메뉴 건너뛰기




Volumn 19, Issue 10, 2009, Pages 542-551

Crosstalk in Met receptor oncogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; NK 4; PROTEIN TYROSINE KINASE; RECEPTOR BLOCKING AGENT; SCATTER FACTOR RECEPTOR; SCATTER FACTOR RECEPTOR ANTAGONIST; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 70349329537     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2009.07.002     Document Type: Review
Times cited : (181)

References (96)
  • 1
    • 33847292778 scopus 로고    scopus 로고
    • From Tpr-Met to Met, tumorigenesis and tubes
    • Peschard P., and Park M. From Tpr-Met to Met, tumorigenesis and tubes. Oncogene 26 (2007) 1276-1285
    • (2007) Oncogene , vol.26 , pp. 1276-1285
    • Peschard, P.1    Park, M.2
  • 2
    • 33645235265 scopus 로고    scopus 로고
    • Structural basis of hepatocyte growth factor/scatter factor and MET signalling
    • Gherardi E., et al. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4046-4051
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 4046-4051
    • Gherardi, E.1
  • 3
    • 0345601083 scopus 로고    scopus 로고
    • Met, metastasis, motility and more
    • Birchmeier C., et al. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4 (2003) 915-925
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 915-925
    • Birchmeier, C.1
  • 4
    • 24944462226 scopus 로고    scopus 로고
    • CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
    • Vasyutina E., et al. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev 19 (2005) 2187-2198
    • (2005) Genes Dev , vol.19 , pp. 2187-2198
    • Vasyutina, E.1
  • 5
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    • Huh C.G., et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4477-4482
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4477-4482
    • Huh, C.G.1
  • 6
    • 3242663197 scopus 로고    scopus 로고
    • Met provides essential signals for liver regeneration
    • Borowiak M., et al. Met provides essential signals for liver regeneration. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10608-10613
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10608-10613
    • Borowiak, M.1
  • 7
    • 2942583980 scopus 로고    scopus 로고
    • Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing
    • Neuss S., et al. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 22 (2004) 405-414
    • (2004) Stem Cells , vol.22 , pp. 405-414
    • Neuss, S.1
  • 8
    • 33645506693 scopus 로고    scopus 로고
    • Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation
    • Forte G., et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 24 (2006) 23-33
    • (2006) Stem Cells , vol.24 , pp. 23-33
    • Forte, G.1
  • 9
    • 0033020148 scopus 로고    scopus 로고
    • The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun C.R., et al. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol 19 (1999) 1784-1799
    • (1999) Mol Cell Biol , vol.19 , pp. 1784-1799
    • Maroun, C.R.1
  • 10
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • Kong-Beltran M., et al. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6 (2004) 75-84
    • (2004) Cancer Cell , vol.6 , pp. 75-84
    • Kong-Beltran, M.1
  • 11
    • 0042030799 scopus 로고    scopus 로고
    • Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain
    • Lock L.S., et al. Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain. J Biol Chem 278 (2003) 30083-30090
    • (2003) J Biol Chem , vol.278 , pp. 30083-30090
    • Lock, L.S.1
  • 12
    • 0038386452 scopus 로고    scopus 로고
    • Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases
    • Peschard P., and Park M. Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell 3 (2003) 519-523
    • (2003) Cancer Cell , vol.3 , pp. 519-523
    • Peschard, P.1    Park, M.2
  • 13
    • 66349098064 scopus 로고    scopus 로고
    • Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor
    • 10.1128/MCB.01286-08
    • Paliouras G.N., et al. Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol (2009). http://mcb.asm.org/cgi/content/abstract/MCB.01286-08v1 10.1128/MCB.01286-08
    • (2009) Mol Cell Biol
    • Paliouras, G.N.1
  • 14
    • 0036000104 scopus 로고    scopus 로고
    • Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
    • Lamorte L., et al. Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell 13 (2002) 1449-1461
    • (2002) Mol Biol Cell , vol.13 , pp. 1449-1461
    • Lamorte, L.1
  • 15
    • 17144388214 scopus 로고    scopus 로고
    • CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells
    • Rodrigues S.P., et al. CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells. Mol Cancer Res 3 (2005) 183-194
    • (2005) Mol Cancer Res , vol.3 , pp. 183-194
    • Rodrigues, S.P.1
  • 16
    • 38449120668 scopus 로고    scopus 로고
    • Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor
    • Frigault M.M., et al. Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor. J Cell Physiol 214 (2008) 694-705
    • (2008) J Cell Physiol , vol.214 , pp. 694-705
    • Frigault, M.M.1
  • 17
    • 0035901973 scopus 로고    scopus 로고
    • Down-regulation of MET, the receptor for hepatocyte growth factor
    • Hammond D.E., et al. Down-regulation of MET, the receptor for hepatocyte growth factor. Oncogene 20 (2001) 2761-2770
    • (2001) Oncogene , vol.20 , pp. 2761-2770
    • Hammond, D.E.1
  • 18
    • 0035316576 scopus 로고    scopus 로고
    • Cbl: many adaptations to regulate protein tyrosine kinases
    • Thien C.B., and Langdon W.Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2 (2001) 294-307
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 294-307
    • Thien, C.B.1    Langdon, W.Y.2
  • 19
    • 34848888401 scopus 로고    scopus 로고
    • Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase
    • Kozlov G., et al. Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J Biol Chem 282 (2007) 27547-27555
    • (2007) J Biol Chem , vol.282 , pp. 27547-27555
    • Kozlov, G.1
  • 20
    • 27144512084 scopus 로고    scopus 로고
    • Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
    • Abella J.V., et al. Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol 25 (2005) 9632-9645
    • (2005) Mol Cell Biol , vol.25 , pp. 9632-9645
    • Abella, J.V.1
  • 21
    • 66149149720 scopus 로고    scopus 로고
    • Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases
    • Abella J.V., and Park M. Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. Am J Physiol Endocrinol Metab 296 (2009) E973-E984
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Abella, J.V.1    Park, M.2
  • 22
    • 36049051915 scopus 로고    scopus 로고
    • Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic degradative pathway
    • Mak H.H., et al. Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic degradative pathway. Oncogene 26 (2007) 7213-7221
    • (2007) Oncogene , vol.26 , pp. 7213-7221
    • Mak, H.H.1
  • 23
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato R., et al. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 4 (2009) 5-11
    • (2009) J Thorac Oncol , vol.4 , pp. 5-11
    • Onozato, R.1
  • 24
    • 31544462584 scopus 로고    scopus 로고
    • Somatic mutations lead to an oncogenic deletion of met in lung cancer
    • Kong-Beltran M., et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 66 (2006) 283-289
    • (2006) Cancer Res , vol.66 , pp. 283-289
    • Kong-Beltran, M.1
  • 25
    • 57749119550 scopus 로고    scopus 로고
    • Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
    • Sangwan V., et al. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem 283 (2008) 34374-34383
    • (2008) J Biol Chem , vol.283 , pp. 34374-34383
    • Sangwan, V.1
  • 26
    • 33644858301 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure
    • Sangwan V., et al. Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem 281 (2006) 221-228
    • (2006) J Biol Chem , vol.281 , pp. 221-228
    • Sangwan, V.1
  • 27
    • 57349175862 scopus 로고    scopus 로고
    • Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs
    • Goldoni S., and Iozzo R.V. Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer 123 (2008) 2473-2479
    • (2008) Int J Cancer , vol.123 , pp. 2473-2479
    • Goldoni, S.1    Iozzo, R.V.2
  • 28
    • 33947651745 scopus 로고    scopus 로고
    • LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?
    • Hedman H., and Henriksson R. LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?. Eur J Cancer 43 (2007) 676-682
    • (2007) Eur J Cancer , vol.43 , pp. 676-682
    • Hedman, H.1    Henriksson, R.2
  • 29
    • 20844462896 scopus 로고    scopus 로고
    • LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation
    • Gur G., et al. LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. EMBO J 23 (2004) 3270-3281
    • (2004) EMBO J , vol.23 , pp. 3270-3281
    • Gur, G.1
  • 30
    • 8744267487 scopus 로고    scopus 로고
    • The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases
    • Laederich M.B., et al. The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. J Biol Chem 279 (2004) 47050-47056
    • (2004) J Biol Chem , vol.279 , pp. 47050-47056
    • Laederich, M.B.1
  • 31
    • 66149095761 scopus 로고    scopus 로고
    • Decorin is a novel antagonistic ligand of the Met receptor
    • Goldoni S., et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol 185 (2009) 743-754
    • (2009) J Cell Biol , vol.185 , pp. 743-754
    • Goldoni, S.1
  • 32
    • 33847181657 scopus 로고    scopus 로고
    • LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy
    • Shattuck D.L. LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy. Mol Cell Biol 27 (2007) 1934-1946
    • (2007) Mol Cell Biol , vol.27 , pp. 1934-1946
    • Shattuck, D.L.1
  • 33
    • 0029759716 scopus 로고    scopus 로고
    • Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor
    • Wang R., et al. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 8425-8430
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 8425-8430
    • Wang, R.1
  • 34
    • 36949005451 scopus 로고    scopus 로고
    • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines
    • Nakamura Y., et al. Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Cancer Sci 99 (2008) 14-22
    • (2008) Cancer Sci , vol.99 , pp. 14-22
    • Nakamura, Y.1
  • 35
    • 65549125978 scopus 로고    scopus 로고
    • Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
    • Liu Y., et al. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development 136 (2009) 843-853
    • (2009) Development , vol.136 , pp. 843-853
    • Liu, Y.1
  • 36
    • 0035977147 scopus 로고    scopus 로고
    • A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    • Trusolino L.A., et al. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 107 (2001) 643-654
    • (2001) Cell , vol.107 , pp. 643-654
    • Trusolino, L.A.1
  • 37
    • 33645837225 scopus 로고    scopus 로고
    • Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis
    • Wilhelmsen K., et al. Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol 26 (2006) 2877-2886
    • (2006) Mol Cell Biol , vol.26 , pp. 2877-2886
    • Wilhelmsen, K.1
  • 38
    • 35648976145 scopus 로고    scopus 로고
    • Intrinsic signaling functions of the beta4 integrin intracellular domain
    • Merdek K.D., et al. Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem 282 (2007) 30322-30330
    • (2007) J Biol Chem , vol.282 , pp. 30322-30330
    • Merdek, K.D.1
  • 39
    • 33745468872 scopus 로고    scopus 로고
    • Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
    • Chen S.Y., and Chen H.C. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 26 (2006) 5155-5167
    • (2006) Mol Cell Biol , vol.26 , pp. 5155-5167
    • Chen, S.Y.1    Chen, H.C.2
  • 40
    • 38349167245 scopus 로고    scopus 로고
    • ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1
    • Swiercz J.M., et al. ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1. J Biol Chem 283 (2008) 1893-1901
    • (2008) J Biol Chem , vol.283 , pp. 1893-1901
    • Swiercz, J.M.1
  • 41
  • 42
    • 2442520826 scopus 로고    scopus 로고
    • Interplay between scatter factor receptors and B plexins controls invasive growth
    • Conrotto P., et al. Interplay between scatter factor receptors and B plexins controls invasive growth. Oncogene 23 (2004) 5131-5137
    • (2004) Oncogene , vol.23 , pp. 5131-5137
    • Conrotto, P.1
  • 43
    • 0036711644 scopus 로고    scopus 로고
    • The semaphorin 4D receptor controls invasive growth by coupling with Met
    • Giordano S., et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol 4 (2002) 720-724
    • (2002) Nat Cell Biol , vol.4 , pp. 720-724
    • Giordano, S.1
  • 44
    • 0033709223 scopus 로고    scopus 로고
    • Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer
    • Wielenga V.J., et al. Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer. Am J Pathol 157 (2000) 1563-1573
    • (2000) Am J Pathol , vol.157 , pp. 1563-1573
    • Wielenga, V.J.1
  • 45
    • 0036896923 scopus 로고    scopus 로고
    • CD44 is required for two consecutive steps in HGF/c-Met signaling
    • Orian-Rousseau V., et al. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev 16 (2002) 3074-3086
    • (2002) Genes Dev , vol.16 , pp. 3074-3086
    • Orian-Rousseau, V.1
  • 46
    • 33846077485 scopus 로고    scopus 로고
    • 1Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
    • Orian-Rousseau V., et al. 1Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell 8 (2007) 76-83
    • (2007) Mol Biol Cell , vol.8 , pp. 76-83
    • Orian-Rousseau, V.1
  • 47
    • 35648962884 scopus 로고    scopus 로고
    • CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
    • Singleton P.A., et al. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem 282 (2007) 30643-30657
    • (2007) J Biol Chem , vol.282 , pp. 30643-30657
    • Singleton, P.A.1
  • 48
    • 37549044247 scopus 로고    scopus 로고
    • Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo
    • Matzke A., et al. Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo. Mol Cell Biol 27 (2007) 8797-8806
    • (2007) Mol Cell Biol , vol.27 , pp. 8797-8806
    • Matzke, A.1
  • 49
    • 3142707564 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
    • Fischer O.M., et al. Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem 279 (2004) 28970-28978
    • (2004) J Biol Chem , vol.279 , pp. 28970-28978
    • Fischer, O.M.1
  • 50
    • 0034702178 scopus 로고    scopus 로고
    • Cross-talk between the proto-oncogenes Met and Ron
    • Follenzi A., et al. Cross-talk between the proto-oncogenes Met and Ron. Oncogene 19 (2000) 3041-3049
    • (2000) Oncogene , vol.19 , pp. 3041-3049
    • Follenzi, A.1
  • 51
    • 59849127924 scopus 로고    scopus 로고
    • Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology
    • Ishibe S., et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136 (2009) 337-345
    • (2009) Development , vol.136 , pp. 337-345
    • Ishibe, S.1
  • 52
    • 0345352666 scopus 로고    scopus 로고
    • GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
    • Popsueva A., et al. GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase. J Cell Biol 161 (2003) 119-129
    • (2003) J Cell Biol , vol.161 , pp. 119-129
    • Popsueva, A.1
  • 53
    • 0025881838 scopus 로고
    • Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing
    • Rodrigues G.A., et al. Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing. Mol Cell Biol 11 (1991) 2962-2970
    • (1991) Mol Cell Biol , vol.11 , pp. 2962-2970
    • Rodrigues, G.A.1
  • 54
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
    • Smolen G.A., et al. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 2316-2321
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 2316-2321
    • Smolen, G.A.1
  • 55
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman J.A., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316 (2007) 1039-1043
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 56
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K., et al. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci 99 (2008) 2280-2285
    • (2008) Cancer Sci , vol.99 , pp. 2280-2285
    • Okuda, K.1
  • 57
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • Cappuzzo F., et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 20 (2009) 298-304
    • (2009) Ann Oncol , vol.20 , pp. 298-304
    • Cappuzzo, F.1
  • 58
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
    • Cancer Genome Atlas Research Network1
  • 59
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti S., et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3 (2003) 347-361
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1
  • 60
    • 57749110627 scopus 로고    scopus 로고
    • MicroRNAs impair MET-mediated invasive growth
    • Migliore C., et al. MicroRNAs impair MET-mediated invasive growth. Cancer Res 68 (2008) 10128-10136
    • (2008) Cancer Res , vol.68 , pp. 10128-10136
    • Migliore, C.1
  • 61
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L., et al. A microRNA component of the p53 tumour suppressor network. Nature 447 (2007) 1130-1134
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1
  • 62
    • 0028937152 scopus 로고
    • Met Proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients
    • Rong S., et al. Met Proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res 55 (1995) 1963-1970
    • (1995) Cancer Res , vol.55 , pp. 1963-1970
    • Rong, S.1
  • 63
    • 13444278808 scopus 로고    scopus 로고
    • The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    • Lewis B.C., et al. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol. Cell. Biol. 25 (2005) 1228-1237
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1228-1237
    • Lewis, B.C.1
  • 64
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
    • Ma P.C., et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 65 (2005) 1479-1488
    • (2005) Cancer Res , vol.65 , pp. 1479-1488
    • Ma, P.C.1
  • 65
    • 57149092131 scopus 로고    scopus 로고
    • Expression and mutational analysis of MET in human solid cancers
    • Ma P.C., et al. Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer 47 (2008) 1025-1037
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 1025-1037
    • Ma, P.C.1
  • 66
    • 0027965021 scopus 로고
    • Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site
    • Lee C.C., and Yamada K.M. Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site. J Biol Chem 269 (1994) 19457-19461
    • (1994) J Biol Chem , vol.269 , pp. 19457-19461
    • Lee, C.C.1    Yamada, K.M.2
  • 67
    • 0028084984 scopus 로고
    • Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
    • Gandino L., et al. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem 269 (1994) 1815-1820
    • (1994) J Biol Chem , vol.269 , pp. 1815-1820
    • Gandino, L.1
  • 68
    • 0034673699 scopus 로고    scopus 로고
    • Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas
    • Di Renzo M.F., et al. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene 19 (2000) 1547-1555
    • (2000) Oncogene , vol.19 , pp. 1547-1555
    • Di Renzo, M.F.1
  • 69
    • 0036896226 scopus 로고    scopus 로고
    • Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion
    • Lorenzato A., et al. Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion. Cancer Res 62 (2002) 7025-7030
    • (2002) Cancer Res , vol.62 , pp. 7025-7030
    • Lorenzato, A.1
  • 70
    • 10344220547 scopus 로고    scopus 로고
    • Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele
    • Graveel C., et al. Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 17198-17203
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17198-17203
    • Graveel, C.1
  • 71
    • 40449113978 scopus 로고    scopus 로고
    • Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    • Shattuck D.L., et al. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 68 (2008) 1471-1477
    • (2008) Cancer Res , vol.68 , pp. 1471-1477
    • Shattuck, D.L.1
  • 72
    • 0033135820 scopus 로고    scopus 로고
    • The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas
    • Nakajima M., et al. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer 85 (1999) 1894-1902
    • (1999) Cancer , vol.85 , pp. 1894-1902
    • Nakajima, M.1
  • 73
    • 0034708826 scopus 로고    scopus 로고
    • Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
    • Jo M., et al. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem 275 (2000) 8806-8811
    • (2000) J Biol Chem , vol.275 , pp. 8806-8811
    • Jo, M.1
  • 74
    • 51449104064 scopus 로고    scopus 로고
    • Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer
    • Tang Z., et al. Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. Br J Cancer 99 (2008) 911-922
    • (2008) Br J Cancer , vol.99 , pp. 911-922
    • Tang, Z.1
  • 75
    • 34547881522 scopus 로고    scopus 로고
    • Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
    • Huang P.H., et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 12867-12872
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 12867-12872
    • Huang, P.H.1
  • 76
    • 65949106827 scopus 로고    scopus 로고
    • Pillay, V. et al. (2009) The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases. Neoplasia 11, 448-58, 2 p following 458
    • Pillay, V. et al. (2009) The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases. Neoplasia 11, 448-58, 2 p following 458
  • 77
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel J.M., et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318 (2007) 287-290
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1
  • 78
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S., et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res 68 (2008) 9479-9487
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1
  • 79
    • 34250186410 scopus 로고    scopus 로고
    • Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing
    • Xu K.P., and Yu F.S. Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing. Invest Ophthalmol Vis Sci 48 (2007) 2242-2248
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2242-2248
    • Xu, K.P.1    Yu, F.S.2
  • 80
    • 34548278840 scopus 로고    scopus 로고
    • Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells
    • Bonine-Summers A.R., et al. Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells. Cancer Biol Ther 6 (2007) 561-570
    • (2007) Cancer Biol Ther , vol.6 , pp. 561-570
    • Bonine-Summers, A.R.1
  • 81
    • 56249137901 scopus 로고    scopus 로고
    • HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
    • Bachleitner-Hofmann T., et al. HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol Cancer Ther 7 (2008) 3499-3508
    • (2008) Mol Cancer Ther , vol.7 , pp. 3499-3508
    • Bachleitner-Hofmann, T.1
  • 82
    • 12844262147 scopus 로고    scopus 로고
    • HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion
    • Khoury H., et al. HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion. Mol Biol Cell 16 (2005) 550-561
    • (2005) Mol Biol Cell , vol.16 , pp. 550-561
    • Khoury, H.1
  • 83
    • 0035074356 scopus 로고    scopus 로고
    • Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase
    • Nath D., et al. Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase. J Cell Sci 114 (2001) 1213-1220
    • (2001) J Cell Sci , vol.114 , pp. 1213-1220
    • Nath, D.1
  • 84
    • 34250804017 scopus 로고    scopus 로고
    • Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue
    • Lindemann K., et al. Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue. Histopathology 51 (2007) 54-62
    • (2007) Histopathology , vol.51 , pp. 54-62
    • Lindemann, K.1
  • 85
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K., et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131 (2007) 1190-1203
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1
  • 86
    • 38649119730 scopus 로고    scopus 로고
    • Signaling networks assembled by oncogenic EGFR and c-Met
    • Guo A., et al. Signaling networks assembled by oncogenic EGFR and c-Met. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 692-697
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 692-697
    • Guo, A.1
  • 87
    • 44849139232 scopus 로고    scopus 로고
    • Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
    • Mueller K.L., et al. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res 68 (2008) 3314-3322
    • (2008) Cancer Res , vol.68 , pp. 3314-3322
    • Mueller, K.L.1
  • 88
    • 40749101512 scopus 로고    scopus 로고
    • Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
    • Reznik T.E., et al. Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor. Mol Cancer Res 6 (2008) 139-150
    • (2008) Mol Cancer Res , vol.6 , pp. 139-150
    • Reznik, T.E.1
  • 89
    • 67449085889 scopus 로고    scopus 로고
    • Deletion of the ectodomain unleashes the transforming, invasive, and tumorigenic potential of the MET oncogene
    • Merlin S., et al. Deletion of the ectodomain unleashes the transforming, invasive, and tumorigenic potential of the MET oncogene. Cancer Sci 100 (2009) 633-638
    • (2009) Cancer Sci , vol.100 , pp. 633-638
    • Merlin, S.1
  • 90
    • 8644229302 scopus 로고    scopus 로고
    • Proapoptotic Function of the MET Tyrosine Kinase Receptor through Caspase Cleavage
    • Tulasne D., et al. Proapoptotic Function of the MET Tyrosine Kinase Receptor through Caspase Cleavage. Mol. Cell. Biol. 24 (2004) 10328-10339
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10328-10339
    • Tulasne, D.1
  • 91
    • 33644531889 scopus 로고    scopus 로고
    • Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and gefitinib (ZD1839, Iressa) for disseminated peritoneal scirrhous gastric cancer
    • Namiki Y., et al. Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and gefitinib (ZD1839, Iressa) for disseminated peritoneal scirrhous gastric cancer. Int J Cancer 118 (2006) 1545-1555
    • (2006) Int J Cancer , vol.118 , pp. 1545-1555
    • Namiki, Y.1
  • 92
    • 43749091506 scopus 로고    scopus 로고
    • Showering c-MET-dependent cancers with drugs
    • Knudsen B.S., and Vande Woude G. Showering c-MET-dependent cancers with drugs. Curr Opin Genet Dev 18 (2008) 87-96
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 87-96
    • Knudsen, B.S.1    Vande Woude, G.2
  • 93
    • 33846026370 scopus 로고    scopus 로고
    • Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism
    • Hoffmann K.M., et al. Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism. J Biol Chem 281 (2006) 37705-37719
    • (2006) J Biol Chem , vol.281 , pp. 37705-37719
    • Hoffmann, K.M.1
  • 94
    • 19344364598 scopus 로고    scopus 로고
    • Sema4D induces angiogenesis through Met recruitment by Plexin B1
    • Conrotto P., et al. Sema4D induces angiogenesis through Met recruitment by Plexin B1. Blood 105 (2005) 4321-4329
    • (2005) Blood , vol.105 , pp. 4321-4329
    • Conrotto, P.1
  • 95
    • 0033525829 scopus 로고    scopus 로고
    • Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met
    • van der Voort R., et al. Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met. J. Biol. Chem. 274 (1999) 6499-6506
    • (1999) J. Biol. Chem. , vol.274 , pp. 6499-6506
    • van der Voort, R.1
  • 96
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 20932-20937
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 20932-20937
    • Bean, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.