Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis

Metabolic Engineering

Volumn 7, Issue 1 SPEC. ISS., 2005, Pages 27-37

  Stutzman Engwall, Kim ^a   Conlon, Steve ^a   Fedechko, Ronald ^a   McArthur, Hamish ^a   Pekrun, Katja ^b   Chen, Yan ^b   Jenne, Stephane ^c   La, Charlene ^c   Trinh, Na ^c   Kim, Seran ^c   Zhang, Ying Xin ^c   Fox, Richard ^c   Gustafsson, Claes ^b   Krebber, Anke ^c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Maxygen   (United States)

^c Codexis ^*  (United States)

Author keywords

aveC; Semi synthetic DNA shuffling; Streptomyces avermitilis

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BIOSYNTHESIS; BYPRODUCTS; GENES; MASS SPECTROMETRY;

DORAMECTIN; GENE ENCODING; GENE VARIANTS; MUTATION;

DNA;

DORAMECTIN;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOSYNTHESIS; CHROMOSOME INSERTION; DNA SHUFFLING; DRUG MANUFACTURE; GENE AVEC; GENE LIBRARY; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

STREPTOMYCES AVERMITILIS;

EID: 20844451538     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2004.07.003     Document Type: Article

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