Antidepressant action: To the nucleus and beyond

Trends in Pharmacological Sciences

Volumn 26, Issue 12, 2005, Pages 631-638

  Malberg, Jessica E ^a   Blendy, Julie A ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; KETANSERIN; LITHIUM CHLORIDE; MONOAMINE OXIDASE INHIBITOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NEUROTRANSMITTER; NORADRENALIN; REBOXETINE; ROLIPRAM; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SOMATOMEDIN; SUMATRIPTAN; TACHYKININ RECEPTOR ANTAGONIST; TIANEPTINE; TRANYLCYPROMINE; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID; VASOPRESSIN V3 RECEPTOR; VENLAFAXINE;

AMYGDALOID NUCLEUS; DENTATE GYRUS; DRUG MECHANISM; DRUG RECEPTOR BINDING; HIPPOCAMPUS; MECHANOTRANSDUCTION; NERVOUS SYSTEM DEVELOPMENT; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PSYCHOPHARMACOLOGY; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SECOND MESSENGER; SEROTONIN RELEASE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSION; HUMANS; SECOND MESSENGER SYSTEMS; SOMATOMEDINS; TRANS-ACTIVATION (GENETICS);

EID: 27744485503     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2005.10.005     Document Type: Review

References (78)

1. M. Briley Understanding Antidepressants 2000 Martin Dunitz Ltd
2. M. van Baardewijk Cost effectiveness of duloxetine compared with venlafaxine-XR in the treatment of major depressive disorder Curr. Med. Res. Opin. 21 2005 1271 1279
3. J.E. Malberg Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J. Neurosci. 20 2000 9104 9110
4. B. Czeh Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine Proc. Natl. Acad. Sci. U. S. A. 98 2001 12796 12801
5. Schildkraut The catecholamine hypothesis of affective disorder: a review of supporting evidence Am. J. Psychiatry 122 1965 509 522
6. D.S. Charney Monoamine dysfunction and the pathophysiology and treatment of depression J. Clin. Psychiatry 59 Suppl. 14 1998 11 14
7. H. Ozawa, and M.M. Rasenick Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs J. Neurochem. 56 1991 330 338
8. D.B. Menkes Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment Science 219 1983 65 67
9. E.J. Nestler Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex J. Neurochem. 53 1989 1644 1647
10. G. Hansen Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D Proc. Natl. Acad. Sci. U. S. A. 97 2000 6751 6756
11. T. Itoh Effects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behavior, CRE-binding activity and BDNF level in learned helplessness rats Eur. J. Pharmacol. 498 2004 135 142
12. H.T. Zhang Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme Neuropsychopharmacology 27 2002 587 595
13. M. Takahashi Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms J. Neurosci. 19 1999 610 618
14. M. Popoli Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs J. Neurochem. 74 2000 21 33
15. E. Tiraboschi Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades Neuropsychopharmacology 29 2004 1831 1840
16. M. Johannessen What turns CREB on? Cell. Signal. 16 2004 1211 1227
17. K.K. Yamamoto Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB Nature 334 1988 494 498
18. M. Sheng CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases Science 252 1991 1427 1430
19. P. Sun Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity Genes Dev. 8 1994 2527 2539
20. J. Xing Coupling of the RAS-MAPK pathway to gene activation by RSK2, A growth factor-regulated CREB kinase Science 273 1996 959 963
21. J. Thome cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment J. Neurosci. 20 2000 4030 4036
22. A.C. Chen Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect Biol. Psychiatry 49 2001 753 762
23. T.L. Wallace Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety Biol. Psychiatry 56 2004 151 160
24. A.M. Pliakas Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens J. Neurosci. 21 2001 7397 7403
25. S.S. Newton Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect J. Neurosci. 22 2002 10883 10890
26. J.A. Blendy Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform EMBO J. 15 1996 1098 1106
27. C.L. Walters, and J.A. Blendy Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse J. Neurosci. 21 2001 9438 9444
28. A.C. Conti cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs J. Neurosci. 22 2002 3262 3268
29. A.F. Schinder Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation Neuron 25 2000 151 163
30. E.J. Huang, and L.F. Reichardt Neurotrophins: roles in neuronal development and function Annu. Rev. Neurosci. 24 2001 677 736
31. P. Ernfors Mice lacking brain-derived neurotrophic factor develop with sensory deficits Nature 368 1994 147 150
32. M. Nibuya Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J. Neurosci. 15 1995 7539 7547
33. M. Nibuya Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus J. Neurosci. 16 1996 2365 2372
34. A.L. Coppell Bi-phasic change in BDNF gene expression following antidepressant drug treatment Neuropharmacology 44 2003 903 910
35. B.G. Dias Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain Neuropharmacology 45 2003 553 563
36. M.A. Smith Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers NeuroReport 8 1997 1829 1834
37. T.S. Zetterstrom Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain Neuropharmacology 38 1999 1063 1073
38. C.A. Altar Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain Biol. Psychiatry 54 2003 703 709
39. M.A. Smith Effects of stress on neurotrophic factor expression in the rat brain Ann. N. Y. Acad. Sci. 771 1995 234 239
40. M.A. Smith Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus J. Neurosci. 15 1995 1768 1777
41. X. Tao Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism Neuron 20 1998 709 726
42. J.A. Siuciak Antidepressant-like effect of brain-derived neurotrophic factor (BDNF) Pharmacol. Biochem. Behav. 56 1997 131 137
43. Y. Shirayama Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression J. Neurosci. 22 2002 3251 3261
44. A.J. Eisch Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression Biol. Psychiatry 54 2003 994 1005
45. V. Pencea Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus J. Neurosci. 21 2001 6706 6717
46. I.Y. Liu Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning J. Neurosci. 24 2004 7958 7963
47. A. Bartoletti Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation J. Neurosci. 22 2002 10072 10077
48. K. Olofsdotter Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor Neuroscience 101 2000 531 539
49. G.M. MacQueen Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression Behav. Neurosci. 115 2001 1145 1153
50. T. Saarelainen Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects J. Neurosci. 23 2003 349 357
51. L.M. Monteggia Essential role of brain-derived neurotrophic factor in adult hippocampal function Proc. Natl. Acad. Sci. U. S. A. 101 2004 10827 10832
52. B. Zorner Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive" Biol. Psychiatry 54 2003 972 982
53. M.A. Aberg IGF-I has a direct proliferative effect in adult hippocampal progenitor cells Mol. Cell. Neurosci. 24 2003 23 40
54. M.A. Aberg Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus J. Neurosci. 20 2000 2896 2903
55. B.A. Hoshaw Central administration of IGF-1 and BDNF leads to long-lasting antidepressant-like effects Brain Res. 1037 2005 204 208
56. G.M. Leinninger Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons FASEB J. 18 2004 1544 1546
57. M.P. Mattson A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin Ageing Res. Rev. 3 2004 445 464
58. M. Holzenberger IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 2003 182 187
59. Y.I. Sheline Untreated depression and hippocampal volume loss Am. J. Psychiatry 160 2003 1516 1518
60. Y.I. Sheline Hippocampal atrophy in recurrent major depression Proc. Natl. Acad. Sci. U. S. A. 93 1996 3908 3913
61. E. Vermetten Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder Biol. Psychiatry 54 2003 693 702
62. J.E. Malberg, and L.E. Schechter Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs Curr. Pharm. Des. 11 2005 145 155
63. S. Nakagawa Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein J. Neurosci. 22 2002 3673 3682
64. S. Nakagawa Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus J. Neurosci. 22 2002 9868 9876
65. T. Fujioka Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus J. Neurosci. 24 2004 319 328
66. N.B. Hastings Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3 J. Comp. Neurol. 452 2002 324 333
67. J. Lee Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice J. Neurochem. 82 2002 1367 1375
68. M. Sairanen Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus J. Neurosci. 25 2005 1089 1094
69. G.E. Wood Stress-induced structural remodeling in hippocampus: prevention by lithium treatment Proc. Natl. Acad. Sci. U. S. A. 101 2004 3973 3978
70. L. Santarelli Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 2003 805 809
71. G. Silasi Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females Biochem. Biophys. Res. Commun. 325 2004 1223 1235
72. X. Khawaja Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: implications for depressive disorders and future therapies J. Neurosci. Res. 75 2004 451 460
73. N.M. Rupniak Elucidating the antidepressant actions of substance P (NK1 receptor) antagonists Curr. Opin. Investig. Drugs 3 2002 257 261
74. R. Alonso Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression Mol. Psychiatry 9 2004 278 286
75. M.F. Anderson Insulin-like growth factor-I and neurogenesis in the adult mammalian brain Brain Res. Dev. Brain Res. 134 2002 115 122
76. H.K. Manji Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness Biol. Psychiatry 48 2000 740 754
77. J.J. Radley, and B.L. Jacobs 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus Brain Res. 955 2002 264 267
78. M. Banasr Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone Neuropsychopharmacology 29 2004 450 460