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41
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0343434726
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note
-
Attempts to convert the syn isomer to the anti isomer via the Mitsunobu inversion led only to Michael addition of the acetylenic ester in the hydrolysis step.
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42
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0000224619
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Nakamura, E.; Kuwajima, I. J. Am. Chem. Soc. 1984, 106, 3368. Nakamura, E.; Aoki, S.; Sekia, K.; Oshino, H.; Kuwajima, I. J. Am. Chem. Soc. 1987, 109, 8056.
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0343434727
-
-
note
-
Energy minimizations were performed in MM2 by restricting the interatomic distance of the enone β-carbon and the alkene carbon to 2.5 Å and allowing the conformation to be minimized.
-
-
-
-
48
-
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0342999208
-
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note
-
The use of secondary amides was also investigated, and although selectivies in the photocycloaddition were improved (∼5:1 desired: undesired), yields were low and the mass balance implied competitive decomposition in the photoreaction.
-
-
-
-
49
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0343434725
-
-
note
-
All attempts to preform the D ring bridged lactone prior to the photoaddition were unsuccessful.
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The structure of 80 is supported by NOE studies.
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Fétizon, M.1
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