Slow-onset feedback inhibition: Inhibition of Mycobacterium tuberculosis α-isopropylmalate synthase by L-leucine

Journal of the American Chemical Society

Volumn 127, Issue 28, 2005, Pages 10004-10005

  De Carvalho, Luiz P S ^a   Argyrou, Argyrides ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOPROPYLMALATE SYNTHASE; LEUCINE;

AMINO ACID SYNTHESIS; ARTICLE; BINDING COMPETITION; BINDING KINETICS; BINDING SITE; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; CURVE FITTING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ISOMERIZATION; MYCOBACTERIUM TUBERCULOSIS;

2-ISOPROPYLMALATE SYNTHASE; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDBACK, BIOCHEMICAL; KINETICS; LEUCINE; MYCOBACTERIUM TUBERCULOSIS; TIME FACTORS;

EID: 22244449030     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja052513h     Document Type: Article

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