Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 22, 2003, Pages 12654-12659

  Schiering, Nikolaus ^a,c   Knapp, Stefan ^a   Marconi, Marina ^a   Flocco, Maria M ^a   Cui, Jean ^b   Perego, Rita ^a   Rusconi, Luisa ^a   Cristiani, Cinzia ^a  

^a PFIZER INC   (United States)

^b SUGEN INC   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; C MET KINASE; FURANOSYLATED INDOLOCARBAZOLE; K 252A; PHOSPHOTYROSINE; PROTEIN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; STAUROSPORINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; C MET GENE; C MET KINASE DOMAIN; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CRYSTAL STRUCTURE; EPITHELIUM CELL; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTO ONCOGENE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; TYROSINE KINASE DOMAIN;

AMINO ACID SEQUENCE; BINDING SITES; CARBAZOLES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; METHIONINE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-MET; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 0242268455     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1734128100     Document Type: Article

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