Dopaminergic dysfunction in schizophrenia: Salience attribution revisited

Schizophrenia Bulletin

Volumn 36, Issue 3, 2010, Pages 472-485

  Heinz, Andreas ^a   Schlagenhauf, Florian ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Delusion; FDOPA; FMRI; Psychosis; Reward; Ventral striatum

Indexed keywords

CORPUS STRIATUM; DELUSION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; HUMAN; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; REVIEW; REWARD; SCHIZOPHRENIA; STRESS;

ANIMALS; CONDITIONING (PSYCHOLOGY); DELUSIONS; DOPAMINE; HUMANS; MAGNETIC RESONANCE IMAGING; MOTIVATION; NERVE NET; NEURONS; OXYGEN CONSUMPTION; PERSONAL CONSTRUCT THEORY; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; REFERENCE VALUES; REWARD; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SIGNAL TRANSDUCTION; SUBSTANCE-RELATED DISORDERS;

EID: 77953227595     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbq031     Document Type: Review

References (78)

1. Carlsson A. The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1988;1(3):179-186.
2. Wong DF, Wagner HN, Jr, Tune LE, et al. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science. 1986;234:1558-1563.
3. Farde L, Wiesel FA, Hall H, Halldin C, Stone-Elander S, Sedvall G. No D2 receptor increase in PET study of schizophrenia. Arch Gen Psychiatry. 1987;44:671-672.
4. Talkowski ME, Bamne M, Mansour H, Nimgaonkar VL. Dopamine genes and schizophrenia: case closed or evidence pending? Schizophr Bull. 2007;33:1071-1081.
5. Laruelle M, bi-Dargham A, van Dyck CH, et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA. 1996;93:9235-9240.
6. Breier A, Su TP, Saunders R, et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations:evidence fromanovelpositronemission tomography method. Proc Natl Acad Sci USA. 1997;94:2569-2574.
7. Heinz A, Saunders RC, Kolachana BS, et al. Striatal dopa-mine receptors and transporters in monkeys with neonatal temporal limbic damage. Synapse. 1999;32(2):71-79.
8. Hietala J, Syvalahti E, Vuorio K, et al. Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet. 1995;346:1130-1131.
9. Grunder G, Vernaleken I, Muller MJ, et al. Subchronic hal-operidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo. Neuropsychopharma-cology. 2003;28:787-794.
10. Guillin O, Abi-Dargham A, Laruelle M. Neurobiology of dopamine in schizophrenia. Int Rev Neurobiol. 2007;78:1-39.
11. Kumakura Y, Cumming P, Vernaleken I, et al. Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study. J Neurosci. 2007;27:8080-8087.
12. Abi-Dargham A, Rodenhiser J, Printz D, et al. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA. 2000;97:8104-8109.
13. Gefvert O, Lindstrom LH, Waters N, Waters S, Carlsson A, Tedroff J. Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine. Scand J Psychol. 2003;44:289-292.
14. Di Chiara G. The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend. 1995;38:95-137.
15. Robbins TW, Everitt BJ. Neurobehavioural mechanisms of reward and motivation. Curr Opin Neurobiol. 1996;6:228-236.
16. Wise RA. Neuroleptics and operant-behavior\the Anhedonia hypothesis. Behav Brain Sci. 1982;5:39-53.
17. Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward. Science. 1997;275:1593-1599.
18. Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993;18:247-291.
19. Heinz A. [Psychopathological correlates of dopaminergic dysfunction in alcoholic and schizophrenic patients]. Nerve-narzt. 1999;70:399-407.
20. Heinz A. Dopaminergic dysfunction in alcoholism and schizophrenia\ psychopathological and behavioral correlates. Eur Psychiatry. 2002;17(1):9-16.
21. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry. 2003;160:13-23.
22. Morrison PD, Murray RM. From real-world events to psychosis: the emerging neuropharmacology of delusions. Schizophr Bull. 2009;35:668-674.
23. Conrad C. Die beginnende Schizophrenie. Stuttgart, Germany: Thieme; 1992.
24. MillerR.Schizophrenic psychology, associative learningand the role of forebrain dopamine. Med Hypotheses. 1976;2:203-211.
25. Maher BA. Delusional thinking and perceptual disorder. J Individ Psychol. 1974;30(1):98-113.
26. Dodds CM, Muller U, ClarkL, van Loon A, Cools R,Robbins TW. Methylphenidate has differential effects on blood oxygen-ation level-dependent signal related to cognitive subprocesses of reversal learning. J Neurosci. 2008;28:5976-5982.
27. Grant KA, Shively CA, Nader MA, et al. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse. 1998;29(1):80-83.
28. Morgan D, Grant KA, Gage HD, et al. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci. 2002;5:169-174.
29. Abercrombie ED, Keefe KA, DiFrischia DS, Zigmond MJ. Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex. J Neurochem. 1989;52:1655-1658.
30. Abi-Dargham A, Mawlawi O, Lombardo I, et al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci. 2002;22:3708-3719.
31. Heinz A, Romero B, Gallinat J, Juckel G, Weinberger DR. Molecular brain imaging and the neurobiology and genetics of schizophrenia. Pharmacopsychiatry. 2003;36(suppl 3): S152-S157.
32. Durstewitz D, Seamans JK. The computational role of dopa-mine D1 receptors in working memory. Neural Netw. 2002;15:561-572.
33. Glahn DC, Ragland JD, Abramoff A, et al. Beyond hypo-frontality: a quantitative meta-analysis of functional neuroi-maging studies of working memory in schizophrenia. Hum Brain Mapp. 2005;25(1):60-69.
34. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry. 2003;160:2209-2215.
35. Tan HY, Sust S, Buckholtz JW, et al. Dysfunctional prefron-tal regional specialization and compensation in schizophrenia. Am J Psychiatry. 2006;163:1969-1977.
36. Seamans JK, Durstewitz D, Christie BR, Stevens CF, Sejnowski TJ. Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proc Natl Acad Sci USA. 2001;98:301-306.
37. SeamansJK,GorelovaN,DurstewitzD,YangCR.Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci. 2001;21:3628-3638.
38. Kegeles LS, Abi-Dargham A, Zea-Ponce Y, et al. Modulation of amphetamine-induced striatal dopamine release by ket-amine in humans: implications for schizophrenia. Biol Psychiatry. 2000;48:627-640.
39. Sesack SR, Carr DB. Selective prefrontal cortex inputs to do-pamine cells: implications for schizophrenia. Physiol Behav. 2002;77:513-517.
40. Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci. 2000;20:2369-2382.
41. Haber SN, Kim KS, Mailly P, Calzavara R. Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning. J Neurosci. 2006; 26:8368-8376.
42. Meyer-Lindenberg A, Miletich RS, Kohn PD, et al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci. 2002;5:267-271.
43. Schlagenhauf F, Wustenberg T, Schmack K, et al. Switching schizophrenia patients from typical neuroleptics to olanza-pine: effects on BOLD response during attention and working memory. Eur Neuropsychopharmacol. 2008;18:589-599.
44. Carter OL, Burr DC, Pettigrew JD, Wallis GM, Hasler F, Vollenweider FX. Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors. J Cogn Neurosci. 2005;17:1497-1508.
45. Allen PP, Cleare AJ, Lee F, et al. Effect of acute tryptophan depletion on pre-frontal engagement. Psychopharmacology (Berl). 2006;187:486-497.
46. Juckel G, Schlagenhauf F, Koslowski M, et al. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuro-image. 2006;29:409-416.
47. Juckel G, Schlagenhauf F, Koslowski M, et al. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychophar-macology (Berl). 2006;187:222-228.
48. Jensen J, Willeit M, Zipursky RB, et al. The formation of abnormal associations in schizophrenia: neural and behavioral evidence. Neuropsychopharmacology. 2007;28:294-302.
49. Murray GK, Corlett PR, Clark L, et al. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry. 2008;13:239 267-239, 276.
50. Corlett PR, Murray GK, Honey GD, et al. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain. 2007;130(pt 9):2387-2400.
51. Schlagenhauf F, Juckel G, Koslowski M, et al. Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology (Berl). 2008;196:673-684.
52. Walter H, Kammerer H, Frasch K, Spitzer M, Abler B. Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia. Psychopharmacology (Berl). 2009;206:121-132.
53. Schlagenhauf F, Sterzer P, Schmack K, et al. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol Psychiatry. 2009;65: 1032-1039.
54. Knutson B, Adams CM, Fong GW, Hommer D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci. 2001;21:RC159.
55. Zhang Z, Andersen A, Grondin R, et al. Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage. 2001;14: 1159-1167.
56. Knutson B, Gibbs SE. Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology (Berl). 2007;191:813-822.
57. Knutson B, Bjork JM, Fong GW, Hommer D, Mattay VS, Weinberger DR. Amphetamine modulates human incentive processing. Neuron. 2004;43:261-269.
58. Knutson B, Fong GW, Adams CM, Varner JL, Hommer D. Dissociation of reward anticipation and outcome with event-related fMRI. Neuroreport. 2001;12:3683-3687.
59. Heinz A, Knable MB, Coppola R, et al. Psychomotor slowing, negative symptoms and dopamine receptor availability\an IBZM SPECT study in neuroleptic-treated and drug-free schizophrenic patients. Schizophr Res. 1998; 31:19-26.
60. Schlagenhauf F, Beck A, Deserno L, et al. Altered prediction error signal during reversal learning in drug-free schizophrenia patients. 2009; Program No. 838.15/M4. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. October 17-21.
61. Kahnt T, Park SQ, Cohen MX, Beck A, Heinz A, Wrase J. Dorsal striatal-midbrain connectivity in humans predicts how reinforcements are used to guide decisions. J Cogn Neurosci. 2009;21:1332-1345.
62. Kegeles L, Frankle W, Gil R, et al. Schizophrenia is associated with increased synaptic dopamine in associative rather than limbic regions of the striatum: implications for mechanisms of action of antipsychotic drugs. J Nucl Med Meeting Abstracts. 2006;47(suppl 1):139P-139a.
63. Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010;35:4-26.
64. Fudge JL, Kunishio K, Walsh P, Richard C, Haber SN. Amygdaloid projections to ventromedial striatal subterrito-ries in the primate. Neuroscience. 2002;110:257-275.
65. Friedman DP, Aggleton JP, Saunders RC. Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: combined anterograde and retrograde tracing study in the Macaque brain. J Comp Neurol. 2002; 450:345-365.
66. Gimenez-Amaya JM, McFarland NR, de Las HS, Haber SN. Organization of thalamic projections to the ventral striatum in the primate. J Comp Neurol. 1995;354:127-149.
67. Nieuwenhuys R, Voogd J, van Huijzen C. The Human Central Nervous System. 4th ed Berlin, Heidelberg: Springer; 2008.
68. Siessmeier T, Kienast T, Wrase J, et al. Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli. Eur J Neurosci. 2006;24:305-313.
69. Kienast T, Siessmeier T, Wrase J, et al. Ratio of dopa-mine synthesis capacity to D2 receptor availability in ventral striatum correlates with central processing of affective stimuli. Eur J Nucl Med Mol Imaging. 2008;35: 1147-1158.
70. Robbins TW, Cador M, Taylor JR, Everitt BJ. Limbic-stria-tal interactions in reward-related processes. Neurosci Biobe-hav Rev. 1989;13:155-162.
71. Blankenburg W. Der Verlust der natürlichen Selbstverständ- lichkeit: Ein Beitrag zur Psychopathologie symptomarmer Schizophrenien. Stuttgart, Germany: Enke; 1971.
72. Schultz W, Apicella P, Ljungberg T. Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J Neuro-sci. 1993;13:900-913.
73. Shen W, Flajolet M, Greengard P, Surmeier DJ. Dichoto-mous dopaminergic control of striatal synaptic plasticity. Science. 2008;321:848-851.
74. Kreitzer AC, Malenka RC. Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models. Nature. 2007;445:643-647.
75. Robinson TE, Kolb B. Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J Neurosci. 1997;17:8491-8497.
76. Kienast T, Hariri AR, Schlagenhauf F, et al. Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nat Neurosci. 2008;11:1381-1382.
77. O'Doherty JP. Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol. 2004;14:769-776.
78. O'Doherty JP, Hampton A, Kim H. Model-based fMRI and its application to reward learning and decision making. Ann N Y Acad Sci. 2007;1104:35-53.