Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

Science

Volumn 319, Issue 5869, 2008, Pages 1539-1543

  Bashor, Caleb J ^a,b   Helman, Noah C ^a   Yan, Shude ^a   Lim, Wendell A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN STE5; UNCLASSIFIED DRUG;

BIOTECHNOLOGY; ENZYME; PHYSIOLOGICAL RESPONSE; PROTEIN; YEAST;

ADAPTATION; ARTICLE; BINDING SITE; BIOTECHNOLOGY; ENZYME ENGINEERING; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; FEEDBACK, BIOCHEMICAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUCINE ZIPPERS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS; PROTEIN TYROSINE PHOSPHATASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SYSTEMS BIOLOGY;

EID: 40849100220     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1151153     Document Type: Article

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