A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 37, 2007, Pages 14592-14597

  Tolbert, W David ^a   Daugherty, Jennifer ^a   Gao, ChongFeng ^a   Xie, Qian ^a   Miranti, Cindy ^a   Gherardi, Ermanno ^b   Woude, George Vande ^a   Xu, H Eric ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Cancer therapy; Heparin; Hepatocyte growth factor; Met antagonist; Tumor metastasis

Indexed keywords

GROWTH FACTOR RECEPTOR; HEPARIN; PROTEIN TYROSINE KINASE; RECEPTOR TYROSINE KINASE AGONIST; RECEPTOR TYROSINE KINASE ANTAGONIST; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL INVASION; CELL PROLIFERATION; CRYSTAL STRUCTURE; DIMERIZATION; DRUG MECHANISM; ENZYME ASSAY; ENZYME BINDING; GENE MUTATION; HUMAN; HUMAN CELL; KRINGLE DOMAIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE; DIMERIZATION; DISULFIDES; DOGS; ESCHERICHIA COLI; HEPARIN; HEPATOCYTE GROWTH FACTOR; HISTIDINE; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; KRINGLES; LIGHT; MICE; MODELS, BIOLOGICAL; MUTATION; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, NEUROKININ-1; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; X-RAY DIFFRACTION;

EID: 35548953605     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0704290104     Document Type: Article

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