. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients Psychiatry Res 110 2002 249 257
145. Tsai G., Passani L.A., Slusher B.S., Carter R., Baer L., and Kleinman J.E. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains Arch Gen Psychiatry 52 1995 829 836
146. Vezzani A., Ravizza T., Moneta D., Conti M., Borroni A., and Rizzi M. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y Neuroscience 90 1999 1445 1461
147. Virgos C., Martorell L., Valero J., Figuera L., Civeira F., and Joven J. Association study of schizophrenia with polymorphisms at six candidate genes Schizophr Res 49 2001 65 71
148. Wagner J.A., and Kostyk S.K. Regulation of neural cell survival and differentiation by peptide growth factors Curr Opin Cell Biol 2 1990 1050 1057
149. Wang S., Sun C., Walczak C.A., Ziegle J.S., Kipps B.R., and Goldin L.R. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22 Nat Genet 10 1995 41 46
150. Wassink T.H., Nelson J.J., Crowe R.R., and Andreasen N.C. Heritability of BDNF alleles and their effects on brain morphology in schizophrenia Am J Med Genet 88 1999 724 728
151. Weickert C.S., Hyde T.M., Lipska B.K., Herman M.M., Weinberger D.R., and Kleinman J.E. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia Mol Psychiatry 8 2003 592 610
152. Weinberger D.R. From neuropathology to neurodevelopment Lancet 346 1995 552 557
153. Weinberger D.R., and Lipska B.K. Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground Schizophr Res 16 1995 87 110
154. Widmer H.R., and Hefti F. Nuerotrophin-4/5 promotes survival and differentiation of rat striatal neurons developing in culture Eur J Neurosci 6 1994 1669 1679
155. Winter C.G., Saotome Y., Levison S.W., and Hirsh D. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury Proc Natl Acad Sci USA 92 1995 5865 5869
156. Wozniak W. Brain-derived neurotrophic factor (BDNF): role in neuronal development and survival Folia Morphol (Warsz) 52 1993 173 181
157. Wright A.F., and Carothers A.D. CNTF in the embryo Nat Genet 7 1994 460