-
1
-
-
0036038421
-
In vivo evolution of the Aeromonas punctata polyhydroxyalkanoate (PHA) synthase: isolation and characterization of modified PHA synthases with enhanced activity
-
Amara A.A., Steinbuchel A., Rehm B.H. In vivo evolution of the Aeromonas punctata polyhydroxyalkanoate (PHA) synthase: isolation and characterization of modified PHA synthases with enhanced activity. Appl Microbiol Biotechnol 2002, 59:477-482.
-
(2002)
Appl Microbiol Biotechnol
, vol.59
, pp. 477-482
-
-
Amara, A.A.1
Steinbuchel, A.2
Rehm, B.H.3
-
2
-
-
38049001166
-
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
-
Atsumi S., Hanai T., Liao J.C. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 2008, 451:86-89.
-
(2008)
Nature
, vol.451
, pp. 86-89
-
-
Atsumi, S.1
Hanai, T.2
Liao, J.C.3
-
3
-
-
57449098845
-
Directed evolution of Methanococcus jannaschii citramalate synthase for biosynthesis of 1-propanol and 1-butanol by Escherichia coli
-
Atsumi S., Liao J.C. Directed evolution of Methanococcus jannaschii citramalate synthase for biosynthesis of 1-propanol and 1-butanol by Escherichia coli. Appl Environ Microbiol 2008, 74:7802-7808.
-
(2008)
Appl Environ Microbiol
, vol.74
, pp. 7802-7808
-
-
Atsumi, S.1
Liao, J.C.2
-
4
-
-
4344573757
-
Metabolic engineering and protein directed evolution increase the yield of l-phenylalanine synthesized from glucose in Escherichia coli
-
Baez-Viveros J.L., Osuna J., Hernandez-Chavez G., Soberon X., Bolivar F., Gosset G. Metabolic engineering and protein directed evolution increase the yield of l-phenylalanine synthesized from glucose in Escherichia coli. Biotechnol Bioeng 2004, 87:516-524.
-
(2004)
Biotechnol Bioeng
, vol.87
, pp. 516-524
-
-
Baez-Viveros, J.L.1
Osuna, J.2
Hernandez-Chavez, G.3
Soberon, X.4
Bolivar, F.5
Gosset, G.6
-
5
-
-
40849100220
-
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics
-
Bashor C.J., Helman N.C., Yan S., Lim W.A. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science 2008, 319:1539-1543.
-
(2008)
Science
, vol.319
, pp. 1539-1543
-
-
Bashor, C.J.1
Helman, N.C.2
Yan, S.3
Lim, W.A.4
-
6
-
-
80052261824
-
Development of an enzyme-linked immunosorbent assay analytical platform for refolding yield determination of recombinant hepatitis B virus X (HBx) protein
-
Basu A., Leong S.S. Development of an enzyme-linked immunosorbent assay analytical platform for refolding yield determination of recombinant hepatitis B virus X (HBx) protein. Anal Biochem 2011, 418:155-157.
-
(2011)
Anal Biochem
, vol.418
, pp. 155-157
-
-
Basu, A.1
Leong, S.S.2
-
7
-
-
40149094037
-
Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro
-
Bate C., Tayebi M., Williams A. Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro. Mol Neurodegeneration 2008, 3:1.
-
(2008)
Mol Neurodegeneration
, vol.3
, pp. 1
-
-
Bate, C.1
Tayebi, M.2
Williams, A.3
-
9
-
-
33751120932
-
Production of isoprenoid pharmaceuticals by engineered microbes
-
Chang M.C., Keasling J.D. Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol 2006, 2:674-681.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 674-681
-
-
Chang, M.C.1
Keasling, J.D.2
-
10
-
-
77955052132
-
High productivity refolding of an inclusion body protein using pulsed-fed size exclusion chromatography
-
Chen Y., Leong S.S.J. High productivity refolding of an inclusion body protein using pulsed-fed size exclusion chromatography. Process Biochem 2010, 45:1570-1576.
-
(2010)
Process Biochem
, vol.45
, pp. 1570-1576
-
-
Chen, Y.1
Leong, S.S.J.2
-
11
-
-
13444262309
-
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones
-
Collins C.H., Arnold F.H., Leadbetter J.R. Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Mol Microbiol 2005, 55:712-723.
-
(2005)
Mol Microbiol
, vol.55
, pp. 712-723
-
-
Collins, C.H.1
Arnold, F.H.2
Leadbetter, J.R.3
-
12
-
-
33745111577
-
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR
-
Collins C.H., Leadbetter J.R., Arnold F.H. Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nat Biotechnol 2006, 24:708-712.
-
(2006)
Nat Biotechnol
, vol.24
, pp. 708-712
-
-
Collins, C.H.1
Leadbetter, J.R.2
Arnold, F.H.3
-
13
-
-
0033824824
-
The total synthesis of (±)-Ginkgolide B
-
Crimmins M.T., Pace J.M., Nantermet P.G., Kim-Meade A.S., Thomas J.B., Watterson S.H., et al. The total synthesis of (±)-Ginkgolide B. J Am Chem Soc 2000, 122:8453-8463.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 8453-8463
-
-
Crimmins, M.T.1
Pace, J.M.2
Nantermet, P.G.3
Kim-Meade, A.S.4
Thomas, J.B.5
Watterson, S.H.6
-
14
-
-
22244449030
-
Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by l-leucine
-
de Carvalho L.P., Argyrou A., Blanchard J.S. Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by l-leucine. J Am Chem Soc 2005, 127:10004-10005.
-
(2005)
J Am Chem Soc
, vol.127
, pp. 10004-10005
-
-
de Carvalho, L.P.1
Argyrou, A.2
Blanchard, J.S.3
-
15
-
-
21044439802
-
Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine
-
Deng M.D., Severson D.K., Grund A.D., Wassink S.L., Burlingame R.P., Berry A., et al. Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine. Metab Eng 2005, 7:201-214.
-
(2005)
Metab Eng
, vol.7
, pp. 201-214
-
-
Deng, M.D.1
Severson, D.K.2
Grund, A.D.3
Wassink, S.L.4
Burlingame, R.P.5
Berry, A.6
-
16
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
Dueber J.E., Wu G.C., Malmirchegini G.R., Moon T.S., Petzold C.J., Ullal A.V., et al. Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol 2009, 27:753-759.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 753-759
-
-
Dueber, J.E.1
Wu, G.C.2
Malmirchegini, G.R.3
Moon, T.S.4
Petzold, C.J.5
Ullal, A.V.6
-
17
-
-
40849116488
-
Structure and function of enzymes involved in the biosynthesis of phenylpropanoids
-
Ferrer J.L., Austin M.B., Stewart C., Noel J.P. Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. Plant Physiol Biochem 2008, 46:356-370.
-
(2008)
Plant Physiol Biochem
, vol.46
, pp. 356-370
-
-
Ferrer, J.L.1
Austin, M.B.2
Stewart, C.3
Noel, J.P.4
-
18
-
-
77954739001
-
Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme
-
Foo J.L., Jackson C.J., Carr P.D., Kim H.K., Schenk G., Gahan L.R., et al. Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme. Biochem J 2010, 429:313-321.
-
(2010)
Biochem J
, vol.429
, pp. 313-321
-
-
Foo, J.L.1
Jackson, C.J.2
Carr, P.D.3
Kim, H.K.4
Schenk, G.5
Gahan, L.R.6
-
19
-
-
45049086849
-
Biofuel alternatives to ethanol: pumping the microbial well
-
Fortman J.L., Chhabra S., Mukhopadhyay A., Chou H., Lee T.S., Steen E., et al. Biofuel alternatives to ethanol: pumping the microbial well. Trends Biotechnol 2008, 26:375-381.
-
(2008)
Trends Biotechnol
, vol.26
, pp. 375-381
-
-
Fortman, J.L.1
Chhabra, S.2
Mukhopadhyay, A.3
Chou, H.4
Lee, T.S.5
Steen, E.6
-
20
-
-
31944447797
-
Transcriptional regulators a la carte: engineering new effector specificities in bacterial regulatory proteins
-
Galvao T.C., de Lorenzo V. Transcriptional regulators a la carte: engineering new effector specificities in bacterial regulatory proteins. Curr Opin Biotechnol 2006, 17:34-42.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 34-42
-
-
Galvao, T.C.1
de Lorenzo, V.2
-
21
-
-
0001425337
-
The enzymology of control by feedback inhibition
-
Gerhart J.C., Pardee A.B. The enzymology of control by feedback inhibition. J Biol Chem 1962, 237:891-896.
-
(1962)
J Biol Chem
, vol.237
, pp. 891-896
-
-
Gerhart, J.C.1
Pardee, A.B.2
-
22
-
-
77952473769
-
Strategies for protein synthetic biology
-
Grunberg R., Serrano L. Strategies for protein synthetic biology. Nucleic Acids Res 2010, 38:2663-2675.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2663-2675
-
-
Grunberg, R.1
Serrano, L.2
-
23
-
-
2542536213
-
Synthesis of aminoshikimic acid
-
Guo J., Frost J.W. Synthesis of aminoshikimic acid. Org Lett 2004, 6:1585-1588.
-
(2004)
Org Lett
, vol.6
, pp. 1585-1588
-
-
Guo, J.1
Frost, J.W.2
-
24
-
-
0042433113
-
Putting engineering back into protein engineering: bioinformatic approaches to catalyst design
-
Gustafsson C., Govindarajan S., Minshull J. Putting engineering back into protein engineering: bioinformatic approaches to catalyst design. Curr Opin Biotechnol 2003, 14:366-370.
-
(2003)
Curr Opin Biotechnol
, vol.14
, pp. 366-370
-
-
Gustafsson, C.1
Govindarajan, S.2
Minshull, J.3
-
25
-
-
52649129870
-
-
Anjinomoto Co., Inc, United States, (Tokyo, JP)
-
Gusyatiner M.M., Lunts M.G., Kozlov Y.I., Ivanovskaya L.V., Voroshilova E.B. DNA coding for mutant isopropylmalate synthase l-leucine-producing microorganism and method for producing l-leucine 2002, Anjinomoto Co., Inc, United States, (Tokyo, JP).
-
(2002)
DNA coding for mutant isopropylmalate synthase l-leucine-producing microorganism and method for producing l-leucine
-
-
Gusyatiner, M.M.1
Lunts, M.G.2
Kozlov, Y.I.3
Ivanovskaya, L.V.4
Voroshilova, E.B.5
-
26
-
-
40049097594
-
Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs
-
Hale V., Keasling J.D., Renninger N., Diagana T.T. Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs. Am J Trop Med Hyg 2007, 77:198-202.
-
(2007)
Am J Trop Med Hyg
, vol.77
, pp. 198-202
-
-
Hale, V.1
Keasling, J.D.2
Renninger, N.3
Diagana, T.T.4
-
27
-
-
0036168140
-
An unnatural base pair for incorporating amino acid analogs into proteins
-
Hirao I., Ohtsuki T., Fujiwara T., Mitsui T., Yokogawa T., Okuni T., et al. An unnatural base pair for incorporating amino acid analogs into proteins. Nat Biotechnol 2002, 20:177-182.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 177-182
-
-
Hirao, I.1
Ohtsuki, T.2
Fujiwara, T.3
Mitsui, T.4
Yokogawa, T.5
Okuni, T.6
-
28
-
-
0019330505
-
Gene surgery: on the threshold of synthetic biology
-
Hobom B. Gene surgery: on the threshold of synthetic biology. Med Klin 1980, 75:834-841.
-
(1980)
Med Klin
, vol.75
, pp. 834-841
-
-
Hobom, B.1
-
29
-
-
37549047246
-
In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
-
Jackson C.J., Foo J.L., Kim H.K., Carr P.D., Liu J.W., Salem G., et al. In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase. J Mol Biol 2008, 375:1189-1196.
-
(2008)
J Mol Biol
, vol.375
, pp. 1189-1196
-
-
Jackson, C.J.1
Foo, J.L.2
Kim, H.K.3
Carr, P.D.4
Liu, J.W.5
Salem, G.6
-
30
-
-
76049124264
-
Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
-
Jackson C.J., Foo J.L., Tokuriki N., Afriat L., Carr P.D., Kim H.K., et al. Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase. Proc Natl Acad Sci USA 2009, 106:21631-21636.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21631-21636
-
-
Jackson, C.J.1
Foo, J.L.2
Tokuriki, N.3
Afriat, L.4
Carr, P.D.5
Kim, H.K.6
-
31
-
-
67651252932
-
Structure-based rational design of a phosphotriesterase
-
Jackson C.J., Weir K., Herlt A., Khurana J., Sutherland T.D., Horne I., et al. Structure-based rational design of a phosphotriesterase. Appl Environ Microbiol 2009, 75:5153-5156.
-
(2009)
Appl Environ Microbiol
, vol.75
, pp. 5153-5156
-
-
Jackson, C.J.1
Weir, K.2
Herlt, A.3
Khurana, J.4
Sutherland, T.D.5
Horne, I.6
-
32
-
-
40449116114
-
De novo computational design of retro-aldol enzymes
-
Jiang L., Althoff E.A., Clemente F.R., Doyle L., Rothlisberger D., Zanghellini A., et al. De novo computational design of retro-aldol enzymes. Science 2008, 319:1387-1391.
-
(2008)
Science
, vol.319
, pp. 1387-1391
-
-
Jiang, L.1
Althoff, E.A.2
Clemente, F.R.3
Doyle, L.4
Rothlisberger, D.5
Zanghellini, A.6
-
33
-
-
33644527950
-
The model organism as a system: integrating 'omics' data sets
-
Joyce A.R., Palsson B.O. The model organism as a system: integrating 'omics' data sets. Nat Rev Mol Cell Biol 2006, 7:198-210.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 198-210
-
-
Joyce, A.R.1
Palsson, B.O.2
-
34
-
-
0037870583
-
Breaking the degeneracy of the genetic code
-
Kwon I., Kirshenbaum K., Tirrell D.A. Breaking the degeneracy of the genetic code. J Am Chem Soc 2003, 125:7512-7513.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 7512-7513
-
-
Kwon, I.1
Kirshenbaum, K.2
Tirrell, D.A.3
-
35
-
-
39549087460
-
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet
-
Leconte A.M., Hwang G.T., Matsuda S., Capek P., Hari Y., Romesberg F.E. Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet. J Am Chem Soc 2008, 130:2336-2343.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 2336-2343
-
-
Leconte, A.M.1
Hwang, G.T.2
Matsuda, S.3
Capek, P.4
Hari, Y.5
Romesberg, F.E.6
-
36
-
-
57049098094
-
Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
-
Lee S.K., Chou H., Ham T.S., Lee T.S., Keasling J.D. Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels. Curr Opin Biotechnol 2008, 19:556-563.
-
(2008)
Curr Opin Biotechnol
, vol.19
, pp. 556-563
-
-
Lee, S.K.1
Chou, H.2
Ham, T.S.3
Lee, T.S.4
Keasling, J.D.5
-
37
-
-
34648828365
-
Directed evolution of AraC for improved compatibility of arabinose- and lactose-inducible promoters
-
Lee S.K., Chou H.H., Pfleger B.F., Newman J.D., Yoshikuni Y., Keasling J.D. Directed evolution of AraC for improved compatibility of arabinose- and lactose-inducible promoters. Appl Environ Microbiol 2007, 73:5711-5715.
-
(2007)
Appl Environ Microbiol
, vol.73
, pp. 5711-5715
-
-
Lee, S.K.1
Chou, H.H.2
Pfleger, B.F.3
Newman, J.D.4
Yoshikuni, Y.5
Keasling, J.D.6
-
38
-
-
77956371200
-
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
-
Leonard E., Ajikumar P.K., Thayer K., Xiao W.H., Mo J.D., Tidor B., et al. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc Natl Acad Sci USA 2010, 107:13654-13659.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13654-13659
-
-
Leonard, E.1
Ajikumar, P.K.2
Thayer, K.3
Xiao, W.H.4
Mo, J.D.5
Tidor, B.6
-
39
-
-
33847616971
-
Growth of novel protein structural data
-
Levitt M. Growth of novel protein structural data. Proc Natl Acad Sci USA 2007, 104:3183-3188.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3183-3188
-
-
Levitt, M.1
-
41
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin V.J., Pitera D.J., Withers S.T., Newman J.D., Keasling J.D. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 2003, 21:796-802.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 796-802
-
-
Martin, V.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
42
-
-
77955658243
-
Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars
-
Nair N.U., Zhao H. Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars. Metab Eng 2010, 12:462-468.
-
(2010)
Metab Eng
, vol.12
, pp. 462-468
-
-
Nair, N.U.1
Zhao, H.2
-
43
-
-
77949772551
-
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome
-
Neumann H., Wang K., Davis L., Garcia-Alai M., Chin J.W. Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 2010, 464:441-444.
-
(2010)
Nature
, vol.464
, pp. 441-444
-
-
Neumann, H.1
Wang, K.2
Davis, L.3
Garcia-Alai, M.4
Chin, J.W.5
-
44
-
-
0032485881
-
Enzymes harboring unnatural amino acids: mechanistic and structural analysis of the enhanced catalytic activity of a glutathione transferase containing 5-fluorotryptophan
-
Parsons J.F., Xiao G., Gilliland G.L., Armstrong R.N. Enzymes harboring unnatural amino acids: mechanistic and structural analysis of the enhanced catalytic activity of a glutathione transferase containing 5-fluorotryptophan. Biochemistry 1998, 37:6286-6294.
-
(1998)
Biochemistry
, vol.37
, pp. 6286-6294
-
-
Parsons, J.F.1
Xiao, G.2
Gilliland, G.L.3
Armstrong, R.N.4
-
45
-
-
33847309176
-
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
-
Pitera D.J., Paddon C.J., Newman J.D., Keasling J.D. Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng 2007, 9:193-207.
-
(2007)
Metab Eng
, vol.9
, pp. 193-207
-
-
Pitera, D.J.1
Paddon, C.J.2
Newman, J.D.3
Keasling, J.D.4
-
46
-
-
66249088017
-
The second wave of synthetic biology: from modules to systems
-
Purnick P.E., Weiss R. The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol 2009, 10:410-422.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 410-422
-
-
Purnick, P.E.1
Weiss, R.2
-
47
-
-
3042777950
-
Creation of a shikimate pathway variant
-
Ran N., Draths K.M., Frost J.W. Creation of a shikimate pathway variant. J Am Chem Soc 2004, 126:6856-6857.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 6856-6857
-
-
Ran, N.1
Draths, K.M.2
Frost, J.W.3
-
48
-
-
34249012749
-
Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase
-
Ran N., Frost J.W. Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase. J Am Chem Soc 2007, 129:6130-6139.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 6130-6139
-
-
Ran, N.1
Frost, J.W.2
-
49
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro D.K., Paradise E.M., Ouellet M., Fisher K.J., Newman K.L., Ndungu J.M., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440:940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
-
50
-
-
33645325418
-
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli
-
Ryu Y., Schultz P.G. Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nat Methods 2006, 3:263-265.
-
(2006)
Nat Methods
, vol.3
, pp. 263-265
-
-
Ryu, Y.1
Schultz, P.G.2
-
51
-
-
80051910411
-
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
-
Saeidi N., Wong C.K., Lo T.-M., Nguyen H.X., Ling H., Leong S.S.J., et al. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Mol Syst Biol 2011, 7:521.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 521
-
-
Saeidi, N.1
Wong, C.K.2
Lo, T.-M.3
Nguyen, H.X.4
Ling, H.5
Leong, S.S.J.6
-
52
-
-
39649119874
-
Melanin-based high-throughput screen for l-tyrosine production in Escherichia coli
-
Santos C.N., Stephanopoulos G. Melanin-based high-throughput screen for l-tyrosine production in Escherichia coli. Appl Environ Microbiol 2008, 74:1190-1197.
-
(2008)
Appl Environ Microbiol
, vol.74
, pp. 1190-1197
-
-
Santos, C.N.1
Stephanopoulos, G.2
-
53
-
-
77951221728
-
Protein structure prediction begins well but ends badly
-
Saunders R., Deane C.M. Protein structure prediction begins well but ends badly. Proteins 2010, 78:1282-1290.
-
(2010)
Proteins
, vol.78
, pp. 1282-1290
-
-
Saunders, R.1
Deane, C.M.2
-
54
-
-
0014429843
-
The effect of amino acid analogues on alkaline phosphatase. Formation in Escherichia coli K-12. II. Replacement of tryptophan by azatryptophan and by tryptazan
-
Schlesinger S. The effect of amino acid analogues on alkaline phosphatase. Formation in Escherichia coli K-12. II. Replacement of tryptophan by azatryptophan and by tryptazan. J Biol Chem 1968, 243:3877-3883.
-
(1968)
J Biol Chem
, vol.243
, pp. 3877-3883
-
-
Schlesinger, S.1
-
55
-
-
0033941389
-
Molecular breeding of carotenoid biosynthetic pathways
-
Schmidt-Dannert C., Umeno D., Arnold F.H. Molecular breeding of carotenoid biosynthetic pathways. Nat Biotechnol 2000, 18:750-753.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 750-753
-
-
Schmidt-Dannert, C.1
Umeno, D.2
Arnold, F.H.3
-
56
-
-
44649153450
-
Rewiring the specificity of two-component signal transduction systems
-
Skerker J.M., Perchuk B.S., Siryaporn A., Lubin E.A., Ashenberg O., Goulian M., et al. Rewiring the specificity of two-component signal transduction systems. Cell 2008, 133:1043-1054.
-
(2008)
Cell
, vol.133
, pp. 1043-1054
-
-
Skerker, J.M.1
Perchuk, B.S.2
Siryaporn, A.3
Lubin, E.A.4
Ashenberg, O.5
Goulian, M.6
-
57
-
-
75749125061
-
Microbial production of fatty-acid-derived fuels and chemicals from plant biomass
-
Steen E.J., Kang Y., Bokinsky G., Hu Z., Schirmer A., McClure A., et al. Microbial production of fatty-acid-derived fuels and chemicals from plant biomass. Nature 2010, 463:559-562.
-
(2010)
Nature
, vol.463
, pp. 559-562
-
-
Steen, E.J.1
Kang, Y.2
Bokinsky, G.3
Hu, Z.4
Schirmer, A.5
McClure, A.6
-
58
-
-
0037420737
-
Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis
-
Stutzman-Engwall K., Conlon S., Fedechko R., Kaczmarek F., McArthur H., Krebber A., et al. Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. Biotechnol Bioeng 2003, 82:359-369.
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 359-369
-
-
Stutzman-Engwall, K.1
Conlon, S.2
Fedechko, R.3
Kaczmarek, F.4
McArthur, H.5
Krebber, A.6
-
59
-
-
20844451538
-
Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis
-
Stutzman-Engwall K., Conlon S., Fedechko R., McArthur H., Pekrun K., Chen Y., et al. Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis. Metab Eng 2005, 7:27-37.
-
(2005)
Metab Eng
, vol.7
, pp. 27-37
-
-
Stutzman-Engwall, K.1
Conlon, S.2
Fedechko, R.3
McArthur, H.4
Pekrun, K.5
Chen, Y.6
-
60
-
-
42149120662
-
AraC regulatory protein mutants with altered effector specificity
-
Tang S.Y., Fazelinia H., Cirino P.C. AraC regulatory protein mutants with altered effector specificity. J Am Chem Soc 2008, 130:5267-5271.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 5267-5271
-
-
Tang, S.Y.1
Fazelinia, H.2
Cirino, P.C.3
-
61
-
-
33749451187
-
Engineering a beta-carotene ketolase for astaxanthin production
-
Tao L., Wilczek J., Odom J.M., Cheng Q. Engineering a beta-carotene ketolase for astaxanthin production. Metab Eng 2006, 8:523-531.
-
(2006)
Metab Eng
, vol.8
, pp. 523-531
-
-
Tao, L.1
Wilczek, J.2
Odom, J.M.3
Cheng, Q.4
-
62
-
-
78751488915
-
A new bioproduction route for a novel antimicrobial peptide
-
Tay D.K., Rajagopalan G., Li X., Chen Y., Lua L.H., Leong S.S. A new bioproduction route for a novel antimicrobial peptide. Biotechnol Bioeng 2010, 108:572-581.
-
(2010)
Biotechnol Bioeng
, vol.108
, pp. 572-581
-
-
Tay, D.K.1
Rajagopalan, G.2
Li, X.3
Chen, Y.4
Lua, L.H.5
Leong, S.S.6
-
64
-
-
78651389634
-
Improving a natural enzyme activity through incorporation of unnatural amino acids
-
Ugwumba I.N., Ozawa K., Xu Z.Q., Ely F., Foo J.L., Herlt A.J., et al. Improving a natural enzyme activity through incorporation of unnatural amino acids. J Am Chem Soc 2011, 133:326-333.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 326-333
-
-
Ugwumba, I.N.1
Ozawa, K.2
Xu, Z.Q.3
Ely, F.4
Foo, J.L.5
Herlt, A.J.6
-
65
-
-
0037978128
-
A C35 carotenoid biosynthetic pathway
-
Umeno D., Arnold F.H. A C35 carotenoid biosynthetic pathway. Appl Environ Microbiol 2003, 69:3573-3579.
-
(2003)
Appl Environ Microbiol
, vol.69
, pp. 3573-3579
-
-
Umeno, D.1
Arnold, F.H.2
-
66
-
-
1342304132
-
Evolution of a pathway to novel long-chain carotenoids
-
Umeno D., Arnold F.H. Evolution of a pathway to novel long-chain carotenoids. J Bacteriol 2004, 186:1531-1536.
-
(2004)
J Bacteriol
, vol.186
, pp. 1531-1536
-
-
Umeno, D.1
Arnold, F.H.2
-
67
-
-
0036882112
-
Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway
-
Umeno D., Tobias A.V., Arnold F.H. Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. J Bacteriol 2002, 184:6690-6699.
-
(2002)
J Bacteriol
, vol.184
, pp. 6690-6699
-
-
Umeno, D.1
Tobias, A.V.2
Arnold, F.H.3
-
68
-
-
79960130724
-
Gingkolide B as migraine preventive treatment in young age: results at 1-year follow-up
-
Usai S., Grazzi L., Bussone G. Gingkolide B as migraine preventive treatment in young age: results at 1-year follow-up. Neurol Sci 2011, 32(Suppl 1):S197-S199.
-
(2011)
Neurol Sci
, vol.32
, Issue.SUPPL. 1
-
-
Usai, S.1
Grazzi, L.2
Bussone, G.3
-
69
-
-
72949090352
-
Incorporation of unnatural amino acids for synthetic biology
-
Voloshchuk N., Montclare J.K. Incorporation of unnatural amino acids for synthetic biology. Mol Biosyst 2009, 6:65-80.
-
(2009)
Mol Biosyst
, vol.6
, pp. 65-80
-
-
Voloshchuk, N.1
Montclare, J.K.2
-
70
-
-
0034518317
-
Directed evolution of metabolically engineered Escherichia coli for carotenoid production
-
Wang C., Oh M.K., Liao J.C. Directed evolution of metabolically engineered Escherichia coli for carotenoid production. Biotechnol Prog 2000, 16:922-926.
-
(2000)
Biotechnol Prog
, vol.16
, pp. 922-926
-
-
Wang, C.1
Oh, M.K.2
Liao, J.C.3
-
71
-
-
0035917812
-
Expanding the genetic code of Escherichia coli
-
Wang L., Brock A., Herberich B., Schultz P.G. Expanding the genetic code of Escherichia coli. Science 2001, 292:498-500.
-
(2001)
Science
, vol.292
, pp. 498-500
-
-
Wang, L.1
Brock, A.2
Herberich, B.3
Schultz, P.G.4
-
72
-
-
0028118162
-
A valine-resistant mutant of Arabidopsis thaliana displays an acetolactate synthase with altered feedback control
-
Wu K., Mourad G., King J. A valine-resistant mutant of Arabidopsis thaliana displays an acetolactate synthase with altered feedback control. Planta 1994, 192:249-255.
-
(1994)
Planta
, vol.192
, pp. 249-255
-
-
Wu, K.1
Mourad, G.2
King, J.3
-
73
-
-
33749019097
-
A chemical toolkit for proteins-an expanded genetic code
-
Xie J., Schultz P.G. A chemical toolkit for proteins-an expanded genetic code. Nat Rev Mol Cell Biol 2006, 7:775-782.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 775-782
-
-
Xie, J.1
Schultz, P.G.2
-
74
-
-
44949201614
-
Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways
-
Yoshikuni Y., Dietrich J.A., Nowroozi F.F., Babbitt P.C., Keasling J.D. Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways. Chem Biol 2008, 15:607-618.
-
(2008)
Chem Biol
, vol.15
, pp. 607-618
-
-
Yoshikuni, Y.1
Dietrich, J.A.2
Nowroozi, F.F.3
Babbitt, P.C.4
Keasling, J.D.5
-
75
-
-
33646178621
-
Designed divergent evolution of enzyme function
-
Yoshikuni Y., Ferrin T.E., Keasling J.D. Designed divergent evolution of enzyme function. Nature 2006, 440:1078-1082.
-
(2006)
Nature
, vol.440
, pp. 1078-1082
-
-
Yoshikuni, Y.1
Ferrin, T.E.2
Keasling, J.D.3
-
76
-
-
30744464570
-
Engineering cotton (+)-delta-cadinene synthase to an altered function: germacrene d-4-ol synthase
-
Yoshikuni Y., Martin V.J., Ferrin T.E., Keasling J.D. Engineering cotton (+)-delta-cadinene synthase to an altered function: germacrene d-4-ol synthase. Chem Biol 2006, 13:91-98.
-
(2006)
Chem Biol
, vol.13
, pp. 91-98
-
-
Yoshikuni, Y.1
Martin, V.J.2
Ferrin, T.E.3
Keasling, J.D.4
-
77
-
-
79952181220
-
Challenges and advances in computational docking: 2009 in review
-
Yuriev E., Agostino M., Ramsland P.A. Challenges and advances in computational docking: 2009 in review. J Mol Recognit 2011, 24:149-164.
-
(2011)
J Mol Recognit
, vol.24
, pp. 149-164
-
-
Yuriev, E.1
Agostino, M.2
Ramsland, P.A.3
-
78
-
-
77950899704
-
Expanding metabolism for total biosynthesis of the nonnatural amino acid l-homoalanine
-
Zhang K., Li H., Cho K.M., Liao J.C. Expanding metabolism for total biosynthesis of the nonnatural amino acid l-homoalanine. Proc Natl Acad Sci USA 2010, 107:6234-6239.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6234-6239
-
-
Zhang, K.1
Li, H.2
Cho, K.M.3
Liao, J.C.4
-
79
-
-
58549111802
-
Expanding metabolism for biosynthesis of nonnatural alcohols
-
Zhang K., Sawaya M.R., Eisenberg D.S., Liao J.C. Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci USA 2008, 105:20653-20658.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20653-20658
-
-
Zhang, K.1
Sawaya, M.R.2
Eisenberg, D.S.3
Liao, J.C.4
-
80
-
-
44949145113
-
Progress and challenges in protein structure prediction
-
Zhang Y. Progress and challenges in protein structure prediction. Curr Opin Struct Biol 2008, 18:342-348.
-
(2008)
Curr Opin Struct Biol
, vol.18
, pp. 342-348
-
-
Zhang, Y.1
-
81
-
-
64549115839
-
Protein structure prediction: when is it useful?
-
Zhang Y. Protein structure prediction: when is it useful?. Curr Opin Struct Biol 2009, 19:145-155.
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 145-155
-
-
Zhang, Y.1
-
82
-
-
73949132404
-
High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides
-
Zhou C., Qi X., Li P., Chen W.N., Mouad L., Chang M.W., et al. High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides. Biomacromolecules 2010, 11:60-67.
-
(2010)
Biomacromolecules
, vol.11
, pp. 60-67
-
-
Zhou, C.1
Qi, X.2
Li, P.3
Chen, W.N.4
Mouad, L.5
Chang, M.W.6
|