Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Journal of Molecular Biology

Volumn 346, Issue 5, 2005, Pages 1335-1349

  Shia, Steven ^a   Stamos, Jennifer ^a,b   Kirchhofer, Daniel ^a   Fan, Bin ^a   Wu, Judy ^a   Corpuz, Raquel T ^a   Santell, Lydia ^a   Lazarus, Robert A ^a   Eigenbrot, Charles ^a  

^a GENENTECH INC   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme specificity; Hepatocyte growth factor; Hepatocyte growth factor activator; Hepatocyte growth factor activator inhibitor; X ray crystallography

Indexed keywords

APROTININ; HEPATOCYTE GROWTH FACTOR ACTIVATOR; HEPATOCYTE GROWTH FACTOR ACTIVATOR INHIBITOR 1B; HEPSIN; KALLIKREIN; MATRIPTASE; PROTEIN INHIBITOR; SCATTER FACTOR; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME BINDING; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; MOLECULAR DYNAMICS; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; X RAY;

EID: 13844296946     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.12.048     Document Type: Article

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