Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20666-20676

  Eathiraj, Sudharshan ^a   Palma, Rocio ^a   Volckova, Erika ^a   Hirschi, Marscha ^a   France, Dennis S ^a   Ashwell, Mark A ^a   Chan, Thomas C K ^a  

^a ARQULE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; CATALYTIC RESIDUE; CLINICAL TESTING; GENE AMPLIFICATION; HUMAN MALIGNANCIES; IN-PHASE; IN-SILICO; INHIBITORY MECHANISM; KINASE DOMAINS; NON SMALL CELL LUNG CANCER; PROTEIN KINASE; RECEPTOR TYROSINE KINASE; REGULATORY ELEMENTS; STRUCTURAL BASIS;

AMINO ACIDS; GENE EXPRESSION; PROTEINS;

ENZYMES;

SCATTER FACTOR RECEPTOR; TIVANTINIB;

AMINO ACID SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN;

CARCINOMA, NON-SMALL-CELL LUNG; CATALYTIC DOMAIN; CLINICAL TRIALS, PHASE III AS TOPIC; CRYSTALLOGRAPHY, X-RAY; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MET; PYRROLIDINONES; QUINOLINES;

EID: 79957985551     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.213801     Document Type: Article

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