Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor

Journal of Biological Chemistry

Volumn 283, Issue 48, 2008, Pages 33375-33383

  Fletcher, Jordan M ^a   Morton, Craig J ^a,b   Zwar, Richard A ^a,b   Murray, Simon S ^a   O'Leary, Paul D ^a   Hughes, Richard A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CONFORMATIONS; LEAD COMPOUNDS; MOLECULAR WEIGHT; NEURONS; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; PLASMA STABILITY; PROTEINS;

CLINICAL TRIALS; DORSAL ROOT GANGLIONS; IN VITRO; NEURODEGENERATIVE DISEASES; NEURONAL SURVIVALS; NEUROTROPHIC FACTORS; NEUROTROPHIN; NEUROTROPHIN RECEPTORS; NMR STUDIES; PROTEOLYTIC STABILITIES; RAT PLASMAS; RECEPTOR TYROSINE KINASES; SENSORY NEURONS; SIGNALING MOLECULES; SOLUTION CONFORMATIONS; TRI PEPTIDES;

ENZYME INHIBITION;

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLO DEXTRO PROLYLALANYLLYSYLARGININE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN RECEPTOR P75; PENTAPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHICK; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; EMBRYO; MOLECULAR WEIGHT; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; BIOMIMETIC MATERIALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CELL SURVIVAL; CHICK EMBRYO; DRUG DESIGN; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; OLIGOPEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKB;

RATTUS;

EID: 57749120457     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802789200     Document Type: Article

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