Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA

Biochemical Journal

Volumn 426, Issue 2, 2010, Pages 219-228

  Owen, Kate A ^a   Qiu, Deyi ^a   Alves, Juliano ^b   Schumacher, Andrew M ^b   Kilpatrick, Lynette M ^a   Li, Jun ^b   Harris, Jennifer L ^b   Ellis, Vincent ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Hepatocyte growth factor (HGF); Pericellular proteolysis; Plasminogen activation; Proteolytic processing; Substrate specificity; Type II transmembrane serine protease (TTSP)

Indexed keywords

HEPATOCYTE GROWTH FACTOR; PERICELLULAR PROTEOLYSIS; PROTEOLYTIC PROCESSING; SERINE PROTEASE; SUBSTRATE SPECIFICITY; TRANSMEMBRANES;

ACTIVATION ANALYSIS; AMINO ACIDS; BIOACTIVITY; CELL MEMBRANES; ENZYME ACTIVITY; ENZYME INHIBITION; PEPTIDES; PHOSPHATASES; RNA;

CHEMICAL ACTIVATION;

HEPARIN; HEPSIN; MATRIPTASE; SCATTER FACTOR; SMALL INTERFERING RNA; UROKINASE; UROKINASE RECEPTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL SURFACE; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; DOGS; HEPATOCYTE GROWTH FACTOR; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SERINE ENDOPEPTIDASES; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 76549122581     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091448     Document Type: Article

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