Structural basis for selective small molecule kinase inhibition of activated c-Met

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11218-11225

  Rickert, Keith W ^a   Patel, Sangita B ^a   Allison, Timothy J ^a   Byrne, Noel J ^a   Darke, Paul L ^a   Ford, Rachael E ^a   Guerin, David J ^a   Hall, Dawn L ^a   Kornienko, Maria ^a   Lu, Jun ^a   Munshi, Sanjeev K ^a   Reid, John C ^a   Shipman, Jennifer M ^a   Stanton, Elizabeth F ^a   Wilson, Kevin J ^a   Young, Jonathon R ^a   Soisson, Stephen M ^a   Lumb, Kevin J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; ACTIVE SITE; AUTOPHOSPHORYLATION; CELL SURFACE RECEPTORS; CLINICAL TRIAL; CONFORMATIONAL CHANGE; HEPATOCYTE GROWTH FACTOR; INDUCED FIT; KINASE DOMAINS; LIGAND BINDING; ONCOGENESIS; RECEPTOR TYROSINE KINASE; SMALL MOLECULES; STRUCTURAL BASIS;

AMINO ACIDS; CELL MEMBRANES; ENZYMES; MOLECULES; PHOSPHORYLATION;

CRYSTAL STRUCTURE;

MK 2461; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTHALPY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953213695     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204404     Document Type: Article

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