Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: An association study

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 30, Issue 5, 2006, Pages 924-933

  Jönsson, Erik G ^a   Edman Ahlbom, Bodil ^a   Sillén, Anna ^a   Gunnar, Agneta ^a   Kulle, Bettina ^b   Frigessi, Arnoldo ^b   Vares, Maria ^a   Ekholm, Birgit ^a   Wode Helgodt, Birgitta ^a   Schumacher, Johannes ^c   Cichon, Sven ^c   Agartz, Ingrid ^a,d   Sedvall, Göran C ^a   Hall, Håkan ^a   Terenius, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Department of Biostatistics   (Norway)

^c UNIVERSITY OF BONN   (Germany)

^d Psykiatrisk Institutt   (Norway)

Author keywords

Brain derived neurotrophic factor (BDNF); Genetics; Meta analysis; Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PSYCHOSIS; SCHIZOPHRENIA;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SWEDEN; VARIATION (GENETICS);

EID: 33744519074     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2006.02.008     Document Type: Article

References (87)

1. Ahmadian A., Gharizadeh B., Gustafsson A.C., Sterky F., Nyrén P., Uhlén M., et al. Single-nucleotide polymorphism analysis by pyrosequencing. Anal Biochem 280 (2000) 103-110
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Third edition-revised (1987), American Psychiatric Association, Washington (DC)
3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Fourth edition (1995), American Psychiatric Association, Washington (DC) International Version
4. Anttila S., Illi A., Kampman O., Mattila K.M., Lehtimaki T., and Leinonen E. Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics. J Neural Transm 112 (2004) 885-890
5. Ashe P.C., Berry M.D., and Boulton A.A. Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents. Prog Neuropsychopharmacol Biol Psychiatry 25 (2001) 691-707
6. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
7. Carlsson A., Waters N., Holm-Waters S., Tedroff J., Nilsson M., and Carlsson M.L. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu Rev Pharmacol Toxicol 41 (2001) 237-260
8. Cohen J. Statistical power analysis for the behavioral sciences (1988), Lawrence Erlbaum Associates, Hillsdale (NJ)
9. Crow T.J. Nature of the genetic contribution to psychotic illness-a continuum viewpoint. Acta Psychiatr Scand 81 (1990) 401-408
10. Damberg M., Berggård C., Farde L., Sedvall G.C., and Jönsson E.G. Transcription factor AP-2b genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans. J Neural Transm 111 (2004) 537-545
11. de Krom M., Bakker S.C., Hendriks J., van Elburg A., Hoogendoorn M., Verduijn W., et al. Polymorphisms in the brain-derived neurotrophic factor gene are not associated with either anorexia nervosa or schizophrenia in Dutch patients. Psychiatr Genet 15 (2005) 81
12. Durany N., Michel T., Zochling R., Boissl K.W., Cruz-Sanchez F.F., Riederer P., et al. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res 52 (2001) 79-86
13. Eaton M.J., Staley J.K., Globus M.Y., and Whittemore S.R. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Dev Biol 170 (1995) 169-182
14. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
15. Ekholm B., Ekholm A., Adolfsson R., Vares M., Ösby U., and Sedvall G.C. Evaluation of diagnostic procedures in Swedish patients with schizophrenia and related psychoses. Nord J Psychiatry 59 (2005) 457-464
16. Emery A.E.H. Methodology in medical genetics (1986), Churchill Livingstone, Edinburgh
17. Erdfelder E., Faul F., and Buchner A. GPower: a general power analysis program. Behav Res Methods Instrum Comput 28 (1996) 1-11
18. Fanous A.H., Neale M.C., Straub R.E., Webb B.T., O'Neill A.F., Walsh D., et al. Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. Am J Med Genet 125B (2004) 69-78
19. 11C]raclopride in man. Synapse 20 (1995) 200-208
20. Galderisi S., Maj M., Kirkpatrick B., Piccardi P., Mucci A., Invernizzi G., et al. COMT Val(158)Met and BDNF C(270)T polymorphisms in schizophrenia: a case-control study. Schizophr Res 73 (2005) 27-30
21. Geijer T., Neiman J., Rydberg U., Gyllander A., Jönsson E., Sedvall G., et al. Dopamine D2 receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci 244 (1994) 26-32
22. Geller B., Badner J.A., Tillman R., Christian S.L., Bolhofner K., and Cook Jr. E.H. Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 161 (2004) 1698-1700
23. Gourion D., Goldberger C., Leroy S., Bourdel M.C., Olié J.P., and Krebs M.O. Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants. NeuroReport 16 (2005) 1407-1410
24. Green E., and Craddock N. Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications. Curr Psychiatry Rep 5 (2003) 469-476
25. Hall D., Dhilla A., Charalambous A., Gogos J.A., and Karayiorgou M. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet 73 (2003) 370-376
26. Hanson I.M., Seawright A., and van Heyningen V. The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 13 (1992) 1331-1333
27. Hawi Z., Straub R.E., O'Neill A., Kendler K.S., Walsh D., and Gill M. No linkage or linkage disequilibrium between brain-derived neurotrophic factor (BDNF) dinucleotide repeat polymorphism and schizophrenia in Irish families. Psychiatry Res 81 (1998) 111-116
28. Hong C.J., Huo S.J., Yen F.C., Tung C.L., Pan G.M., and Tsai S.J. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48 (2003) 186-189
29. Hong C.J., Yu Y.W., Lin C.H., and Tsai S.J. An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients. Neurosci Lett 349 (2003) 206-208
30. Jockers-Scherübl M.C., Danker-Hopfe H., Mahlberg R., Selig F., Rentzsch J., Schürer F., et al. Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. Neurosci Lett 371 (2004) 79-83
31. Jones P., and Murray R.M. The genetics of schizophrenia is the genetics of neurodevelopment. Br J Psychiatry 158 (1991) 615-623
32. Jönsson E. Thesis: genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites. Focus on association studies with candidate genes. Karolinska Institutet, Stockholm; 1997.
33. Jönsson E., Lannfelt L., Sokoloff P., Schwartz J.-C., and Sedvall G. Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene. Acta Psychiatr Scand 87 (1993) 345-349
34. Jönsson E.G., Geijer T., Gyllander A., Terenius L., and Sedvall G.C. Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia. Eur Arch Psychiatry Clin Neurosci 248 (1998) 61-63
35. Jönsson E.G., Sillén A., Vares M., Ekholm B., Terenius L., and Sedvall G.C. Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta-analysis. Am J Med Genet 119B (2003) 28-34
36. Jönsson E.G., Kaiser R., Brockmöller J., Nimgaonkar V.L., and Crocq M.-A. Meta-analysis of dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatr Genet 14 (2004) 9-12
37. Kahn H.A., and Sempos C.T. Statistical methods in epidemiology (1989), Oxford University Press, New York
38. Koizumi H., Hashimoto K., Shimizu E., Iyo M., Mashimo Y., and Hata A. Further analysis of microsatellite marker in the BDNF gene. Am J Med Genet 135 (2005) 103
39. Kornhuber J., Wiltfang J., and Bleich S. The etiopathogenesis of schizophrenias. Pharmacopsychiatry 37 (2004) S103-S112
40. Krebs M.O., Guillin O., Bourdell M.C., Schwartz J.C., Olie J.P., Poirier M.F., et al. Brain derived neurotrophic factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia. Mol Psychiatry 5 (2000) 558-562
41. Kunugi H., Ueki A., Otsuka M., Isse K., Hirasawa H., Kato N., et al. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 6 (2001) 83-86
42. Kunugi H., Iijima Y., Tatsumi M., Yoshida M., Hashimoto R., Kato T., et al. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry 56 (2004) 376-378
43. Lohoff F.W., Sander T., Ferraro T.N., Dahl J.P., Gallinat J., and Berrettini W.H. Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet 139 (2005) 51-53
44. Maisonpierre P.C., Le Beau M.M., Espinosa III R., Ip N.Y., Belluscio L., de la Monte S.M., et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10 (1991) 558-568
45. McClure R.K., and Lieberman J.A. Neurodevelopmental and neurodegenerative hypotheses of schizophrenia: a review and critique. Curr Opin Psychiatry 16 (2003) S15-S28
46. McGuffin P., Owen M.J., and Farmer A.E. Genetic basis of schizophrenia. Lancet 346 (1995) 678-682
47. Mercader J.M., Ribasés M., Gratacòs M., Fernández-Aranda F., and Estivill X. Increased blood levels of BDNF in patients with eating disorders are independent of the Val66Met variant and are associated with the - 270 C/T variant. Am J Med Genet 138B (2005) 96
48. Meszaros K., Lenzinger E., Hornik K., Fureder T., Stompe T., Willinger U., et al. Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special?. Psychiatry Res 96 (2000) 179-183
49. Mjellem N., and Kringlen E. Schizophrenia: a review, with emphasis on the neurodevelopmental hypothesis. Nord J Psychiatry 55 (2001) 301-309
50. Molteni R., Lipska B.K., Weinberger D.R., Racagni G., and Riva M.A. Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia. Mol Psychiatry 6 (2001) 285-292
51. Muglia P., Vicente A.M., Verga M., King N., Macciardi F., and Kennedy J.L. Association between the BDNF gene and schizophrenia. Mol Psychiatry 8 (2003) 146-147
52. Nakata K., Ujike H., Sakai A., Uchida N., Nomura A., Imamura T., et al. Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neurosci Lett 337 (2003) 17-20
53. Nanko S., Kunugi H., Hirasawa H., Kato N., Nabika T., and Kobayashi S. Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62 (2003) 281-283
54. Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., and Kennedy J.L. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71 (2002) 651-655
55. Neves-Pereira M., Cheung J.K., Pasdar A., Zhang F., Breen G., Yates P., et al. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10 (2005) 208-212
56. Oswald P., Del-Favero J., Massat I., Souery D., Claes S., Van Broeckhoven C., et al. Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study. Am J Med Genet 129B (2004) 34-35
57. Oxenstierna G., Edman G., Iselius L., Oreland L., Ross S.B., and Sedvall G. Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals-a genetic study. J Psychiatr Res 20 (1986) 19-29
58. Oxenstierna G., Bergstrand G., Edman G., Flyckt L., Nybäck H., and Sedvall G. Increased frequency of abberant CSF circulation in schizophrenic patients compared to healthy volunteers. Eur Psychiatry 11 (1996) 16-20
59. Pirildar S., Gönül A.S., Taneli F., and Akdeniz F. Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 709-713
60. Sasaki T., Dai X.-Y., Kuwata S., Fukuda R., Kunugi H., Hattori M., et al. Brain-derived neurotrophic factor gene and schizophrenia in Japanese subjects. Am J Med Genet 74 (1997) 443-444
61. Schumacher J., Abou Jamra R., Becker T., Ohlraun S., Klopp N., Binder E.B., et al. Evidence for a relationship between genetic variants at the Brain-Derived Neurotrophic Factor (BDNF) locus and major depression. Biol Psychiatry 58 (2005) 307-314
62. Shimizu E., Hashimoto K., Watanabe H., Komatsu N., Okamura N., Koike K., et al. Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls. Neurosci Lett 351 (2003) 111-114
63. Skibinska M., Hauser J., Czerski P., Leszczynska-Rodziewicz A., Kosmowska M., Kapelski P., et al. Association Analysis of Brain-Derived Neurotrophic Factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World J Biol Psychiatry 5 (2004) 215-220
64. Sklar P., Gabriel S.B., McInnis M.G., Bennett P., Lim Y.M., Tsan G., et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol Psychiatry 7 (2002) 579-593
65. Spenger C., Hyman C., Studer L., Egli M., Evtouchenko L., Jackson C., et al. Effects of BDNF on dopaminergic, serotonergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon. Exp Neurol 133 (1995) 50-63
66. Spitzer R.L., Williams J.B.W., and Gibbon M. Structured Clinical Interview for DSM-III-R-Non Patient version (SCID-NP) (1986), Biometrics Research Department, New York State Psychiatric Institute, New York
67. Spitzer R.L., Williams J.B.W., Gibbon M., and First M.B. Structured Clinical Interview for DSM-III-R-Patient version (SCID-P) (1988), Biometrics Research Department, New York State Psychiatric Institute, New York
68. Stephens M., and Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73 (2003) 1162-1169
69. Studer L., Spenger C., Seiler R.W., Altar C.A., Lindsay R.M., and Hyman C. Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra. Eur J Neurosci 7 (1995) 223-233
70. Szczepankiewicz A., Skibinska M., Czerski P.M., Kapelski P., Leszczynska-Rodziewicz A., Slopien A., et al. No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia. Schizophr Res 76 (2005) 187-193
71. Szekeres G., Juhász A., Rimanóczy A., Kéri S., and Janka Z. The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res 65 (2003) 15-18
72. Szeszko P.R., Lipsky R., Mentschel C., Robinson D., Gunduz-Bruce H., Sevy S., et al. Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 10 (2005) 631-636
73. Takahashi M., Shirakawa O., Toyooka K., Kitamura N., Hashimoto T., Maeda K., et al. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol Psychiatry 5 (2000) 293-300
74. Tan Y.L., Zhou D.F., Cao L.Y., Zou Y.Z., Wu G.Y., and Zhang X.Y. Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia. Schizophr Res 77 (2005) 355-356
75. Tan Y.L., Zhou D.F., Cao L.Y., Zou Y.Z., and Zhang X.Y. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neurosci Lett 382 (2005) 27-32
76. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., et al. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res 110 (2002) 249-257
77. van Kammen D.P., and Kelley M. Dopamine and norepinephrine activity in schizophrenia. An integrative perspective. Schizophr Res 4 (1991) 173-191
78. van Rossum J.M. The significance of dopamine-receptor blockade for the action of neuroleptic drugs. In: Brill H., Cole J.O., Deniker P., Hippius H., and Bradley P.B. (Eds). 5th Collegium Internationale Neuropsychopharmacologicum (1967), Excerpta Medica, Amsterdam 321-329
79. Vares M, Ekholm A, Sedvall GC, Hall H, Jönsson EG. Characterisation of patients with schizophrenia and related psychosis: evaluation of different diagnostic procedures. Psychopathology in press.
80. Virgos C., Martorell L., Valero J., Figuera L., Civeira F., Joven J., et al. Association study of schizophrenia with polymorphisms at six candidate genes. Schizophr Res 49 (2001) 65-71
81. Wassink T.H., Nelson J.J., Crowe R.R., and Andreasen N.C. Heritability of BDNF alleles and their effect on brain morphology in schizophrenia. Am J Med Genet 88 (1999) 724-728
82. Weinberger D.R. From neuropathology to neurodevelopment. Lancet 346 (1995) 552-557
83. Wing J.K., Babor T., Brugha T., Burke J., Cooper J.E., Giel R., et al. SCAN. Schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 47 (1990) 589-593
84. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet 19 (1955) 251-253
85. Woolley D.W., and Shaw E. A biochemical and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci U S A 40 (1954) 228-231
86. Zhou J., Bradford H.F., and Stern G.M. The response of human and rat fetal ventral mesencephalon in culture to the brain-derived neurotrophic factor treatment. Brain Res 656 (1994) 147-156
87. Zhou J., Bradford H.F., and Stern G.M. The stimulatory effect of brain-derived neurotrophic factor on dopaminergic phenotype expression of embryonic rat cortical neurons in vitro. Brain Res Dev Brain Res 81 (1994) 318-324