-
1
-
-
0026749442
-
Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2
-
Adachi, M., Sekiya, M., Miyachi, T., Matsuno, K., Hinoda, Y., Imai, K., Yachi, A., Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2. FEBS Lett. 314 (1992), 335–339.
-
(1992)
FEBS Lett.
, vol.314
, pp. 335-339
-
-
Adachi, M.1
Sekiya, M.2
Miyachi, T.3
Matsuno, K.4
Hinoda, Y.5
Imai, K.6
Yachi, A.7
-
2
-
-
0027531954
-
A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains
-
Ahmad, S., Banville, D., Zhao, Z., Fischer, E.H., Shen, S.H., A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Natl. Acad. Sci. USA 90 (1993), 2197–2201.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2197-2201
-
-
Ahmad, S.1
Banville, D.2
Zhao, Z.3
Fischer, E.H.4
Shen, S.H.5
-
3
-
-
0028859281
-
Selective requirement for MAP kinase activation in thymocyte differentiation
-
Alberola-Ila, J., Forbush, K.A., Seger, R., Krebs, E.G., Perlmutter, R.M., Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373 (1995), 620–623.
-
(1995)
Nature
, vol.373
, pp. 620-623
-
-
Alberola-Ila, J.1
Forbush, K.A.2
Seger, R.3
Krebs, E.G.4
Perlmutter, R.M.5
-
4
-
-
0030051779
-
PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation
-
Ali, S., Chen, Z., Lebrun, J.J., Vogel, W., Kharitonenkov, A., Kelly, P.A., Ullrich, A., PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. EMBO J. 15 (1996), 135–142.
-
(1996)
EMBO J.
, vol.15
, pp. 135-142
-
-
Ali, S.1
Chen, Z.2
Lebrun, J.J.3
Vogel, W.4
Kharitonenkov, A.5
Kelly, P.A.6
Ullrich, A.7
-
5
-
-
0346101802
-
SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor
-
Ali, S., Nouhi, Z., Chughtai, N., Ali, S., SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J. Biol. Chem. 278 (2003), 52021–52031.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52021-52031
-
-
Ali, S.1
Nouhi, Z.2
Chughtai, N.3
Ali, S.4
-
6
-
-
0029975822
-
The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf
-
Allard, J.D., Chang, H.C., Herbst, R., McNeill, H., Simon, M.A., The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122 (1996), 1137–1146.
-
(1996)
Development
, vol.122
, pp. 1137-1146
-
-
Allard, J.D.1
Chang, H.C.2
Herbst, R.3
McNeill, H.4
Simon, M.A.5
-
7
-
-
0016365161
-
Juvenile “chronic granulocytic” leukemia: a panmyelopathy with prominent monocytic involvement and circulating monocyte colony-forming cells
-
Altman, A.J., Palmer, C.G., Baehner, R.L., Juvenile “chronic granulocytic” leukemia: a panmyelopathy with prominent monocytic involvement and circulating monocyte colony-forming cells. Blood 43 (1974), 341–350.
-
(1974)
Blood
, vol.43
, pp. 341-350
-
-
Altman, A.J.1
Palmer, C.G.2
Baehner, R.L.3
-
8
-
-
0142211311
-
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
-
Araki, T., Nawa, H., Neel, B.G., Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. 278 (2003), 41677–41684.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 41677-41684
-
-
Araki, T.1
Nawa, H.2
Neel, B.G.3
-
9
-
-
4043056497
-
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
-
Araki, T., Mohi, M.G., Ismat, F.A., Bronson, R.T., Williams, I.R., Kutok, J.L., Yang, W., Pao, L.I., Gilliland, D.G., Epstein, J.A., Neel, B.G., Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat. Med. 10 (2004), 849–857.
-
(2004)
Nat. Med.
, vol.10
, pp. 849-857
-
-
Araki, T.1
Mohi, M.G.2
Ismat, F.A.3
Bronson, R.T.4
Williams, I.R.5
Kutok, J.L.6
Yang, W.7
Pao, L.I.8
Gilliland, D.G.9
Epstein, J.A.10
Neel, B.G.11
-
10
-
-
63849250390
-
Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation
-
Araki, T., Chan, G., Newbigging, S., Morikawa, L., Bronson, R.T., Neel, B.G., Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc. Natl. Acad. Sci. USA 106 (2009), 4736–4741.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4736-4741
-
-
Araki, T.1
Chan, G.2
Newbigging, S.3
Morikawa, L.4
Bronson, R.T.5
Neel, B.G.6
-
11
-
-
0032574824
-
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
-
Arman, E., Haffner-Krausz, R., Chen, Y., Heath, J.K., Lonai, P., Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. USA 95 (1998), 5082–5087.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5082-5087
-
-
Arman, E.1
Haffner-Krausz, R.2
Chen, Y.3
Heath, J.K.4
Lonai, P.5
-
12
-
-
0029787277
-
Insulin signaling in mice expressing reduced levels of Syp
-
Arrandale, J.M., Gore-Willse, A., Rocks, S., Ren, J.M., Zhu, J., Davis, A., Livingston, J.N., Rabin, D.U., Insulin signaling in mice expressing reduced levels of Syp. J. Biol. Chem. 271 (1996), 21353–21358.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21353-21358
-
-
Arrandale, J.M.1
Gore-Willse, A.2
Rocks, S.3
Ren, J.M.4
Zhu, J.5
Davis, A.6
Livingston, J.N.7
Rabin, D.U.8
-
13
-
-
18844411108
-
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
-
Bard-Chapeau, E.A., Hevener, A.L., Long, S., Zhang, E.E., Olefsky, J.M., Feng, G.S., Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat. Med. 11 (2005), 567–571.
-
(2005)
Nat. Med.
, vol.11
, pp. 567-571
-
-
Bard-Chapeau, E.A.1
Hevener, A.L.2
Long, S.3
Zhang, E.E.4
Olefsky, J.M.5
Feng, G.S.6
-
14
-
-
33745034466
-
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection
-
Bard-Chapeau, E.A., Yuan, J., Droin, N., Long, S., Zhang, E.E., Nguyen, T.V., Feng, G.S., Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol. Cell. Biol. 26 (2006), 4664–4674.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4664-4674
-
-
Bard-Chapeau, E.A.1
Yuan, J.2
Droin, N.3
Long, S.4
Zhang, E.E.5
Nguyen, T.V.6
Feng, G.S.7
-
15
-
-
0032521428
-
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2
-
Barford, D., Neel, B.G., Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. Structure 6 (1998), 249–254.
-
(1998)
Structure
, vol.6
, pp. 249-254
-
-
Barford, D.1
Neel, B.G.2
-
16
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
Bates, S.H., Stearns, W.H., Dundon, T.A., Schubert, M., Tso, A.W., Wang, Y., Banks, A.S., Lavery, H.J., Haq, A.K., Maratos-Flier, E., Neel, B.G., Schwartz, M.W., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 (2003), 856–859.
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
Neel, B.G.11
Schwartz, M.W.12
-
17
-
-
10844290923
-
Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia
-
Bentires-Alj, M., Paez, J.G., David, F.S., Keilhack, H., Halmos, B., Naoki, K., Maris, J.M., Richardson, A., Bardelli, A., Sugarbaker, D.J., Richards, W.G., Du, J., et al. Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 64 (2004), 8816–8820.
-
(2004)
Cancer Res.
, vol.64
, pp. 8816-8820
-
-
Bentires-Alj, M.1
Paez, J.G.2
David, F.S.3
Keilhack, H.4
Halmos, B.5
Naoki, K.6
Maris, J.M.7
Richardson, A.8
Bardelli, A.9
Sugarbaker, D.J.10
Richards, W.G.11
Du, J.12
-
18
-
-
0032230241
-
Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription
-
Berchtold, S., Volarevic, S., Moriggl, R., Mercep, M., Groner, B., Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription. Mol. Endocrinol. 12 (1998), 556–567.
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 556-567
-
-
Berchtold, S.1
Volarevic, S.2
Moriggl, R.3
Mercep, M.4
Groner, B.5
-
19
-
-
62649106306
-
ErbB receptors and the development of the nervous system
-
Birchmeier, C., ErbB receptors and the development of the nervous system. Exp. Cell Res. 315 (2009), 611–618.
-
(2009)
Exp. Cell Res.
, vol.315
, pp. 611-618
-
-
Birchmeier, C.1
-
20
-
-
0030708523
-
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
-
Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D.A., Rozovsky, I., Stahl, N., Yancopoulos, G.D., Greenberg, M.E., Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278 (1997), 477–483.
-
(1997)
Science
, vol.278
, pp. 477-483
-
-
Bonni, A.1
Sun, Y.2
Nadal-Vicens, M.3
Bhatt, A.4
Frank, D.A.5
Rozovsky, I.6
Stahl, N.7
Yancopoulos, G.D.8
Greenberg, M.E.9
-
21
-
-
3242663197
-
Met provides essential signals for liver regeneration
-
Borowiak, M., Garratt, A.N., Wustefeld, T., Strehle, M., Trautwein, C., Birchmeier, C., Met provides essential signals for liver regeneration. Proc. Natl. Acad. Sci. USA 101 (2004), 10608–10613.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10608-10613
-
-
Borowiak, M.1
Garratt, A.N.2
Wustefeld, T.3
Strehle, M.4
Trautwein, C.5
Birchmeier, C.6
-
22
-
-
33644680809
-
Building the mammalian heart from two sources of myocardial cells
-
Buckingham, M., Meilhac, S., Zaffran, S., Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 6 (2005), 826–835.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 826-835
-
-
Buckingham, M.1
Meilhac, S.2
Zaffran, S.3
-
23
-
-
33745265268
-
Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype
-
Carta, C., Pantaleoni, F., Bocchinfuso, G., Stella, L., Vasta, I., Sarkozy, A., Digilio, C., Palleschi, A., Pizzuti, A., Grammatico, P., Zampino, G., Dallapiccola, B., et al. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am. J. Hum. Genet. 79 (2006), 129–135.
-
(2006)
Am. J. Hum. Genet.
, vol.79
, pp. 129-135
-
-
Carta, C.1
Pantaleoni, F.2
Bocchinfuso, G.3
Stella, L.4
Vasta, I.5
Sarkozy, A.6
Digilio, C.7
Palleschi, A.8
Pizzuti, A.9
Grammatico, P.10
Zampino, G.11
Dallapiccola, B.12
-
24
-
-
18244395853
-
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor
-
Chan, R.J., Leedy, M.B., Munugalavadla, V., Voorhorst, C.S., Li, Y., Yu, M., Kapur, R., Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood 105 (2005), 3737–3742.
-
(2005)
Blood
, vol.105
, pp. 3737-3742
-
-
Chan, R.J.1
Leedy, M.B.2
Munugalavadla, V.3
Voorhorst, C.S.4
Li, Y.5
Yu, M.6
Kapur, R.7
-
25
-
-
43049093663
-
The tyrosine phosphatase Shp2 (PTPN11) in cancer
-
Chan, G., Kalaitzidis, D., Neel, B.G., The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Rev. 27 (2008), 179–192.
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 179-192
-
-
Chan, G.1
Kalaitzidis, D.2
Neel, B.G.3
-
26
-
-
63849313577
-
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis
-
Chan, G., Kalaitzidis, D., Usenko, T., Kutok, J.L., Yang, W., Mohi, M.G., Neel, B.G., Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113 (2009), 4414–4424.
-
(2009)
Blood
, vol.113
, pp. 4414-4424
-
-
Chan, G.1
Kalaitzidis, D.2
Usenko, T.3
Kutok, J.L.4
Yang, W.5
Mohi, M.G.6
Neel, B.G.7
-
27
-
-
0033214903
-
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
-
Chapman, R.S., Lourenco, P.C., Tonner, E., Flint, D.J., Selbert, S., Takeda, K., Akira, S., Clarke, A.R., Watson, C.J., Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev. 13 (1999), 2604–2616.
-
(1999)
Genes Dev.
, vol.13
, pp. 2604-2616
-
-
Chapman, R.S.1
Lourenco, P.C.2
Tonner, E.3
Flint, D.J.4
Selbert, S.5
Takeda, K.6
Akira, S.7
Clarke, A.R.8
Watson, C.J.9
-
28
-
-
0037593839
-
Identification of Shp-2 as a Stat5A phosphatase
-
Chen, Y., Wen, R., Yang, S., Schuman, J., Zhang, E.E., Yi, T., Feng, G.S., Wang, D., Identification of Shp-2 as a Stat5A phosphatase. J. Biol. Chem. 278 (2003), 16520–16527.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16520-16527
-
-
Chen, Y.1
Wen, R.2
Yang, S.3
Schuman, J.4
Zhang, E.E.5
Yi, T.6
Feng, G.S.7
Wang, D.8
-
29
-
-
0033504544
-
Juvenile myelomonocytic leukemia and Noonan syndrome
-
Choong, K., Freedman, M.H., Chitayat, D., Kelly, E.N., Taylor, G., Zipursky, A., Juvenile myelomonocytic leukemia and Noonan syndrome. J. Pediatr. Hematol. Oncol. 21 (1999), 523–527.
-
(1999)
J. Pediatr. Hematol. Oncol.
, vol.21
, pp. 523-527
-
-
Choong, K.1
Freedman, M.H.2
Chitayat, D.3
Kelly, E.N.4
Taylor, G.5
Zipursky, A.6
-
30
-
-
0033709933
-
Molecular control of neural crest formation, migration and differentiation
-
Christiansen, J.H., Coles, E.G., Wilkinson, D.G., Molecular control of neural crest formation, migration and differentiation. Curr. Opin. Cell Biol. 12 (2000), 719–724.
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 719-724
-
-
Christiansen, J.H.1
Coles, E.G.2
Wilkinson, D.G.3
-
31
-
-
0037163109
-
Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells
-
Chughtai, N., Schimchowitsch, S., Lebrun, J.J., Ali, S., Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. J. Biol. Chem. 277 (2002), 31107–31114.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31107-31114
-
-
Chughtai, N.1
Schimchowitsch, S.2
Lebrun, J.J.3
Ali, S.4
-
34
-
-
0029846756
-
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
-
Cressman, D.E., Greenbaum, L.E., DeAngelis, R.A., Ciliberto, G., Furth, E.E., Poli, V., Taub, R., Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274 (1996), 1379–1383.
-
(1996)
Science
, vol.274
, pp. 1379-1383
-
-
Cressman, D.E.1
Greenbaum, L.E.2
DeAngelis, R.A.3
Ciliberto, G.4
Furth, E.E.5
Poli, V.6
Taub, R.7
-
35
-
-
0030602798
-
The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
-
Crompton, T., Gilmour, K.C., Owen, M.J., The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86 (1996), 243–251.
-
(1996)
Cell
, vol.86
, pp. 243-251
-
-
Crompton, T.1
Gilmour, K.C.2
Owen, M.J.3
-
36
-
-
0034500793
-
Genetic insights into trophoblast differentiation and placental morphogenesis
-
Cross, J.C., Genetic insights into trophoblast differentiation and placental morphogenesis. Semin. Cell Dev. Biol. 11 (2000), 105–113.
-
(2000)
Semin. Cell Dev. Biol.
, vol.11
, pp. 105-113
-
-
Cross, J.C.1
-
37
-
-
10744221281
-
Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations
-
Digilio, M.C., Pacileo, G., Sarkozy, A., Limongelli, G., Conti, E., Cerrato, F., Marino, B., Pizzuti, A., Calabro, R., Dallapiccola, B., Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations. Birth Defects Res. A Clin. Mol. Teratol. 70 (2004), 95–98.
-
(2004)
Birth Defects Res. A Clin. Mol. Teratol.
, vol.70
, pp. 95-98
-
-
Digilio, M.C.1
Pacileo, G.2
Sarkozy, A.3
Limongelli, G.4
Conti, E.5
Cerrato, F.6
Marino, B.7
Pizzuti, A.8
Calabro, R.9
Dallapiccola, B.10
-
38
-
-
0029146540
-
Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors
-
Dong, Z., Brennan, A., Liu, N., Yarden, Y., Lefkowitz, G., Mirsky, R., Jessen, K.R., Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 15 (1995), 585–596.
-
(1995)
Neuron
, vol.15
, pp. 585-596
-
-
Dong, Z.1
Brennan, A.2
Liu, N.3
Yarden, Y.4
Lefkowitz, G.5
Mirsky, R.6
Jessen, K.R.7
-
39
-
-
0026063878
-
Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors
-
Emanuel, P.D., Bates, L.J., Castleberry, R.P., Gualtieri, R.J., Zuckerman, K.S., Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood 77 (1991), 925–929.
-
(1991)
Blood
, vol.77
, pp. 925-929
-
-
Emanuel, P.D.1
Bates, L.J.2
Castleberry, R.P.3
Gualtieri, R.J.4
Zuckerman, K.S.5
-
40
-
-
0030280090
-
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy
-
Emanuel, P.D., Shannon, K.M., Castleberry, R.P., Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. Mol. Med. Today 2 (1996), 468–475.
-
(1996)
Mol. Med. Today
, vol.2
, pp. 468-475
-
-
Emanuel, P.D.1
Shannon, K.M.2
Castleberry, R.P.3
-
41
-
-
0037213389
-
The role of hepatocytes and oval cells in liver regeneration and repopulation
-
Fausto, N., Campbell, J.S., The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev. 120 (2003), 117–130.
-
(2003)
Mech. Dev.
, vol.120
, pp. 117-130
-
-
Fausto, N.1
Campbell, J.S.2
-
42
-
-
0029557319
-
Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration
-
Fausto, N., Laird, A.D., Webber, E.M., Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J. 9 (1995), 1527–1536.
-
(1995)
FASEB J.
, vol.9
, pp. 1527-1536
-
-
Fausto, N.1
Laird, A.D.2
Webber, E.M.3
-
43
-
-
0028910939
-
Requirement of FGF-4 for postimplantation mouse development
-
Feldman, B., Poueymirou, W., Papaioannou, V.E., DeChiara, T.M., Goldfarb, M., Requirement of FGF-4 for postimplantation mouse development. Science 267 (1995), 246–249.
-
(1995)
Science
, vol.267
, pp. 246-249
-
-
Feldman, B.1
Poueymirou, W.2
Papaioannou, V.E.3
DeChiara, T.M.4
Goldfarb, M.5
-
44
-
-
33846193741
-
Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation
-
Feng, G.S., Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res. 17 (2007), 37–41.
-
(2007)
Cell Res.
, vol.17
, pp. 37-41
-
-
Feng, G.S.1
-
45
-
-
0027531637
-
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
-
Feng, G.S., Hui, C.C., Pawson, T., SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259 (1993), 1607–1611.
-
(1993)
Science
, vol.259
, pp. 1607-1611
-
-
Feng, G.S.1
Hui, C.C.2
Pawson, T.3
-
46
-
-
33749577870
-
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth
-
Fornaro, M., Burch, P.M., Yang, W., Zhang, L., Hamilton, C.E., Kim, J.H., Neel, B.G., Bennett, A.M., SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J. Cell Biol. 175 (2006), 87–97.
-
(2006)
J. Cell Biol.
, vol.175
, pp. 87-97
-
-
Fornaro, M.1
Burch, P.M.2
Yang, W.3
Zhang, L.4
Hamilton, C.E.5
Kim, J.H.6
Neel, B.G.7
Bennett, A.M.8
-
47
-
-
1542619343
-
Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation
-
Fragale, A., Tartaglia, M., Wu, J., Gelb, B.D., Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation. Hum. Mutat. 23 (2004), 267–277.
-
(2004)
Hum. Mutat.
, vol.23
, pp. 267-277
-
-
Fragale, A.1
Tartaglia, M.2
Wu, J.3
Gelb, B.D.4
-
48
-
-
0026471539
-
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew
-
Freeman, R.M. Jr., Plutzky, J., Neel, B.G., Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc. Natl. Acad. Sci. USA 89 (1992), 11239–11243.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11239-11243
-
-
Freeman, R.M.1
Plutzky, J.2
Neel, B.G.3
-
49
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
Gao, Q., Wolfgang, M.J., Neschen, S., Morino, K., Horvath, T.L., Shulman, G.I., Fu, X.Y., Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. USA 101 (2004), 4661–4666.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4661-4666
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
Morino, K.4
Horvath, T.L.5
Shulman, G.I.6
Fu, X.Y.7
-
50
-
-
0034610999
-
A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool
-
Garratt, A.N., Voiculescu, O., Topilko, P., Charnay, P., Birchmeier, C., A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J. Cell Biol. 148 (2000), 1035–1046.
-
(2000)
J. Cell Biol.
, vol.148
, pp. 1035-1046
-
-
Garratt, A.N.1
Voiculescu, O.2
Topilko, P.3
Charnay, P.4
Birchmeier, C.5
-
51
-
-
34147169468
-
Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome
-
Gauthier, A.S., Furstoss, O., Araki, T., Chan, R., Neel, B.G., Kaplan, D.R., Miller, F.D., Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron 54 (2007), 245–262.
-
(2007)
Neuron
, vol.54
, pp. 245-262
-
-
Gauthier, A.S.1
Furstoss, O.2
Araki, T.3
Chan, R.4
Neel, B.G.5
Kaplan, D.R.6
Miller, F.D.7
-
52
-
-
0037644786
-
Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm
-
Goldin, S.N., Papaioannou, V.E., Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm. Genesis 36 (2003), 40–47.
-
(2003)
Genesis
, vol.36
, pp. 40-47
-
-
Goldin, S.N.1
Papaioannou, V.E.2
-
53
-
-
20144372283
-
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
-
Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., Hamada, Y., Hiroe, T., Ito, M., Kurihara, T., Nakazato, H., Shibuya, M., et al. The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. Mol. Cell. Biol. 25 (2005), 4105–4116.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 4105-4116
-
-
Gotoh, N.1
Manova, K.2
Tanaka, S.3
Murohashi, M.4
Hadari, Y.5
Lee, A.6
Hamada, Y.7
Hiroe, T.8
Ito, M.9
Kurihara, T.10
Nakazato, H.11
Shibuya, M.12
-
54
-
-
70349728575
-
The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development
-
Grossmann, K.S., Wende, H., Paul, F.E., Cheret, C., Garratt, A.N., Zurborg, S., Feinberg, K., Besser, D., Schulz, H., Peles, E., Selbach, M., Birchmeier, W., et al. The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc. Natl. Acad. Sci. USA 106 (2009), 16704–16709.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 16704-16709
-
-
Grossmann, K.S.1
Wende, H.2
Paul, F.E.3
Cheret, C.4
Garratt, A.N.5
Zurborg, S.6
Feinberg, K.7
Besser, D.8
Schulz, H.9
Peles, E.10
Selbach, M.11
Birchmeier, W.12
-
55
-
-
0032519587
-
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development
-
Gutch, M.J., Flint, A.J., Keller, J., Tonks, N.K., Hengartner, M.O., The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev. 12 (1998), 571–585.
-
(1998)
Genes Dev.
, vol.12
, pp. 571-585
-
-
Gutch, M.J.1
Flint, A.J.2
Keller, J.3
Tonks, N.K.4
Hengartner, M.O.5
-
56
-
-
0031835659
-
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
-
Hadari, Y.R., Kouhara, H., Lax, I., Schlessinger, J., Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell. Biol. 18 (1998), 3966–3973.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3966-3973
-
-
Hadari, Y.R.1
Kouhara, H.2
Lax, I.3
Schlessinger, J.4
-
57
-
-
69949175962
-
Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development
-
Hagihara, K., Zhang, E.E., Ke, Y.H., Liu, G., Liu, J.J., Rao, Y., Feng, G.S., Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Dev. Biol 334 (2009), 276–284.
-
(2009)
Dev. Biol
, vol.334
, pp. 276-284
-
-
Hagihara, K.1
Zhang, E.E.2
Ke, Y.H.3
Liu, G.4
Liu, J.J.5
Rao, Y.6
Feng, G.S.7
-
58
-
-
33646117025
-
Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1
-
Hanna, N., Montagner, A., Lee, W.H., Miteva, M., Vidal, M., Vidaud, M., Parfait, B., Raynal, P., Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1. FEBS Lett. 580 (2006), 2477–2482.
-
(2006)
FEBS Lett.
, vol.580
, pp. 2477-2482
-
-
Hanna, N.1
Montagner, A.2
Lee, W.H.3
Miteva, M.4
Vidal, M.5
Vidaud, M.6
Parfait, B.7
Raynal, P.8
-
60
-
-
0030003293
-
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling
-
Herbst, R., Carroll, P.M., Allard, J.D., Schilling, J., Raabe, T., Simon, M.A., Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85 (1996), 899–909.
-
(1996)
Cell
, vol.85
, pp. 899-909
-
-
Herbst, R.1
Carroll, P.M.2
Allard, J.D.3
Schilling, J.4
Raabe, T.5
Simon, M.A.6
-
61
-
-
0032548830
-
Crystal structure of the tyrosine phosphatase SHP-2
-
Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M.J., Shoelson, S.E., Crystal structure of the tyrosine phosphatase SHP-2. Cell 92 (1998), 441–450.
-
(1998)
Cell
, vol.92
, pp. 441-450
-
-
Hof, P.1
Pluskey, S.2
Dhe-Paganon, S.3
Eck, M.J.4
Shoelson, S.E.5
-
62
-
-
0030028790
-
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
-
Holgado-Madruga, M., Emlet, D.R., Moscatello, D.K., Godwin, A.K., Wong, A.J., A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379 (1996), 560–564.
-
(1996)
Nature
, vol.379
, pp. 560-564
-
-
Holgado-Madruga, M.1
Emlet, D.R.2
Moscatello, D.K.3
Godwin, A.K.4
Wong, A.J.5
-
63
-
-
0035897418
-
Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway
-
Horsley, V., Friday, B.B., Matteson, S., Kegley, K.M., Gephart, J., Pavlath, G.K., Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway. J. Cell Biol. 153 (2001), 329–338.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 329-338
-
-
Horsley, V.1
Friday, B.B.2
Matteson, S.3
Kegley, K.M.4
Gephart, J.5
Pavlath, G.K.6
-
64
-
-
1842428601
-
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
-
Huh, C.G., Factor, V.M., Sanchez, A., Uchida, K., Conner, E.A., Thorgeirsson, S.S., Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl. Acad. Sci. USA 101 (2004), 4477–4482.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4477-4482
-
-
Huh, C.G.1
Factor, V.M.2
Sanchez, A.3
Uchida, K.4
Conner, E.A.5
Thorgeirsson, S.S.6
-
65
-
-
0034091082
-
A case of Noonan's syndrome with possible associated neuroblastoma
-
Ijiri, R., Tanaka, Y., Keisuke, K., Masuno, M., Imaizumi, K., A case of Noonan's syndrome with possible associated neuroblastoma. Pediatr. Radiol. 30 (2000), 432–433.
-
(2000)
Pediatr. Radiol.
, vol.30
, pp. 432-433
-
-
Ijiri, R.1
Tanaka, Y.2
Keisuke, K.3
Masuno, M.4
Imaizumi, K.5
-
66
-
-
1842525884
-
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis
-
Ivins Zito, C., Kontaridis, M.I., Fornaro, M., Feng, G.S., Bennett, A.M., SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J. Cell. Physiol. 199 (2004), 227–236.
-
(2004)
J. Cell. Physiol.
, vol.199
, pp. 227-236
-
-
Ivins Zito, C.1
Kontaridis, M.I.2
Fornaro, M.3
Feng, G.S.4
Bennett, A.M.5
-
67
-
-
25144470229
-
The origin and development of glial cells in peripheral nerves
-
Jessen, K.R., Mirsky, R., The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 6 (2005), 671–682.
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 671-682
-
-
Jessen, K.R.1
Mirsky, R.2
-
68
-
-
0034010326
-
Fate of the mammalian cardiac neural crest
-
Jiang, X., Rowitch, D.H., Soriano, P., McMahon, A.P., Sucov, H.M., Fate of the mammalian cardiac neural crest. Development 127 (2000), 1607–1616.
-
(2000)
Development
, vol.127
, pp. 1607-1616
-
-
Jiang, X.1
Rowitch, D.H.2
Soriano, P.3
McMahon, A.P.4
Sucov, H.M.5
-
69
-
-
0030448423
-
Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
-
Johe, K.K., Hazel, T.G., Muller, T., Dugich-Djordjevic, M.M., McKay, R.D., Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10 (1996), 3129–3140.
-
(1996)
Genes Dev.
, vol.10
, pp. 3129-3140
-
-
Johe, K.K.1
Hazel, T.G.2
Muller, T.3
Dugich-Djordjevic, M.M.4
McKay, R.D.5
-
70
-
-
33845939336
-
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation
-
Ke, Y., Lesperance, J., Zhang, E.E., Bard-Chapeau, E.A., Oshima, R.G., Muller, W.J., Feng, G.S., Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J. Biol. Chem. 281 (2006), 34374–34380.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 34374-34380
-
-
Ke, Y.1
Lesperance, J.2
Zhang, E.E.3
Bard-Chapeau, E.A.4
Oshima, R.G.5
Muller, W.J.6
Feng, G.S.7
-
71
-
-
34748824069
-
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality
-
Ke, Y., Zhang, E.E., Hagihara, K., Wu, D., Pang, Y., Klein, R., Curran, T., Ranscht, B., Feng, G.S., Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol. Cell. Biol. 27 (2007), 6706–6717.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6706-6717
-
-
Ke, Y.1
Zhang, E.E.2
Hagihara, K.3
Wu, D.4
Pang, Y.5
Klein, R.6
Curran, T.7
Ranscht, B.8
Feng, G.S.9
-
72
-
-
0035313584
-
Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult
-
Kegley, K.M., Gephart, J., Warren, G.L., Pavlath, G.K., Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult. Dev. Biol. 232 (2001), 115–126.
-
(2001)
Dev. Biol.
, vol.232
, pp. 115-126
-
-
Kegley, K.M.1
Gephart, J.2
Warren, G.L.3
Pavlath, G.K.4
-
73
-
-
24744465207
-
Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes
-
Keilhack, H., David, F.S., McGregor, M., Cantley, L.C., Neel, B.G., Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J. Biol. Chem. 280 (2005), 30984–30993.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 30984-30993
-
-
Keilhack, H.1
David, F.S.2
McGregor, M.3
Cantley, L.C.4
Neel, B.G.5
-
74
-
-
18844449616
-
PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience
-
Keren, B., Hadchouel, A., Saba, S., Sznajer, Y., Bonneau, D., Leheup, B., Boute, O., Gaillard, D., Lacombe, D., Layet, V., Marlin, S., Mortier, G., et al. PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience. J. Med. Genet., 41, 2004, e117.
-
(2004)
J. Med. Genet.
, vol.41
, pp. e117
-
-
Keren, B.1
Hadchouel, A.2
Saba, S.3
Sznajer, Y.4
Bonneau, D.5
Leheup, B.6
Boute, O.7
Gaillard, D.8
Lacombe, D.9
Layet, V.10
Marlin, S.11
Mortier, G.12
-
75
-
-
0024992614
-
Role of neural crest in congenital heart disease
-
Kirby, M.L., Waldo, K.L., Role of neural crest in congenital heart disease. Circulation 82 (1990), 332–340.
-
(1990)
Circulation
, vol.82
, pp. 332-340
-
-
Kirby, M.L.1
Waldo, K.L.2
-
76
-
-
0020640517
-
Neural crest cells contribute to normal aorticopulmonary septation
-
Kirby, M.L., Gale, T.F., Stewart, D.E., Neural crest cells contribute to normal aorticopulmonary septation. Science 220 (1983), 1059–1061.
-
(1983)
Science
, vol.220
, pp. 1059-1061
-
-
Kirby, M.L.1
Gale, T.F.2
Stewart, D.E.3
-
77
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W.H. 3rd, Wright, C.V., White, M.F., Arden, K.C., Accili, D., The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 (2002), 1839–1847.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs, W.H.5
Wright, C.V.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
78
-
-
2942589265
-
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway
-
Kontaridis, M.I., Eminaga, S., Fornaro, M., Zito, C.I., Sordella, R., Settleman, J., Bennett, A.M., SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol. Cell. Biol. 24 (2004), 5340–5352.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5340-5352
-
-
Kontaridis, M.I.1
Eminaga, S.2
Fornaro, M.3
Zito, C.I.4
Sordella, R.5
Settleman, J.6
Bennett, A.M.7
-
79
-
-
33646096207
-
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects
-
Kontaridis, M.I., Swanson, K.D., David, F.S., Barford, D., Neel, B.G., PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J. Biol. Chem. 281 (2006), 6785–6792.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6785-6792
-
-
Kontaridis, M.I.1
Swanson, K.D.2
David, F.S.3
Barford, D.4
Neel, B.G.5
-
80
-
-
41649085870
-
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways
-
Kontaridis, M.I., Yang, W., Bence, K.K., Cullen, D., Wang, B., Bodyak, N., Ke, Q., Hinek, A., Kang, P.M., Liao, R., Neel, B.G., Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 117 (2008), 1423–1435.
-
(2008)
Circulation
, vol.117
, pp. 1423-1435
-
-
Kontaridis, M.I.1
Yang, W.2
Bence, K.K.3
Cullen, D.4
Wang, B.5
Bodyak, N.6
Ke, Q.7
Hinek, A.8
Kang, P.M.9
Liao, R.10
Neel, B.G.11
-
81
-
-
43449123047
-
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase
-
Krajewska, M., Banares, S., Zhang, E.E., Huang, X., Scadeng, M., Jhala, U.S., Feng, G.S., Krajewski, S., Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am. J. Pathol. 172 (2008), 1312–1324.
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 1312-1324
-
-
Krajewska, M.1
Banares, S.2
Zhang, E.E.3
Huang, X.4
Scadeng, M.5
Jhala, U.S.6
Feng, G.S.7
Krajewski, S.8
-
82
-
-
57749114779
-
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome
-
Krenz, M., Gulick, J., Osinska, H.E., Colbert, M.C., Molkentin, J.D., Robbins, J., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc. Natl. Acad. Sci. USA 105 (2008), 18930–18935.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18930-18935
-
-
Krenz, M.1
Gulick, J.2
Osinska, H.E.3
Colbert, M.C.4
Molkentin, J.D.5
Robbins, J.6
-
83
-
-
37249074327
-
The protein kinases ERK1/2 and their roles in pancreatic beta cells
-
Lawrence, M., Shao, C., Duan, L., McGlynn, K., Cobb, M.H., The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiol. (Oxf.) 192 (2008), 11–17.
-
(2008)
Acta Physiol. (Oxf.)
, vol.192
, pp. 11-17
-
-
Lawrence, M.1
Shao, C.2
Duan, L.3
McGlynn, K.4
Cobb, M.H.5
-
84
-
-
7244251722
-
Neural crest cell plasticity and its limits
-
Le Douarin, N.M., Creuzet, S., Couly, G., Dupin, E., Neural crest cell plasticity and its limits. Development 131 (2004), 4637–4650.
-
(2004)
Development
, vol.131
, pp. 4637-4650
-
-
Le Douarin, N.M.1
Creuzet, S.2
Couly, G.3
Dupin, E.4
-
85
-
-
33646032137
-
Neuregulin-1 and myelination
-
Lemke, G., Neuregulin-1 and myelination. Sci. STKE, 2006, 2006, pe11.
-
(2006)
Sci. STKE
, vol.2006
, pp. pe11
-
-
Lemke, G.1
-
86
-
-
0032481143
-
Progenitor cells: what do they know and when do they know it?
-
Lillien, L., Progenitor cells: what do they know and when do they know it?. Curr. Biol. 8 (1998), R872–R874.
-
(1998)
Curr. Biol.
, vol.8
, pp. R872-R874
-
-
Lillien, L.1
-
87
-
-
0031057929
-
Stat5a is mandatory for adult mammary gland development and lactogenesis
-
Liu, X., Robinson, G.W., Wagner, K.U., Garrett, L., Wynshaw-Boris, A., Hennighausen, L., Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11 (1997), 179–186.
-
(1997)
Genes Dev.
, vol.11
, pp. 179-186
-
-
Liu, X.1
Robinson, G.W.2
Wagner, K.U.3
Garrett, L.4
Wynshaw-Boris, A.5
Hennighausen, L.6
-
88
-
-
8844272599
-
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group
-
Loh, M.L., Reynolds, M.G., Vattikuti, S., Gerbing, R.B., Alonzo, T.A., Carlson, E., Cheng, J.W., Lee, C.M., Lange, B.J., Meshinchi, S., PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group. Leukemia 18 (2004), 1831–1834.
-
(2004)
Leukemia
, vol.18
, pp. 1831-1834
-
-
Loh, M.L.1
Reynolds, M.G.2
Vattikuti, S.3
Gerbing, R.B.4
Alonzo, T.A.5
Carlson, E.6
Cheng, J.W.7
Lee, C.M.8
Lange, B.J.9
Meshinchi, S.10
-
89
-
-
12144286410
-
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
-
Loh, M.L., Vattikuti, S., Schubbert, S., Reynolds, M.G., Carlson, E., Lieuw, K.H., Cheng, J.W., Lee, C.M., Stokoe, D., Bonifas, J.M., Curtiss, N.P., Gotlib, J., et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood 103 (2004), 2325–2331.
-
(2004)
Blood
, vol.103
, pp. 2325-2331
-
-
Loh, M.L.1
Vattikuti, S.2
Schubbert, S.3
Reynolds, M.G.4
Carlson, E.5
Lieuw, K.H.6
Cheng, J.W.7
Lee, C.M.8
Stokoe, D.9
Bonifas, J.M.10
Curtiss, N.P.11
Gotlib, J.12
-
90
-
-
0030973928
-
Noonan syndrome associated with neuroblastoma: a case report
-
Lopez-Miranda, B., Westra, S.J., Yazdani, S., Boechat, M.I., Noonan syndrome associated with neuroblastoma: a case report. Pediatr. Radiol. 27 (1997), 324–326.
-
(1997)
Pediatr. Radiol.
, vol.27
, pp. 324-326
-
-
Lopez-Miranda, B.1
Westra, S.J.2
Yazdani, S.3
Boechat, M.I.4
-
91
-
-
15744394897
-
erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish
-
Lyons, D.A., Pogoda, H.M., Voas, M.G., Woods, I.G., Diamond, B., Nix, R., Arana, N., Jacobs, J., Talbot, W.S., erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish. Curr. Biol. 15 (2005), 513–524.
-
(2005)
Curr. Biol.
, vol.15
, pp. 513-524
-
-
Lyons, D.A.1
Pogoda, H.M.2
Voas, M.G.3
Woods, I.G.4
Diamond, B.5
Nix, R.6
Arana, N.7
Jacobs, J.8
Talbot, W.S.9
-
92
-
-
0033498871
-
Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal
-
Marino, B., Digilio, M.C., Toscano, A., Giannotti, A., Dallapiccola, B., Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal. J. Pediatr. 135 (1999), 703–706.
-
(1999)
J. Pediatr.
, vol.135
, pp. 703-706
-
-
Marino, B.1
Digilio, M.C.2
Toscano, A.3
Giannotti, A.4
Dallapiccola, B.5
-
93
-
-
0033761488
-
The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
-
Maroun, C.R., Naujokas, M.A., Holgado-Madruga, M., Wong, A.J., Park, M., The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 20 (2000), 8513–8525.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8513-8525
-
-
Maroun, C.R.1
Naujokas, M.A.2
Holgado-Madruga, M.3
Wong, A.J.4
Park, M.5
-
94
-
-
33646022879
-
Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors
-
Martinelli, S., Carta, C., Flex, E., Binni, F., Cordisco, E.L., Moretti, S., Puxeddu, E., Tonacchera, M., Pinchera, A., McDowell, H.P., Dominici, C., Rosolen, A., et al. Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors. Cancer Genet. Cytogenet. 166 (2006), 124–129.
-
(2006)
Cancer Genet. Cytogenet.
, vol.166
, pp. 124-129
-
-
Martinelli, S.1
Carta, C.2
Flex, E.3
Binni, F.4
Cordisco, E.L.5
Moretti, S.6
Puxeddu, E.7
Tonacchera, M.8
Pinchera, A.9
McDowell, H.P.10
Dominici, C.11
Rosolen, A.12
-
95
-
-
18744368072
-
An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis
-
Menard, C., Hein, P., Paquin, A., Savelson, A., Yang, X.M., Lederfein, D., Barnabe-Heider, F., Mir, A.A., Sterneck, E., Peterson, A.C., Johnson, P.F., Vinson, C., et al. An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron 36 (2002), 597–610.
-
(2002)
Neuron
, vol.36
, pp. 597-610
-
-
Menard, C.1
Hein, P.2
Paquin, A.3
Savelson, A.4
Yang, X.M.5
Lederfein, D.6
Barnabe-Heider, F.7
Mir, A.A.8
Sterneck, E.9
Peterson, A.C.10
Johnson, P.F.11
Vinson, C.12
-
96
-
-
0028827104
-
Multiple essential functions of neuregulin in development
-
Meyer, D., Birchmeier, C., Multiple essential functions of neuregulin in development. Nature 378 (1995), 386–390.
-
(1995)
Nature
, vol.378
, pp. 386-390
-
-
Meyer, D.1
Birchmeier, C.2
-
97
-
-
2342444048
-
Axonal neuregulin-1 regulates myelin sheath thickness
-
Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H., Nave, K.A., Axonal neuregulin-1 regulates myelin sheath thickness. Science 304 (2004), 700–703.
-
(2004)
Science
, vol.304
, pp. 700-703
-
-
Michailov, G.V.1
Sereda, M.W.2
Brinkmann, B.G.3
Fischer, T.M.4
Haug, B.5
Birchmeier, C.6
Role, L.7
Lai, C.8
Schwab, M.H.9
Nave, K.A.10
-
98
-
-
0028136280
-
Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin
-
Milarski, K.L., Saltiel, A.R., Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem. 269 (1994), 21239–21243.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21239-21243
-
-
Milarski, K.L.1
Saltiel, A.R.2
-
99
-
-
34247532433
-
Timing is everything: making neurons versus glia in the developing cortex
-
Miller, F.D., Gauthier, A.S., Timing is everything: making neurons versus glia in the developing cortex. Neuron 54 (2007), 357–369.
-
(2007)
Neuron
, vol.54
, pp. 357-369
-
-
Miller, F.D.1
Gauthier, A.S.2
-
100
-
-
44849138413
-
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors
-
Miyamoto, D., Miyamoto, M., Takahashi, A., Yomogita, Y., Higashi, H., Kondo, S., Hatakeyama, M., Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors. Oncogene 27 (2008), 3508–3515.
-
(2008)
Oncogene
, vol.27
, pp. 3508-3515
-
-
Miyamoto, D.1
Miyamoto, M.2
Takahashi, A.3
Yomogita, Y.4
Higashi, H.5
Kondo, S.6
Hatakeyama, M.7
-
101
-
-
13844265841
-
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations
-
Mohi, M.G., Williams, I.R., Dearolf, C.R., Chan, G., Kutok, J.L., Cohen, S., Morgan, K., Boulton, C., Shigematsu, H., Keilhack, H., Akashi, K., Gilliland, D.G., et al. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell 7 (2005), 179–191.
-
(2005)
Cancer Cell
, vol.7
, pp. 179-191
-
-
Mohi, M.G.1
Williams, I.R.2
Dearolf, C.R.3
Chan, G.4
Kutok, J.L.5
Cohen, S.6
Morgan, K.7
Boulton, C.8
Shigematsu, H.9
Keilhack, H.10
Akashi, K.11
Gilliland, D.G.12
-
102
-
-
0026522204
-
Profound block in thymocyte development in mice lacking p56lck
-
Molina, T.J., Kishihara, K., Siderovski, D.P., van Ewijk, W., Narendran, A., Timms, E., Wakeham, A., Paige, C.J., Hartmann, K.U., Veillette, A., et al. Profound block in thymocyte development in mice lacking p56lck. Nature 357 (1992), 161–164.
-
(1992)
Nature
, vol.357
, pp. 161-164
-
-
Molina, T.J.1
Kishihara, K.2
Siderovski, D.P.3
van Ewijk, W.4
Narendran, A.5
Timms, E.6
Wakeham, A.7
Paige, C.J.8
Hartmann, K.U.9
Veillette, A.10
-
103
-
-
14044272770
-
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
-
Montagner, A., Yart, A., Dance, M., Perret, B., Salles, J.P., Raynal, P., A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J. Biol. Chem. 280 (2005), 5350–5360.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 5350-5360
-
-
Montagner, A.1
Yart, A.2
Dance, M.3
Perret, B.4
Salles, J.P.5
Raynal, P.6
-
104
-
-
0033152451
-
Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development
-
Morris, J.K., Lin, W., Hauser, C., Marchuk, Y., Getman, D., Lee, K.F., Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron 23 (1999), 273–283.
-
(1999)
Neuron
, vol.23
, pp. 273-283
-
-
Morris, J.K.1
Lin, W.2
Hauser, C.3
Marchuk, Y.4
Getman, D.5
Lee, K.F.6
-
105
-
-
0037300995
-
Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome
-
Musante, L., Kehl, H.G., Majewski, F., Meinecke, P., Schweiger, S., Gillessen-Kaesbach, G., Wieczorek, D., Hinkel, G.K., Tinschert, S., Hoeltzenbein, M., Ropers, H.H., Kalscheuer, V.M., Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome. Eur. J. Hum. Genet. 11 (2003), 201–206.
-
(2003)
Eur. J. Hum. Genet.
, vol.11
, pp. 201-206
-
-
Musante, L.1
Kehl, H.G.2
Majewski, F.3
Meinecke, P.4
Schweiger, S.5
Gillessen-Kaesbach, G.6
Wieczorek, D.7
Hinkel, G.K.8
Tinschert, S.9
Hoeltzenbein, M.10
Ropers, H.H.11
Kalscheuer, V.M.12
-
106
-
-
0036787607
-
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae, J., Biggs, W.H. 3rd, Kitamura, T., Cavenee, W.K., Wright, C.V., Arden, K.C., Accili, D., Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32 (2002), 245–253.
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.5
Arden, K.C.6
Accili, D.7
-
107
-
-
34547656112
-
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome
-
Nakamura, T., Colbert, M., Krenz, M., Molkentin, J.D., Hahn, H.S., Dorn, G.W. 2nd, Robbins, J., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J. Clin. Invest. 117 (2007), 2123–2132.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2123-2132
-
-
Nakamura, T.1
Colbert, M.2
Krenz, M.3
Molkentin, J.D.4
Hahn, H.S.5
Dorn, G.W.6
Robbins, J.7
-
108
-
-
67650495042
-
Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development
-
Nakamura, T., Gulick, J., Colbert, M.C., Robbins, J., Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development. Proc. Natl. Acad. Sci. USA 106 (2009), 11270–11275.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 11270-11275
-
-
Nakamura, T.1
Gulick, J.2
Colbert, M.C.3
Robbins, J.4
-
109
-
-
70349304424
-
Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations
-
Nakamura, T., Gulick, J., Pratt, R., Robbins, J., Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations. Proc. Natl. Acad. Sci. USA 106 (2009), 15436–15441.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 15436-15441
-
-
Nakamura, T.1
Gulick, J.2
Pratt, R.3
Robbins, J.4
-
110
-
-
0033574767
-
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
-
Nakashima, K., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., Kawabata, M., Miyazono, K., Taga, T., Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284 (1999), 479–482.
-
(1999)
Science
, vol.284
, pp. 479-482
-
-
Nakashima, K.1
Yanagisawa, M.2
Arakawa, H.3
Kimura, N.4
Hisatsune, T.5
Kawabata, M.6
Miyazono, K.7
Taga, T.8
-
111
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
Neel, B.G., Gu, H., Pao, L., The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 28 (2003), 284–293.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
112
-
-
55949088852
-
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
-
Newbern, J., Zhong, J., Wickramasinghe, R.S., Li, X., Wu, Y., Samuels, I., Cherosky, N., Karlo, J.C., O'Loughlin, B., Wikenheiser, J., Gargesha, M., Doughman, Y.Q., et al. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc. Natl. Acad. Sci. USA 105 (2008), 17115–17120.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 17115-17120
-
-
Newbern, J.1
Zhong, J.2
Wickramasinghe, R.S.3
Li, X.4
Wu, Y.5
Samuels, I.6
Cherosky, N.7
Karlo, J.C.8
O'Loughlin, B.9
Wikenheiser, J.10
Gargesha, M.11
Doughman, Y.Q.12
-
113
-
-
33750352843
-
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals
-
Nguyen, T.V., Ke, Y., Zhang, E.E., Feng, G.S., Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J. Immunol. 177 (2006), 5990–5996.
-
(2006)
J. Immunol.
, vol.177
, pp. 5990-5996
-
-
Nguyen, T.V.1
Ke, Y.2
Zhang, E.E.3
Feng, G.S.4
-
114
-
-
21044458262
-
Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia
-
Niihori, T., Aoki, Y., Ohashi, H., Kurosawa, K., Kondoh, T., Ishikiriyama, S., Kawame, H., Kamasaki, H., Yamanaka, T., Takada, F., Nishio, K., Sakurai, M., et al. Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia. J. Hum. Genet. 50 (2005), 192–202.
-
(2005)
J. Hum. Genet.
, vol.50
, pp. 192-202
-
-
Niihori, T.1
Aoki, Y.2
Ohashi, H.3
Kurosawa, K.4
Kondoh, T.5
Ishikiriyama, S.6
Kawame, H.7
Kamasaki, H.8
Yamanaka, T.9
Takada, F.10
Nishio, K.11
Sakurai, M.12
-
115
-
-
0028124504
-
Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation
-
Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y., Kasuga, M., Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol. 14 (1994), 6674–6682.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6674-6682
-
-
Noguchi, T.1
Matozaki, T.2
Horita, K.3
Fujioka, Y.4
Kasuga, M.5
-
116
-
-
0014337521
-
Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease
-
Noonan, J.A., Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am. J. Dis. Child 116 (1968), 373–380.
-
(1968)
Am. J. Dis. Child
, vol.116
, pp. 373-380
-
-
Noonan, J.A.1
-
117
-
-
33947147117
-
Noonan syndrome and related disorders: alterations in growth and puberty
-
Noonan, J.A., Noonan syndrome and related disorders: alterations in growth and puberty. Rev. Endocr. Metab. Disord. 7 (2006), 251–255.
-
(2006)
Rev. Endocr. Metab. Disord.
, vol.7
, pp. 251-255
-
-
Noonan, J.A.1
-
118
-
-
0000269268
-
Associated non cardiac malformations in children with congenital heart disease
-
Noonan, J., Ehmke, D., Associated non cardiac malformations in children with congenital heart disease. J. Pediatr. 63 (1963), 468–470.
-
(1963)
J. Pediatr.
, vol.63
, pp. 468-470
-
-
Noonan, J.1
Ehmke, D.2
-
119
-
-
20444371557
-
PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes
-
Ogata, T., Yoshida, R., PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes. Pediatr. Endocrinol. Rev. 2 (2005), 669–674.
-
(2005)
Pediatr. Endocrinol. Rev.
, vol.2
, pp. 669-674
-
-
Ogata, T.1
Yoshida, R.2
-
120
-
-
0032932203
-
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
-
Oh, E.S., Gu, H., Saxton, T.M., Timms, J.F., Hausdorff, S., Frevert, E.U., Kahn, B.B., Pawson, T., Neel, B.G., Thomas, S.M., Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol. Cell. Biol. 19 (1999), 3205–3215.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3205-3215
-
-
Oh, E.S.1
Gu, H.2
Saxton, T.M.3
Timms, J.F.4
Hausdorff, S.5
Frevert, E.U.6
Kahn, B.B.7
Pawson, T.8
Neel, B.G.9
Thomas, S.M.10
-
121
-
-
32144447245
-
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations
-
Oishi, K., Gaengel, K., Krishnamoorthy, S., Kamiya, K., Kim, I.K., Ying, H., Weber, U., Perkins, L.A., Tartaglia, M., Mlodzik, M., Pick, L., Gelb, B.D., Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum. Mol. Genet. 15 (2006), 543–553.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 543-553
-
-
Oishi, K.1
Gaengel, K.2
Krishnamoorthy, S.3
Kamiya, K.4
Kim, I.K.5
Ying, H.6
Weber, U.7
Perkins, L.A.8
Tartaglia, M.9
Mlodzik, M.10
Pick, L.11
Gelb, B.D.12
-
122
-
-
57649203360
-
Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development
-
Oishi, K., Zhang, H., Gault, W.J., Wang, C.J., Tan, C.C., Kim, I.K., Ying, H., Rahman, T., Pica, N., Tartaglia, M., Mlodzik, M., Gelb, B.D., Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development. Hum. Mol. Genet. 18 (2009), 193–201.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 193-201
-
-
Oishi, K.1
Zhang, H.2
Gault, W.J.3
Wang, C.J.4
Tan, C.C.5
Kim, I.K.6
Ying, H.7
Rahman, T.8
Pica, N.9
Tartaglia, M.10
Mlodzik, M.11
Gelb, B.D.12
-
123
-
-
0021856560
-
The Noonan syndrome
-
Opitz, J.M., The Noonan syndrome. Am. J. Med. Genet. 21 (1985), 515–518.
-
(1985)
Am. J. Med. Genet.
, vol.21
, pp. 515-518
-
-
Opitz, J.M.1
-
124
-
-
0033989423
-
Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
-
O'Reilly, A.M., Pluskey, S., Shoelson, S.E., Neel, B.G., Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol. Cell. Biol. 20 (2000), 299–311.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 299-311
-
-
O'Reilly, A.M.1
Pluskey, S.2
Shoelson, S.E.3
Neel, B.G.4
-
125
-
-
70349451178
-
The phosphatase SHP2 regulates the spacing effect for long-term memory induction
-
Pagani, M.R., Oishi, K., Gelb, B.D., Zhong, Y., The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell 139 (2009), 186–198.
-
(2009)
Cell
, vol.139
, pp. 186-198
-
-
Pagani, M.R.1
Oishi, K.2
Gelb, B.D.3
Zhong, Y.4
-
126
-
-
34547530823
-
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
-
Pandit, B., Sarkozy, A., Pennacchio, L.A., Carta, C., Oishi, K., Martinelli, S., Pogna, E.A., Schackwitz, W., Ustaszewska, A., Landstrom, A., Bos, J.M., Ommen, S.R., et al. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat. Genet. 39 (2007), 1007–1012.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1007-1012
-
-
Pandit, B.1
Sarkozy, A.2
Pennacchio, L.A.3
Carta, C.4
Oishi, K.5
Martinelli, S.6
Pogna, E.A.7
Schackwitz, W.8
Ustaszewska, A.9
Landstrom, A.10
Bos, J.M.11
Ommen, S.R.12
-
127
-
-
0033506613
-
Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner
-
Park, J.K., Williams, B.P., Alberta, J.A., Stiles, C.D., Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J. Neurosci. 19 (1999), 10383–10389.
-
(1999)
J. Neurosci.
, vol.19
, pp. 10383-10389
-
-
Park, J.K.1
Williams, B.P.2
Alberta, J.A.3
Stiles, C.D.4
-
128
-
-
0026630991
-
Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
-
Perkins, L.A., Larsen, I., Perrimon, N., Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70 (1992), 225–236.
-
(1992)
Cell
, vol.70
, pp. 225-236
-
-
Perkins, L.A.1
Larsen, I.2
Perrimon, N.3
-
129
-
-
0030601974
-
The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila
-
Perkins, L.A., Johnson, M.R., Melnick, M.B., Perrimon, N., The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev. Biol. 180 (1996), 63–81.
-
(1996)
Dev. Biol.
, vol.180
, pp. 63-81
-
-
Perkins, L.A.1
Johnson, M.R.2
Melnick, M.B.3
Perrimon, N.4
-
130
-
-
58249115040
-
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death
-
Princen, F., Bard, E., Sheikh, F., Zhang, S.S., Wang, J., Zago, W.M., Wu, D., Trelles, R.D., Bailly-Maitre, B., Kahn, C.R., Chen, Y., Reed, J.C., et al. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol. Cell. Biol. 29 (2009), 378–388.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 378-388
-
-
Princen, F.1
Bard, E.2
Sheikh, F.3
Zhang, S.S.4
Wang, J.5
Zago, W.M.6
Wu, D.7
Trelles, R.D.8
Bailly-Maitre, B.9
Kahn, C.R.10
Chen, Y.11
Reed, J.C.12
-
131
-
-
0037064549
-
Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
-
Qu, C.K., Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim. Biophys. Acta 1592 (2002), 297–301.
-
(2002)
Biochim. Biophys. Acta
, vol.1592
, pp. 297-301
-
-
Qu, C.K.1
-
132
-
-
0030797548
-
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development
-
Qu, C.K., Shi, Z.Q., Shen, R., Tsai, F.Y., Orkin, S.H., Feng, G.S., A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol. Cell. Biol. 17 (1997), 5499–5507.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5499-5507
-
-
Qu, C.K.1
Shi, Z.Q.2
Shen, R.3
Tsai, F.Y.4
Orkin, S.H.5
Feng, G.S.6
-
133
-
-
0031708674
-
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells
-
Qu, C.K., Yu, W.M., Azzarelli, B., Cooper, S., Broxmeyer, H.E., Feng, G.S., Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol. Cell. Biol. 18 (1998), 6075–6082.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6075-6082
-
-
Qu, C.K.1
Yu, W.M.2
Azzarelli, B.3
Cooper, S.4
Broxmeyer, H.E.5
Feng, G.S.6
-
134
-
-
0035865690
-
Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development
-
Qu, C.K., Nguyen, S., Chen, J., Feng, G.S., Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood 97 (2001), 911–914.
-
(2001)
Blood
, vol.97
, pp. 911-914
-
-
Qu, C.K.1
Nguyen, S.2
Chen, J.3
Feng, G.S.4
-
135
-
-
0034235176
-
Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex
-
Raballo, R., Rhee, J., Lyn-Cook, R., Leckman, J.F., Schwartz, M.L., Vaccarino, F.M., Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J. Neurosci. 20 (2000), 5012–5023.
-
(2000)
J. Neurosci.
, vol.20
, pp. 5012-5023
-
-
Raballo, R.1
Rhee, J.2
Lyn-Cook, R.3
Leckman, J.F.4
Schwartz, M.L.5
Vaccarino, F.M.6
-
136
-
-
0030685807
-
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
-
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G.R., Birchmeier, C., Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389 (1997), 725–730.
-
(1997)
Nature
, vol.389
, pp. 725-730
-
-
Riethmacher, D.1
Sonnenberg-Riethmacher, E.2
Brinkmann, V.3
Yamaai, T.4
Lewin, G.R.5
Birchmeier, C.6
-
137
-
-
33845900943
-
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
-
Roberts, A.E., Araki, T., Swanson, K.D., Montgomery, K.T., Schiripo, T.A., Joshi, V.A., Li, L., Yassin, Y., Tamburino, A.M., Neel, B.G., Kucherlapati, R.S., Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat. Genet. 39 (2007), 70–74.
-
(2007)
Nat. Genet.
, vol.39
, pp. 70-74
-
-
Roberts, A.E.1
Araki, T.2
Swanson, K.D.3
Montgomery, K.T.4
Schiripo, T.A.5
Joshi, V.A.6
Li, L.7
Yassin, Y.8
Tamburino, A.M.9
Neel, B.G.10
Kucherlapati, R.S.11
-
138
-
-
0038697632
-
How to make tubes: signaling by the Met receptor tyrosine kinase
-
Rosário, M., Birchmeier, W., How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol. 13 (2003), 328–335.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 328-335
-
-
Rosário, M.1
Birchmeier, W.2
-
139
-
-
34547586623
-
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
-
Rosário, M., Franke, R., Bednarski, C., Birchmeier, W., The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. J. Cell Biol. 178 (2007), 503–516.
-
(2007)
J. Cell Biol.
, vol.178
, pp. 503-516
-
-
Rosário, M.1
Franke, R.2
Bednarski, C.3
Birchmeier, W.4
-
140
-
-
0035176425
-
Stem cells from the Mammalian blastocyst
-
Rossant, J., Stem cells from the Mammalian blastocyst. Stem Cells 19 (2001), 477–482.
-
(2001)
Stem Cells
, vol.19
, pp. 477-482
-
-
Rossant, J.1
-
141
-
-
0035406530
-
Placental development: lessons from mouse mutants
-
Rossant, J., Cross, J.C., Placental development: lessons from mouse mutants. Nat. Rev. Genet. 2 (2001), 538–548.
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 538-548
-
-
Rossant, J.1
Cross, J.C.2
-
142
-
-
0242607637
-
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil, M.K., Vella, F.D., Vernay, B., Voisin, L., Chen, L., Labrecque, N., Ang, S.L., Meloche, S., An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4 (2003), 964–968.
-
(2003)
EMBO Rep.
, vol.4
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
143
-
-
0030921502
-
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
-
Saxton, T.M., Henkemeyer, M., Gasca, S., Shen, R., Rossi, D.J., Shalaby, F., Feng, G.S., Pawson, T., Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16 (1997), 2352–2364.
-
(1997)
EMBO J.
, vol.16
, pp. 2352-2364
-
-
Saxton, T.M.1
Henkemeyer, M.2
Gasca, S.3
Shen, R.4
Rossi, D.J.5
Shalaby, F.6
Feng, G.S.7
Pawson, T.8
-
144
-
-
0034717590
-
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
-
Schaeper, U., Gehring, N.H., Fuchs, K.P., Sachs, M., Kempkes, B., Birchmeier, W., Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J. Cell Biol. 149 (2000), 1419–1432.
-
(2000)
J. Cell Biol.
, vol.149
, pp. 1419-1432
-
-
Schaeper, U.1
Gehring, N.H.2
Fuchs, K.P.3
Sachs, M.4
Kempkes, B.5
Birchmeier, W.6
-
145
-
-
0034735945
-
The protein tyrosine phosphatase Shp-2 regulates RhoA activity
-
Schoenwaelder, S.M., Petch, L.A., Williamson, D., Shen, R., Feng, G.S., Burridge, K., The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr. Biol. 10 (2000), 1523–1526.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1523-1526
-
-
Schoenwaelder, S.M.1
Petch, L.A.2
Williamson, D.3
Shen, R.4
Feng, G.S.5
Burridge, K.6
-
146
-
-
22044452124
-
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
-
Schubbert, S., Lieuw, K., Rowe, S.L., Lee, C.M., Li, X., Loh, M.L., Clapp, D.W., Shannon, K.M., Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood 106 (2005), 311–317.
-
(2005)
Blood
, vol.106
, pp. 311-317
-
-
Schubbert, S.1
Lieuw, K.2
Rowe, S.L.3
Lee, C.M.4
Li, X.5
Loh, M.L.6
Clapp, D.W.7
Shannon, K.M.8
-
147
-
-
33644622238
-
Germline KRAS mutations cause Noonan syndrome
-
Schubbert, S., Zenker, M., Rowe, S.L., Boll, S., Klein, C., Bollag, G., van der Burgt, I., Musante, L., Kalscheuer, V., Wehner, L.E., Nguyen, H., West, B., et al. Germline KRAS mutations cause Noonan syndrome. Nat. Genet. 38 (2006), 331–336.
-
(2006)
Nat. Genet.
, vol.38
, pp. 331-336
-
-
Schubbert, S.1
Zenker, M.2
Rowe, S.L.3
Boll, S.4
Klein, C.5
Bollag, G.6
van der Burgt, I.7
Musante, L.8
Kalscheuer, V.9
Wehner, L.E.10
Nguyen, H.11
West, B.12
-
148
-
-
0031927945
-
Stem cells in the embryonic cerebral cortex: their role in histogenesis and patterning
-
Shen, Q., Qian, X., Capela, A., Temple, S., Stem cells in the embryonic cerebral cortex: their role in histogenesis and patterning. J. Neurobiol. 36 (1998), 162–174.
-
(1998)
J. Neurobiol.
, vol.36
, pp. 162-174
-
-
Shen, Q.1
Qian, X.2
Capela, A.3
Temple, S.4
-
149
-
-
0032570586
-
The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases
-
Shi, Z.Q., Lu, W., Feng, G.S., The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J. Biol. Chem. 273 (1998), 4904–4908.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4904-4908
-
-
Shi, Z.Q.1
Lu, W.2
Feng, G.S.3
-
150
-
-
33748621746
-
Making or breaking the heart: from lineage determination to morphogenesis
-
Srivastava, D., Making or breaking the heart: from lineage determination to morphogenesis. Cell 126 (2006), 1037–1048.
-
(2006)
Cell
, vol.126
, pp. 1037-1048
-
-
Srivastava, D.1
-
151
-
-
0035830503
-
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
-
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Zubiaga, A., Hua, X., Fan, G., Greenberg, M.E., Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104 (2001), 365–376.
-
(2001)
Cell
, vol.104
, pp. 365-376
-
-
Sun, Y.1
Nadal-Vicens, M.2
Misono, S.3
Lin, M.Z.4
Zubiaga, A.5
Hua, X.6
Fan, G.7
Greenberg, M.E.8
-
153
-
-
0032509321
-
Promotion of trophoblast stem cell proliferation by FGF4
-
Tanaka, S., Kunath, T., Hadjantonakis, A.K., Nagy, A., Rossant, J., Promotion of trophoblast stem cell proliferation by FGF4. Science 282 (1998), 2072–2075.
-
(1998)
Science
, vol.282
, pp. 2072-2075
-
-
Tanaka, S.1
Kunath, T.2
Hadjantonakis, A.K.3
Nagy, A.4
Rossant, J.5
-
154
-
-
0028878979
-
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
-
Tang, T.L., Freeman, R.M. Jr., O'Reilly, A.M., Neel, B.G., Sokol, S.Y., The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80 (1995), 473–483.
-
(1995)
Cell
, vol.80
, pp. 473-483
-
-
Tang, T.L.1
Freeman, R.M.2
O'Reilly, A.M.3
Neel, B.G.4
Sokol, S.Y.5
-
155
-
-
18444401014
-
Noonan syndrome and related disorders: genetics and pathogenesis
-
Tartaglia, M., Gelb, B.D., Noonan syndrome and related disorders: genetics and pathogenesis. Annu. Rev. Genomics Hum. Genet. 6 (2005), 45–68.
-
(2005)
Annu. Rev. Genomics Hum. Genet.
, vol.6
, pp. 45-68
-
-
Tartaglia, M.1
Gelb, B.D.2
-
156
-
-
18344385476
-
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
-
Tartaglia, M., Mehler, E.L., Goldberg, R., Zampino, G., Brunner, H.G., Kremer, H., van der Burgt, I., Crosby, A.H., Ion, A., Jeffery, S., Kalidas, K., Patton, M.A., et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat. Genet. 29 (2001), 465–468.
-
(2001)
Nat. Genet.
, vol.29
, pp. 465-468
-
-
Tartaglia, M.1
Mehler, E.L.2
Goldberg, R.3
Zampino, G.4
Brunner, H.G.5
Kremer, H.6
van der Burgt, I.7
Crosby, A.H.8
Ion, A.9
Jeffery, S.10
Kalidas, K.11
Patton, M.A.12
-
157
-
-
18344370436
-
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity
-
Tartaglia, M., Kalidas, K., Shaw, A., Song, X., Musat, D.L., van der Burgt, I., Brunner, H.G., Bertola, D.R., Crosby, A., Ion, A., Kucherlapati, R.S., Jeffery, S., et al. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Am. J. Hum. Genet. 70 (2002), 1555–1563.
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 1555-1563
-
-
Tartaglia, M.1
Kalidas, K.2
Shaw, A.3
Song, X.4
Musat, D.L.5
van der Burgt, I.6
Brunner, H.G.7
Bertola, D.R.8
Crosby, A.9
Ion, A.10
Kucherlapati, R.S.11
Jeffery, S.12
-
158
-
-
0038278866
-
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
-
Tartaglia, M., Niemeyer, C.M., Fragale, A., Song, X., Buechner, J., Jung, A., Hahlen, K., Hasle, H., Licht, J.D., Gelb, B.D., Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat. Genet. 34 (2003), 148–150.
-
(2003)
Nat. Genet.
, vol.34
, pp. 148-150
-
-
Tartaglia, M.1
Niemeyer, C.M.2
Fragale, A.3
Song, X.4
Buechner, J.5
Jung, A.6
Hahlen, K.7
Hasle, H.8
Licht, J.D.9
Gelb, B.D.10
-
159
-
-
3142620903
-
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia
-
Tartaglia, M., Martinelli, S., Cazzaniga, G., Cordeddu, V., Iavarone, I., Spinelli, M., Palmi, C., Carta, C., Pession, A., Arico, M., Masera, G., Basso, G., et al. Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Blood 104 (2004), 307–313.
-
(2004)
Blood
, vol.104
, pp. 307-313
-
-
Tartaglia, M.1
Martinelli, S.2
Cazzaniga, G.3
Cordeddu, V.4
Iavarone, I.5
Spinelli, M.6
Palmi, C.7
Carta, C.8
Pession, A.9
Arico, M.10
Masera, G.11
Basso, G.12
-
160
-
-
20844439887
-
Somatic PTPN11 mutations in childhood acute myeloid leukaemia
-
Tartaglia, M., Martinelli, S., Iavarone, I., Cazzaniga, G., Spinelli, M., Giarin, E., Petrangeli, V., Carta, C., Masetti, R., Arico, M., Locatelli, F., Basso, G., et al. Somatic PTPN11 mutations in childhood acute myeloid leukaemia. Br. J. Haematol. 129 (2005), 333–339.
-
(2005)
Br. J. Haematol.
, vol.129
, pp. 333-339
-
-
Tartaglia, M.1
Martinelli, S.2
Iavarone, I.3
Cazzaniga, G.4
Spinelli, M.5
Giarin, E.6
Petrangeli, V.7
Carta, C.8
Masetti, R.9
Arico, M.10
Locatelli, F.11
Basso, G.12
-
161
-
-
31544452561
-
Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease
-
Tartaglia, M., Martinelli, S., Stella, L., Bocchinfuso, G., Flex, E., Cordeddu, V., Zampino, G., Burgt, I., Palleschi, A., Petrucci, T.C., Sorcini, M., Schoch, C., et al. Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am. J. Hum. Genet. 78 (2006), 279–290.
-
(2006)
Am. J. Hum. Genet.
, vol.78
, pp. 279-290
-
-
Tartaglia, M.1
Martinelli, S.2
Stella, L.3
Bocchinfuso, G.4
Flex, E.5
Cordeddu, V.6
Zampino, G.7
Burgt, I.8
Palleschi, A.9
Petrucci, T.C.10
Sorcini, M.11
Schoch, C.12
-
162
-
-
33845884026
-
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
-
Tartaglia, M., Pennacchio, L.A., Zhao, C., Yadav, K.K., Fodale, V., Sarkozy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., Ustaszewska, A., Martin, J., et al. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat. Genet. 39 (2007), 75–79.
-
(2007)
Nat. Genet.
, vol.39
, pp. 75-79
-
-
Tartaglia, M.1
Pennacchio, L.A.2
Zhao, C.3
Yadav, K.K.4
Fodale, V.5
Sarkozy, A.6
Pandit, B.7
Oishi, K.8
Martinelli, S.9
Schackwitz, W.10
Ustaszewska, A.11
Martin, J.12
-
163
-
-
23944503110
-
Neuregulin-1 type III determines the ensheathment fate of axons
-
Taveggia, C., Zanazzi, G., Petrylak, A., Yano, H., Rosenbluth, J., Einheber, S., Xu, X., Esper, R.M., Loeb, J.A., Shrager, P., Chao, M.V., Falls, D.L., et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 47 (2005), 681–694.
-
(2005)
Neuron
, vol.47
, pp. 681-694
-
-
Taveggia, C.1
Zanazzi, G.2
Petrylak, A.3
Yano, H.4
Rosenbluth, J.5
Einheber, S.6
Xu, X.7
Esper, R.M.8
Loeb, J.A.9
Shrager, P.10
Chao, M.V.11
Falls, D.L.12
-
164
-
-
33646351975
-
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
-
Ueki, K., Okada, T., Hu, J., Liew, C.W., Assmann, A., Dahlgren, G.M., Peters, J.L., Shackman, J.G., Zhang, M., Artner, I., Satin, L.S., Stein, R., et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat. Genet. 38 (2006), 583–588.
-
(2006)
Nat. Genet.
, vol.38
, pp. 583-588
-
-
Ueki, K.1
Okada, T.2
Hu, J.3
Liew, C.W.4
Assmann, A.5
Dahlgren, G.M.6
Peters, J.L.7
Shackman, J.G.8
Zhang, M.9
Artner, I.10
Satin, L.S.11
Stein, R.12
-
165
-
-
33144473897
-
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling
-
Uhlen, P., Burch, P.M., Zito, C.I., Estrada, M., Ehrlich, B.E., Bennett, A.M., Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc. Natl. Acad. Sci. USA 103 (2006), 2160–2165.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2160-2165
-
-
Uhlen, P.1
Burch, P.M.2
Zito, C.I.3
Estrada, M.4
Ehrlich, B.E.5
Bennett, A.M.6
-
166
-
-
0027399168
-
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation
-
Vogel, W., Lammers, R., Huang, J., Ullrich, A., Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259 (1993), 1611–1614.
-
(1993)
Science
, vol.259
, pp. 1611-1614
-
-
Vogel, W.1
Lammers, R.2
Huang, J.3
Ullrich, A.4
-
167
-
-
42549142931
-
Mammary development in the embryo and adult: a journey of morphogenesis and commitment
-
Watson, C.J., Khaled, W.T., Mammary development in the embryo and adult: a journey of morphogenesis and commitment. Development 135 (2008), 995–1003.
-
(2008)
Development
, vol.135
, pp. 995-1003
-
-
Watson, C.J.1
Khaled, W.T.2
-
168
-
-
0030970876
-
A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells
-
Williams, B.P., Park, J.K., Alberta, J.A., Muhlebach, S.G., Hwang, G.Y., Roberts, T.M., Stiles, C.D., A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron 18 (1997), 553–562.
-
(1997)
Neuron
, vol.18
, pp. 553-562
-
-
Williams, B.P.1
Park, J.K.2
Alberta, J.A.3
Muhlebach, S.G.4
Hwang, G.Y.5
Roberts, T.M.6
Stiles, C.D.7
-
169
-
-
0033214223
-
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development
-
Woldeyesus, M.T., Britsch, S., Riethmacher, D., Xu, L., Sonnenberg-Riethmacher, E., Abou-Rebyeh, F., Harvey, R., Caroni, P., Birchmeier, C., Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 13 (1999), 2538–2548.
-
(1999)
Genes Dev.
, vol.13
, pp. 2538-2548
-
-
Woldeyesus, M.T.1
Britsch, S.2
Riethmacher, D.3
Xu, L.4
Sonnenberg-Riethmacher, E.5
Abou-Rebyeh, F.6
Harvey, R.7
Caroni, P.8
Birchmeier, C.9
-
170
-
-
0037033046
-
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei
-
Wu, T.R., Hong, Y.K., Wang, X.D., Ling, M.Y., Dragoi, A.M., Chung, A.S., Campbell, A.G., Han, Z.Y., Feng, G.S., Chin, Y.E., SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J. Biol. Chem. 277 (2002), 47572–47580.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47572-47580
-
-
Wu, T.R.1
Hong, Y.K.2
Wang, X.D.3
Ling, M.Y.4
Dragoi, A.M.5
Chung, A.S.6
Campbell, A.G.7
Han, Z.Y.8
Feng, G.S.9
Chin, Y.E.10
-
171
-
-
62849093631
-
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase
-
Wu, D., Pang, Y., Ke, Y., Yu, J., He, Z., Tautz, L., Mustelin, T., Ding, S., Huang, Z., Feng, G.S., A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS ONE, 4, 2009, e4914.
-
(2009)
PLoS ONE
, vol.4
, pp. e4914
-
-
Wu, D.1
Pang, Y.2
Ke, Y.3
Yu, J.4
He, Z.5
Tautz, L.6
Mustelin, T.7
Ding, S.8
Huang, Z.9
Feng, G.S.10
-
172
-
-
0037648511
-
Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
-
Wuestefeld, T., Klein, C., Streetz, K.L., Betz, U., Lauber, J., Buer, J., Manns, M.P., Muller, W., Trautwein, C., Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J. Biol. Chem. 278 (2003), 11281–11288.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11281-11288
-
-
Wuestefeld, T.1
Klein, C.2
Streetz, K.L.3
Betz, U.4
Lauber, J.5
Buer, J.6
Manns, M.P.7
Muller, W.8
Trautwein, C.9
-
173
-
-
27644446391
-
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
-
Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R.F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J., Gotoh, N., Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. Proc. Natl. Acad. Sci. USA 102 (2005), 15983–15988.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15983-15988
-
-
Yamamoto, S.1
Yoshino, I.2
Shimazaki, T.3
Murohashi, M.4
Hevner, R.F.5
Lax, I.6
Okano, H.7
Shibuya, M.8
Schlessinger, J.9
Gotoh, N.10
-
174
-
-
33745861321
-
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia
-
Yamamoto, T., Isomura, M., Xu, Y., Liang, J., Yagasaki, H., Kamachi, Y., Kudo, K., Kiyoi, H., Naoe, T., Kojma, S., PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Leuk. Res. 30 (2006), 1085–1089.
-
(2006)
Leuk. Res.
, vol.30
, pp. 1085-1089
-
-
Yamamoto, T.1
Isomura, M.2
Xu, Y.3
Liang, J.4
Yagasaki, H.5
Kamachi, Y.6
Kudo, K.7
Kiyoi, H.8
Naoe, T.9
Kojma, S.10
-
175
-
-
33644547703
-
An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
-
Yang, W., Klaman, L.D., Chen, B., Araki, T., Harada, H., Thomas, S.M., George, E.L., Neel, B.G., An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev. Cell 10 (2006), 317–327.
-
(2006)
Dev. Cell
, vol.10
, pp. 317-327
-
-
Yang, W.1
Klaman, L.D.2
Chen, B.3
Araki, T.4
Harada, H.5
Thomas, S.M.6
George, E.L.7
Neel, B.G.8
-
176
-
-
52049107372
-
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival
-
Yang, Z., Li, Y., Yin, F., Chan, R.J., Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Exp. Hematol. 36 (2008), 1285–1296.
-
(2008)
Exp. Hematol.
, vol.36
, pp. 1285-1296
-
-
Yang, Z.1
Li, Y.2
Yin, F.3
Chan, R.J.4
-
177
-
-
3242739935
-
Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome
-
Yoshida, R., Hasegawa, T., Hasegawa, Y., Nagai, T., Kinoshita, E., Tanaka, Y., Kanegane, H., Ohyama, K., Onishi, T., Hanew, K., Okuyama, T., Horikawa, R., et al. Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome. J. Clin. Endocrinol. Metab. 89 (2004), 3359–3364.
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 3359-3364
-
-
Yoshida, R.1
Hasegawa, T.2
Hasegawa, Y.3
Nagai, T.4
Kinoshita, E.5
Tanaka, Y.6
Kanegane, H.7
Ohyama, K.8
Onishi, T.9
Hanew, K.10
Okuyama, T.11
Horikawa, R.12
-
178
-
-
0035176070
-
Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor
-
You, M., Flick, L.M., Yu, D., Feng, G.S., Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J. Exp. Med. 193 (2001), 101–110.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 101-110
-
-
You, M.1
Flick, L.M.2
Yu, D.3
Feng, G.S.4
-
179
-
-
3543036342
-
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
-
Yu, D.H., Qu, C.K., Henegariu, O., Lu, X., Feng, G.S., Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273 (1998), 21125–21131.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21125-21131
-
-
Yu, D.H.1
Qu, C.K.2
Henegariu, O.3
Lu, X.4
Feng, G.S.5
-
180
-
-
33646842917
-
Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
-
Yu, W.M., Daino, H., Chen, J., Bunting, K.D., Qu, C.K., Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. J. Biol. Chem. 281 (2006), 5426–5434.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5426-5434
-
-
Yu, W.M.1
Daino, H.2
Chen, J.3
Bunting, K.D.4
Qu, C.K.5
-
181
-
-
12144286459
-
Genotype-phenotype correlations in Noonan syndrome
-
Zenker, M., Buheitel, G., Rauch, R., Koenig, R., Bosse, K., Kress, W., Tietze, H.U., Doerr, H.G., Hofbeck, M., Singer, H., Reis, A., Rauch, A., Genotype-phenotype correlations in Noonan syndrome. J. Pediatr. 144 (2004), 368–374.
-
(2004)
J. Pediatr.
, vol.144
, pp. 368-374
-
-
Zenker, M.1
Buheitel, G.2
Rauch, R.3
Koenig, R.4
Bosse, K.5
Kress, W.6
Tietze, H.U.7
Doerr, H.G.8
Hofbeck, M.9
Singer, H.10
Reis, A.11
Rauch, A.12
-
182
-
-
0036258332
-
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2
-
Zhang, S.Q., Tsiaras, W.G., Araki, T., Wen, G., Minichiello, L., Klein, R., Neel, B.G., Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Mol. Cell. Biol. 22 (2002), 4062–4072.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4062-4072
-
-
Zhang, S.Q.1
Tsiaras, W.G.2
Araki, T.3
Wen, G.4
Minichiello, L.5
Klein, R.6
Neel, B.G.7
-
183
-
-
8644268830
-
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
-
Zhang, E.E., Chapeau, E., Hagihara, K., Feng, G.S., Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. USA 101 (2004), 16064–16069.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 16064-16069
-
-
Zhang, E.E.1
Chapeau, E.2
Hagihara, K.3
Feng, G.S.4
-
184
-
-
66149101020
-
Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells
-
Zhang, S.S., Hao, E., Yu, J., Liu, W., Wang, J., Levine, F., Feng, G.S., Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc. Natl. Acad. Sci. USA 106 (2009), 7531–7536.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 7531-7536
-
-
Zhang, S.S.1
Hao, E.2
Yu, J.3
Liu, W.4
Wang, J.5
Levine, F.6
Feng, G.S.7
-
185
-
-
69249118196
-
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia
-
Zhang, W., Chan, R.J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L.C., Payne, R.M., Zhang, Z.Y., et al. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J. Biol. Chem. 284 (2009), 22353–22363.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22353-22363
-
-
Zhang, W.1
Chan, R.J.2
Chen, H.3
Yang, Z.4
He, Y.5
Zhang, X.6
Luo, Y.7
Yin, F.8
Moh, A.9
Miller, L.C.10
Payne, R.M.11
Zhang, Z.Y.12
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