메뉴 건너뛰기




Volumn 1806, Issue 2, 2010, Pages 208-219

The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas

Author keywords

B cell lymphoproliferative disorder; Diffuse large B cell lymphoma; HGF; MET; Multiple myeloma

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; ADENOVIRUS VECTOR; AMG 102; ANTINEOPLASTIC AGENT; ARQ 197; BORTEZOMIB; DEXAMETHASONE; DOCETAXEL; ERLOTINIB; JNJ 38877605; LENALIDOMIDE; MGCD 265; MITOGEN ACTIVATED PROTEIN KINASE; MK 2461; MONOCLONAL ANTIBODY 5D5; MONOCLONAL ANTIBODY DN30; MONOCLONAL ANTIBODY L2G7; MP 470; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; PF 04217903; PRO 143966; PROTEIN NK2; PROTEIN NK4; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SGX 523; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 184; XL 880; ADAPTOR PROTEIN; AMUVATINIB; CABOZANTINIB; CRIZOTINIB; FORETINIB; HEPATOCYTE GROWTH FACTOR ANTIBODY; ONARTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ANTIBODY; PROTEIN GAB1; PROTEIN KINASE INHIBITOR; RILOTUMUMAB; SCATTER FACTOR RECEPTOR ANTIBODY; TIVANTINIB;

EID: 78649456121     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2010.07.006     Document Type: Review
Times cited : (49)

References (151)
  • 1
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    • Uehara Y., Minowa O., Mori C., Shiota K., Kuno J., Noda T., Kitamura N. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995, 373:702-705.
    • (1995) Nature , vol.373 , pp. 702-705
    • Uehara, Y.1    Minowa, O.2    Mori, C.3    Shiota, K.4    Kuno, J.5    Noda, T.6    Kitamura, N.7
  • 3
    • 44449151030 scopus 로고    scopus 로고
    • Drug development of MET inhibitors: targeting oncogene addiction and expedience
    • Comoglio P.M., Giordano S., Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat. Rev. Drug Discov. 2008, 7:504-516.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 504-516
    • Comoglio, P.M.1    Giordano, S.2    Trusolino, L.3
  • 4
    • 0028168441 scopus 로고
    • The Met/hepatocyte growth factor receptor (HGFR) gene is overexpressed in some cases of human leukemia and lymphoma
    • Jucker M., Gunther A., Gradl G., Fonatsch C., Krueger G., Diehl V., Tesch H. The Met/hepatocyte growth factor receptor (HGFR) gene is overexpressed in some cases of human leukemia and lymphoma. Leuk. Res. 1994, 18:7-16.
    • (1994) Leuk. Res. , vol.18 , pp. 7-16
    • Jucker, M.1    Gunther, A.2    Gradl, G.3    Fonatsch, C.4    Krueger, G.5    Diehl, V.6    Tesch, H.7
  • 6
    • 0030897081 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins
    • Weimar I.S., de Jong D., Muller E.J., Nakamura T., van Gorp J.M., de Gast G.C., Gerritsen W.R. Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins. Blood 1997, 89:990-1000.
    • (1997) Blood , vol.89 , pp. 990-1000
    • Weimar, I.S.1    de Jong, D.2    Muller, E.J.3    Nakamura, T.4    van Gorp, J.M.5    de Gast, G.C.6    Gerritsen, W.R.7
  • 7
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M., Gherardi E., Perryman M., Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987, 327:239-242.
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 10
    • 0026699904 scopus 로고
    • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer
    • Naka D., Ishii T., Yoshiyama Y., Miyazawa K., Hara H., Hishida T., Kidamura N. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J. Biol. Chem. 1992, 267:20114-20119.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20114-20119
    • Naka, D.1    Ishii, T.2    Yoshiyama, Y.3    Miyazawa, K.4    Hara, H.5    Hishida, T.6    Kidamura, N.7
  • 11
    • 0028912994 scopus 로고
    • Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator
    • Shimomura T., Miyazawa K., Komiyama Y., Hiraoka H., Naka D., Morimoto Y., Kitamura N. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur. J. Biochem. 1995, 229:257-261.
    • (1995) Eur. J. Biochem. , vol.229 , pp. 257-261
    • Shimomura, T.1    Miyazawa, K.2    Komiyama, Y.3    Hiraoka, H.4    Naka, D.5    Morimoto, Y.6    Kitamura, N.7
  • 17
    • 0036551486 scopus 로고    scopus 로고
    • Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    • Trusolino L., Comoglio P.M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat. Rev. Cancer 2002, 2:289-300.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 289-300
    • Trusolino, L.1    Comoglio, P.M.2
  • 18
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • Kong-Beltran M., Stamos J., Wickramasinghe D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 2004, 6:75-84.
    • (2004) Cancer Cell , vol.6 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 21
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • Weidner K.M., Di Cesare S., Sachs M., Brinkmann V., Behrens J., Birchmeier W. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1996, 384:173-176.
    • (1996) Nature , vol.384 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 22
    • 0030843307 scopus 로고    scopus 로고
    • Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
    • Nguyen L., Holgado-Madruga M., Maroun C., Fixman E.D., Kamikura D., Fournier T., Charest A., Tremblay M.L., Wong A.J., Park M. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356. J. Biol. Chem. 1997, 272:20811-20819.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20811-20819
    • Nguyen, L.1    Holgado-Madruga, M.2    Maroun, C.3    Fixman, E.D.4    Kamikura, D.5    Fournier, T.6    Charest, A.7    Tremblay, M.L.8    Wong, A.J.9    Park, M.10
  • 23
    • 0033624921 scopus 로고    scopus 로고
    • Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
    • Itoh M., Yoshida Y., Nishida K., Narimatsu M., Hibi M., Hirano T. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol. 2000, 20:3695-3704.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3695-3704
    • Itoh, M.1    Yoshida, Y.2    Nishida, K.3    Narimatsu, M.4    Hibi, M.5    Hirano, T.6
  • 24
    • 0025824738 scopus 로고
    • Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
    • Montesano R., Matsumoto K., Nakamura T., Orci L. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 1991, 67:901-908.
    • (1991) Cell , vol.67 , pp. 901-908
    • Montesano, R.1    Matsumoto, K.2    Nakamura, T.3    Orci, L.4
  • 25
    • 0034673786 scopus 로고    scopus 로고
    • Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis
    • Gual P., Giordano S., Williams T.A., Rocchi S., Van Obberghen E., Comoglio P.M. Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene 2000, 19:1509-1518.
    • (2000) Oncogene , vol.19 , pp. 1509-1518
    • Gual, P.1    Giordano, S.2    Williams, T.A.3    Rocchi, S.4    Van Obberghen, E.5    Comoglio, P.M.6
  • 26
    • 0034693753 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase: enhanced signaling through adapter proteins
    • Furge K.A., Zhang Y.W., Vande Woude G.F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene 2000, 19:5582-5589.
    • (2000) Oncogene , vol.19 , pp. 5582-5589
    • Furge, K.A.1    Zhang, Y.W.2    Vande Woude, G.F.3
  • 27
    • 0034939549 scopus 로고    scopus 로고
    • Pathway specificity for Met signalling
    • Comoglio P.M. Pathway specificity for Met signalling. Nat. Cell Biol. 2001, 3:E161-E162.
    • (2001) Nat. Cell Biol. , vol.3
    • Comoglio, P.M.1
  • 28
    • 0033615691 scopus 로고    scopus 로고
    • A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis
    • Maroun C.R., Moscatello D.K., Naujokas M.A., Holgado-Madruga M., Wong A.J., Park M. A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis. J. Biol. Chem. 1999, 274:31719-31726.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31719-31726
    • Maroun, C.R.1    Moscatello, D.K.2    Naujokas, M.A.3    Holgado-Madruga, M.4    Wong, A.J.5    Park, M.6
  • 29
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C., Bardelli A., Zhen Z., Maina F., dalla Zonca P., Giordano S., Graziani A., Panayotou G., Comoglio P.M. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994, 77:261-271.
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3    Maina, F.4    dalla Zonca, P.5    Giordano, S.6    Graziani, A.7    Panayotou, G.8    Comoglio, P.M.9
  • 30
    • 0032750817 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
    • Liu Y. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am. J. Physiol. 1999, 277:F624-F633.
    • (1999) Am. J. Physiol. , vol.277
    • Liu, Y.1
  • 32
    • 34248151416 scopus 로고    scopus 로고
    • Met acts on Mdm2 via mTOR to signal cell survival during development
    • Moumen A., Patane S., Porras A., Dono R., Maina F. Met acts on Mdm2 via mTOR to signal cell survival during development. Development 2007, 134:1443-1451.
    • (2007) Development , vol.134 , pp. 1443-1451
    • Moumen, A.1    Patane, S.2    Porras, A.3    Dono, R.4    Maina, F.5
  • 33
    • 0033761488 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun C.R., Naujokas M.A., Holgado-Madruga M., Wong A.J., Park M. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 2000, 20:8513-8525.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8513-8525
    • Maroun, C.R.1    Naujokas, M.A.2    Holgado-Madruga, M.3    Wong, A.J.4    Park, M.5
  • 34
    • 0033845178 scopus 로고    scopus 로고
    • Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering
    • Kodama A., Matozaki T., Fukuhara A., Kikyo M., Ichihashi M., Takai Y. Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol. Biol. Cell 2000, 11:2565-2575.
    • (2000) Mol. Biol. Cell , vol.11 , pp. 2565-2575
    • Kodama, A.1    Matozaki, T.2    Fukuhara, A.3    Kikyo, M.4    Ichihashi, M.5    Takai, Y.6
  • 35
    • 19444363140 scopus 로고    scopus 로고
    • The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading
    • Koch A., Mancini A., El Bounkari O., Tamura T. The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. Oncogene 2005, 24:3436-3447.
    • (2005) Oncogene , vol.24 , pp. 3436-3447
    • Koch, A.1    Mancini, A.2    El Bounkari, O.3    Tamura, T.4
  • 36
    • 33749380038 scopus 로고    scopus 로고
    • Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts
    • Duan H.F., Qu C.K., Zhang Q.W., Yu W.M., Wang H., Wu C.T., Wang L.S. Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts. Cell. Signal. 2006, 18:2049-2055.
    • (2006) Cell. Signal. , vol.18 , pp. 2049-2055
    • Duan, H.F.1    Qu, C.K.2    Zhang, Q.W.3    Yu, W.M.4    Wang, H.5    Wu, C.T.6    Wang, L.S.7
  • 37
    • 0028142230 scopus 로고
    • The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras
    • Hartmann G., Weidner K.M., Schwarz H., Birchmeier W. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras. J. Biol. Chem. 1994, 269:21936-21939.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21936-21939
    • Hartmann, G.1    Weidner, K.M.2    Schwarz, H.3    Birchmeier, W.4
  • 38
    • 0029809118 scopus 로고    scopus 로고
    • Branching tubulogenesis but not scatter of Madin-Darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase
    • Fournier T.M., Kamikura D., Teng K., Park M. Branching tubulogenesis but not scatter of Madin-Darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase. J. Biol. Chem. 1996, 271:22211-22217.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22211-22217
    • Fournier, T.M.1    Kamikura, D.2    Teng, K.3    Park, M.4
  • 39
    • 0034646610 scopus 로고    scopus 로고
    • Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
    • Sakkab D., Lewitzky M., Posern G., Schaeper U., Sachs M., Birchmeier W., Feller S.M. Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J. Biol. Chem. 2000, 275:10772-10778.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10772-10778
    • Sakkab, D.1    Lewitzky, M.2    Posern, G.3    Schaeper, U.4    Sachs, M.5    Birchmeier, W.6    Feller, S.M.7
  • 44
    • 0037082492 scopus 로고    scopus 로고
    • Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
    • Derksen P.W., Keehnen R.M., Evers L.M., van Oers M.H., Spaargaren M., Pals S.T. Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma. Blood 2002, 99:1405-1410.
    • (2002) Blood , vol.99 , pp. 1405-1410
    • Derksen, P.W.1    Keehnen, R.M.2    Evers, L.M.3    van Oers, M.H.4    Spaargaren, M.5    Pals, S.T.6
  • 45
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995, 376:768-771.
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 48
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: a MET-driven genetic programme for cancer and stem cells
    • Boccaccio C., Comoglio P.M. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat. Rev. Cancer 2006, 6:637-645.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 49
    • 0028349254 scopus 로고
    • Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium
    • Nusrat A., Parkos C.A., Bacarra A.E., Godowski P.J., Delp-Archer C., Rosen E.M., Madara J.L. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J. Clin. Invest. 1994, 93:2056-2065.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2056-2065
    • Nusrat, A.1    Parkos, C.A.2    Bacarra, A.E.3    Godowski, P.J.4    Delp-Archer, C.5    Rosen, E.M.6    Madara, J.L.7
  • 51
    • 0034526510 scopus 로고    scopus 로고
    • Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF
    • Nakamura T., Mizuno S., Matsumoto K., Sawa Y., Matsuda H. Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J. Clin. Invest. 2000, 106:1511-1519.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1511-1519
    • Nakamura, T.1    Mizuno, S.2    Matsumoto, K.3    Sawa, Y.4    Matsuda, H.5
  • 52
    • 0141426705 scopus 로고    scopus 로고
    • Reciprocal functions of hepatocyte growth factor and transforming growth factor-beta1 in the progression of renal diseases: a role for CD44?
    • Florquin S., Rouschop K.M. Reciprocal functions of hepatocyte growth factor and transforming growth factor-beta1 in the progression of renal diseases: a role for CD44?. Kidney Int. Suppl. 2003, S15-S20.
    • (2003) Kidney Int. Suppl.
    • Florquin, S.1    Rouschop, K.M.2
  • 53
    • 0026485121 scopus 로고
    • Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells
    • Kmiecik T.E., Keller J.R., Rosen E., Vande Woude G.F. Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells. Blood 1992, 80:2454-2457.
    • (1992) Blood , vol.80 , pp. 2454-2457
    • Kmiecik, T.E.1    Keller, J.R.2    Rosen, E.3    Vande Woude, G.F.4
  • 54
    • 0031028327 scopus 로고    scopus 로고
    • Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis
    • Takai K., Hara J., Matsumoto K., Hosoi G., Osugi Y., Tawa A., Okada S., Nakamura T. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 1997, 89:1560-1565.
    • (1997) Blood , vol.89 , pp. 1560-1565
    • Takai, K.1    Hara, J.2    Matsumoto, K.3    Hosoi, G.4    Osugi, Y.5    Tawa, A.6    Okada, S.7    Nakamura, T.8
  • 55
    • 0031873964 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+)
    • Weimar I.S., Miranda N., Muller E.J., Hekman A., Kerst J.M., de Gast G.C., Gerritsen W.R. Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+). Exp. Hematol. 1998, 26:885-894.
    • (1998) Exp. Hematol. , vol.26 , pp. 885-894
    • Weimar, I.S.1    Miranda, N.2    Muller, E.J.3    Hekman, A.4    Kerst, J.M.5    de Gast, G.C.6    Gerritsen, W.R.7
  • 58
    • 0030956759 scopus 로고    scopus 로고
    • Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway
    • van der Voort R., Taher T.E., Keehnen R.M., Smit L., Groenink M., Pals S.T. Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J. Exp. Med. 1997, 185:2121-2131.
    • (1997) J. Exp. Med. , vol.185 , pp. 2121-2131
    • van der Voort, R.1    Taher, T.E.2    Keehnen, R.M.3    Smit, L.4    Groenink, M.5    Pals, S.T.6
  • 59
    • 0029825852 scopus 로고    scopus 로고
    • Hepatocyte growth factor and its receptor c-met in multiple myeloma
    • Borset M., Hjorth-Hansen H., Seidel C., Sundan A., Waage A. Hepatocyte growth factor and its receptor c-met in multiple myeloma. Blood 1996, 88:3998-4004.
    • (1996) Blood , vol.88 , pp. 3998-4004
    • Borset, M.1    Hjorth-Hansen, H.2    Seidel, C.3    Sundan, A.4    Waage, A.5
  • 62
    • 0036221263 scopus 로고    scopus 로고
    • Dysregulation of Met receptor tyrosine kinase activity in invasive tumors
    • Danilkovitch-Miagkova A., Zbar B. Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J. Clin. Invest. 2002, 109:863-867.
    • (2002) J. Clin. Invest. , vol.109 , pp. 863-867
    • Danilkovitch-Miagkova, A.1    Zbar, B.2
  • 64
    • 0037105707 scopus 로고    scopus 로고
    • Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    • Boon E.M., van der Neut R., van de Wetering M., Clevers H., Pals S.T. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res. 2002, 62:5126-5128.
    • (2002) Cancer Res. , vol.62 , pp. 5126-5128
    • Boon, E.M.1    van der Neut, R.2    van de Wetering, M.3    Clevers, H.4    Pals, S.T.5
  • 70
    • 45549109525 scopus 로고    scopus 로고
    • Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis
    • Zeilstra J., Joosten S.P., Dokter M., Verwiel E., Spaargaren M., Pals S.T. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res. 2008, 68:3655-3661.
    • (2008) Cancer Res. , vol.68 , pp. 3655-3661
    • Zeilstra, J.1    Joosten, S.P.2    Dokter, M.3    Verwiel, E.4    Spaargaren, M.5    Pals, S.T.6
  • 71
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: role in B-cell physiology and malignancy
    • Klein U., Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 2008, 8:22-33.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 73
    • 23844502568 scopus 로고    scopus 로고
    • Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator
    • Tjin E.P., Bende R.J., Derksen P.W., van Huijstee A.P., Kataoka H., Spaargaren M., Pals S.T. Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator. J. Immunol. 2005, 175:2807-2813.
    • (2005) J. Immunol. , vol.175 , pp. 2807-2813
    • Tjin, E.P.1    Bende, R.J.2    Derksen, P.W.3    van Huijstee, A.P.4    Kataoka, H.5    Spaargaren, M.6    Pals, S.T.7
  • 74
    • 0034676013 scopus 로고    scopus 로고
    • Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans
    • van der Voort R., Keehnen R.M., Beuling E.A., Spaargaren M., Pals S.T. Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans. J. Exp. Med. 2000, 192:1115-1124.
    • (2000) J. Exp. Med. , vol.192 , pp. 1115-1124
    • van der Voort, R.1    Keehnen, R.M.2    Beuling, E.A.3    Spaargaren, M.4    Pals, S.T.5
  • 75
    • 0036784661 scopus 로고    scopus 로고
    • C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination
    • Taher T.E., Tjin E.P., Beuling E.A., Borst J., Spaargaren M., Pals S.T. c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. J. Immunol. 2002, 169:3793-3800.
    • (2002) J. Immunol. , vol.169 , pp. 3793-3800
    • Taher, T.E.1    Tjin, E.P.2    Beuling, E.A.3    Borst, J.4    Spaargaren, M.5    Pals, S.T.6
  • 76
    • 0035047992 scopus 로고    scopus 로고
    • The role of hepatocyte growth factor and its receptor c-met in interactions between lymphocytes and stromal cells in secondary human lymphoid organs
    • Skibinski G., Skibinska A., James K. The role of hepatocyte growth factor and its receptor c-met in interactions between lymphocytes and stromal cells in secondary human lymphoid organs. Immunology 2001, 102:506-514.
    • (2001) Immunology , vol.102 , pp. 506-514
    • Skibinski, G.1    Skibinska, A.2    James, K.3
  • 77
    • 0025853549 scopus 로고
    • Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways
    • Koopman G., Parmentier H.K., Schuurman H.J., Newman W., Meijer C.J., Pals S.T. Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. J. Exp. Med. 1991, 173:1297-1304.
    • (1991) J. Exp. Med. , vol.173 , pp. 1297-1304
    • Koopman, G.1    Parmentier, H.K.2    Schuurman, H.J.3    Newman, W.4    Meijer, C.J.5    Pals, S.T.6
  • 78
    • 0028195006 scopus 로고
    • Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells
    • Koopman G., Keehnen R.M., Lindhout E., Newman W., Shimizu Y., van Seventer G.A., de Groot C., Pals S.T. Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J. Immunol. 1994, 152:3760-3767.
    • (1994) J. Immunol. , vol.152 , pp. 3760-3767
    • Koopman, G.1    Keehnen, R.M.2    Lindhout, E.3    Newman, W.4    Shimizu, Y.5    van Seventer, G.A.6    de Groot, C.7    Pals, S.T.8
  • 79
    • 0037818485 scopus 로고    scopus 로고
    • Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation
    • Tarte K., Zhan F., De Vos J., Klein B., Shaughnessy J. Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation. Blood 2003, 102:592-600.
    • (2003) Blood , vol.102 , pp. 592-600
    • Tarte, K.1    Zhan, F.2    De Vos, J.3    Klein, B.4    Shaughnessy, J.5
  • 80
    • 77249120064 scopus 로고    scopus 로고
    • Treatment of multiple myeloma: a comprehensive review
    • Kyle R.A., Rajkumar S.V. Treatment of multiple myeloma: a comprehensive review. Clin. Lymphoma Myeloma 2009, 9:278-288.
    • (2009) Clin. Lymphoma Myeloma , vol.9 , pp. 278-288
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 82
    • 0032006829 scopus 로고    scopus 로고
    • Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group
    • Seidel C., Borset M., Turesson I., Abildgaard N., Sundan A., Waage A. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group. Blood 1998, 91:806-812.
    • (1998) Blood , vol.91 , pp. 806-812
    • Seidel, C.1    Borset, M.2    Turesson, I.3    Abildgaard, N.4    Sundan, A.5    Waage, A.6
  • 84
    • 54249125034 scopus 로고    scopus 로고
    • Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma
    • Wader K.F., Fagerli U.M., Holt R.U., Stordal B., Borset M., Sundan A., Waage A. Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma. Eur. J. Haematol. 2008, 81:380-383.
    • (2008) Eur. J. Haematol. , vol.81 , pp. 380-383
    • Wader, K.F.1    Fagerli, U.M.2    Holt, R.U.3    Stordal, B.4    Borset, M.5    Sundan, A.6    Waage, A.7
  • 85
    • 0037381271 scopus 로고    scopus 로고
    • Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity
    • Alexandrakis M.G., Passam F.H., Sfiridaki A., Kandidaki E., Roussou P., Kyriakou D.S. Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity. Am. J. Hematol. 2003, 72:229-233.
    • (2003) Am. J. Hematol. , vol.72 , pp. 229-233
    • Alexandrakis, M.G.1    Passam, F.H.2    Sfiridaki, A.3    Kandidaki, E.4    Roussou, P.5    Kyriakou, D.S.6
  • 87
    • 77949479635 scopus 로고    scopus 로고
    • Treatment response to bortezomib in multiple myeloma correlates with plasma hepatocyte growth factor concentration and bone marrow thrombospondin concentration
    • Ludek P., Hana S., Zdenek A., Martina A., Dana K., Tomas B., Lucie K., Marta K., Jaroslav M., Miroslav P., Jiri V., Roman H. Treatment response to bortezomib in multiple myeloma correlates with plasma hepatocyte growth factor concentration and bone marrow thrombospondin concentration. Eur. J. Haematol. 2010, 84:332-336.
    • (2010) Eur. J. Haematol. , vol.84 , pp. 332-336
    • Ludek, P.1    Hana, S.2    Zdenek, A.3    Martina, A.4    Dana, K.5    Tomas, B.6    Lucie, K.7    Marta, K.8    Jaroslav, M.9    Miroslav, P.10    Jiri, V.11    Roman, H.12
  • 90
    • 4644258648 scopus 로고    scopus 로고
    • Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    • Tjin E.P., Derksen P.W., Kataoka H., Spaargaren M., Pals S.T. Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. Blood 2004, 104:2172-2175.
    • (2004) Blood , vol.104 , pp. 2172-2175
    • Tjin, E.P.1    Derksen, P.W.2    Kataoka, H.3    Spaargaren, M.4    Pals, S.T.5
  • 91
    • 5144226615 scopus 로고    scopus 로고
    • A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
    • Hov H., Holt R.U., Ro T.B., Fagerli U.M., Hjorth-Hansen H., Baykov V., Christensen J.G., Waage A., Sundan A., Borset M. A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells. Clin. Cancer Res. 2004, 10:6686-6694.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6686-6694
    • Hov, H.1    Holt, R.U.2    Ro, T.B.3    Fagerli, U.M.4    Hjorth-Hansen, H.5    Baykov, V.6    Christensen, J.G.7    Waage, A.8    Sundan, A.9    Borset, M.10
  • 92
    • 35448969250 scopus 로고    scopus 로고
    • Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase
    • Stellrecht C.M., Phillip C.J., Cervantes-Gomez F., Gandhi V. Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase. Cancer Res. 2007, 67:9913-9920.
    • (2007) Cancer Res. , vol.67 , pp. 9913-9920
    • Stellrecht, C.M.1    Phillip, C.J.2    Cervantes-Gomez, F.3    Gandhi, V.4
  • 96
    • 2342614186 scopus 로고    scopus 로고
    • Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor
    • Vande Broek I., Asosingh K., Allegaert V., Leleu X., Facon T., Vanderkerken K., Van Camp B., Van Riet I. Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor. Leukemia 2004, 18:976-982.
    • (2004) Leukemia , vol.18 , pp. 976-982
    • Vande Broek, I.1    Asosingh, K.2    Allegaert, V.3    Leleu, X.4    Facon, T.5    Vanderkerken, K.6    Van Camp, B.7    Van Riet, I.8
  • 101
    • 70350038004 scopus 로고    scopus 로고
    • Syndecan-1 is required for robust growth, vascularization, and metastasis of myeloma tumors in vivo
    • Khotskaya Y.B., Dai Y., Ritchie J.P., MacLeod V., Yang Y., Zinn K., Sanderson R.D. Syndecan-1 is required for robust growth, vascularization, and metastasis of myeloma tumors in vivo. J. Biol. Chem. 2009, 284:26085-26095.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26085-26095
    • Khotskaya, Y.B.1    Dai, Y.2    Ritchie, J.P.3    MacLeod, V.4    Yang, Y.5    Zinn, K.6    Sanderson, R.D.7
  • 103
    • 38449111543 scopus 로고    scopus 로고
    • NK4 gene therapy targeting HGF-Met and angiogenesis
    • Matsumoto K., Nakamura T. NK4 gene therapy targeting HGF-Met and angiogenesis. Front. Biosci. 2008, 13:1943-1951.
    • (2008) Front. Biosci. , vol.13 , pp. 1943-1951
    • Matsumoto, K.1    Nakamura, T.2
  • 106
    • 0345534770 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a possible role for HGF in myeloma-associated osteolytic bone disease
    • Hjertner O., Torgersen M.L., Seidel C., Hjorth-Hansen H., Waage A., Borset M., Sundan A. Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a possible role for HGF in myeloma-associated osteolytic bone disease. Blood 1999, 94:3883-3888.
    • (1999) Blood , vol.94 , pp. 3883-3888
    • Hjertner, O.1    Torgersen, M.L.2    Seidel, C.3    Hjorth-Hansen, H.4    Waage, A.5    Borset, M.6    Sundan, A.7
  • 107
    • 0028281827 scopus 로고
    • Interleukin-11 - a new cytokine critical for osteoclast development, J. Clin. Invest.
    • G. Girasole, G. Passeri, R.L. Jilka and S.C. Manolagas, Interleukin-11 - a new cytokine critical for osteoclast development, J. Clin. Invest. 93 (1994) 1516-1524.
    • (1994) , vol.93 , pp. 1516-1524
    • Girasole, G.1    Passeri, G.2    Jilka, R.L.3    Manolagas, S.C.4
  • 108
    • 33947605189 scopus 로고    scopus 로고
    • HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
    • Standal T., Abildgaard N., Fagerli U.M., Stordal B., Hjertner O., Borset M., Sundan A. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood 2007, 109:3024-3030.
    • (2007) Blood , vol.109 , pp. 3024-3030
    • Standal, T.1    Abildgaard, N.2    Fagerli, U.M.3    Stordal, B.4    Hjertner, O.5    Borset, M.6    Sundan, A.7
  • 109
    • 33947605712 scopus 로고    scopus 로고
    • NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
    • Du W., Hattori Y., Yamada T., Matsumoto K., Nakamura T., Sagawa M., Otsuki T., Niikura T., Nukiwa T., Ikeda Y. NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor. Blood 2007, 109:3042-3049.
    • (2007) Blood , vol.109 , pp. 3042-3049
    • Du, W.1    Hattori, Y.2    Yamada, T.3    Matsumoto, K.4    Nakamura, T.5    Sagawa, M.6    Otsuki, T.7    Niikura, T.8    Nukiwa, T.9    Ikeda, Y.10
  • 110
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 2005, 5:251-262.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 111
    • 7944238214 scopus 로고    scopus 로고
    • Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma
    • Kawano R., Ohshima K., Karube K., Yamaguchi T., Kohno S., Suzumiya J., Kikuchi M., Tamura K. Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2004, 127:305-307.
    • (2004) Br. J. Haematol. , vol.127 , pp. 305-307
    • Kawano, R.1    Ohshima, K.2    Karube, K.3    Yamaguchi, T.4    Kohno, S.5    Suzumiya, J.6    Kikuchi, M.7    Tamura, K.8
  • 114
    • 0032171594 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor and its receptor c-met in human leukemia-lymphoma cell lines
    • Pons E., Uphoff C.C., Drexler H.G. Expression of hepatocyte growth factor and its receptor c-met in human leukemia-lymphoma cell lines. Leuk. Res. 1998, 22:797-804.
    • (1998) Leuk. Res. , vol.22 , pp. 797-804
    • Pons, E.1    Uphoff, C.C.2    Drexler, H.G.3
  • 115
    • 0029778863 scopus 로고    scopus 로고
    • Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines
    • Borset M., Lien E., Espevik T., Helseth E., Waage A., Sundan A. Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. J. Biol. Chem. 1996, 271:24655-24661.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24655-24661
    • Borset, M.1    Lien, E.2    Espevik, T.3    Helseth, E.4    Waage, A.5    Sundan, A.6
  • 119
    • 58149147368 scopus 로고    scopus 로고
    • Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer
    • Toschi L., Janne P.A. Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer. Clin. Cancer Res. 2008, 14:5941-5946.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5941-5946
    • Toschi, L.1    Janne, P.A.2
  • 120
    • 65249122512 scopus 로고    scopus 로고
    • Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
    • Eder J.P., Vande Woude G.F., Boerner S.A., LoRusso P.M. Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin. Cancer Res. 2009, 15:2207-2214.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2207-2214
    • Eder, J.P.1    Vande Woude, G.F.2    Boerner, S.A.3    LoRusso, P.M.4
  • 121
  • 124
    • 0035912757 scopus 로고    scopus 로고
    • Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
    • Cao B., Su Y., Oskarsson M., Zhao P., Kort E.J., Fisher R.J., Wang L.M., Vande Woude G.F. Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models. Proc. Natl. Acad. Sci. USA 2001, 98:7443-7448.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7443-7448
    • Cao, B.1    Su, Y.2    Oskarsson, M.3    Zhao, P.4    Kort, E.J.5    Fisher, R.J.6    Wang, L.M.7    Vande Woude, G.F.8
  • 126
    • 47249110366 scopus 로고    scopus 로고
    • Interim results from a first-in-human study with AMG102, a fully human monoclonal antibody that neutralizes hepatocyte growth factor (HGF), the ligand to c-Met receptor, in patients (pts) with advanced solid tumors
    • 2007 ASCO Annual Meeting Proceedings
    • Gordon M.S., Mendelson D.S., Sweeney C., Erbeck N., Patel R., Kakkar T., Yan L., Eckhardt S.G., Gore L. Interim results from a first-in-human study with AMG102, a fully human monoclonal antibody that neutralizes hepatocyte growth factor (HGF), the ligand to c-Met receptor, in patients (pts) with advanced solid tumors. Journal of Clinical Oncology 2007, Vol 25, No. 18S:3551.
    • (2007) Journal of Clinical Oncology , pp. 3551
    • Gordon, M.S.1    Mendelson, D.S.2    Sweeney, C.3    Erbeck, N.4    Patel, R.5    Kakkar, T.6    Yan, L.7    Eckhardt, S.G.8    Gore, L.9
  • 127
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • Kim K.J., Wang L., Su Y.C., Gillespie G.Y., Salhotra A., Lal B., Laterra J. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin. Cancer Res. 2006, 12:1292-1298.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.C.3    Gillespie, G.Y.4    Salhotra, A.5    Lal, B.6    Laterra, J.7
  • 130
    • 19544389146 scopus 로고    scopus 로고
    • C-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
    • Christensen J.G., Burrows J., Salgia R. c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett. 2005, 225:1-26.
    • (2005) Cancer Lett. , vol.225 , pp. 1-26
    • Christensen, J.G.1    Burrows, J.2    Salgia, R.3
  • 133
    • 34249984736 scopus 로고    scopus 로고
    • HER3 and mutant EGFR meet MET
    • Arteaga C.L. HER3 and mutant EGFR meet MET. Nat. Med. 2007, 13:675-677.
    • (2007) Nat. Med. , vol.13 , pp. 675-677
    • Arteaga, C.L.1
  • 135
    • 38049124932 scopus 로고    scopus 로고
    • Phase I experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors
    • No. 18S (June 20 Supplement), ASCO Annual Meeting Proceedings Part I
    • Eder J., Heath E., Appleman L., Shapiro G., Wang D., Malburg L., Zhu A., Leader T., Wolanski A., LoRusso P. Phase I experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors. Journal of Clinical Oncology 2007, Vol. 25, No. 18S (June 20 Supplement):3526.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 3526
    • Eder, J.1    Heath, E.2    Appleman, L.3    Shapiro, G.4    Wang, D.5    Malburg, L.6    Zhu, A.7    Leader, T.8    Wolanski, A.9    LoRusso, P.10
  • 136
    • 71049154727 scopus 로고    scopus 로고
    • A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC)
    • (suppl; abstr 5103)
    • Srinivasan R., Linehan W., Vaishampayan U., Logan T., Shankar S., Sherman L., Liu Y., Choueiri K. A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC). J. Clin. Oncol. 2009, 27:15s. (suppl; abstr 5103).
    • (2009) J. Clin. Oncol. , vol.27
    • Srinivasan, R.1    Linehan, W.2    Vaishampayan, U.3    Logan, T.4    Shankar, S.5    Sherman, L.6    Liu, Y.7    Choueiri, K.8
  • 137
    • 77950558200 scopus 로고    scopus 로고
    • Assessment of two dosing schedules of GSK1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in metastatic gastric cancer (GC): interim results of a multicenter phase II study
    • (suppl; abstr 4502)
    • Jhawer M., Kindler H., Wainberg Z., Ford J., Kunz P., Tang L., McCallum S., Kallender H., Shah M. Assessment of two dosing schedules of GSK1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in metastatic gastric cancer (GC): interim results of a multicenter phase II study. J. Clin. Oncol. 2009, 27:15s. (suppl; abstr 4502).
    • (2009) J. Clin. Oncol. , vol.27
    • Jhawer, M.1    Kindler, H.2    Wainberg, Z.3    Ford, J.4    Kunz, P.5    Tang, L.6    McCallum, S.7    Kallender, H.8    Shah, M.9
  • 139
    • 67349243424 scopus 로고    scopus 로고
    • Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule
    • (May 20 suppl; abstr 3584)
    • Yap T., Harris D., Barriuso J., Wright W., Riisnaes R., Clark J., Ledaki I., Savage R., Chen T., De Bono J. Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule. J. Clin. Oncol. 2008, 26. (May 20 suppl; abstr 3584).
    • (2008) J. Clin. Oncol. , vol.26
    • Yap, T.1    Harris, D.2    Barriuso, J.3    Wright, W.4    Riisnaes, R.5    Clark, J.6    Ledaki, I.7    Savage, R.8    Chen, T.9    De Bono, J.10
  • 140
    • 76749109321 scopus 로고    scopus 로고
    • Final results: a dose escalation phase I study of ARQ 197, a selective c-Met inhibitor, in patients with metastatic solid tumors
    • (suppl; abstr 3548)
    • Mekhail T., Rich T., Rosen L., Chai F., Semic-Suka Z., Savage R., Senzer N. Final results: a dose escalation phase I study of ARQ 197, a selective c-Met inhibitor, in patients with metastatic solid tumors. J. Clin. Oncol. 2009, 27:15s. (suppl; abstr 3548).
    • (2009) J. Clin. Oncol. , vol.27
    • Mekhail, T.1    Rich, T.2    Rosen, L.3    Chai, F.4    Semic-Suka, Z.5    Savage, R.6    Senzer, N.7
  • 141
    • 76749168413 scopus 로고    scopus 로고
    • Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib
    • (suppl; abstr 3549)
    • Laux I., Goldman J., Just R., Brady K., Li J., Schwartz B., Savage R., Garmey E., Rosen L. Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib. J. Clin. Oncol. 2009, 27:15s. (suppl; abstr 3549).
    • (2009) J. Clin. Oncol. , vol.27
    • Laux, I.1    Goldman, J.2    Just, R.3    Brady, K.4    Li, J.5    Schwartz, B.6    Savage, R.7    Garmey, E.8    Rosen, L.9
  • 142
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen J.G., Zou H.Y., Arango M.E., Li Q., Lee J.H., McDonnell S.R., Yamazaki S., Alton G.R., Mroczkowski B., Los G. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol. Cancer Ther. 2007, 6:3314-3322.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3    Li, Q.4    Lee, J.H.5    McDonnell, S.R.6    Yamazaki, S.7    Alton, G.R.8    Mroczkowski, B.9    Los, G.10
  • 143
    • 70350140489 scopus 로고    scopus 로고
    • Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
    • (suppl; abstr 3509)
    • Kwak E., Camidge D., Clark J., Shapiro G., Maki G., Ratain M., Solomon B., Bang Y., Ou S., Salgia R. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J. Clin. Oncol. 2009, 27:15s. (suppl; abstr 3509).
    • (2009) J. Clin. Oncol. , vol.27
    • Kwak, E.1    Camidge, D.2    Clark, J.3    Shapiro, G.4    Maki, G.5    Ratain, M.6    Solomon, B.7    Bang, Y.8    Ou, S.9    Salgia, R.10
  • 149
    • 36549021634 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies
    • ASCO Annual Meeting Proceedings Part I
    • Salgia R., Hong D., Camacho L., Ng C., Janisch L., Ratain M., Kurzrock R. A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies. Journal of Clinical Oncology 2007, Vol 25, No. 18S (June 20 Supplement):14031.
    • (2007) Journal of Clinical Oncology , pp. 14031
    • Salgia, R.1    Hong, D.2    Camacho, L.3    Ng, C.4    Janisch, L.5    Ratain, M.6    Kurzrock, R.7
  • 150
    • 56849132326 scopus 로고    scopus 로고
    • A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC)
    • (May 20 suppl; abstr 3522)
    • Salgia R., Sherman S., Hong D., Ng C., Frye J., Janisch L., Ratain M., Kurzrock R. A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC). J. Clin. Oncol. 2008, 26. (May 20 suppl; abstr 3522).
    • (2008) J. Clin. Oncol. , vol.26
    • Salgia, R.1    Sherman, S.2    Hong, D.3    Ng, C.4    Frye, J.5    Janisch, L.6    Ratain, M.7    Kurzrock, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.