The role of large-scale motions in catalysis by dihydrofolate reductase

Journal of the American Chemical Society

Volumn 133, Issue 50, 2011, Pages 20561-20570

  Loveridge, E Joel ^a,d   Tey, Lai Hock ^a,e   Behiry, Enas M ^a   Dawson, William M ^a   Evans, Rhiannon M ^a,f   Whittaker, Sara B M ^b   Günther, Ulrich L ^b   Williams, Christopher ^c   Crump, Matthew P ^c   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d SWANSEA UNIVERSITY   (United Kingdom)

^e UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYZED REACTIONS; COLD-ADAPTED BACTERIA; CONFORMATIONAL ENSEMBLE; COSOLVENTS; DIHYDROFOLATE REDUCTASE; HYDRIDE TRANSFERS; HYDROGEN/DEUTERIUM EXCHANGE; KINETIC ISOTOPE EFFECTS; LARGE AMPLITUDE; MODEL SYSTEM; NMR-SPECTROSCOPY; PROTEIN MOTION; TEMPERATURE DEPENDENCE;

BACTERIA; CARRIER MOBILITY; CATALYSIS; CONFORMATIONS; ENZYMES; ESCHERICHIA COLI; ISOTOPES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; REACTION RATES;

HYDRIDES;

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE; MORITELLA PROFUNDA DIHYDROFOLATE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVITY; ENZYME CONFORMATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TEMPERATURE DEPENDENCE;

BIOCATALYSIS; CIRCULAR DICHROISM; KINETICS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 83755168786     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208844j     Document Type: Article

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