Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ signaling pathways in mouse brain

Neuropsychopharmacology

Volumn 32, Issue 10, 2007, Pages 2152-2162

  Rantamäki, Tomi ^a   Hendolin, Panu ^b   Kankaanpää, Aino ^c   Mijatovic, Jelena ^a   Piepponen, Petteri ^a   Domenici, Enrico ^d   Chao, Moses V ^e   Männistö, Pekka T ^a   Castrén, Eero ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Oy Jurilab Ltd   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d GSK   (Italy)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP response element binding protein; Forced swim test; Norepinephrine; Serotonin; TrkB tyrosine phosphorylation; TrkB.T1 overexpression

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CITALOPRAM; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN RECEPTOR; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; REBOXETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CINGULATE GYRUS; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; HIPPOCAMPUS; IN VIVO STUDY; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEROTONINERGIC SYSTEM;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSIVE DISORDER; GYRUS CINGULI; HIPPOCAMPUS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MORPHOLINES; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; RECEPTOR, TRKB; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 34447121927     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301345     Document Type: Article

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